Examining Bias in Jury Selection for Criminal Trials in Dallas County

One of the hallmarks of the American judicial system is the concept of trial by jury, and for said trial to consist of an impartial jury of your peers. Several landmark legal cases in the history of the United States have challenged this notion of equal representation by jury—most notably Batson v. Kentucky, 476 U.S. 79 (1986). Most of the previous research, focus, and legal precedence has centered around peremptory challenges and attempting to prove if bias was suspected in excluding certain jurors from serving. Few studies, however, focus on examining challenges for cause based on self-reported biases from the venire, the group of potential jurors. This paper evaluates if there are any relationships of interest with respect to juror demographics and location regarding challenges for cause in non-death penalty felony criminal trials in Dallas County, TX

Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism

Clostridium difficile is the most common cause of antibiotic-associated nosocomial infection in the United States. C. difficile secretes two homologous toxins, TcdA and TcdB, which are responsible for the symptoms of C. difficile associated disease. The mechanism of toxin action includes an autoprocessing event where a cysteine protease domain (CPD) releases a glucosyltransferase domain (GTD) into the cytosol. The GTD acts to modify and inactivate Rho-family GTPases. The presumed importance of autoprocessing in toxicity, and the apparent specificity of the CPD active site make it, potentially, an attractive target for small molecule drug discovery. In the course of exploring this potential, we have discovered that both wild-type TcdB and TcdB mutants with impaired autoprocessing or glucosyltransferase activities are able to induce rapid, necrotic cell death in HeLa and Caco-2 epithelial cell lines. The concentrations required to induce this phenotype correlate with pathology in a porcine colonic explant model of epithelial damage. We conclude that autoprocessing and GTD release is not required for epithelial cell necrosis and that targeting the autoprocessing activity of TcdB for the development of novel therapeutics will not prevent the colonic tissue damage that occurs in C. difficile - associated disease

Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial

Background: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. Methods: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. Findings: Treatment took place between March 3, 2014, and Oct 19, 2015. 22 754 patients were assessed for elegibility. Of 15 873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96–1·28). Interpretation: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. Funding: National Institute for Health Research Health Services and Delivery Research Programme

Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial

BACKGROUND: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. METHODS: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. FINDINGS: Treatment took place between March 3, 2014, and Oct 19, 2015. 22 754 patients were assessed for elegibility. Of 15 873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96-1·28). INTERPRETATION: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. FUNDING: National Institute for Health Research Health Services and Delivery Research Programme

An Analysis of Stress Levels of Female Graduate Students in an Online Program

This quantitative study was designed to investigate the differences in stressors and demographic variables of women enrolled in an online master's degree program in education. Participants were women with multiple personal, career, and family responsibilities. Survey data and demographic data were used to identify which stressors were most frequently experienced and whether there was a significant difference between stress scale scores and demographic variables. Seven hundred and fifty women completed the Social Readjustment Rating Scale — Revised (Hobson, 1998) and non-parametric tests were used to analyze the data. Findings indicated the stressors most common to female graduate students were related to family, finances, and health-related issues. The results also suggested there were significant differences among the demographic variables of age, ethnicity, program start date, number of courses completed, and marital status.For institutions of higher education these findings may offer insight for incorporating student services such as learning communities, flexible financing options, and accelerated programs to allow for increased retention of women in online programs. For women seeking to enroll into an online graduate program, this study may provide insight into assessing their resources for successful completion of an online master's degre

An Analysis of Stress Levels of Female Graduate Students in an Online Program

This quantitative study was designed to investigate the differences in stressors and demographic variables of women enrolled in an online master's degree program in education. Participants were women with multiple personal, career, and family responsibilities. Survey data and demographic data were used to identify which stressors were most frequently experienced and whether there was a significant difference between stress scale scores and demographic variables. Seven hundred and fifty women completed the Social Readjustment Rating Scale -Revised (Hobson, 1998) and non-parametric tests were used to analyze the data. Findings indicated the stressors most common to female graduate students were related to family, finances, and health-related issues. The results also suggested there were significant differences among the demographic variables of age, ethnicity, program start date, number of courses completed, and marital status. For institutions of higher education these findings may offer insight for incorporating student services such as learning communities, flexible financing options, and accelerated programs to allow for increased retention of women in online programs. For women seeking to enroll into an online graduate program, this study may provide insight into assessing their resources for successful completion of an online master's degree

Examining Bias in Jury Selection for Criminal Trials in Dallas County

One of the hallmarks of the American judicial system is the concept of trial by jury, and for said trial to consist of an impartial jury of your peers. Several landmark legal cases in the history of the United States have challenged this notion of equal representation by jury—most notably Batson v. Kentucky, 476 U.S. 79 (1986). Most of the previous research, focus, and legal precedence has centered around peremptory challenges and attempting to prove if bias was suspected in excluding certain jurors from serving. Few studies, however, focus on examining challenges for cause based on self-reported biases from the venire, the group of potential jurors. This paper evaluates if there are any relationships of interest with respect to juror demographics and location regarding challenges for cause in non-death penalty felony criminal trials in Dallas County, TX

Abstract P2-06-19: Transferrin Receptor (CD71) identifies poor response to Tamoxifen in oestrogen receptor positive breast cancer patients [Abstract]

Background: CD71 is involved in the cellular uptake of iron and is expressed on cells with high proliferation. Interestingly, we have Interestingly, we shown that its expression is associated with elevated tumour proliferation, shortened breast cancer specific survival and worsened outlook in ER+ adjuvant tamoxifen treated early breast cancer patients (Habashy et al, 2010). Here we extend our studies of the relationship between CD71 and tamoxifen outcome by study of an exploratory series of patients where endocrine response was directly assessable. Material and Methods: CD71 (clone 10F11 antibody; Abcam, Cambridge, UK) and proliferation (MIB1) immunohistochemistry were performed as described in Habashy et al (2010) on 87 formalin fixed paraffin-embedded breast cancers. These were obtained from patients within the Nottingham Tenovus Multiple Antibody Study who had received systemic tamoxifen therapy for locally advanced primary carcinoma or metastatic disease or for recurrence after surgery alone. All had lesions assessable for response quality at 6 months, with survival and duration of antihormone response measured from initiation of antihormone to death or progression on therapy respectively. 48 tumours were classified as ER+ and 39 ER-. Results: Within this tamoxifen treated series, 68/87 patients were deemed positive for CD71 (plasma membrane and cytoplasmic), showing HScore values >=5. In the ER+ subgroup, a greater clinical response rate to tamoxifen was seen in CD71 — tumours (10 CR/PR, 3 S and 2 P) versus their CD71+ counterparts (CR/PR, 11 S and 16 P, p=0.015). CD71 positivity was associated with a significantly shortened time to progression and death (Kaplan Meier Test, p=0.026 and p=0.005 respectively). Examination of the proliferation marker MIB1 in ER+ tumours revealed a positive association with CD71 expression (Spearman's Test, p=0.01). In ER-patients, comprising predominantly progressive disease on tamoxifen therapy, CD71 status showed no impact on either time to progression of the disease or death. Discussion: The present study extends our novel findings relating CD71 expression to loss of response to tamoxifen in ER+ breast cancer and reveals CD71 associates with increased tumour cell proliferation in clinical disease. Whether CD71 plays a causative role in the direction of these events and can be targeted to improve endocrine response requires to be ascertained