79 research outputs found
The Equivalence Theorem and Effective Lagrangians
We point out that the equivalence theorem, which relates the amplitude for a
process with external longitudinally polarized vector bosons to the amplitude
in which the longitudinal vector bosons are replaced by the corresponding
pseudo-Goldstone bosons, is not valid for effective Lagrangians. However, a
more general formulation of this theorem also holds for effective interactions.
The generalized theorem can be utilized to determine the high-energy behaviour
of scattering processes just by power counting and to simplify the calculation
of the corresponding amplitudes. We apply this method to the phenomenologically
most interesting terms describing effective interactions of the electroweak
vector and Higgs bosons in order to examine their effects on vector-boson
scattering and on vector-boson-pair production in annihilation. The
use of the equivalence theorem in the literature is examined.Comment: 20 pages LaTeX, BI-TP 94/1
Wytyczne ESC dotycza̧ce rozpoznania oraz leczenia ostrej i przewlekłej niewydolności serca na 2012 rok
The G0 Experiment: Apparatus for Parity-Violating Electron Scattering Measurements at Forward and Backward Angles
In the G0 experiment, performed at Jefferson Lab, the parity-violating
elastic scattering of electrons from protons and quasi-elastic scattering from
deuterons is measured in order to determine the neutral weak currents of the
nucleon. Asymmetries as small as 1 part per million in the scattering of a
polarized electron beam are determined using a dedicated apparatus. It consists
of specialized beam-monitoring and control systems, a cryogenic hydrogen (or
deuterium) target, and a superconducting, toroidal magnetic spectrometer
equipped with plastic scintillation and aerogel Cerenkov detectors, as well as
fast readout electronics for the measurement of individual events. The overall
design and performance of this experimental system is discussed.Comment: Submitted to Nuclear Instruments and Method
Supernova Interaction with a Circumstellar Medium
The explosion of a core collapse supernova drives a powerful shock front into
the wind from the progenitor star. A layer of shocked circumstellar gas and
ejecta develops that is subject to hydrodynamic instabilities. The hot gas can
be observed directly by its X-ray emission, some of which is absorbed and
re-radiated at lower frequencies by the ejecta and the circumstellar gas.
Synchrotron radiation from relativistic electrons accelerated at the shock
fronts provides information on the mass loss density if free-free absorption
dominates at early times or the size of the emitting region if synchrotron
self-absorption dominates. Analysis of the interaction leads to information on
the density and structure of the ejecta and the circumstellar medium, and the
abundances in these media. The emphasis here is on the physical processes
related to the interaction.Comment: 22 pages, 7 figures, to appear as a Chapter in "Supernovae and
Gamma-Ray Bursts," edited by K. W. Weiler (Springer-Verlag
Optical Light Curves of Supernovae
Photometry is the most easily acquired information about supernovae. The
light curves constructed from regular imaging provide signatures not only for
the energy input, the radiation escape, the local environment and the
progenitor stars, but also for the intervening dust. They are the main tool for
the use of supernovae as distance indicators through the determination of the
luminosity. The light curve of SN 1987A still is the richest and longest
observed example for a core-collapse supernova. Despite the peculiar nature of
this object, as explosion of a blue supergiant, it displayed all the
characteristics of Type II supernovae. The light curves of Type Ib/c supernovae
are more homogeneous, but still display the signatures of explosions in massive
stars, among them early interaction with their circumstellar material. Wrinkles
in the near-uniform appearance of thermonuclear (Type Ia) supernovae have
emerged during the past decade. Subtle differences have been observed
especially at near-infrared wavelengths. Interestingly, the light curve shapes
appear to correlate with a variety of other characteristics of these
supernovae. The construction of bolometric light curves provides the most
direct link to theoretical predictions and can yield sorely needed constraints
for the models. First steps in this direction have been already made.Comment: To be published in:"Supernovae and Gamma Ray Bursters", Lecture Notes
in Physics (http://link.springer.de/series/lnpp
QCD Corrections and Non-standard Three Vector Boson Couplings in Production at Hadron Colliders
The process p\,p\hskip-7pt\hbox{^{^{(\!-\!)}}} \rightarrow W^{+} W^{-} + X
\rightarrow \ell^+_1 \nu_1 \ell^-_2 \bar \nu_2 + X is calculated to for general and conserving couplings (). The prospects for probing the couplings in this reaction are
explored. The impact of QCD corrections and various
background processes on the observability of non-standard couplings in
production at the Tevatron and the Large Hadron Collider (LHC) is
discussed in detail. Sensitivity limits for anomalous couplings are
derived at next-to-leading order for the Tevatron and LHC center of mass
energies, and are compared to the bounds which can be achieved in other
processes. Unless a jet veto or a cut on the total transverse momentum of the
hadrons in the event is imposed, the QCD corrections and
the background from top quark production decrease the sensitivity of
p\,p\hskip-7pt\hbox{^{^{(\!-\!)}}} \rightarrow W^{+} W^{-} + X \rightarrow
\ell^+_1 \nu_1 \ell^-_2 \bar \nu_2 + X to anomalous couplings by a
factor two to five.Comment: REVTEX 3, 62 pages, 21 Figures (not included available upon request),
the postscript file of the complete paper is available at
ftp://ucdhep.ucdavis.edu/han/ww/ww_paper.p
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Epstein-Barr virus: clinical and epidemiological revisits and genetic basis of oncogenesis
Epstein-Barr virus (EBV) is classified as a member in the order herpesvirales, family herpesviridae, subfamily gammaherpesvirinae and the genus lymphocytovirus. The virus is an exclusively human pathogen and thus also termed as human herpesvirus 4 (HHV4). It was the first oncogenic virus recognized and has been incriminated in the causation of tumors of both lymphatic and epithelial nature. It was reported in some previous studies that 95% of the population worldwide are serologically positive to the virus. Clinically, EBV primary infection is almost silent, persisting as a life-long asymptomatic latent infection in B cells although it may be responsible for a transient clinical syndrome called infectious mononucleosis. Following reactivation of the virus from latency due to immunocompromised status, EBV was found to be associated with several tumors. EBV linked to oncogenesis as detected in lymphoid tumors such as Burkitt's lymphoma (BL), Hodgkin's disease (HD), post-transplant lymphoproliferative disorders (PTLD) and T-cell lymphomas (e.g. Peripheral T-cell lymphomas; PTCL and Anaplastic large cell lymphomas; ALCL). It is also linked to epithelial tumors such as nasopharyngeal carcinoma (NPC), gastric carcinomas and oral hairy leukoplakia (OHL). In vitro, EBV many studies have demonstrated its ability to transform B cells into lymphoblastoid cell lines (LCLs). Despite these malignancies showing different clinical and epidemiological patterns when studied, genetic studies have suggested that these EBV- associated transformations were characterized generally by low level of virus gene expression with only the latent virus proteins (LVPs) upregulated in both tumors and LCLs. In this review, we summarize some clinical and epidemiological features of EBV- associated tumors. We also discuss how EBV latent genes may lead to oncogenesis in the different clinical malignancie
The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies
The German Centre for Cardiovascular Research (DZHK) is one of the German Centres for Health Research and aims to conduct early and guideline-relevant studies to develop new therapies and diagnostics that impact the lives of people with cardiovascular disease. Therefore, DZHK members designed a collaboratively organised and integrated research platform connecting all sites and partners. The overarching objectives of the research platform are the standardisation of prospective data and biological sample collections among all studies and the development of a sustainable centrally standardised storage in compliance with general legal regulations and the FAIR principles. The main elements of the DZHK infrastructure are web-based and central units for data management, LIMS, IDMS, and transfer office, embedded in a framework consisting of the DZHK Use and Access Policy, and the Ethics and Data Protection Concept. This framework is characterised by a modular design allowing a high standardisation across all studies. For studies that require even tighter criteria additional quality levels are defined. In addition, the Public Open Data strategy is an important focus of DZHK. The DZHK operates as one legal entity holding all rights of data and biological sample usage, according to the DZHK Use and Access Policy. All DZHK studies collect a basic set of data and biosamples, accompanied by specific clinical and imaging data and biobanking. The DZHK infrastructure was constructed by scientists with the focus on the needs of scientists conducting clinical studies. Through this, the DZHK enables the interdisciplinary and multiple use of data and biological samples by scientists inside and outside the DZHK. So far, 27 DZHK studies recruited well over 11,200 participants suffering from major cardiovascular disorders such as myocardial infarction or heart failure. Currently, data and samples of five DZHK studies of the DZHK Heart Bank can be applied for
Left ventricular structure and function in transthyretin-related versus light-chain cardiac amyloidosis
Background - : Immunoglobulin amyloid light-chain (AL)-related cardiac amyloidosis (CA) has a worse prognosis than either wild-type (ATTRwt) or mutant (ATTRm) transthyretin (TTR) CA. Detailed echocardiographic studies have been performed in AL amyloidosis but not in TTR amyloidosis and might give insight into this difference. We assessed cardiac structure and function and outcome in a large population of patients with CA and compared findings in TTR and AL-related disease. Methods and Results - : We analyzed 172 patients with CA (AL amyloidosis, n=80; ATTRm, n=36; ATTRwt, n=56) by standard echocardiography and 2-dimensional speckle-tracking imaging-derived left ventricular (LV) longitudinal (LS), radial, and circumferential strains. Despite a preserved LV ejection fraction (55\ub112%), LS was severely impaired in CA. Standard measures of LV function and speckle-tracking imaging worsened as wall thickness increased, whereas apical LS was preserved regardless of the pathogenesis of CA and the degree of wall thickening. Compared with ATTRm and AL amyloidosis, ATTRwt was characterized by greater LV wall thickness and lower ejection fraction. LS was more depressed in both ATTRwt and AL amyloidosis (-11\ub13% and -12\ub14%, respectively, P=0.54) than in ATTRm (-15\ub14%, P<0.01 versus AL amyloidosis and ATTRwt). TTR-related causes were favorable predictors of survival, whereas LS and advanced New York Heart Association class were negative predictors. CONCLUSIONS - : In patients with CA, worsening LV function correlated with increasing wall thickness regardless of pathogenesis. Patients with ATTRwt had a statistically greater wall thickness but lesser mortality than those with AL amyloidosis, despite very similar degrees of LS impairment. This paradox suggests an additional mechanism for LV dysfunction in AL amyloidosis, such as previously demonstrated light-chain toxicity. \ua9 2014 American Heart Association, Inc
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