Confidence in College Athletics

I researched the processes used by intercollegiate athletes to maintain confidence throughout their sports career, including how they prepared for games/competitions, how they dealt with pressures, and how other factors affected their performance and thought process during games. For this research, I created and administered an online survey to 70 college athletes across four sports. I found that many things gave the athletes confidence in themselves to play their sport such as family and preparation. However, some things also lowered the respondents’ confidence levels such as failing and negativity. Results imply that athletes, for the most part, seem confident and optimistic. The majority of participants had past struggles with confidence, but were able to overcome them with the support of teammates, coaches, family, and friends

A dietary supplementation with leucine and antioxidants is capable to accelerate muscle mass recovery after immobilization in adult rats

Prolonged inactivity induces muscle loss due to an activation of proteolysis and decreased protein synthesis; the latter is also involved in the recovery of muscle mass. The aim of the present work was to explore the evolution of muscle mass and protein metabolism during immobilization and recovery and assess the effect of a nutritional strategy for counteracting muscle loss and facilitating recovery. Adult rats (6-8 months) were subjected to unilateral hindlimb casting for 8 days (10-18) and then permitted to recover for 10 to 40 days (R10-R40). They were fed a Control or Experimental diet supplemented with antioxidants/polyphenols (AOX) (10 to 18), AOX and leucine (AOX + LEU) (18 to R15) and LEU alone (R15 to R40). Muscle mass, absolute protein synthesis rate and proteasome activities were measured in gastrocnemius muscle in casted and non-casted legs in post prandial (PP) and post absorptive (PA) states at each time point. Immobilized gastrocnemius protein content was similarly reduced (-37%) in both diets compared to the non-casted leg. Muscle mass recovery was accelerated by the AOX and LEU supplementation (+6% AOX+LEU vs. Control, P<0.05 at R40) due to a higher protein synthesis both in PA and PP states (+23% and 31% respectively, Experimental vs. Control diets, P<0.05, R40) without difference in trypsin-and chymotrypsin-like activities between diets. Thus, this nutritional supplementation accelerated the recovery of muscle mass via a stimulation of protein synthesis throughout the entire day (in the PP and PA states) and could be a promising strategy to be tested during recovery from bed rest in humans

A MAP6-Related Protein Is Present in Protozoa and Is Involved in Flagellum Motility

In vertebrates the microtubule-associated proteins MAP6 and MAP6d1 stabilize cold-resistant microtubules. Cilia and flagella have cold-stable microtubules but MAP6 proteins have not been identified in these organelles. Here, we describe TbSAXO as the first MAP6-related protein to be identified in a protozoan, Trypanosoma brucei. Using a heterologous expression system, we show that TbSAXO is a microtubule stabilizing protein. Furthermore we identify the domains of the protein responsible for microtubule binding and stabilizing and show that they share homologies with the microtubule-stabilizing Mn domains of the MAP6 proteins. We demonstrate, in the flagellated parasite, that TbSAXO is an axonemal protein that plays a role in flagellum motility. Lastly we provide evidence that TbSAXO belongs to a group of MAP6-related proteins (SAXO proteins) present only in ciliated or flagellated organisms ranging from protozoa to mammals. We discuss the potential roles of the SAXO proteins in cilia and flagella function

Le syndrome métabolique après transplantation rénale

MONTPELLIER-BU Médecine UPM (341722108) / SudocMONTPELLIER-BU Médecine (341722104) / SudocSudocFranceF

L' éducation thérapeutique à l'officine (application à l'asthme et la bronchopneumopathie chronique obstructive)

L asthme et la bronchopneumopathie chronique obstructive sont des maladies respiratoires chroniques, à l origine de conséquences importantes en termes de qualité de vie et de dépenses de santé, représentant un problème de santé majeur. La prise en charge de ces pathologies ne se résume pas aux traitements médicamenteux mais l éducation thérapeutique fait partie intégrante de la stratégie de prise en charge. Elle permet aux patients d acquérir et maintenir des compétences et des connaissances sur la maladie et le traitement, qui les aideront à vivre mieux avec leur maladie au quotidien. L éducation thérapeutique est un processus structuré par étapes, s inscrivant dans la durée, qui donne une réponse adaptée aux besoins du patient devenant acteur de sa propre santé. Le pharmacien, se plaçant comme professionnel de santé de proximité, a un rôle clé à jouer dans la mise en œuvre de l éducation thérapeutique de ces patients en ce qui concerne notamment la compréhension de la maladie et des traitements, l observance médicamenteuse, le bon usage des médicaments, la maîtrise des facteurs déclenchants, l apprentissage des techniques d inhalation et de l autosurveillance. Cette nouvelle mission demande au pharmacien une formation spécifique afin d acquérir les compétences adaptées pour proposer une éducation thérapeutique de qualité. A l heure où la pharmacie d officine traverse une crise professionnelle grave, la participation à une éducation du patient est une véritable opportunité pour le pharmacien de refonder son métier et d améliorer la prise en charge des patients.ANGERS-BU Médecine-Pharmacie (490072105) / SudocSudocFranceF

Effect of the injection of water-containing diluents on band broadening in analytical supercritical fluid chromatography

The authors are deeply grateful to Agilent Technologies for the loan of the Infinity I fixed-loop injection module and especially Audrey Menet for her technical advices. Marion Burlet-Parendel is acknowledged for preliminary results.International audienc