The effect of Sertraline, Paroxetine, Fluoxetine and Escitalopram on testicular tissue and oxidative stress parameters in rats

Introduction: The aim of this study was to evaluate the effect of selective serotonin reuptake inhibitors (SSRIs) on testicular tissue and serum malondialdehyde (MDA) levels in rats. Materials and methods: A total of 40 male Wistar albino rats, 5.5-6 months old, were equally divided at random into five groups: group 1 was the control group, group 2 received sertraline 10mg/kg (p.o), group 3 was administered fluoxetine 10mg/kg (p.o), group 4 received escitalopram 10mg/kg (p.o), and group 5 (n = 8) was administered paroxetine 20mg/kg. Each dose was administered orally for two months. Johnsen&#8217;s criteria were used to categorize spermatogenesis. Johnsen&#8217;s method assigns a score of 1 to 10 to each tubule cross-section examined. In this system, a Johnsen score of 9 and 10 indicates normal histology. Serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone levels were evaluated. Serum MDA levels were also measured. Results: The mean Johnsen scores were 9.36 &#177; 0.33, 9.29 &#177; 0.32, 8.86 &#177; 0.48, 9.10 &#177; 0.56, and 8.33 &#177; 0.90 in control group, sertraline group, fluoxetine group, escitalopram group, and paroxetine group, respectively. The Johnsen score was significantly lower for paroxetine group compared with the control group (p < 0.05). The mean FSH level increased only in the sertraline group. With the exception of the fluoxetine group, the testosterone levels were lower in all groups compared with the control group. The total testosterone level was significantly lower in the sertraline group compared with the control group [40.87 (22.37-46.8) vs. 15.87 (13.53-19.88), p < 0.01]. There were no significant differences between the groups with respect to the MDA and LH levels (p = 0.090 and p = 0.092). Conclusion: These data suggest that SSRIs have a negative effect on testicular tissues. This negative impact is markedly greater in the paroxetine group. To determine the exact mechanism of action of these drugs on testicular tissue, well-designed randomized controlled clinical studies are needed on a larger population

Effect of Funalia trogii in heart tissue of rats exposed to deltamethrin

WOS: 000314288600003Objective: Environmental exposure to deltamethrin can cause alterations in structure and function of different organs. F. Trogii, a white-rot fungus, has antioxidative enzymes such as superoxide dismutase, catalase and glutathione reductase. It is hypothesized that there is an antioxidative role of F. trogii resulting in reducing the extent of heart injury as a result of oxidative stress. The aim of this study to investigate the effect of deltamethrin on heart and to evaluate possible protective role of F. trogii in alleviating the detrimental effect of deltamethrin on heart. Materials and Methods: Twenty-one adult albino female Wistar rats were randomly divided into three groups of seven each: group 1 control, group 2 received deltamethrin, group 3 received deltamethrin plus F. trogii extract. Results: The heart rate was increased and amplitude of QRS complex, duration of P wave and QRS complex were decreased due to deltamethrin administration. The superoxide dismutase and catalase activities were decreased, malondialdehyde level was increased in deltamethrin group. Ultrastructurally, dilatation in sarcoplasmic reticulum cisternaes and disorganisation in the myofibrils were observed in the deltamethrin group. In the deltamethrin plus F. trogii extract group, a decreasing lipid peroxidation and an increasing antioxidant enzyme activity, normal heart electrical activity and normal heart muscle structure was observed as similar to control group Conclusion: F. trogii could protect against deltamethrin induced oxidative stress by decreasing lipid peroxidation and increasing superoxide dismutase and catalase activity. The results indicate the protective effect of F. trogii against heart injury and thereby support its traditional use.Mersin University Research FoundationMersin University [BAP-FEF-BB (BM) 2006-3]This research was funded by Mersin University Research Foundation (BAP-FEF-BB (BM) 2006-3)

Hyponatremia prolongs hospital stay and hypernatremia better predicts mortality than hyponatremia in hospitalized patients with community-acquired pneumonia

Introduction: Dysnatremia is reported to have a prognostic effect in various diseases. A limited number of studies have been published on dysnatremia-related parameters and clinical outcome in patients with pneumonia. The aim of the study is to analyze the factors related to baseline dysnatremia and to evaluate the clinical outcome of dysnatremia on hospital stay, 30-day and 1-year mortality in hospitalized patients with community-acquired pneumonia (CAP)

A genetic probe into the ancient and medieval history of Southern Europe and West Asia

Literary and archaeological sources have preserved a rich history of Southern Europe and West Asia since the Bronze Age that can be complemented by genetics. Mycenaean period elites in Greece did not differ from the general population and included both people with some steppe ancestry and others, like the Griffin Warrior, without it. Similarly, people in the central area of the Urartian Kingdom around Lake Van lacked the steppe ancestry characteristic of the kingdom’s northern provinces. Anatolia exhibited extraordinary continuity down to the Roman and Byzantine periods, with its people serving as the demographic core of much of the Roman Empire, including the city of Rome itself. During medieval times, migrations associated with Slavic and Turkic speakers profoundly affected the region