309 research outputs found

    Low temperature dielectric relaxation in ordinary perovskite ferroelectrics: enlightenment from high-energy x-ray diffraction

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    Ordinary ferroelectrics exhibit a second order phase transition that is characterized by a sharp peak in the dielectric permittivity at a frequency-independent temperature. Furthermore, these materials show a low temperature dielectric relaxation that appears to be a common behavior of perovskite systems. Tetragonal lead zirconate titanate is used here as a model system in order to explore the origin of such an anomaly, since there is no consensus about the physical phenomenon involved in it. Crystallographic and domain structure studies are performed from temperature dependent synchrotron x-ray diffraction measurement. Results indicate that the dielectric relaxation cannot be associated with crystallographic or domain configuration changes. The relaxation process is then parameterized by using the Vogel–Fulcher–Tammann phenomenological equation. Results allow us to hypothesize that the observed phenomenon is due to changes in the dynamic behavior of the ferroelectric domains related to the fluctuation of the local polarization.Postprint (author's final draft

    Microwave ac Zeeman Force for Ultracold Atoms

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    We measure the ac Zeeman force on an ultracold gas of 87Rb due to a microwave magnetic field targeted to the 6.8 GHz hyperfine splitting of these atoms. An atom chip produces a microwave near field with a strong amplitude gradient, and we observe a force over three times the strength of gravity. Our measurements are consistent with a simple two-level theory for the ac Zeeman effect and demonstrate its resonant, bipolar, and spin-dependent nature. We observe that the dressed-atom eigenstates gradually mix over time and have mapped out this behavior as a function of magnetic field and detuning. We demonstrate the practical spin selectivity of the force by pushing or pulling a specific spin state while leaving other spin states unmoved

    A Retrospective Analysis Of Risk Factors That Influence Intravenous Busulfan Kinetics In Adult Patients

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    Age and growth of Astarte borealis (Bivalvia) from the southwestern Baltic Sea using secondary ion mass spectrometry

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    Traditional isotope sclerochronology employing isotope ratio mass spectrometry has been used for decades to determine the periodicity of growth increment formation in marine organisms with accretionary growth. Despite its well-demonstrated capabilities, it is not without limitation. The most significant of these being the volume of carbonate powder required for analysis with conventional drill-sampling techniques, which limit sampling to early in ontogeny when growth is fast or to species that reach relatively large sizes. In species like Astarte borealis (Schumacher, 1817), a common component of Arctic boreal seas, traditional methods of increment analysis are difficult, because the species is typically long-lived, slow growing, and forms extremely narrowly spaced growth increments. Here, we use Secondary Ion Mass Spectrometry (SIMS) to analyze δ18O in 10-μm-diameter spots and resolve the seasonal timing of growth increment formation in Astarte borealis in the southeastern Baltic Sea. In the individaul sampled here, dark growth increments can form in either the fall, winter, or spring. Furthermore, growth increment data from two populations (RFP3S = 54.7967° N, 12.38787° E; WA = 54.86775° N, 14.09832° E) indicate that in the Baltic Sea, A. borealis is moderately long-lived (at least 43 years) and slow growing (von Bertalanffy k values 0.08 and 0.06). Our results demonstrate the potential of A. borealis to be a recorder of Baltic Sea seasonality over the past century using both live- and dead-collected shells, and also the ability of SIMS analysis to broaden the spectrum of bivalves used in sclerocrhonological work

    The Peak of the Fallback Rate from Tidal Disruption Events: Dependence on Stellar Type

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    A star completely destroyed in a tidal disruption event (TDE) ignites a luminous flare that is powered by the fallback of tidally stripped debris to a supermassive black hole (SMBH) of mass M∙M_{\bullet}. We analyze two estimates for the peak fallback rate in a TDE, one being the "frozen-in" model, which predicts a strong dependence of the time to peak fallback rate, tpeakt_{\rm peak}, on both stellar mass and age, with 15 days≲tpeak≲1015\textrm{ days} \lesssim t_{\rm peak} \lesssim 10 yr for main sequence stars with masses 0.2≤M⋆/M⊙≤50.2\le M_{\star}/M_{\odot} \le 5 and M∙=106M⊙M_{\bullet} = 10^6M_{\odot}. The second estimate, which postulates that the star is completely destroyed when tides dominate the maximum stellar self-gravity, predicts that tpeakt_{\rm peak} is very weakly dependent on stellar type, with tpeak=(23.2±4.0 days)(M∙/106M⊙)1/2t_{\rm peak} = \left(23.2\pm4.0\textrm{ days}\right)\left(M_{\bullet}/10^6M_{\odot}\right)^{1/2} for 0.2≤M⋆/M⊙≤50.2\le M_{\star}/M_{\odot} \le 5, while tpeak=(29.8±3.6 days)(M∙/106M⊙)1/2t_{\rm peak} = \left(29.8\pm3.6\textrm{ days}\right)\left(M_{\bullet}/10^6M_{\odot}\right)^{1/2} for a Kroupa initial mass function truncated at 1.5M⊙1.5 M_{\odot}. This second estimate also agrees closely with hydrodynamical simulations, while the frozen-in model is discrepant by orders of magnitude. We conclude that (1) the time to peak luminosity in complete TDEs is almost exclusively determined by SMBH mass, and (2) massive-star TDEs power the largest accretion luminosities. Consequently, (a) decades-long extra-galactic outbursts cannot be powered by complete TDEs, including massive-star disruptions, and (b) the most highly super-Eddington TDEs are powered by the complete disruption of massive stars, which -- if responsible for producing jetted TDEs -- would explain the rarity of jetted TDEs and their preference for young and star-forming host galaxies.Comment: 10 pages, 4 figures, ApJL accepte

    Ursinus College Bulletin, Summer 1980

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    Fellow alumni: Advice to future ambassadors • For this P. R. man letting off steam is a really hot story • Making it in the long run • He\u27s not just a passing fancy: Or, how will Howard ever learn to say Ursinus • Filling the gap: Or, what I did on my summer vacation • East meets West at Ursinus College (and the Philadelphia area reads about an Ursinus cultural exchange program) • To the wall and back again: Ursinus\u27 elder statesman visits China • His career\u27s on the right track • New faculty appointments • Archivist needed • Kane named to post • Gifts to Ursinus College • Lost alumni: Reunion years 1981 • News notes • Evening School • Births • Marriages • Deathshttps://digitalcommons.ursinus.edu/new_bulletin/1027/thumbnail.jp

    Rapid progression is associated with lymphoid follicle dysfunction in SIV-infected infant rhesus macaques.

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    HIV-infected infants are at an increased risk of progressing rapidly to AIDS in the first weeks of life. Here, we evaluated immunological and virological parameters in 25 SIV-infected infant rhesus macaques to understand the factors influencing a rapid disease outcome. Infant macaques were infected with SIVmac251 and monitored for 10 to 17 weeks post-infection. SIV-infected infants were divided into either typical (TypP) or rapid (RP) progressor groups based on levels of plasma anti-SIV antibody and viral load, with RP infants having low SIV-specific antibodies and high viral loads. Following SIV infection, 11 out of 25 infant macaques exhibited an RP phenotype. Interestingly, TypP had lower levels of total CD4 T cells, similar reductions in CD4/CD8 ratios and elevated activation of CD8 T cells, as measured by the levels of HLA-DR, compared to RP. Differences between the two groups were identified in other immune cell populations, including a failure to expand activated memory (CD21-CD27+) B cells in peripheral blood in RP infant macaques, as well as reduced levels of germinal center (GC) B cells and T follicular helper (Tfh) cells in spleens (4- and 10-weeks post-SIV). Reduced B cell proliferation in splenic germinal GCs was associated with increased SIV+ cell density and follicular type 1 interferon (IFN)-induced immune activation. Further analyses determined that at 2-weeks post SIV infection TypP infants exhibited elevated levels of the GC-inducing chemokine CXCL13 in plasma, as well as significantly lower levels of viral envelope diversity compared to RP infants. Our findings provide evidence that early viral and immunologic events following SIV infection contributes to impairment of B cells, Tfh cells and germinal center formation, ultimately impeding the development of SIV-specific antibody responses in rapidly progressing infant macaques

    Increasing confidence and changing behaviors in primary care providers engaged in genetic counselling.

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    BackgroundScreening and counseling for genetic conditions is an increasingly important part of primary care practice, particularly given the paucity of genetic counselors in the United States. However, primary care physicians (PCPs) often have an inadequate understanding of evidence-based screening; communication approaches that encourage shared decision-making; ethical, legal, and social implication (ELSI) issues related to screening for genetic mutations; and the basics of clinical genetics. This study explored whether an interactive, web-based genetics curriculum directed at PCPs in non-academic primary care settings was superior at changing practice knowledge, attitudes, and behaviors when compared to a traditional educational approach, particularly when discussing common genetic conditions.MethodsOne hundred twenty one PCPs in California and Pennsylvania physician practices were randomized to either an Intervention Group (IG) or Control Group (CG). IG physicians completed a 6 h interactive web-based curriculum covering communication skills, basics of genetic testing, risk assessment, ELSI issues and practice behaviors. CG physicians were provided with a traditional approach to Continuing Medical Education (CME) (clinical review articles) offering equivalent information.ResultsPCPs in the Intervention Group showed greater increases in knowledge compared to the Control Group. Intervention PCPs were also more satisfied with the educational materials, and more confident in their genetics knowledge and skills compared to those receiving traditional CME materials. Intervention PCPs felt that the web-based curriculum covered medical management, genetics, and ELSI issues significantly better than did the Control Group, and in comparison with traditional curricula. The Intervention Group felt the online tools offered several advantages, and engaged in better shared decision making with standardized patients, however, there was no difference in behavior change between groups with regard to increases in ELSI discussions between PCPs and patients.ConclusionWhile our intervention was deemed more enjoyable, demonstrated significant factual learning and retention, and increased shared decision making practices, there were few differences in behavior changes around ELSI discussions. Unfortunately, barriers to implementing behavior change in clinical genetics is not unique to our intervention. Perhaps the missing element is that busy physicians need systems-level support to engage in meaningful discussions around genetics issues. The next step in promoting active engagement between doctors and patients may be to put into place the tools needed for PCPs to easily access the materials they need at the point-of-care to engage in joint discussions around clinical genetics
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