Measuring segregation using patterns of daily travel behavior : a social interaction based model of exposure

Recent advances in transportation geography demonstrate the ability to compute a metropolitan scale metric of social interaction opportunities based on the time-geographic concept of joint accessibility. The method we put forward in this article decomposes the social interaction potential (SIP) metric into interactions within and between social groups, such as people of different race, income level, and occupation. This provides a novel metric of exposure, one of the fundamental spatial dimensions of segregation. In particular, the SIP metric is disaggregated into measures of inter-group and intra-group exposure. While activity spaces have been used to measure exposure in the geographic literature, these approaches do not adequately represent the dynamic nature of the target populations. We make the next step by representing both the source and target population groups by space-time prisms, thus more accurately representing spatial and temporal dynamics and constraints. Additionally, decomposition of the SIP metric means that each of the group-wise components of the SIP metric can be represented at zones of residence, workplace, and specific origin-destination pairs. Consequently, the spatial variation in segregation can be explored and hotspots of segregation and integration potential can be identified. The proposed approach is demonstrated for synthetic cities with different population distributions and daily commute flow characteristics, as well as for a case study of the Detroit-Warren-Livonia MSA

Breaking Down the Stereotypes of Science by Recruiting Young Scientists

Thomas Jefferson University Science Outreach Program brings the scientific method into the classroo

D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish

BACKGROUND: Heparan sulfate (HS) is an ubiquitous component of the extracellular matrix that binds and modulates the activity of growth factors, cytokines and proteases. Animals with defective HS biosynthesis display major developmental abnormalities however the processes that are affected remain to be defined. D-glucuronyl-C5-epimerase (Glce) is a key HS chain modifying enzyme that catalyses the conversion of glucuronic acid into iduronic acid, a biosynthetic step that enhances HS biological activity. In this study the role of Glce during early zebrafish development has been investigated. RESULTS: Two Glce-like proteins (Glce-A and -B) are expressed in zebrafish at all times. They are the products of two distinct genes that, based on chromosomal mapping, are both orthologues of the same single human gene. Transcripts for both proteins were detected in fertilized zebrafish embryos prior to the onset of zygotic transcription indicating their maternal origin. At later developmental stages the epimerases are expressed widely throughout gastrulation and then become restricted to the hindbrain at 24 h post-fertilization. By monitoring the expression of well characterized marker genes during gastrulation, we have found that misexpression of Glce causes a dose-dependent expansion of the ventral structures, whereas protein knockdown using targeted antisense morpholino oligonucleotides promotes axis dorsalization. The ventralizing activity of Bmp2b is enhanced by Glce overexpression whereas Glce knockdown impairs Bmp2b activity. CONCLUSION: Glce activity is an important determinant of of dorso-ventral axis formation and patterning in zebrafish. In particular Glce acts during gastrulation by affecting Bmp-mediated cell specification. The results obtained further corroborate the concept that HS encodes information that affect morphogenesis during early vertebrate development

How access to public transit may have saved many Americans’ homes during the Great Recession

The Great Recession which followed the 2008 financial crash saw massive increases in the number of homes being foreclosed and trillions wiped from homeowners’ equity. But the impact of the recession was not uniform across the country in all places. In new research, Timothy F. Welch, Steven R. Gehrke and Steven Farber look at the effects of access to public transport on house prices during the Great Recession. They find that houses less than a mile from stations in Atlanta, Baltimore or Portland all kept their value to a greater degree than those located farther away from stations.They suggest that this may be down to lower transport-related costs, better local economic conditions and greater access to employment opportunities

Identifying public transport gaps using time-dependent accessibility levels

One of the concerns that has aroused much scholarly attention in transport geography lately is the extent to which public transport provision enables the less privileged population segments, especially those without privately owned motorized vehicles, to participate in activities that are deemed normal within the society they live in. This study contributes to this line of inquiry by proposing a methodology for identifying public transit gaps, a mismatch between the socially driven demand for transit and the supply provided by transit agencies. The methodology draws on the latest accomplishments in the field of modeling time-continuous, schedule-based public transport accessibility. Accessibility levels to key destinations are calculated at regular time intervals, and synoptic metrics of these levels over various peak and off-peak time windows are computed for weekdays and weekends. As a result, a temporally reliable picture of accessibility by public transport is constructed. The obtained index of public transport provision is compared to a public transport needs index based on the spatial distribution of various socio-demographics, in order to highlight spatial mismatches between these two indices. The study area consists of Flanders, which is the northern, Dutch-speaking region of Belgium. The results indicate that mainly suburban areas are characterized by high public transport gaps. Due to the time-variability of public transport frequencies, these gaps differ over time

The Impacts of Urban Growth Policies on Transportation System Usage and Performance: A Simulation Approach

Integrated urban models (IUM) are a useful tool in simulating the long term impacts of transportation and land use policies. In this paper, IMULATE, and IUM for the Hamilton CMA is used to investigate the impacts of several growth policies outlined in the Province of Ontario’s Places to Grow plan. Several intensification strategies are simulated and evaluated with respect to transportation system usage and performance. The simulation results are investigated at the aggregate level and disaggregately, since some impacts to the system such as pollutant emissions vary spatially. While IUMs have been used to compare growth strategies world-wide, little applied work has been published before in Canada. The results indicate that in the absence of modifications to the transportation system, the proposed intensification strategies have little net effect in mitigating growing system usage and weakening system performance over the next 25 years. They do however impact the spatiality of transport related externalities

Pressure loss modeling of non-symmetric gas turbine exhaust ducts using CFD

In typical gas turbine applications, combustion gases that are discharged from the turbine are exhausted into the atmosphere in a direction that is sometimes different from that of the inlet. In such cases, the design of efficient exhaust ducts is a challenging task particularly when the exhaust gases are also swirling. Designers are in need for a tool today that can guide them in assessing qualitatively and quantitatively the different flow physics in these exhaust ducts so as to produce efficient designs. In this thesis, a parametric Computational Fluid Dynamics (CFD) based study was carried out on non-symmetric gas turbine exhaust ducts where the effects of geometry and inlet aerodynamic conditions were examined. The results of the numerical analysis were used to develop a total pressure loss model. These exhaust ducts comprise an annular inlet, a flow splitter, an annular to rectangular transition region, and an exhaust stub. The duct geometry, which is a three-dimensional complex one, is approximated with a five-parameter model, which was coupled with a design of experiment method to generate a relatively small number of exhaust ducts. The flow in these ducts was simulated using CFD for different values of inlet swirl and aerodynamic blockage and the numerical results were reviewed so as to assess the effects of the geometric and aerodynamic parameters on the total pressure loss in the exhaust duct. These flow simulations were used as a data base to generate a total pressure loss model that designers can use as a tool to build more efficient non-symmetric gas turbine exhaust ducts. The resulting correlation has demonstrated satisfactory agreement with the CFD-based dat

Biomarkers of human cardiopulmonary response after short-term exposures to medical laser generated particulate matter from simulated procedures: a pilot study

Objective We conducted an exposure chamber study in humans using a simulated clinical procedure lasing porcine tissue to demonstrate evidence of effects of exposure to laser generated particulate matter (LGPM). Methods We measured pre- and post-exposure changes in exhaled nitric oxide (eNO), spirometry, heart rate variability (HRV), and blood markers of inflammation in five volunteers. Results Change in pre- and post-exposure measurements of eNO and spirometry were unremarkable. Neutrophil and lymphocyte counts increased and fibrinogen levels decreased in four of the five subjects. Measures of HRV showed decreases in the standard deviation of normal between beat intervals and sequential five-minute intervals. Conclusion These data represent the first evidence of human physiologic response to LGPM exposure. Further exploration of coagulation effects and HRV are warranted

Accessibility to health care facilities in Montreal Island: an application of relative accessibility indicators from the perspective of senior and non-senior residents

<p>Abstract</p> <p>Background</p> <p>Geographical access to health care facilities is known to influence health services usage. As societies age, accessibility to health care becomes an increasingly acute public health concern. It is known that seniors tend to have lower mobility levels, and it is possible that this may negatively affect their ability to reach facilities and services. Therefore, it becomes important to examine the mobility situation of seniors vis-a-vis the spatial distribution of health care facilities, to identify areas where accessibility is low and interventions may be required.</p> <p>Methods</p> <p>Accessibility is implemented using a cumulative opportunities measure. Instead of assuming a fixed bandwidth (i.e. a distance threshold) for measuring accessibility, in this paper the bandwidth is defined using model-based estimates of average trip length. Average trip length is an all-purpose indicator of individual mobility and geographical reach. Adoption of a spatial modelling approach allows us to tailor these estimates of travel behaviour to specific locations and person profiles. Replacing a fixed bandwidth with these estimates permits us to calculate customized location- and person-based accessibility measures that allow inter-personal as well as geographical comparisons.</p> <p>Data</p> <p>The case study is Montreal Island. Geo-coded travel behaviour data, specifically average trip length, and relevant traveller's attributes are obtained from the Montreal Household Travel Survey. These data are complemented with information from the Census. Health care facilities, also geo-coded, are extracted from a comprehensive business point database. Health care facilities are selected based on Standard Industrial Classification codes 8011-21 (Medical Doctors and Dentists).</p> <p>Results</p> <p>Model-based estimates of average trip length show that travel behaviour varies widely across space. With the exception of seniors in the downtown area, older residents of Montreal Island tend to be significantly less mobile than people of other age cohorts. The combination of average trip length estimates with the spatial distribution of health care facilities indicates that despite being more mobile, suburban residents tend to have lower levels of accessibility compared to central city residents. The effect is more marked for seniors. Furthermore, the results indicate that accessibility calculated using a fixed bandwidth would produce patterns of exposure to health care facilities that would be difficult to achieve for suburban seniors given actual mobility patterns.</p> <p>Conclusions</p> <p>The analysis shows large disparities in accessibility between seniors and non-seniors, between urban and suburban seniors, and between vehicle owning and non-owning seniors. This research was concerned with potential accessibility levels. Follow up research could consider the results reported here to select case studies of actual access and usage of health care facilities, and related health outcomes.</p