Uncertainties of Smear Zone Characteristics in the Design of Preloading with Prefabricated Vertical Drains

Installing prefabricated vertical drains using mandrels induces disturbance of the soil surrounding the drain, resulting in a smear zone with the reduced permeability. The required time for pore pressure dissipation in preloading design is strongly associated with the smear zone characteristics. In this study, the effects of smear zone properties on preloading time are numerically investigated. Parametric study is conducted to find out the range of smear zone parameters significantly influencing the consolidation period. It is observed that the characteristics of smear zone namely size and permeability have a substantial impact on the preloading design to achieve certain soil strength and stiffness satisfying both bearing capacity and settlement design criteria

Numerical analysis to quantify the influence of smear zone characteristics on preloading design in soft clay

In this paper, the effects of uncertainties of smear zone characteristics induced by installation of prefabricated vertical drains on the preloading design are numerically investigated. FLAC 2D finite difference software with additional developed subroutines has been employed to conduct the numerical simulations. The finite difference analyses have been verified using a case study. Furthermore, a comprehensive parametric study is conducted to investigate the influence of smear zone permeability and extent on the model predictions. Results of this study indicate that the assumptive properties for smear zone characteristics may result in inaccurate predictions of ground deformations and pore water pressures. This may lead to early removal of the surcharge in the construction process causing excessive post construction settlement. It is recommended to practising engineers to use results of trial preloading to back calculate the required smear zone characteristics in the early stages of embankment construction to optimize the design

Orexin 1 receptors in the anterior cingulate and orbitofrontal cortex regulate cost and benefit decision-making

Abstract Orexin neurons are discretely localized within the lateral hypothalamus and have widespread projections into all areas of the brain. In addition, several lines of evidence specify that orexins may also participate in the regulation of a variety of affective and cognitive processes. The Orexin-1 receptor (OX1r) is distributed extensively throughout the prefrontal cortex (PFC). Delay-based decision- making is mediated largely by the orbitofrontal cortex (OFC) while effort- based decision-making is controlled by the anterior cingulated cortex (ACC). Hence, in the present study, a series of experiments were conducted to clarify the role of OX1r in the mPFC (ACC and/or OFC) in cost and benefit decision-making. The rats were trained in a delay and/or effort-based form of cost-benefit T-maze decision-making task. Two goal arms were different in the amount of accessible reward and cost. Before surgery, all animals were selecting the high reward arm and pay the cost on almost every trial. During the test days, the rats received local injections of either DMSO 20% /0.5 μl, as a vehicle, or SB334867 (3, 30 and 300 nM/0.5 μl), as a selective OX1r antagonist, within the ACC and/or OFC. The results of this study showed that the bilateral microinjection of SB334867 into ACC and/or OFC changed the preference to a low reward arm with no cost, indicating the role of OX1 receptors in cost and benefit decision- making. From these results, it can be implied that OX1 receptors in the mPFC play a crucial role for allowing the animal to evaluate and pay the cost to acquire greater rewards. Keywords Delay-based decision-making Effort-based decision-making Orexin Orbitofrontal cortex Anterior cingulate cortex Ra

Effects of soil-pile-structure interaction on seismic response of moment resisting buildings on soft soil

Dynamic response of structures sitting on soft soils is influenced by the soil properties, and the response is significantly different to the fixed base condition owing to the interaction between the ground and the structure, In order to study this effect, a fifteen storey moment resisting building frame, representing a conventional type of regular mid-rise building frame, resting ,on soil type Ee according to Australian Earthquake action code with the shear wave velocity equal to 150 mls is adopted. The numerical analysis using FLAC2D software is carried out for three different cases, namely: (1) fixed-base structure representing the situation excluding the soil-structure interaction (SSI); (2) structure supported by shallow foundation on soft soil; and (3) structure supported by pile foundation in soft soil. Benchmark earthquakes including the 1995 Kobe, the 1994 Northridge, the 1968 Hachinohe, and the 1940 EI Centro earthquakes are adopted. Results indicate that considering soil-structure interaction in both cases with shallow and pile fouudations is vital, and the conventional desigu procedure excluding soil-structure interaction is not adequate to guarantee the structural safety for the moment resisting buildings resting on the soft soil

Significance of bedrock depth in dynamic soil-structure interaction analysis for moment resisting frames

In this study, a fifteen storey moment resisting building frame, resting on a shallow foundation, is selected in conjunction with two clayey soils with the shear wave velocities less than 600m/s, representing soil classes De and Ee, according to AS 1170.4. Different bedrock depths including 10m, 20m, and 30 m are employed in the numerical modelling using finite difference software FLAC 2D. Fully nonlinear dynamic analysis under the influence of different earthquake records is conducted, and the results of the three different cases are compared and discussed. The results indicate that the dynamic properties of the subsoil such as shear wave velocity as well as bedrock depth play significant roles in seismic response of the building frames under the influence of soil-structure interaction. As the bedrock depth increases, lateral deflections and inter-storey drifts of the structures increase. These effects can change the performance level of structures from life safe to near collapse or total collapse. Therefore, the conventional design procedure excluding SSI is not adequate enough to guarantee the structural safety for the building frames resting on soft soil deposits

Analyzing consolidation data to predict smear zone characteristics induced by vertical drain installation for soft soil improvement

In this paper, the effects of variability of smear zone characteristics induced by installation of prefabricated vertical drains on the preloading design are investigated employing analytical and numerical approaches. Conventional radial consolidation theory has been adopted to conduct analytical parametric studies considering variations of smear zone permeability and extent. FLAC 2D finite difference software has been employed to conduct the numerical simulations. The finite difference analyses have been verified using three case studies including two embankments and a large-scale laboratory consolidometer with a central geosynthetic vertical drain. A comprehensive numerical parametric study is conducted to investigate the influence of smear zone permeability and extent on the model predictions. Furthermore, the construction of the trial embankment is recommended as a reliable solution to estimate accurate smear zone properties and minimise the post construction settlement. A back-calculation procedure is employed to determine the minimum required waiting time after construction of the trial embankment to predict the smear zone characteristics precisely. Results of this study indicate that the accurate smear zone permeability and extent can be back-calculated when 30% degree of consolidation is obtained after construction of the trial embankment. © 2014 Techno-Press, Ltd

Characterization of Iranian grapevine cultivars using microsatellite markers

Sixty-two grapevine (Vitis spp.) accessions from Iran and the USA were characterized at 9 highly polymorphic microsatellite loci using fluorescent primers and a capillary electrophoresis fragment sizing system. The number of alleles observed per locus ranged from 4 to 16 and heterozygosity values ranged from 0.47 to 0.86. Genetic similarity was estimated for each pair of accessions as the proportion of shared alleles. A phenogram constructed from genetic dissimilarity values revealed three clusters, one each for table grapes, wine grapes and rootstocks. The phenogram also revealed three clonal sets (Askari, Bidane and Yaghoti) as well as some synonyms and homonyms among Iranian table grape cultivars.

The impact of probiotic yogurt consumption on lipid profiles in subjects with mild to moderate hypercholesterolemia: A systematic review and meta-analysis of randomized controlled trials

Background and aims: Potential beneficial effect of probiotic yogurt on the lipid profile has raised much interest. However, the results are inconsistent in this regard. The aim of the study is to determine the effects of probiotic yogurt on serum lipid profile in individuals with mild to moderate hypercholesterolemia. Methods and results: Online databases including PubMed, Scopus, ISI Web of Science, Cochrane Central Register of Controlled Trials, Science Direct, Google Scholar and Igaku Chuo Zasshi were searched until March 19th 2019. The effect sizes were expressed as the weighted mean difference (WMD) with 95 confidence interval (CI). Seven eligible trials with 274 participants were included in this systematic review. Pooling of 9 effect sizes from these seven articles revealed a significant reduction in total cholesterol and low density lipoprotein cholesterol levels following probiotic yogurt consumption (mean difference: �8.73 mg/dl, 95 CI: �15.98, �1.48, p-value = 0.018 and mean difference: �10.611 mg/dl, 95 CI: �16.529, �4.693, p-value = 0.000, respectively) without significant heterogeneity among the studies (I2 = 40.6, p-value = 0.1 and I2 = 24.2, p-value = 0.229, respectively). The results showed no significant changes in high density lipoprotein cholesterol and triglyceride levels. Also, none of the variables showed a significant change for sensitivity analysis. Conclusion: Available evidence suggests that probiotic yogurt can significantly reduce total cholesterol and LDL-c in subjects with mild to moderate hypercholesterolemia without a significant effect on HDL-c and triglyceride levels. © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II Universit

Seed germination and seedling establishment of some wild almond species

Wild almond species are important genetic resources for resistance to unsuitable condition, especially drought stress. They have been used traditionally as rootstocks in some areas of Iran. So far, 21 wild almond species and 7 inter species hybrids have been identified in Iran. To study seed germination and seedling establishment of some of these species, three separate experiments were designed. In the first experiment, the application of gibberellic acid (GA3) (0, 250, 500 and 750 ppm) for 24 h was studied on germination characteristics of four wild almond accessions after stratification at 5 ± 0.5°C in Perlite media. Germination percentage, index vigor and root initiation factors were different in almond accessions, but were not affected by hormonal treatments. In the second experiment, seeds of another six wild almond accessions were stratified to compare their germination ability. Germination percentage, index vigor and root initiation were different among accessions significantly. In the last experiment, the establishment and vigor of 14 accessions from eight almond species have been evaluated in plastic bags in outdoor conditions. Two ecotypes of Prunus spp. had the highest stem diameter and length at all growing stages.Keywords: Amygdalus, germination percentage, index vigor, root initiation, stem length, stem diameter

Comparative ergonomic workflow and user experience analysis of MRI versus fluoroscopy-guided vascular interventions:an iliac angioplasty exemplar case study

Purpose A methodological framework is introduced to assess and compare a conventional fluoroscopy protocol for peripheral angioplasty with a new magnetic resonant imaging (MRI)-guided protocol. Different scenarios were considered during interventions on a perfused arterial phantom with regard to time-based and cognitive task analysis, user experience and ergonomics. Methods Three clinicians with different expertise performed a total of 43 simulated common iliac angioplasties (9 fluoroscopic, 34 MRI-guided) in two blocks of sessions. Six different configurations for MRI guidance were tested in the first block. Four of them were evaluated in the second block and compared to the fluoroscopy protocol. Relevant stages’ durations were collected, and interventions were audio-visually recorded from different perspectives. A cued retrospective protocol analysis (CRPA) was undertaken, including personal interviews. In addition, ergonomic constraints in the MRI suite were evaluated. Results Significant differences were found when comparing the performance between MRI configurations versus fluoroscopy. Two configurations [with times of 8.56 (0.64) and 9.48 (1.13) min] led to reduce procedure time for MRI guidance, comparable to fluoroscopy [8.49 (0.75) min]. The CRPA pointed out the main influential factors for clinical procedure performance. The ergonomic analysis quantified musculoskeletal risks for interventional radiologists when utilising MRI. Several alternatives were suggested to prevent potential low-back injuries. Conclusions This work presents a step towards the implementation of efficient operational protocols for MRI-guided procedures based on an integral and multidisciplinary framework, applicable to the assessment of current vascular protocols. The use of first-user perspective raises the possibility of establishing new forms of clinical training and education