Demonstrating 24-hour continuous vertical monitoring of atmospheric optical turbulence

We report what is believed to be the first example of fully continuous, 24-hour vertical monitoring of atmospheric optical turbulence. This is achieved using a novel instrument, the 24-hour Shack-Hartmann Image Motion Monitor (24hSHIMM). Optical turbulence is a fundamental limitation for applications such as free-space optical communications, where it limits the achievable bandwidth, and ground-based optical astronomy, restricting the observational precision. Knowledge of the turbulence enables us to select the best sites, design optical instrumentation and optimise the operation of ground-based optical systems. The 24hSHIMM estimates the vertical optical turbulence coherence length, time, angle and Rytov variance from the measurement of a four-layer vertical turbulence profile and a wind speed profile retrieved from meteorological forecasts. To illustrate our advance we show the values of these parameters recorded during a 36-hour, continuous demonstration of the instrument. Due to its portability and ability to work in stronger turbulence, the 24hSHIMM can also operate in urban locations, providing the field with a truly continuous, versatile turbulence monitor for all but the most demanding of applications

Oxygen isotope geochemistry of oceanic-arc lava

Variations of oxygen isotope ratios in arc-related lavas can constrain the contributions of subducted crustal igneous rocks, sediments, and fluids to the sub-arc mantle. We have measured oxygen isotope ratios in 72 arc and back-arc lavas from five ocean–ocean subduction zone systems using laser-fluorination analyses of olivine and other phenocrysts and glass. Eighty percent of our samples have {delta}18O values for any given phase (olivine, plagioclase, glass, or biotite) within 0·2{per thousand} of the average value for that phase in upper-mantle peridotites and mid-ocean ridge basalt (MORB); the range for each phase is <=1·0{per thousand}. This result contrasts with previous studies of whole-rock samples (which are significantly more variable even after exclusion of samples believed to be altered or fractionated by magmatic differentiation) and demonstrates that most arc-related lavas contain <=1–2% of 18O-enriched crustal oxygen from any source (i.e. assimilation or subducted contributions). Elevations in {delta}18O that do occur in these basic, arc-derived magmas relative to values most common for mantle-derived lavas are associated both with ‘enriched’ radiogenic isotope signatures and, even more strongly, with chemical indices consistent with high integrated extents of melting of their peridotite sources. We interpret these relationships as evidence that melting in the sources of the high-{delta}18O lavas we have studied was fluxed by addition of high-{delta}18O aqueous fluid (or perhaps a hydrous melt) from the subducted slab, such that sources that contain relatively large components of slab-derived fluid or melt are both relatively 18O enriched and also experienced relatively large amounts of melting. We have developed a quantitative model linking the amount of melting to the extents of 18O, radiogenic isotope, and trace-element enrichment in a mantle source being fluxed by addition of aqueous fluid. Comparison of this model with observed variations in the geochemistry of lavas from the Vanuatu–Fiji–New Caledonia region (the suite of related samples showing the greatest range in {delta}18O observed in this study) constrains the amounts and chemical and isotopic compositions of slab-derived phases in the sources of these arc-related lavas. Assuming a {delta}18O value of 20{per thousand} for the slab-derived fluid, 0·5–1·0 wt % is added to the sources of most mantle-derived arc magmas; the maximum amount of slab-derived flux in the sources of arc magmas according to our results is 2·5 wt %

Building a sustainable and desirable economy-in-society-in-nature

This report is a synthesis of ideas about what this new economy-in-society-innature could look like and how we might get there. Most of the ideas presented here are not new. The coauthors of this report have published them in various forms over the last several decades, and many others have expressed similar ideas in venues too numerous to mention. What is new is the timing and the situation. The time has come when we must make a transition. We have no choice. Our present path is clearly unsustainable. As Paul Raskin has said, Contrary to the conventional wisdom, it is business as usual that is the utopian fantasy; forging a new vision is the pragmatic necessity [10]. But we do have a choice about how to make the transition and what the new state of the world will be. We can engage in a global dialogue to envision the future we want, the theme of Rio+20, and then devise an adaptive strategy to get us there, or we can allow the current system to collapse and rebuild from a much worse starting point. We obviously argue for the former strategy. In this report, we discuss the need to focus more directly on the goal of sustainable human well-being rather than merely GDP growth. This includes protecting and restoring nature, achieving social and intergenerational fairness (including poverty alleviation), stabilizing population, and recognizing the significant nonmarket contributions to human well-being from natural and social capital. To do this, we need to develop better measures of progress that go well beyond GDP and begin to measure human well-being and its sustainability more directly

Building a Sustainable and Desirable Economy-in-Society-in-Nature

The world has changed dramatically. We no longer live in a world relatively empty of humans and their artifacts. We now live in the “Anthropocene,” era in a full world where humans are dramatically altering our ecological life-support system. Our traditional economic concepts and models were developed in an empty world. If we are to create sustainable prosperity, if we seek “improved human well-being and social equity, while significantly reducing environmental risks and ecological scarcities,” we are going to need a new vision of the economy and its relationship to the rest of the world that is better adapted to the new conditions we face. We are going to need an economics that respects planetary boundaries, that recognizes the dependence of human well-being on social relations and fairness, and that recognizes that the ultimate goal is real, sustainable human well-being, not merely growth of material consumption. This new economics recognizes that the economy is embedded in a society and culture that are themselves embedded in an ecological life-support system, and that the economy cannot grow forever on this finite planet. In this report, we discuss the need to focus more directly on the goal of sustainable human well-being rather than merely GDP growth. This includes protecting and restoring nature, achieving social and intergenerational fairness (including poverty alleviation), stabilizing population, and recognizing the significant nonmarket contributions to human well-being from natural and social capital. To do this, we need to develop better measures of progress that go well beyond GDP and begin to measure human well-being and its sustainability more directly

ISBS 2018 AUCKLAND CONFERENCE KIWIANA & INDUSTRY PARTNER PLAYING FIELD OPENING RECEPTION - ORDER OF PROCEEDINGS

The aim of the Kiwiana and Industry Partner Playing Field Opening Reception is to enable conference delegates to meet colleagues, make new acquaintances, learn about New Zealand (NZ) culture, experience quality NZ cuisine, and interact with new digital technology. The informative speeches (e.g. wine and food matching, cloudy bay clam research, Kiwiana research), thematic food stations (i.e. beach bach, farm, modern Kiwiana), interactive “ice-breaking” activities and competitions (e.g. jig saw building, gum boot throwing, number 8 wire sculpture, fishing), and social media photo opportunities (e.g. Kiwiana photo booth with VUTA) have been designed to help delegates achieve these goals. Native bird songs play while delegates walk into the fern and flax adorned atrium after the official opening. Delegates will receive a bubbly, beer, juice or mineral water on entry. Mr Kelly Sheerin, as the coordinator of the ISBS 2018 Conference industry partnership engagement programme, will outline the evening’s fun activities in the “Industry Playing Field” interactive events, and opportunities to win prizes. Dr Sarah-Kate Millar will provide the Karakia—blessing of the food. AUT Group Chef Matthew Farley, AUT Hospitality Services will explain the food and the Sileni wine for the evening. There are three savoury and two sweet canapés from cookbooks written by lecturers at AUT’s School of Hospitality and Tourism. Food is available from the Beach Bach, Farm, and Kiwiana themed areas. Lindsay Neill, kiwiana and Kiwi identity researcher, School of Hospitality, Tourism and Events, will outline the importance of kiwiana to New Zealand. His showcase will include the famous Buzzy Bee and findings from his latest research on kiwiana. Lindsay will highlight the uses of beetroot, tomato sauce, chocolate fish, Tip Top ice cream, and hokey pokey – regular food items for many NZers! We are really excited to showcase a special modern kiwiana food station with finger food adapted from books by AUT School of Hospitality, Tourism and Events staff. Students from the School’s culinary programmes are assisting to prepare and serve the food for your enjoyment including: Cured salmon, rice cracker, pickled ginger, spring onion; Corn fritters; Suqaar Digaag Somali chicken; White chocolate tart with chocolate cremeux and Swiss merengue; Misiluki banana pudding with Siamu Popo. Professor Lindsay White, Cloudy Bay Clams researcher, School of Applied Sciences, will outline the research behind producing Cloudy Bay Clams. His showcase will provide tastings of fresh seafood. Surf clams is the collective term for seven commercially harvested molluscs that live on almost all of NZ sandy, high wave energy beaches. They live buried in the sand, just in or behind the breaking waves. Regional small-scale studies indicate that surf clams have the potential to be NZ’s most valuable fishery resource, but a lack of scientific knowledge about these species allows only a tiny fraction of the sustainable harvest to be currently harvested. Our research to date has had a huge impact on the national fishery, more than doubling the total catch of surf clams, which equates to increases in annual export earnings of over $27 million. Based on this work, in 2013 we jointly won the Kiwi Supreme Prize for Commercialisation of Research. Tim Davison’s team will introduce the interactive virtual AUTer (VUTA). VUTA is the virtual MC for the Opening Kiwiana event alongside Kelly Sheerin as the in-the-flesh MC! Tim will explain how delegates can interact with VUTA by scanning the code in messenger. VUTA can make announcements, answer questions, display messages, greet people, and move around. Tim has been able to customise her to do just about anything. Samsung flip screens (https://displaysolutions.samsung.com/digital-signage/e-board/flip) are used for directional information and Tim’s VUTA. Thanks to Industry partner Samsung for providing the hardware to enable VUTA to come to life. Professor Len Gillman, School of Applied Sciences - Conference Sustainability—ecological responsibility, will explain the food and waste compositing, no single use plastics, and vegan options for the conference. Len and Professor Thomas Neitzert (School of Engineering) have calculated the carbon footprint for international delegates flying to NZ for the conference is 186.5 tonnes of carbon! Therefore 1.86 hectares (4.6 acres) will need to be planted to offset the conference travel. Strategies undertaken by the ISBS 2018 conference organising committee to help offset the carbon cost include the planting of native trees, promotion of recycling of bottles and compositing of food during the conference, vegan meal options, use of low energy LED lights and solar lights, minimised use of plastic products with no single-use plastic, digital posters rather than printing posters, and puffer jackets as the ‘conference bag’ as a useful reusable item. Lindsey du Preez is the AUT Sustainability Officer. Lindsey has worked with the AUT Hospitality Services team to provide initiatives that have a strong focus on sustainability for the conference. Some of the key initiatives are: This is a paperless conference and all material is digital including conference proceedings and posters; AUT is working towards eliminating ‘single use plastic’, so this is avoided wherever possible. Water will be provided in jugs with glass containers, and unpacked teabags and chocolates have been sourced directly from suppliers to reduce unnecessary packaging; Reusable cutlery and crockery will be provided to avoid unnecessary waste; Serviettes are compostable; 25% of the food provided is vegetarian and food is sourced locally wherever possible; three bin-system will be provided for rubbish, mixed recycling (plastic bottles types 1 & 2, essentially milk bottles and drink bottles, glass, cans) and organic waste; All leftover food will be composted, and every effort made to avoid over catering; Support of Fair Trade and all coffee is Fair Trade; The conference is next to a major bus terminus for easy access to public transport. The Kiwiana interactive showcase photo competition will be run by Kylie Robinson. Post the best photo of you and fellow delegates in the Kiwiana interactive showcase photo booth that includes jandals, flora (flax, punga ferns), fauna (Tui, Kiwi, geko, pukeko, kea), paua, a rugby ball, NZ sliver fern, flags, sheep, swandri, gumboots, #8 wire, L&P bottle, chocolate fish, tomato sauce bottle, buzzy bee, kiwi fruit. Thanks to AMTI for the chocolate fish. We have taken a different approach to our “sponsors” for the conference, preferring to have engaged industry partners. Industry Partners are treated like any other conference delegates in terms of registration, with an expectation that there is active engagement and preparation of a workshop, applied session or industry partner playing field event – just like a delegate would prepare an oral podium or a poster pitch and digital poster. Our industry partners have adapted to this new format with enthusiasm. We hope that delegates take up the opportunity to interact with the Industry Partner delegates, particularly in the playing field sessions where there are participatory games. Aerobe will be demonstrating their simple to use active marker technology Codamotion system to track the knee and ankle joints during a series of jump activities. Thanks to the industry partners who have participated in the industry partner programme. Platinum industry partner VICON are providing the ISBS 2018 conference puffer jackets to those who registered by the standard registration date. Vicon are also providing beverages for conference events. Diamond industry partner SILENI are providing amazing wines for all the conference events. We have a large selection from the Sileni range including Marlborough Sauvignon blanc, pinot gris, pinot noir, sparkling cuvee brut, merlot etc. Diamond industry partner SAMSUNG are providing new FLIP technology screens, 55” screens for the digital poster sessions, and the Note9 and DeX station for social media interaction and prizes. Gold industry partner ACC is supporting the Keynote panel speakers and a round table luncheon. Gold industry partner KISTLER are supporting two round table luncheons, and Olympic athletes at the AUT Millennium event. Gold industry partners QUALISYS and NORAXON are providing workshops and AUT Millennium applied sessions. Gold industry partner AMTI are supporting the chocolate box stations and the student evening at the marae. Silver industry partner FORCEDECKS are supporting the Commercialisation and Funding Monday workshop. Bronze industry partner CHANUI are providing tea and biscuits for breaks. Bronze industry partner AEROBE are supporting the Wise Wizards keynote panel. Bronze industry partner TEKSCAN are supporting the Sports Technology long table luncheon. Bronze industry partner STT Systems are supporting the fruit baskets. Bronze industry partner ASICS are providing shoes for social media prizes and a chill-out zone. Bronze industry partner SIMI are showcasing their technology at an industry booth

Systematic review: Safety of surgical male circumcision in context of HIV prevention public health programmes [version 2; peer review: 2 approved]

Background: Since the recommendation of voluntary medical male circumcision (VMMC) to reduce the risk of heterosexually acquired HIV, a number of adolescent boys and men in 15 priority countries in Africa have been circumcised. Our primary goal was to identify the incidence of adverse events (AEs) associated with VMMC and to assess the safety profile among adolescent boys 10 – 14 years. Methods: We searched the databases MEDLINE and Embase, WHO, and conference abstracts from 2005 to 2019. The incidence of AEs was estimated by type of AE, size of study and age. Results: We retained 40 studies. Severe and moderate AEs overall were estimated at 0.30 per 100 VMMC clients with wide variability per study type. A higher rate was noted in small and moderate scale programmes and device method research studies compared with larger scale programmes. There was a limited number of studies reporting AEs among younger adolescent boys and they had higher infection-related AEs than those aged 20 years and older. Case studies noted rare AEs such as necrotizing fasciitis, tetanus, and glans injury. Conclusions: AE rates were comparable to those from the randomized controlled trials (RCTs) that led to recommendations and implementation of VMMC in high HIV burden countries, despite being implemented in low resource settings. Clients over time have increasingly included adolescents under the age of 15 years. Studies suggest potentially higher risks in this age group. As VMMC services are sustained, patient safety surveillance systems and promoting a patient safety culture are crucial to identify and mitigate potential harms from medical male circumcision

WHO guidance grounded in a comprehensive approach to sexual and reproductive health and human rights: topical pre-exposure prophylaxis

Introduction: Two new microbicide products based on topical (vaginal) application of antiretroviral drugs – 1% tenofovir gel and the dapivirine ring – are currently in late-stage clinical testing, and results on their safety and effectiveness are expected to become available in early 2015. WHO guidelines on the use of topical pre-exposure prophylaxis (topical PrEP) are important in order to ensure that these new prevention products are optimally used. Discussion: Given that these new topical PrEP products are designed to be woman initiated and will likely be delivered in reproductive health settings, it is important to ensure that the guidance be framed in the context of comprehensive sexual and reproductive health and human rights. In addition to the safety and effectiveness data resulting from clinical trials, and the regulatory approval required for new products, the WHO normative guidelines on the use of topical PrEP will be essential for rapid roll-out in countries. Conclusions: Human rights standards and principles provide a framework for the provision of woman-initiated HIV prevention products. These include addressing issues related to the gender inequities which are linked to the provision of HIV-prevention, treatment and care for young girls and women. Effective programming for women and girls must therefore be based on understanding the local, social and community contexts of the AIDS epidemic in the country, and adapting HIV strategies and programmes accordingly. Such a framework therefore is needed not only to ensure optimal uptake of these new products by women and girls but also to address sociocultural barriers to women’s and girls’ access to these products

A 3-year multicentre randomized controlled trial of etonogestrel- and levonorgestrel-releasing contraceptive implants, with non-randomized matched copper-intrauterine device controls

STUDY QUESTION Is there any difference in the clinical performance of the 3-year one-rod etonogestrel (ENG)- and the 5-year two-rod levonorgestrel (LNG)-releasing contraceptive implants during 3 years of insertion, and between implant and intrauterine device (IUD) contraception, in particular complaints possibly related to hormonal contraceptives? SUMMARY ANSWER The cumulative contraceptive effectiveness after 3 years and method continuation through 2.5 years were not significantly different between ENG and LNG implants, but both outcomes were significantly worse in the non-randomized age-matched group of IUD users than in the combined implant group. WHAT IS KNOWN ALREADY ENG- and LNG-releasing implants are safe and highly efficacious contraceptives with pregnancy rates reported to be 0.0-0.5 per 100 women-years (W-Y). No head-to-head comparative study of the two implants has been undertaken, and little information is available on comparisons of complaints of side effects of implant and copper IUD users. STUDY DESIGN, SIZE, DURATION This was an open parallel group RCT with 1:1 allocation ratio of the ENG and the LNG implants with non-randomized control group of women choosing TCu380A IUD to address lack of reliable data on common side effects typically attributed to the use of progestogen-only contraceptives. After device(s) placement, follow-ups were at 2 weeks, 3 and 6 months, and semi-annually thereafter for 3 years or until pregnancy, removal or expulsion of the implant/IUD occurred. PARTICIPANTS, SETTING, METHODS The study took place in family planning clinics in Brazil, Chile, Dominican Republic, Hungary, Thailand, Turkey and Zimbabwe. Women seeking long-term contraception were enlisted after an eligibility check and informed consent, and 2982 women were enrolled: 1003, 1005 and 974 in the ENG-implant, LNG-implant and IUD groups, respectively; 995, 997 and 971, respectively, were included in the per protocol analysis reported here. MAIN RESULTS AND THE ROLE OF CHANCE ENG and LNG implants each had the same 3-year cumulative pregnancy rate of 0.4 per 100 W-Y [95% confidence interval (CI) 0.1-1.4]. A weight of ≥70 kg at admission was unrelated to pregnancy. Method continuation rates for ENG and LNG implants at 2.5 years were 69.8 (95% CI 66.8-72.6) and 71.8 per 100 W-Y (68.8-74.5), and at 3 years 12.1 (95% CI 5.2-22.0) and 52.0 per 100 W-Y (95% CI 41.8-61.2), respectively. Bleeding disturbances, the most frequent reason for method discontinuation, were significantly more common in the ENG group [16.7 (95% CI 14.4-19.3)] than in the LNG group [12.5 (95% CI 10.5-14.9)] (P 0.019). The 3-year cumulative loss to follow-up was lower in the ENG- than in the LNG-implant group, 8.1 (95% CI 6.4-10.2) and 14.4 per 100 W-Y (95% CI 12.1-17.1), respectively. The median duration of implant removal was 50 s shorter among women with ENG than among women with LNG implant (P < 0.0001). In the observational comparison between IUD and implant users, the 3-year relative risk for pregnancy in IUD group compared with the combined implant group was 5.7 per 100 W-Y (95% CI 4.4-7.3) (P = 0.0003). The 3-year expulsion rate of the IUD was 17.8 per 100 W-Y (95% CI 14.5-21.9), while the discontinuation rate for bleeding disturbances was 8.5 (95% CI 6.7-10.9). Frequency of complaints of headache and dizziness was not significantly different between implant and IUD users (P = 0.16 and 0.77, respectively), acne and bleeding irregularities were more frequent among implant users (P < 0.0001), while heavy bleeding and lower abdominal pain occurred more often among IUD than implant users (P < 0.0001). LIMITATIONS, REASONS FOR CAUTION Few women were ≤19 years old or nulligravida, the proportion of implant users ≥70 kg was <20% and <8% were obese. WIDER IMPLICATIONS OF THE FINDINGS Findings of the study can inform policy makers and clinicians about choice of implant, but also about TCu380A IUD in relation to implants. STUDY FUNDING/COMPETING INTEREST(S) UNDP/UNFPA/WHO/UNICEF/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Reproductive Health and Research (RHR), World Health Organization (WHO). This report contains the views of an international expert group and does not necessarily represent the decisions or the stated policy of the WHO. TRIAL REGISTRATION ISRCTN33378571 registered on 22 March 2004. The first participant was enrolled on 12 May 200