570 research outputs found
Germanium Detector with Internal Amplification for Investigation of Rare Processes
Device of new type is suggested - germanium detector with internal
amplification. Such detector having effective threshold about 10 eV opens up
fresh opportunity for investigation of dark matter, measurement of neutrino
magnetic moment, of neutrino coherent scattering at nuclei and for study of
solar neutrino problem. Construction of germanium detector with internal
amplification and perspectives of its use are described.Comment: 13 pages, latex, 3 figures, report at NANP-99, International
Conference on Non-Accelerator Physics, Dubna, Russia, June 29- July 3, 1999.
To be published in the Proceeding
ROGUE:an R Shiny app for RNA sequencing analysis and biomarker discovery
Background: The growing power and ever decreasing cost of RNA sequencing (RNA-Seq) technologies have resulted in an explosion of RNA-Seq data production. Comparing gene expression values within RNA-Seq datasets is relatively easy for many interdisciplinary biomedical researchers; however, user-friendly software applications increase the ability of biologists to efficiently explore available datasets. Results: Here, we describe ROGUE (RNA-Seq Ontology Graphic User Environment, https://marisshiny.research.chop.edu/ROGUE/), a user-friendly R Shiny application that allows a biologist to perform differentially expressed gene analysis, gene ontology and pathway enrichment analysis, potential biomarker identification, and advanced statistical analyses. We use ROGUE to identify potential biomarkers and show unique enriched pathways between various immune cells. Conclusions: User-friendly tools for the analysis of next generation sequencing data, such as ROGUE, will allow biologists to efficiently explore their datasets, discover expression patterns, and advance their research by allowing them to develop and test hypotheses.</p
Model for nucleation in GaAs homoepitaxy derived from first principles
The initial steps of MBE growth of GaAs on beta 2-reconstructed GaAs(001) are
investigated by performing total energy and electronic structure calculations
using density functional theory and a repeated slab model of the surface. We
study the interaction and clustering of adsorbed Ga atoms and the adsorption of
As_2 molecules onto Ga atom clusters adsorbed on the surface. The stable nuclei
consist of bound pairs of Ga adatoms, which originate either from dimerization
or from an indirect interaction mediated through the substrate reconstruction.
As_2 adsorption is found to be strongly exothermic on sites with a square array
of four Ga dangling bonds. Comparing two scenarios where the first As_2 gets
incorporated in the incomplete surface layer, or alternatively in a new added
layer, we find the first scenario to be preferable. In summary, the
calculations suggest that nucleation of a new atomic layer is most likely on
top of those surface regions where a partial filling of trenches in the surface
has occurred before.Comment: 8 pages, 14 figures, Submitted to Phys. Rev. B (December 15, 1998).
Other related publications can be found at
http://www.fhi-berlin.mpg.de/th/paper.htm
Eigenvector statistics in non-Hermitian random matrix ensembles
We study statistical properties of the eigenvectors of non-Hermitian random
matrices, concentrating on Ginibre's complex Gaussian ensemble, in which the
real and imaginary parts of each element of an N x N matrix, J, are independent
random variables. Calculating ensemble averages based on the quantity , where and are left and right eigenvectors of J, we show for large N that
eigenvectors associated with a pair of eigenvalues are highly correlated if the
two eigenvalues lie close in the complex plane. We examine consequences of
these correlations that are likely to be important in physical applications.Comment: 4 pages, no figure
Comparison of Real-time PCR to ELISA for the detection of human cytomegalovirus infection in renal transplant patients in the Sudan
<p>Abstract</p> <p>Background</p> <p>This study was carried out to detect human cytomegalovirus (HCMV) IgG and IgM antibodies using an Enzyme-linked immunosorbent assay (ELISA) in renal transplant patients in Khartoum state, Sudan and to improve the diagnosis of HCMV through the introduction of Real-time Polymerase Chain Reaction (PCR) testing. A total of 98 plasma samples were collected randomly from renal transplant patients at Ibin Sina Hospital and Salma Centre for Transplantation and Haemodialysis during the period from August to September 2006.</p> <p>Results</p> <p>Among the 98 renal transplant patients, 65 were males and 33 females. The results revealed that HCMV IgG was present in all patients' plasma 98/98 (100%), while only 6/98 (6.1%) had IgM antibodies in their plasma. HCMV DNA viral loads were detected in 32 patients 32/98 (32.7%) using Real-time PCR.</p> <p>Conclusions</p> <p>The HCMV IgG results indicate a high prevalence of past HCMV infection in all tested groups, while the finding of IgM may reflect a recent infection or reactivation. HCMV detection by real-time PCR in the present study indicated a high prevalence among renal transplant patients in Khartoum. In conclusion, the prevalence of HCMV in Khartoum State was documented through detection of HCMV-specific antibodies. Further study using various diagnostic methods should be considered to determine the prevalence of HCMV disease at the national level.</p
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Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design.
Accelerating cures for children with cancer remains an immediate challenge as a result of extensive oncogenic heterogeneity between and within histologies, distinct molecular mechanisms evolving between diagnosis and relapsed disease, and limited therapeutic options. To systematically prioritize and rationally test novel agents in preclinical murine models, researchers within the Pediatric Preclinical Testing Consortium are continuously developing patient-derived xenografts (PDXs)-many of which are refractory to current standard-of-care treatments-from high-risk childhood cancers. Here, we genomically characterize 261 PDX models from 37 unique pediatric cancers; demonstrate faithful recapitulation of histologies and subtypes; and refine our understanding of relapsed disease. In addition, we use expression signatures to classify tumors for TP53 and NF1 pathway inactivation. We anticipate that these data will serve as a resource for pediatric oncology drug development and will guide rational clinical trial design for children with cancer
Optically-stimulated desorption of 'hot' excimers from pre-irradiated Ar solids
Electronically-induced desorption from solid Ar pre-irradiated by a
low-energy electron beam was investigated by activation spectroscopy methods -
photon-stimulated exoelectron emission and photon-stimulated luminescence in
combination with spectrally-resolved measurements in the VUV range of the
spectrum. Desorption of vibrationally excited argon molecules Ar2^*(v) from the
surface of pre-irradiated solid Ar was observed for the first time. It was
shown that desorption of 'hot' Ar2^*(v) molecules is caused by recombination of
self-trapped holes with electrons released from traps by visible range photons.
The possibility of optical stimulation of the phenomenon is evidenced.Comment: The complete version of the paper will be published in Fiz. Nizk.
Temp. (Low Temp. Phys.
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