Bioactive compounds from marine Stachybotrys sp. QL23

During our ongoing search for bioactive compounds from microorganisms, the marine fungus Stachybotrys sp. QL23 was isolated from a sediment sample collected from Qarun Lake, El Fayoum governorate, Egypt and biologically screened to produce bioactive compounds. The fungal extract showed moderate to high activity against Gram positive and Gram-negative bacteria assayed. The genotypic characterization of Stachybotrys sp QL23 has been deduced basically on its 18S rDNA gene sequencing. Pre-chemical studies of the strain extract using different chromatographic techniques afforded the major bioactive metabolites, ergosterol (1) and linoleic acid (2), and their chemical structures were assigned using 1D and 2D NMR and Spectroscopy and HR-EI mass spectrometry. In this article, we present the isolation and taxonomical characterization of the producing fungal strain, along with the study of antimicrobial activity of the strain extract and compounds 1-2 using a set of microorganisms. The study of the QL23 using cervix carcinoma cell line (KB-3-1) extract has been reported as well

Bioactive compounds from marine <em>Stachybotrys</em> sp. QL23

322-328During our ongoing search for bioactive compounds from microorganisms, the marine fungus Stachybotrys sp. QL23 was isolated from a sediment sample collected from Qarun Lake, El Fayoum governorate, Egypt and biologically screened to produce bioactive compounds. The fungal extract showed moderate to high activity against Gram positive and Gram-negative bacteria assayed. The genotypic characterisation of Stachybotrys sp QL23 has been deduced basically on its 18S rRNA gene sequencing. Pre-chemical studies of the strain extract using different chromatographic techniques afforded the major bioactive metabolites, ergosterol (1) and linoleic acid (2), and their chemical structures were assigned using 1D and 2D NMR and Spectroscopy and HR-EI mass spectrometry. In this article, we present the isolation and taxonomical characterisation of the producing fungal strain, along with the study of antimicrobial activity of the strain extract and compounds 1-2 using a set of microorganisms. The study of the QL23 using cervix carcinoma cell line (KB-3-1) extract has been reported as well

Recent updates of marine antimicrobial peptides

Antimicrobial peptides are group of proteins showing broad-spectrum antimicrobial activity that have been known to be powerful agents against a variety of pathogens. This class of compounds contributed to solving the microbial resistance dilemma that limited the use of many potent antimicrobial agents. The marine environment is known to be one of the richest sources for antimicrobial peptides, yet this environment is not fully explored. Hence, the scientific research attention should be directed toward the marine ecosystem as enormous amount of useful discoveries could be brought to the forefront. In the current article, the marine antimicrobial peptides reported from mid 2012 to 2017 have been reviewed