12 research outputs found
The Opinion Of The Patient and Patient Relatives On Giving Đnformation A bout The Cancer Diagnosis
Günümüzde kanser yıl içerisinde yüzbin civarında vakayla karşımıza çıkmaktadır. Mortalitesi halen yüksek olan bir hastalıktır. Ölümcül olması nedeniyle hasta yakınları hastalığın hastanın kendisine söylenmesini genelde istememektedir. Ancak tıbbi etik hastanın hastalığını bilmesini ve isbirliği yapmasını gerektirmektedir. Hala tartısılmakta olan bu konuyu bir anket çalısması ile aydınlatmayı amaçladık. Çalışmamız Afyon Kocatepe Üniversitesi Tıp Fakültesi Araştırma ve Uygulama Hastanesi Kemoterapi ünitesi ve diğer ünitelerde yatan 50 kanser hastası ve 50 hasta yakınından oluşmaktadır. Toplanan verilerin değerlendirilmesinde yüzdelik ve kikare (x2) testleri uygulanmıştır. Anketimiz hasta ve hasta yakınlarına ayrı sekilde hazırlanmıştır. Her iki ankette de birinci bölümde tanıtıcı özellikler, ikinci ve üçüncü bölümlerde ise verileri toplamaya yönelik sorular yer almaktadır. Araştırmada elde edilen veriler doğrultusunda öneriler geliştirilmiştir.Today, we are facing up cancer issues approximately a hundred thousand times in a year. Its mortality rate is stil high due to the fact that patient relatives, in general, is not eager to talk about the cancer to the patient. Though, medical ethics call for patients to know his/her illness and to make cooperation. It is our aim to enlight this argumentative issue with a inquery project. Our project is applied on 50 patients and 50 patient relatives in Afyon Kocatepe Research and Practical Hospital at the chemotherapy unit and the other units. Percentage and
chi-square tests are applied to evaluate the datas gained. Our inquiries are prepared differently for the patients and patient relatives. In both inquiries, it includes introductive features in the first section and there are the questions to take the datas in the second and third sections.
Based on the findings obtained in the study, recommendations have been put forth
Analysis of changes on meibomian glands with lower lid ectropion model applied on rabbits
YÖK Tez ID: 563684AMAÇ: Tavşanlara deneysel ektropiyon modeli uygulayarak ektropiyonun meibomian bezleri üzerine etkisini infrared meibografi ile ve histopatolojik olarak incelemektir. GEREÇ VE YÖNTEM: Çalışmamızda 11 adet tavşanın her birinin bilateral alt göz kapakları çalışmaya dahil edildi. Tavşanların 3'ü kontrol grubunu oluşturdu. Kalan 8 adet tavşanın 3'ü 1.grubu, 5'i 2.grubu oluşturdu. Grup 1 ve grup 2'deki tavşanlara, alt kapak ektropiyon oluşturacak şekilde perioküler cilde sütüre edildi. Üçüncü hafta kontrolünde sütürlerin gevşediği görüldü. Birinci ayda konrol grubu ve 1. grubu oluşturan tavşanlar ötanazi yapılarak alt kapaklar eksize edildi. Meibomian bezleri meibografi ve histopatoloji ile değerlendirildi. İkinci grubu oluşturan tavşanların birinci ayda alt kapaklarına medial-lateral katotomi ve alt bacak kantoliz yöntemi ile kalıcı ektropiyon modeli oluşturuldu. İkinci ayda 2.grup tavşanlar ötanazi yapılarak alt kapaklar eksize edildi. Meibomian bezleri infrared meibografi ve histopatoloji ile değerlendirildi. BULGULAR: Meibografi yüzdeleri (meibomian bez hasarı yüzdesi) ortalama değerleri kontrol grubu, Grup 1 ve grup 2'de sırasıyla 12,86 ± 0.4, 24,58 ± 1.9 ve 31,23 ± 3.8 olarak bulundu ve gruplar arasında istatiksel olarak anlamlı fark saptandı (p < 0.01). Meibografi derecesine göre grup 1, grup 2 ve kontrol grubu arasında istatiksel olarak anlamlı farklılık saptandı (p < 0.01) . Histopatolojik incelemede ektropiyon olgularında duktal dilatasyon, asiner atrofi, asiniler arası fibrotik değişiklikler saptandı ve uzayan ektropiyonda bulgular anlamlı derecede artmış idi (p < 0.01). Meibomian bez hasarını gösteren artan meibografi yüzdeleri ile histopatolojik gradeleme arasında pozitif korelasyon saptandı (R=0.903 , p<0.001). Meibografi derecesi ile histopatolojik gradeleme arasında pozitif korelasyon saptandı (R=0.866 , p<0.001) . SONUÇ: Ektropiyonun ve uzamış ektropiyon süresinin meibomian bezi üzerinde artan olumsuz etkisi infrared meibografi ve histopatoloji ile doğrulanabilir. Ektropiyonun tedavisinde gecikmenin meibomian bezlerde hasara neden olacağının göz önünde bulundurulması faydalı olacaktır. Anahtar Kelimeler: Tavşan, Ektropiyon, Meibomian bez, Meibografi,PURPOSE: To investigate the effects of ectropion on meibomian glands using infrared meibography and histopathology by applying experimental ectropion model on rabbits. MATERIALS AND METHODS: Bilateral lower eyelids of every one of 11 rabbits were included in the study. 3 rabbits were assigned to control group. 3 and 5 of the remaining 8 rabbits were assigned to group 1 and group 2, respectively. Periocular skin of rabbits in group 1 and group 2 were sutured to form lower lid ectropion. At the third week, it is observed that sutures were loosened. In the first month, by euthanizing rabbits assigned to control group and group 1, lower eyelids were excised. Meibomian glands were evaluated by meibography and histopathology. Permanent ectropion model was formed in rabbits of the second group by applying medial-lateral cathotomy to the lower eyelids and lower leg cantolysis method in the first month. In the second month, by euthanizing rabbits in group 2, lower eyelids were excised. Meibomian glands were evaluated by infrared meibography and histopathology. RESULTS: It is found that the mean value of meibography percentages (percentage of meibomian gland damage) were 12,86 ± 0.4 , 24.58 ± 1.9 , 31,23 ± 3.8 for control group, group 1, and group 2, respectively and there was a statistically significant difference among groups (p <0.01). According to the degree of meibography, statistically a significant difference was found between group1, group 2 and control group (p <0.01). Based on histopathological examination, the ductal dilatation, acinar atrophy, fibrotic changes between acinis were detected in ectropion cases and findings were significantly increased in prolonged ectropion (p < 0.01). There was a positive correlation between increased meibography percentages showing meibomian gland damage and histopathological grading (R = 0.903, p <0.001). A positive correlation was found between meibography grade and histopathological grading (R=0.866 , p<0.001) . CONCLUSIONS: Increased negative effects of ectropion and prolonged ectropion on meibomian gland can be verified by using infrared meibography and histopathology. It will be beneficial to consider that delay in ectropion treatment will cause damage to meibomian glands. Key words: Rabbit, Ectropion, Meibomian gland, Meibograph
Tavşanlarda alt kapak ektropiyon modelinde meibomian bez değişikliklerinin incelenmesi
Tez (Tıpta Uzmanlık) -- Kırıkkale Üniversitesi119316
The Opinion Of The Patient and Patient Relatives On Giving Đnformation A bout The Cancer Diagnosis
Günümüzde kanser yıl içerisinde yüzbin civarında vakayla karşımıza çıkmaktadır. Mortalitesi halen yüksek olan bir hastalıktır. Ölümcül olması nedeniyle hasta yakınları hastalığın hastanın kendisine söylenmesini genelde istememektedir. Ancak tıbbi etik hastanın hastalığını bilmesini ve isbirliği yapmasını gerektirmektedir. Hala tartısılmakta olan bu konuyu bir anket çalısması ile aydınlatmayı amaçladık. Çalışmamız Afyon Kocatepe Üniversitesi Tıp Fakültesi Araştırma ve Uygulama Hastanesi Kemoterapi ünitesi ve diğer ünitelerde yatan 50 kanser hastası ve 50 hasta yakınından oluşmaktadır. Toplanan verilerin değerlendirilmesinde yüzdelik ve kikare (x2) testleri uygulanmıştır. Anketimiz hasta ve hasta yakınlarına ayrı sekilde hazırlanmıştır. Her iki ankette de birinci bölümde tanıtıcı özellikler, ikinci ve üçüncü bölümlerde ise verileri toplamaya yönelik sorular yer almaktadır. Araştırmada elde edilen veriler doğrultusunda öneriler geliştirilmiştir.Today, we are facing up cancer issues approximately a hundred thousand times in a year. Its mortality rate is stil high due to the fact that patient relatives, in general, is not eager to talk about the cancer to the patient. Though, medical ethics call for patients to know his/her illness and to make cooperation. It is our aim to enlight this argumentative issue with a inquery project. Our project is applied on 50 patients and 50 patient relatives in Afyon Kocatepe Research and Practical Hospital at the chemotherapy unit and the other units. Percentage and
chi-square tests are applied to evaluate the datas gained. Our inquiries are prepared differently for the patients and patient relatives. In both inquiries, it includes introductive features in the first section and there are the questions to take the datas in the second and third sections.
Based on the findings obtained in the study, recommendations have been put forth
Evaluation effectiveness of 0.1% nepafenac on injection-related pain in patients undergoing intravitreal Ozurdex injection
0000-0003-0658-2286WOS: 000478596400001PubMed: 31317125Purpose: To evaluate the analgesic effect of topical 0.1% nepafenac solution during intravitreal Ozurdex injection. Methods: This prospective, randomized, double-blind placebo-controlled study included 59 patients who were diagnosed with retinal vein occlusion or pseudophakic cystoid macular edema and were selected to receive intravitreal Ozurdex injection. The patients were divided into two groups. Group 1, consisting of 31 eyes of 31 patients, received topical 0.1% nepafenac with topical anesthesia (0.5% proparacaine HCl, Alcaine; Alcon, TX, USA), and group 2, consisting of 28 eyes of 28 patients, received placebo with topical anesthesia. Results: There were 14 (45.2%) men and 17 (54.8%) women in group 1 and 16 (57.1%) men and 12 (42.9%) women in group 2. The mean age of the subjects was 64.42 +/- 5.51 years in group 1 and 62.32 +/- 7.54 years in group 2. The median visual analog scale pain score was 2 (1-3) in group 1 and 4 (1-6) in group 2. The visual analog scale pain score was significantly lower in group 1 than in group 2 (p < 0.001). Conclusion: Topical 0.1% nepafenac has an additive analgesic effect when combined with topical anesthesia for intravitreal Ozurdex injection
Primary Cutaneous Diffuse Large B Cell Lymphoma: A Case Presentation and the Review of Primary Cutaneous B-Cell Lymphoma Classifications
Decreased choroidal thickness in vitiligo patients
Abstract Background Vitiligo is a disease characterized by depigmented macules and patches that occur as a result of the loss of functional melanocytes from the affected skin through a mechanism which has not been elucidated yet. Destruction of pigment cells in vitiligo may not remain limited to the skin; the eyelashes, iris, ciliary body, choroid, retinal pigment epithelium and meninges may also be affected. This study aims to compare the choroidal thickness of patients with and without vitiligo using optical coherence tomography (OCT). Methods Spectral-domain optical coherence tomography (SD-OCT) (Retina Scan Advanced RS-3000 NIDEK, Japan) instrument (with λ = 840 nm, 27,000 A-scans/second and 5 μm axial resolution) was used for the imaging. Statistical analysis was performed using SPSS 21.0 software package. Results In all values except optic nevre area measurements, the choroidal thickness of all vitiligo patients was found out to be thinner compared to the control group. Conclusions In vitiligo, the choroidal thickness may be affected by the loss of melanocytes
The effects of plasma immersion ion implantation and deposition (PIII&D) process voltages on the morphology, phase formation and E. coli adhesion of Ag coatings obtained on the surface of Ti6Al4V orthopedic implant material in nitrogen plasma
Gümüşün antimikrobiyal etkisini ve titanyum nitrürün mekanik ve kimyasal özelliklerini birleştirmek için, ortopedik implant malzemesi olarak kullanılan Ti6Al4V alaşımının yüzeyine N2 plazmasında plazma daldırma iyon implantasyonu ve biriktirme (PIII&D) yöntemi ile gümüş biriktirilmiştir. Kaplamalar, PIII&D prosesinin farklı negatif darbeli yüksek gerilim ve magnetron sıçratma gerilimi değerleri kullanılarak elde edilmiştir. Kaplamaların yüzey morfolojileri atomik kuvvet mikroskobu (AFM) ve kesit morfolojileri ise alan emisyonlu taramalı elektron mikroskobu (FE-SEM) kullanılarak tespit edilmiştir. Kaplamaların fazları ve kimyasal kompozisyonları sırasıyla X-ışını difraksiyonu (XRD) ve X-ışını fotoelektron spektroskopisi (XPS) kullanılarak tespit edilmiştir. Buna ek olarak, numunelerin yüzeyinden içeri Ag+ iyonlarının nüfuziyetini belirlemek için XPS derinlik profili (depth profile) analizi yapılmıştır. In vitro anti-bakteriyel etkinlik deneylerinde numunelerin yüzeylerine 99mTc radyoizotopu ile işaretlenmiş E. coli (Escherichia coli) mikroorganizmasının adezyonu araştırılmıştır. Çalışmada, 8 kV'luk negatif darbeli gerilimin kullanıldığı deneylerle elde edilen kaplamalarda gümüşün dominant olduğu; bunun yanında, negatif darbeli yüksek gerilimin artmasıyla yüzeyde gümüş miktarının azaldığı gözlemlenmiştir.In order to combine the antimicrobial effect of silver with mechanical and chemical properties of titaniumnitrate, Ag was deposited on the surface of Ti6Al4V (orthopedic implant material) in N2 plasma by using plasma immersion ion implantation and deposition (PIII&D) method. The coatings were formed by usingvaried negative pulsed high voltage and magnetron sputtering voltage values of PIII&D process. Surfacemorphologies of coatings were determined with atomic force microscopy (AFM), while cross-section morphologies were determined with field emission scanning electron microscopy (FE-SEM). The phases and chemical compositions of coatings were investigated by using X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS), respectively. XPS depth profile analysis were done to reveal thepenetration of Ag+ ions into the surface of specimen. In in vitro anti-bacterial effectiveness experiments,the adhesion of E. coli (Escherichia coli) microorganism, which were marked with 99mTc radioisotope, on surfaces of specimens was investigated. It was consequently determined that Ag was dominant in thecoatings obtained by applying 8 kV negative pulsed high voltage, while Ag decreased on the surfacedepending on the increase in the voltage
The effects of plasma immersion ion implantation and deposition (PIII&D) process voltages on the morphology, phase formation and E. coli adhesion of Ag coatings obtained on the surface of Ti6Al4V orthopedic implant material in nitrogen plasma
In order to combine the antimicrobial effect of silver with mechanical and chemical properties of titanium nitrate, Ag was deposited on the surface of Ti6Al4V (orthopedic implant material) in N-2 plasma by using plasma immersion ion implantation and deposition (PIII&D) method. The coatings were formed by using varied negative pulsed high voltage and magnetron sputtering voltage values of PIII&D process. Surface morphologies of coatings were determined with atomic force microscopy (AFM), while cross-section morphologies were determined with field emission scanning electron microscopy (FE-SEM). The phases and chemical compositions of coatings were investigated by using X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS), respectively. XPS depth profile analysis were done to reveal the penetration of Ag+ ions into the surface of specimen. In in vitro anti-bacterial effectiveness experiments, the adhesion of E. coli (Escherichia coli) microorganism, which were marked with Tc-99m radioisotope, on surfaces of specimens was investigated. It was consequently determined that Ag was dominant in the coatings obtained by applying 8 kV negative pulsed high voltage, while Ag decreased on the surface depending on the increase in the voltage