Etnografiando las memorias del mar: una mirada compleja al patrimonio marítimo-pesquero andaluz

A partir de un rastreo etnográfico de las iniciativas patrimonialistas de la cultura pesquera y marítima en los entornos portuarios andaluces, pretendemos hacer visible la complejidad de las patrimonializaciones gubernamentales y empresariales. Así mismo también exploramos iniciativas llevadas a término por personas y colectivos locales que cuestionan y desbordan las conceptualizaciones y prácticas hegemónicas del patrimonio.Through an ethnographic description of heritage initiatives related to the fishing and maritime culture within Andalusian ports and their contexts, we intend to make visible the complexity of the initiatives of “heritagisation”, both public and private ones. At the same time we explore initiatives carried out by individuals and local groups that discuss and overwhelm the hegemonic conceptualizations and practices of heritage

Modeling aquatic toxicity through chromatographic systems

Environmental risk assessment requires information about the toxicity of the growing number of chemical products coming from different origins that can contaminate water and become toxicants to aquatic species or other living beings via the trophic chain. Direct toxicity measurements using sensitive aquatic species can be carried out but they may become expensive and ethically questionable. Literature refers to the use of chromatographic measurements that correlate to the toxic effect of a compound over a specific aquatic species as an alternative to get toxicity information. In this work, we have studied the similarity in the response of the toxicity to different species and we have selected eight representative aquatic species (including tadpoles, fish, water fleas, protozoan, and bacteria) with known nonspecific toxicity to chemical substances. Next, we have selected four chromatographic systems offering good perspectives for surrogation of the eight selected aquatic systems, and thus prediction of toxicity from the chromatographic measurement. Then toxicity has been correlated to the chromatographic retention factor. Satisfactory correlation results have been obtained to emulate toxicity in five of the selected aquatic species through some of the chromatographic systems. Other aquatic species with similar characteristics to these five representative ones could also be emulated by using the same chromatographic systems. The final aim of this study is to model chemical products toxicity to aquatic species by means of chromatographic systems to reduce in vivo testing

Transgenic mice overexpressing the PGE2 receptor EP2 on mast cells exhibit a protective phenotype in a model of allergic asthma

Altres ajuts: Acord transformatiu CRUE-CSI

Geological context and origin of the mineralization of the historic and prehistoric iron mines in the Gavà area, Catalonia (NE Iberian Peninsula)

Mining for iron resources in the Gavà area of Catalonia occurred intermittently during the Iberian and Roman epochs, the Middle Ages, and continuing until the industrial era, as evidenced by historical and archaeological documents. Iron mining in this area could have occurred even earlier, during the Neolithic period. Iron ores were formed in two stages: (1) a regional hydrothermal alteration associated with Hercynian thrusts that produced the ankeritization of limestones within the Paleozoic series, and (2) the karstic replacement of these iron-rich carbonates during the Pliocene and Quaternary by means of supergenic fluids that produced ochres with goethite and hematite. The style of mineralization largely depends on the characteristics of the replaced protolith, and three styles of mineralization can be defined: (1)The supergenic replacement of ankeritized massive Pridolian limestones only produced local replacements that were restricted to structural or stratigraphic discontinuities, therefore, the mineralization has reduced dimensions and occurs as irregular veinlets or pipes; (2) The replacement of interbedded ankeritized limestones and pyrite-bearing shales (Lockovian) produced massive ores in pod-shaped bodies rich in silica impurities derived from the altered shales; and (3) The replacement of carbonates overthrust by pyrite- and phosphate-rich shales favored the formation of massive stratabound deposits, which are the largest and highest grade deposits in the study area, and may be locally enriched in minerals of the alunite supergroup and Ca- and Fe-rich phosphates. Outcrops of all of these styles of mineralization were mined by the Iberian cultures, during the roman period and in the Middle Ages, taking advantage of the relatively high metallurgical quality of the ores.Therefore, the exploitation during these epochs was artisanal by means of trenches or small pits. In contrast, during the industrial era only the massive stratabound deposits were exploited in open pits and underground galleries

<i>Staphylococcus aureus </i>Transcriptome Architecture:From Laboratory to Infection-Mimicking Conditions

Staphylococcus aureus is a major pathogen that colonizes about 20% of the human population. Intriguingly, this Gram-positive bacterium can survive and thrive under a wide range of different conditions, both inside and outside the human body. Here, we investigated the transcriptional adaptation of S. aureus HG001, a derivative of strain NCTC 8325, across experimental conditions ranging from optimal growth in vitro to intracellular growth in host cells. These data establish an extensive repertoire of transcription units and non-coding RNAs, a classification of 1412 promoters according to their dependence on the RNA polymerase sigma factors SigA or SigB, and allow identification of new potential targets for several known transcription factors. In particular, this study revealed a relatively low abundance of antisense RNAs in S. aureus, where they overlap only 6% of the coding genes, and only 19 antisense RNAs not co-transcribed with other genes were found. Promoter analysis and comparison with Bacillus subtilis links the small number of antisense RNAs to a less profound impact of alternative sigma factors in S. aureus. Furthermore, we revealed that Rho-dependent transcription termination suppresses pervasive antisense transcription, presumably originating from abundant spurious transcription initiation in this A+T-rich genome, which would otherwise affect expression of the overlapped genes. In summary, our study provides genome-wide information on transcriptional regulation and non-coding RNAs in S. aureus as well as new insights into the biological function of Rho and the implications of spurious transcription in bacteria

Diagnostic Accuracy of Abdominal CT for Locally Advanced Colon Tumors: Can We Really Entrust Certain Decisions to the Reliability of CT?

Many different options of neoadjuvant treatments for advanced colon cancer are emerging. An accurate preoperative staging is crucial to select the most appropriate treatment option. A retrospective study was carried out on a national series of operated patients with T4 tumors. Considering the anatomo-pathological analysis of the surgical specimen as the gold standard, a diagnostic accuracy study was carried out on the variables T and N staging and the presence of peritoneal metastases (M1c). The parameters calculated were sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios, as well as the overall accuracy. A total of 50 centers participated in the study in which 1950 patients were analyzed. The sensitivity of CT for correct staging of T4 colon tumors was 57%. Regarding N staging, the overall accuracy was 63%, with a sensitivity of 64% and a specificity of 62%; however, the positive and negative likelihood ratios were 1.7 and 0.58, respectively. For the diagnosis of peritoneal metastases, the accuracy was 94.8%, with a sensitivity of 40% and specificity of 98%; in the case of peritoneal metastases, the positive and negative likelihood ratios were 24.4 and 0.61, respectively. The diagnostic accuracy of CT in the setting of advanced colon cancer still has some shortcomings for accurate diagnosis of stage T4, correct classification of lymph nodes, and preoperative detection of peritoneal metastases

The Barcelona SGA-SEG student chapter: New fronts for international cooperation in teaching Geology and student exchanges

The Barcelona SGA-SEG Student Chapter is a student organization created and organized by students from the Faculty of Earth Science (University of Barcelona; UB). It offers to students interested in Mineralogy, Mineral Deposits and Economic Geology the opportunity to participate in research projects, student exchanges, seminars and courses in an international level. The students develop capacity of self-organization, team-work and public social skills. Recent activities are international exchange of student groups and participation in the project to update and replicate the mineral collection of the UB

The pilot project of the mineral collections from the University of Barcelona: An opportunity to create updated teaching material to be shared with other universities

The Mineralogy teaching collection from the University of Barcelona has proved to be a successful tool for students. The urge of its renewal to meet the necessities of modernCindustry brought the idea to replicate this collection in order to offer high quality teaching material to other universities worldwide. This project has led to an international collaboration aiming to enhance international solidarity among universities and make evident the importance of Mineralogy in Geology studies

Methods for Analysis of Matrix Metalloproteinase Regulation of Neutrophil-Endothelial Cell Adhesion

Recent evidence indicates novel role for matrix metalloproteinases (MMPs), in particular gelatinase A (MMP-2), in the regulation of vascular biology that are unrelated to their well-known proteolytic breakdown of matrix proteins. We have previously reported that MMP-2 can modulate vascular reactivity by cleavage of the Gly32-Leu33 bound in big endothelin-1 (ET-1) yielding a novel vasoactive peptide ET-1[1-32]. These studies were conducted to investigate whether gelatinolytic MMPs could affect neutrophil-endothelial cell attachment. ET-1[1-32] produced by MMP-2 up-regulated CD11b/CD18 expression on human neutrophils, thereby promoted their adhesion to cultured endothelial cells. ET-1[1-32] evoked release of gelatinase B (MMP-9), which in turn cleaved big ET-1 to yield ET-1[1-32], thus revealing a self-amplifying loop for ET-1[1-32] generation. ET-1[1-32] was rather resistant to cleavage by neutrophil proteases and further metabolism of ET-1[1-32] was not a prerequisite for its biological actions on neutrophils. The neutrophil responses to ET-1[1-32] were mediated via activation of ET(A)receptors through activation of the Ras/Raf-1/MEK/ERK signaling pathway. These results suggest a novel role for gelatinase A and B in the regulation of neutrophil functions and their interactions with endothelial cells. Here we describe the methods in detail as they relate to our previously published work

Educació farmacèutica en la prevenció de l'ictus

Treballs d'Educació Farmacèutica als ciutadans. Unitat Docent d'Estades en Pràctiques Tutelades. Facultat de Farmàcia, Universitat de Barcelona. Curs: 2018-2019. Tutors: Montserrat Iracheta i Marian March Pujol.Des de la farmàcia comunitària podem fer activitats assistencials per la millora en la qualitat de vida de les persones, sent les de caire preventiu de gran relevància. L’Ictus és l’alteració sobtada de la circulació de la sang al cervell així com la causant d’una gran discapacitat en la majoria de les persones que el pateixen. En aquest treball hem volgut apropar-nos a sanitaris (metges, infermers, farmacèutics) i pacients que estan relacionats amb aquest problema de salut, per que ens expliquessin que en pensen, com ho treballen i com ho viuen i el més important, com els farmacèutics comunitaris hi podem intervenir