Identificación de Leishmania infantum en Puerto Iguazú, Misiones, Argentina

The emergence of zoonotic visceral leishmaniasis (ZVL) in Latin America is a growing public health problem. The urbanization of ZVL has been observed in different countries around the world, and there are a growing number of reports drawing attention to the emergence of this infection in new locations, as well as its increase in previously established areas of endemicity. In the city of Posadas, Misiones province, Northeastern Argentina, the transmission of ZVL associated with canines and Lutzomyia longipalpis was first reported in 2006. In the city of Puerto Iguazú, also in Misiones province, the first human case of ZVL was reported in February 2014. From 209 surveyed dogs, 15 (7.17%) were identified as positive by serological and/or parasitological methods. Amplification was observed in 14 samples and in all cases the species implicated was Leishmania infantum. To the authors’ knowledge, this is the first molecular characterization of L. infantum from dogs in this area.La emergencia de leishmaniosis visceral zoonótica (LVZ) en América Latina es problema de salud pública en aumento. La urbanización de la LVZ es un fenómeno observado en diferentes países alrededor del mundo y hay un número creciente tanto de denuncias respecto a la aparición de esta infección en nuevas ubicaciones, como su aumento en zonas endémicas previamente establecidas. En la ciudad de Posadas, provincia de Misiones, nordeste de Argentina, la transmisión de LVZ asociada a canes y Lutzomyia longipalpis fue descrita por primera vez en 2006. En la ciudad de Puerto Iguazú, provincia de Misiones, el primer caso humano de LVZ tuvo lugar en febrero de 2014. De 209 perros muestreados, 15 (7.17%) resultaron positivos mediante métodos serológicos y/o parasitológicos. Se observó amplificación en 14 muestras y en todos los casos la especie implicada fue Leishmania infantum. Según nuestro conocimiento, esta es la primera caracterización molecular de L. infantum en perros procedentes de este área

Diversity of containers and buildings infested with Aedes aegypti in Puerto Iguazú, Argentina.

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2012-11-20T16:40:24Z No. of bitstreams: 1 Costa F Diversity of containers....pdf: 82471 bytes, checksum: a46b0abd09873ded8a5c82de8d02d474 (MD5)Made available in DSpace on 2012-11-20T16:40:24Z (GMT). No. of bitstreams: 1 Costa F Diversity of containers....pdf: 82471 bytes, checksum: a46b0abd09873ded8a5c82de8d02d474 (MD5) Previous issue date: 2012Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundación Mundo Sano. Buenos Aires, ArgentinaFundación Mundo Sano. Buenos Aires, ArgentinaAedes aegypti is the main domestic vector of the dengue virus. Control measures to prevent dengue transmission focus on the treatment and elimination of this vector's oviposition sites. There is limited biological information on Ae. aegypti in Argentina. The aim of this study was to characterize Ae. aegypti oviposition sites in the city of Puerto Iguazú, Argentina. We surveyed an area covering nine neighborhoods in 2005. We identified 191 premises as positive for Ae. aegypti, giving a general house index of 9.6%. Premises classified as residential and vacant lots presented the highest number of infested premises, with 9% and 22% respectively. The total number of surveyed containers was 29,600. The overall container index (CI) was 1.1. The most frequently infested containers were water tanks (CI = 37). These preliminary results suggest that vacant lots and water tanks provide suitable breeding areas and environmental conditions, improving the chances of Ae. aegypti survival in Puerto Iguaz

Antropología médica de la Leishmaniasis Tegumentaria Americana (LTA) : un estudio de caso en alto Paraná misionero

Fil: Mastrangelo, Andrea. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Humanidades Médicas; ArgentinaFil: Fattore, Gladys. Fundación Mundo Sano; ArgentinaFil: Pereira, Sandra G. Universidad de Buenos Aires. Facultad de Filosofía y Letras. Departamento de Geografía; ArgentinaEste escrito es parte de los primeros resultados de un proyecto de investigación cuyo objetivo general es conocer los procesos, representaciones sociales y grupos vulnerables al riesgo de contraer leishmaniasis en el NO de la provincia de Misiones (Argentina). La finalidad del mismo es contribuir a planificar estrategias de prevención y control basadas en la evidencia, para asegurar que la información científica relevante sobre protección y tratamiento de la leishmaniasis circule, en el área de estudio, por redes sociales pertinentes.This paper describes first results of a research project about social representations and practices in a risk group of Tegumentary Leishmaniasis (Argentina NE, Misiones province). Main objective of this field research is to contribute for based on evidence prevention planning, trying to ensure disease scientific information about prevention and treatment flow by proper social nets in the area under studying

Epidemiological aspects of cutaneous leishmaniasis in the Iguazú falls area of Argentina

Over the last three decades the incidence of American cutaneous leishmaniasis (ACL) has increased sharply in Argentina and throughout the world. In the Iguazú Falls area, on the border between Brazil and Paraguay, the incidence of human ACL has risen since 2004. Most of the 36 cases of human ACL reported until 2005 have involved males over 15 years old (75%) infected during deforestation to establish individual farms. Captures carried out in primary forest, periurban areas, and deforested land sites yielded 18,438 sand flies belonging to 13 species; the most prevalent species were Lutzomyia (Nyssomyia) whitmani (87.4%) and Lutzomyia (Mygonemyia.) migonei (7.6%). Cluster analysis was used to group traps according to species and abundance of sand flies. The group of traps located in recently deforested places, in pig and chicken dwellings of houses where ACL cases had been reported in the past, and at one house with an active ACL case, had the highest abundance of Lu. whitmani and Lu. whitmani + Lu. migonei as well as the highest ratio of Lu. whitmani/Lu. migonei. Leishmania sp. infections, both in Lu. whitmani, in Lu. quinquefer, and in smears from human cases were detected by DNA kinetoplast amplification using a generic PCR protocol. The risk of ACL outbreak in the Iguazú Falls area is still associated with economic and leisure activities in primary-secondary forest, including deforestation, rural settlements, fishing, hunting, and ecotourism. In addition, the risk of periurban transmission seems likely, and this is discussed within the framework of surveillance and prevention strategies. © 2008 Elsevier B.V. All rights reserved.Fil: Salomón, Oscar Daniel. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Centro Nacional de Diagnóstico e Investigaciones Endemo-epidémicas; ArgentinaFil: Acardi, Soraya Alejandra. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; ArgentinaFil: Liotta, Domingo Javier. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; ArgentinaFil: Fernández, María Soledad. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Centro Nacional de Diagnóstico e Investigaciones Endemo-epidémicas; ArgentinaFil: Lestani, Eduardo Ariel. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Centro Nacional de Diagnóstico e Investigaciones Endemo-epidémicas; ArgentinaFil: López, Deborah. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Centro Nacional de Diagnóstico e Investigaciones Endemo-epidémicas; ArgentinaFil: Mastrangelo, Andrea Veronica. Facultad de Humanidades y Ciencias Sociales; ArgentinaFil: Figueroa, Marianela. Universidad de Buenos Aires; ArgentinaFil: Fattore, Gladys. Fundación Mundo Sano; Argentin

Diversity of containers and buildings infested with Aedes aegypti in Puerto Iguazú, Argentina Diversidad de recipientes y edificios infestados por Aedes aegypti en Puerto Iguazú, Argentina

Aedes aegypti is the main domestic vector of the dengue virus. Control measures to prevent dengue transmission focus on the treatment and elimination of this vector's oviposition sites. There is limited biological information on Ae. aegypti in Argentina. The aim of this study was to characterize Ae. aegypti oviposition sites in the city of Puerto Iguazú, Argentina. We surveyed an area covering nine neighborhoods in 2005. We identified 191 premises as positive for Ae. aegypti, giving a general house index of 9.6%. Premises classified as residential and vacant lots presented the highest number of infested premises, with 9% and 22% respectively. The total number of surveyed containers was 29,600. The overall container index (CI) was 1.1. The most frequently infested containers were water tanks (CI = 37). These preliminary results suggest that vacant lots and water tanks provide suitable breeding areas and environmental conditions, improving the chances of Ae. aegypti survival in Puerto Iguazú.<br>El mosquito Aedes aegypti es el vector doméstico más importante del virus dengue. Existe limitada información de la biología del Ae. aegypti en Argentina. Con el fin de identificar los sitios de oviposición de Ae. aegypti en la ciudad de Puerto Iguazú, Argentina, se estudió un área compuesta por nueve barrios durante el año 2005. Se registraron 191 inmuebles positivos sobre un total de 1.977 inspeccionados. La categoría "vivienda" fue la más numerosa, y donde se encontró el mayor número de inmuebles positivos, el porcentaje de infestación fue del 9%. La categoría "baldío" registró un porcentaje de infestación de 22%. El número total de recipientes potenciales inspeccionados fue de 29.600 y 1,1% de los recipientes resultaron positivos. Por otro lado, la mayor proporción de criaderos positivos perteneció a la categoría tanques de altura (37%). Estos resultados preliminares sugieren que sitios baldíos y tanques de altura proveen posibles áreas de reproducción y condiciones ambientales que mejoran las posibilidades de supervivencia de Ae. aegypti

T helper type 2 bias and type 17 suppression in primary dengue virus infection in infants and young children

Background: The immune response to dengue virus (DENV) primary infection in infants and young children is not well characterized. In Northern Argentina, .90% of the population was DENV-naı¨ve before the 2009 outbreak, allowing evaluation of age-dependent primary responses to infection. Methods: We conducted a comparative study of the immune response to DENV in 27 infected infants, young children and their mothers. Lymphocyte T helper (Th) 1, Th2, Th17 and inflammatory responses were assayed in blood during the 2009 DENV-1 epidemic. Results: The immune response to DENV-1 was significantly biased to Th2 in infected infants and young children, compared to infants with other febrile illnesses (for IL-4 p,0.001) and to their infected mothers (for IL-4 p,0.01). In addition, IL-17 suppression was observed in the memory response to DENV-1 in infected infants (p,0.01 vs placebo). Conclusion: Age-related differences in the primary response to DENV, characterized by an immature Th2 polarization and Th17 suppression in infants, should be studied further in order to expand our understanding of the mechanism of dengue pathogenesis.Fil: Talarico, Laura Beatriz. Fundación para la Investigación en Infectologia Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bugna Hortoneda, Jimena. Fundación para la Investigación en Infectologia Infantil; ArgentinaFil: Wimmenauer, Vera. Fundación para la Investigación en Infectologia Infantil; ArgentinaFil: Espinoza, Marco A.. Hospital San Vicente de Paul; ArgentinaFil: Quipildor, Marcelo O.. Hospital San Vicente de Paul; ArgentinaFil: Hijano, Diego R.. Vanderbilt University. Department of Pediatrics; Estados Unidos. Fundación para la Investigación en Infectologia Infantil; ArgentinaFil: Beccaria, Martín. Fundación para la Investigación en Infectologia Infantil; ArgentinaFil: Wurster, Victoria. Vanderbilt University. Department of Pediatrics; Estados Unidos. Fundación para la Investigación en Infectologia Infantil; ArgentinaFil: Cavagnaro, Luis E.. Hospital SAMIC Iguazu; ArgentinaFil: Martinez, Daniel. Hospital SAMIC Iguazu; ArgentinaFil: Fattore, Gladys. Fundación Mundo Sano; ArgentinaFil: Batalle, Juan Pio. Fundación para la Investigación en Infectologia Infantil; ArgentinaFil: Acosta, Patricio Leandro. Fundación para la Investigación en Infectologia Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Reynoso, Natalia. Fundación para la Investigación en Infectologia Infantil; ArgentinaFil: Melendi, Guillermina Amanda. Vanderbilt University. Department of Pediatrics; Estados Unidos. Fundación para la Investigación en Infectologia Infantil; ArgentinaFil: Rey, Felix A.. Institut Pasteur. Département de Virologie. Unité de Virologie Structurale; FranciaFil: Libster, Romina Paula. Vanderbilt University. Department of Pediatrics; Estados Unidos. Fundación para la Investigación en Infectologia Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Polack, Fernando Pedro. Vanderbilt University. Department of Pediatrics; Estados Unidos. Fundación para la Investigación en Infectologia Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry

IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes