超小型衛星の組立て統合試験プログラム管理における意思決定方法に関する研究

九州工業大学博士学位論文（要旨）学位記番号：工博甲第438号 学位授与年月日：平成29年6月30

Cal Poly CubeSat Kit - A Technical Introduction to Mk I

The California Polytechnic State University’s Aerospace Engineering Department is developing a CubeSat Kit for educational, professional training, and capacity building purposes. The development of the CubeSat Kit follows phases and since its initiation in Fall 2019, eleven undergraduate students and three graduate students have been involved in the initiative. The first phase, CubeSat Kit Mk I, is planned to be completed by spring 2021. For Mk I, the Kit includes a structure, integrated payload processing module (IPPM), electrical power subsystem (EPS), and a backplane. The Kit’s Mk I structure was designed to enable additive and subtractive manufacturing. Hence, a wide range of the CubeSat community is able to manufacture the structure depending on their use case, manufacturing capabilities, and overall availability of resources. The IPPM is the interface between the CubeSat bus and payloads. The functions of the IPPM are to autonomously manage and operate all the payloads mounted on the CubeSat Kit, such as CMOS camera and thermal sensors. The EPS is based on direct-energy transfer, includes 5V and 3.3V voltage regulation, and implements lithium-ion battery pack. The IPPM and EPS boards are integrated on the CubeSat Kit using the backplane concept. In parallel to the structure, IPPM, EPS, and backplane, flight software is being developed to be integrated on the Kit’s on-board computer for Mk II. Upon completion, the flight software will enable the tasks management of the various elements of the CubeSat Kit. This paper details the design, performances, and verification of the Cal Poly CubeSat Kit Mk I and introduces the design plan for the CubeSat Kit Mk II

Leveraging the Success of the CubeSat Standard to Create a SmallSat Standard for ESPA Spacecraft

The space industry has found significant utility in short turn-around, small satellite missions. There has also been a significant increase in both rideshare and dedicated launch opportunities for small satellites around the world. Small satellites can be developed in much shorter timelines than the traditional, large spacecraft missions. In order to fully leverage the short-development time of small satellites, a standardized design approach is required. Following the success of the CubeSat Design Specification (CDS), it is clear that a standard set of specifications in a concise document allows developers to design their spacecraft without knowledge of their specific launch opportunity. A publicly available standard provides developers and launch vehicles with a set of common parameters for initial design and analyses. CubeSats have shown that a standardization approach is effective at getting missions to space quickly and inexpensively. As the small satellite industry continues to flourish, adapting to the new paradigm is crucial to widespread success

SmallSat Space Solar Power: A Pathway to a Sustainable Future

On the 29th of July, 2019, humanity had already used more resources than the Earth regenerated in the entirety of the year. This is while 13% of people do not have access to electricity, and 40% do not have access to clean energy for cooking. Simply put, the Earth cannot sustain humanity’s energy needs

Sécurisation du circuit du médicament et son administration dans les EHPAD (formation du personnel soignant par le pharmacien)

Devant un vieillissement de la population et une espérance de vie augmentée dans un contexte polypathologique, les Établissements d Hébergement pour Personnes Agées Dépendantes (EHPAD) occupent une place de plus en plus importante dans les structures de soins et de vie pour le secteur gériatrique. Face à la complexité du circuit du médicament en son sein, notamment de par les nombreux acteurs de santé intervenant, sa sécurisation devient primordiale et représente un des objectifs de santé publique prioritaires. En effet, l iatrogénie médicamenteuse serait responsable de plus de 10 % des hospitalisations chez le sujet âgé, dont près d un tiers serait lié à une erreur d administration. Cela peut être dû à une mauvaise utilisation du médicament, plus particulièrement par la modification de la galénique des formes orales solides (comprimés et gélules) effectuée par le personnel soignant devant des patients ayant des difficultés de déglutition (plus d un tiers des résidents par établissement concerné). Mal informé des nombreux risques que cet acte comporte, ce dernier en a fait une pratique banalisée, le plus souvent sans en informer le prescripteur ou le pharmacien. Devant ce constat, un état des lieux des pratiques a été établi dans quatre EHPAD de l Isère, ainsi qu une formation du personnel soignant sur ce sujet, afin d éviter cette pratique au maximum, ou tout du moins de la contrôler.GRENOBLE1-BU Médecine pharm. (385162101) / SudocSudocFranceF

Space Dust Impacts Detector Development for the Evaluation of Ejecta

AbstractThis paper aims at a) introducing the space dust impacts detector developed at Kyushu Institute of Technology (KIT), b) presenting the detector utility for the evaluation of ejecta, and c) raising awareness of the space community regarding the risk represented by orbital debris. The space dust impacts detector introduced into this paper belongs to the in-situ detection systems and has for purposes to be a) light, 30g, b) low cost, about EUR200, c) low power consuming, 0.01W, d) easily adaptable on-board of spacecraft, and e) able to detect impacts of debris with a diameter ranging from 100μm to 600μm. The detector is mounted on the nano-satellite, Horyu-II, developed at KIT and launched on May 18, 2012. The data received will be very helpful to identify the detector's strengths and weaknesses to improve it and create a second version that will aim at evaluating ejecta fragments produced during hypervelocity impact testing. An accurate evaluation of ejecta is critical for orbital debris risk assessment and mitigation. If all space activities were stopped, debris will still be created by chain reaction. The number of debris could then become so large, that the access to certain LEOs will be quasi-impossible, which will jeopardize the space exploration as well as scientific, educational, and security missions that benefit to all mankind. Debris is therefore a serious issue that should be taken into consideration at every step of the development of a small or large spacecraft

BIRDS-2: Multi-Nation Cubesat Constellation Project for Learning and Capacity Building

The BIRDS project began in October, 2015 with an objective to provide hands on experience to the graduate students on satellite technology. In a BIRDS project, the students define missions, design, build, test, and operate satellite within given time frame of the project. A 1U CubeSat is built per participating country which are then released from International Space Station (ISS) into Low Earth Orbit (LEO) and operated through a ground station network, with one ground station established in each member nation. That being the first is series, the second BIRDS project or so called BIRDS-2 project started in November, 2016 with students from, Philippines, Bhutan, Malaysia and Japan. Lean philosophy is adopted for the development of CubeSats and an overlap of a year is created between successive projects so that the lessons learned and knowledge gained from each project is properly passed on. The BIRDS program targets to improve the development process of a CubeSat while maintaining/improving the reliability and reducing waste. But the true success of the program is indicated by the ability of project members to replicate what they learn from this project, at their home country after graduating

A Deeper Look into the Ionospheric Scintillation eXplorer (ISX): A Failure Analysis

The Ionospheric Scintillation eXplorer (ISX) mission is a collaboration between SRI International and Cal Poly. The ISX space weather investigation seeks to better understand the physics of naturally occurring Equatorial Spread F ionospheric irregularities by deploying a passive UHF radio scintillation receiver. Rocket Lab’s Electron-4 launch vehicle successfully placed ISX into a nearly sun synchronous orbit 500km above the surface of the Earth, however contact was never made with the spacecraft. Since this anomaly, Cal Poly has taken an extensive look into the possible failure causes on ISX, including a system level fault tree and additional testing with the engineering test unit. The primary takeaway from the failure analysis is the importance of testing beyond what is considered normal for CubeSats. The second main conclusion reinforces the important role that adequately documenting the spacecraft design, fabrication, and testing plays in performing a post hoc failure analysis. In addition to presenting analysis outcomes, this paper addresses both of these main takeaways

2BC Non-Structural Protein of Enterovirus A71 Interacts with SNARE Proteins to Trigger Autolysosome Formation

Viruses have evolved unique strategies to evade or subvert autophagy machinery. Enterovirus A71 (EV-A71) induces autophagy during infection in vitro and in vivo. In this study, we report that EV-A71 triggers autolysosome formation during infection in human rhabdomyosarcoma (RD) cells to facilitate its replication. Blocking autophagosome-lysosome fusion with chloroquine inhibited virus RNA replication, resulting in lower viral titres, viral RNA copies and viral proteins. Overexpression of the non-structural protein 2BC of EV-A71 induced autolysosome formation. Yeast 2-hybrid and co-affinity purification assays showed that 2BC physically and specifically interacted with a N-ethylmaleimide-sensitive factor attachment receptor (SNARE) protein, syntaxin-17 (STX17). Co-immunoprecipitation assay further showed that 2BC binds to SNARE proteins, STX17 and synaptosome associated protein 29 (SNAP29). Transient knockdown of STX17, SNAP29, and microtubule-associated protein 1 light chain 3B (LC3B), crucial proteins in the fusion between autophagosomes and lysosomes) as well as the lysosomal-associated membrane protein 1 (LAMP1) impaired production of infectious EV-A71 in RD cells. Collectively, these results demonstrate that the generation of autolysosomes triggered by the 2BC non-structural protein is important for EV-A71 replication, revealing a potential molecular pathway targeted by the virus to exploit autophagy. This study opens the possibility for the development of novel antivirals that specifically target 2BC to inhibit formation of autolysosomes during EV-A71 infection.Peer reviewe

Encapsulation of epsilon-Viniferin into Multi-Lamellar Liposomes: Development of a Rapid, Easy and Cost-Efficient Separation Method to Determine the Encapsulation Efficiency

Onion-type multi-lamellar liposomes (MLLs), composed of a mixture of phosphatidylcholine and Tween 80, were analyzed for their ability to encapsulate epsilon-Viniferin (epsilon Vin), a resveratrol dimer. Their encapsulation efficiency (EE) was measured by UV-VIS spectroscopy using three different separation methods-ultracentrifugation, size exclusion chromatography, and a more original and advantageous one, based on adsorption filtration. The adsorption filtration method consists indeed of using syringe filters to retain the molecule of interest, and not the liposomes as usually performed. The process is rapid (less than 10 min), easy to handle, and inexpensive in terms of sample amount (around 2 mg of liposomes) and equipment (one syringe filter is required). Whatever the separation method, a similar EE value was determined, validating the proposed method. A total of 80% +/- 4% of epsilon Vin was found to be encapsulated leading to a 6.1% payload, roughly twice those reported for resveratrol-loaded liposomes. Finally, the release kinetics of epsilon Vin from MLLs was followed for a 77 day period, demonstrating a slow release of the polyphenol