774 research outputs found
What drives renewal of sponsorship principal/agent relationships?
The relationship between advertising agencies and their clients has been the subject of some research, including studies conceptualizing it from an agency theory perspective. The increasingly important relationship between sports (or art) properties and their sponsors, on the other hand, while recognized as crucial for the long-term success of the sponsorship agreement, has remained shrouded in mystery, with little or no research aiming to establish and understand the antecedent of sponsorship renewal. This article reports on an exploratory dyadic study examining the effects of market orientation, trust, and commitment on the principal's willingness to renew the sponsorship relationship. The leading sponsorship property in Australia, the Australian Football League (AFL), and its major sponsors provided the empirical context for this study.Francis Farrelly and Pascale G. Queste
Fractal Weyl law behavior in an open, chaotic Hamiltonian system
We numerically show fractal Weyl law behavior in an open Hamiltonian system
that is described by a smooth potential and which supports numerous
above-barrier resonances. This behavior holds even relatively far away from the
classical limit. The complex resonance wave functions are found to be localized
on the fractal classical repeller.Comment: 4 pages, 3 figures. to appear in Phys Rev
Marijuana and Youth
This paper contains the first estimates of the price sensitivity of the prevalence of youth marijuana use. Survey data on marijuana use by high school seniors from the Monitoring the Future Project are combined with data on marijuana prices and potency from the Drug Enforcement Administration Office of Intelligence or Intelligence Division. Our estimates of the price elasticity of annual marijuana participation range from 0.06 to 0.47, while those for thirty day participation range from 0.002 to 0.69. These estimates clearly imply that changes in the real, quality adjusted price of marijuana contributed significantly to the trends in youth marijuana use between 1982 and 1998, particularly during the contraction in use from 1982 to 1992. Similarly, changes in youth perceptions of the harms associated with regular marijuana use had a substantial impact on both the contraction in use during the 1982 though 1992 period and the subsequent expansion in use after 1992. These findings underscore the usefulness of considering price in addition to more traditional determinants in any analysis of marijuana consumption decisions made by youths.
Quantum equilibration in finite time
It has recently been shown that small quantum subsystems generically
equilibrate, in the sense that they spend most of the time close to a fixed
equilibrium state. This relies on just two assumptions: that the state is
spread over many different energies, and that the Hamiltonian has
non-degenerate energy gaps. Given the same assumptions, it has also been shown
that closed systems equilibrate with respect to realistic measurements. We
extend these results in two important ways. First, we prove equilibration over
a finite (rather than infinite) time-interval, allowing us to bound the
equilibration time. Second, we weaken the non degenerate energy gaps condition,
showing that equilibration occurs provided that no energy gap is hugely
degenerate.Comment: 7 page
Functional land management: A framework for managing soil-based ecosystem services for the sustainable intensification of agriculture
peer-reviewedSustainable food production has re-emerged at the top of the global policy agenda, driven by two challenges: (1) the challenge to produce enough food to feed a growing world population and (2) the challenge to make more efficient and prudent use of the world's natural resources. These challenges have led to a societal expectation that the agricultural sector increase productivity, and at the same time provide environmental ‘ecosystem services’ such as the provision of clean water, air, habitats for biodiversity, recycling of nutrients and mitigation against climate change. Whilst the degree to which agriculture can provide individual ecosystem services has been well researched, it is unclear how and to what extent agriculture can meet all expectations relating to environmental sustainability simultaneously, whilst increasing the quantity of food outputs. In this paper, we present a conceptual framework for the quantification of the ‘supply of’ and ‘demand for’ agricultural, soil-based ecosystem services or ‘soil functions’. We use Irish agriculture as a case-study for this framework, using proxy-indicators to determine the demand for individual soil functions, as set by agri-environmental policies, as well as the supply of soil functions, as defined by land use and soil type. We subsequently discuss how this functionality of soils can be managed or incentivised through policy measures, with a view to minimising the divergence between agronomic policies designed to promote increased agricultural production and environmental policy objectives. Finally, we discuss the applicability of this conceptual framework to agriculture and agri-environmental policies at EU level, and the implications for policy makers
Statistical properties of acoustic emission signals from metal cutting processes
Acoustic Emission (AE) data from single point turning machining are analysed
in this paper in order to gain a greater insight of the signal statistical
properties for Tool Condition Monitoring (TCM) applications. A statistical
analysis of the time series data amplitude and root mean square (RMS) value at
various tool wear levels are performed, �nding that ageing features can
be revealed in all cases from the observed experimental histograms. In
particular, AE data amplitudes are shown to be distributed with a power-law
behaviour above a cross-over value. An analytic model for the RMS values
probability density function (pdf) is obtained resorting to the Jaynes' maximum
entropy principle (MEp); novel technique of constraining the modelling function
under few fractional moments, instead of a greater amount of ordinary moments,
leads to well-tailored functions for experimental histograms.Comment: 16 pages, 7 figure
Spontaneous emission of non-dispersive Rydberg wave packets
Non dispersive electronic Rydberg wave packets may be created in atoms
illuminated by a microwave field of circular polarization. We discuss the
spontaneous emission from such states and show that the elastic incoherent
component (occuring at the frequency of the driving field) dominates the
spectrum in the semiclassical limit, contrary to earlier predictions. We
calculate the frequencies of single photon emissions and the associated rates
in the "harmonic approximation", i.e. when the wave packet has approximately a
Gaussian shape. The results agree well with exact quantum mechanical
calculations, which validates the analytical approach.Comment: 14 pages, 4 figure
Management of hepatocellular carcinoma from diagnosis in routine clinical practice
AIM: To assess real-world management of patients diagnosed with hepatocellular carcinoma (HCC) within an integrated delivery network.
MATERIALS & METHODS: A retrospective cohort analysis of adults newly diagnosed with HCC from January 2014 to March 2019. Overall survival and treatment journey were assessed over the entire available follow-up period per patient.
RESULTS: Of the 462 patients, 85% had ≥1 treatment. The 24-month overall survival rate (95% CI) from first treatment was 77% (72-82%). Majority of Child-Pugh class A (71%) and B (60%) patients received locoregional therapy first. Half (53.6%) of the patients with liver transplantation first were Child-Pugh class C patients. Sorafenib was the predominant systemic therapy.
CONCLUSION: This integrated delivery network data analysis offers a comprehensive insight into the real-world management of HCC
Ganetespib in combination with pemetrexed-platinum chemotherapy in patients with pleural Mesothelioma (MESO-02): A phase Ib trial
Purpose: Ganetespib, a highly potent, small-molecule Heatshock protein 90 inhibitor, has potential efficacy in malignant pleural mesothelioma (MPM) via activity on critical survival pathways and known synergies with antifolates and platinum chemotherapy. We conducted a dose-escalation study to identify the maximum tolerated dose (MTD) of ganetespib in patients with chemotherapy-naïve MPM.
Patients and Methods: MESO-02 (ClinicalTrials.gov: NCT01590160) was a nonrandomized, multicenter, phase Ib trial of 3-weekly ganetespib (100 mg/m2, 150 mg/m2, 200 mg/m2; days 1 and 15) with pemetrexed (500 mg/m2; day 1) and cisplatin (75 mg/m2; day 1) or carboplatin (area under concentration–time curve 5; day 1) in patients with MPM. Dose escalation was performed using the 3 + 3 design (cisplatin) and accelerated titration design (carboplatin). Secondary endpoints included best response, progression-free survival (PFS), and pharmacogenomic analyses.
Results: Of 27 patients enrolled (cisplatin, n = 16; carboplatin, n = 11), 3 experienced dose-limiting toxicities: grade 3 nausea (cisplatin, n = 1; carboplatin, n = 1) and grade 2 infusion-related reaction (carboplatin, n = 1). Ganetespib's MTD was 200 mg/m2. Partial response was observed in 14 of 27 patients (52%; 61% in 23 response-evaluable patients) and 13 of 21 (62%) with epithelioid histology. At the MTD, 10 of 18 patients (56%) had partial response, 15 of 18 (83%) had disease control, and median PFS was 6.3 months (95% CI, 5.0–10.0). One responder exhibited disease control beyond 50 months. Global loss of heterozygosity was associated with shorter time to progression (HR 1.12; 95% CI, 1.02–1.24; P = 0.018).
Conclusions: Ganetespib can be combined safely with pemetrexed and platinum chemotherapy to treat patients with MPM. This class of agent should be investigated in larger randomized studies
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