1,598 research outputs found
Heavy-to-light baryonic form factors at large recoil
We analyze heavy-to-light baryonic form factors at large recoil and derive
the scaling behavior of these form factors in the heavy quark limit. It is
shown that only one universal form factor is needed to parameterize Lambda_b to
p and Lambda_b to Lambda matrix elements in the large recoil limit of light
baryons, while hadronic matrix elements of Lambda_b to Sigma transition vanish
in the large energy limit of Sigma baryon due to the space-time parity
symmetry. The scaling law of the soft form factor eta(P^{\prime} \cdot v),
P^{\prime} and v being the momentum of nucleon and the velocity of Lambda_b
baryon, responsible for Lambda_b to p transitions is also derived using the
nucleon distribution amplitudes in leading conformal spin. In particular, we
verify that this scaling behavior is in full agreement with that from
light-cone sum rule approach in the heavy-quark limit. With these form factors,
we further investigate the Lambda baryon polarization asymmetry alpha in
Lambda_b to Lambda gamma and the forward-backward asymmetry A_{FB} in Lambda_b
to Lambda l^{+} l^{-}. Both two observables (alpha and A_{FB}) are independent
of hadronic form factors in leading power of 1/m_b and in leading order of
alpha_s. We also extend the analysis of hadronic matrix elements for Omega_b to
Omega transitions to rare Omega_b to Omega gamma and Omega_b to Omega l^{+}
l^{-} decays and find that radiative Omega_b to Omega gamma decay is probably
the most promising FCNC b to s radiative baryonic decay channel. In addition,
it is interesting to notice that the zero-point of forward-backward asymmetry
of Omega_b to Omega l^{+} l^{-} is the same as the one for Lambda_b to Lambda
l^{+} l^{-} to leading order accuracy provided that the form factors
\bar{\zeta}_i (i=3, 4, 5) are numerically as small as indicated from the quark
model.Comment: 19 page
Farmers’ selection cues in cowpea for vegetable use in eastern Uganda
This is a research article on participatory cowpea varietal selection was carried out in Eastern Uganda in Kumi district among farmersA participatory cowpea varietal selection was carried out in Eastern Uganda in the Kumi district among farmers (n=30) in the sub-Counties of Ongino, Kumi and Kanyum. An arange of opinions were collected to identify farmers’ selection criteria based on different sensory attributes and their most preferred genotypes for vegetable use. A Apreference analysis was carried out to obtain quantitative preference scores of each plot. This was followed by organoleptic tests which included attributes like taste, aroma and texture of the genotypes at the vegetative and immature R4 stages. Focus group discussions (FGDs) were also held to find a consensus of the independent evaluations made by individual farmers. Data for sixteen (16) cowpea genotypes were collected at the different above-mentioned stages. Quantitative data were analyzed based on farmers’ scores made on the different evaluated attributes and ANOVA was used to provide mean differences between location, gender and genotype at a significant level
of 5%. The preference score for each of the varieties tested was determined and presented.
Data from FGDs were grouped, similarities and differences were later determined
depending on their level of importance to the farmers. Significant differences (p<0.05) in farmer choices were observed for leaf taste, immature pod aroma, taste and texture; mature pod aroma, taste between farmer groups, age genotype and gender. Irrespective of age, gender, farmer group and genotype, farmers seemed to give more importance to the smooth texture, little hard leaves when chewing, sweet taste with a mild aroma (leaves) and a moderate aroma (pods). Majority (9%) of the farmers preferred Ebelat (landrace) at V4 stage; this was followed by Danila (8.7%). On the other hand,
UCUCOW1 (13% at immature and 10.2% at mature cooked R4 stage) followed by
Ebelat (9% and 9.8% for immature and mature R4 stage, respectively) were preferred by the majority of the farmers. In terms of sensory attributes, farmers preferred genotypes with a sweet taste, moderate aroma and tender texture. The information is a baseline for understanding key farmer selection criteria in the utilization of cowpea as a vegetable which can be used in generating a demand-led variety design for the crop
Farmers’ selection cues in cowpea for vegetable use in eastern Uganda
A participatory cowpea varietal selection was carried out in Eastern Uganda in Kumi district among farmers (n=30) in the sub-Counties of: Ongino, Kumi and Kanyum. A range of opinions were collected to identify farmers’ selection criteria based on different sensory attributes and their most preferred genotypes for vegetable use. A preference analysis was carried out to obtain quantitative preference scores of each plot. This was followed by organoleptic tests which included attributes like taste, aroma and texture of the genotypes at the vegetative and immature R4 stages. Focus group discussions (FGDs) were also held to find consensus of the independent evaluations made by individual farmers. Data for sixteen (16) cowpea genotypes were collected at the different above mentioned stages. Quantitative data were analyzed based on farmers’ scores made on the different evaluated attributes and ANOVA was used to provide mean differences between location, gender and genotype at a significant level of 5%. Preference score for each of the varieties tested was determined and presented. Data from FGDs were grouped, similarities and differences were later determined depending on their level of importance to the farmers. Significant differences (p<0.05) in farmer choices were observed for leaf taste, immature pod aroma, taste and texture; mature pod aroma, taste between farmer groups, age genotype and gender. Irrespective of age, gender, farmer group and genotype, farmers seemed to give more importance to the smooth texture, little hard leaves when chewing, sweet taste with a mild aroma (leaves) and a moderate aroma (pods). Majority (9%) of the farmers preferred Ebelat (landrace) at V4 stage; this was followed by Danila (8.7%). On the other hand, UCUCOW1 (13% at immature and 10.2% at mature cooked R4 stage) followed by Ebelat (9% and 9.8% for immature and mature R4 stage, respectively) were preferred by majority of the farmers. In terms of sensory attributes, farmers preferred genotypes with sweet taste, moderate aroma and tender texture. The information is a baseline for understanding key farmer selection criteria in utilization of cowpea as a vegetable which can be used in generating a demand-led variety design for the crop. 
A Comprehensive Analysis of Electric Dipole Moment Constraints on CP-violating Phases in the MSSM
We analyze the constraints placed on individual, flavor diagonal CP-violating
phases in the minimal supersymmetric extension of the Standard Model (MSSM) by
current experimental bounds on the electric dipole moments (EDMs) of the
neutron, Thallium, and Mercury atoms. We identify the four CP-violating phases
that are individually highly constrained by current EDM bounds, and we explore
how these phases and correlations among them are constrained by current EDM
limits. We also analyze the prospective implications of the next generation of
EDM experiments. We point out that all other CP-violating phases in the MSSM
are not nearly as tightly constrained by limits on the size of EDMs. We
emphasize that a rich set of phenomenological consequences is potentially
associated with these generically large EDM-allowed phases, ranging from B
physics, electroweak baryogenesis, and signals of CP-violation at the CERN
Large Hadron Collider and at future linear colliders. Our numerical study takes
into account the complete set of contributions from one- and two-loop EDMs of
the electron and quarks, one- and two-loop Chromo-EDMs of quarks, the Weinberg
3-gluon operator, and dominant 4-fermion CP-odd operator contributions,
including contributions which are both included and not included yet in the
CPsuperH2.0 package. We also introduce an open-source numerical package, 2LEDM,
which provides the complete set of two-loop electroweak diagrams contributing
to the electric dipole moments of leptons and quarks.Comment: 23 pages, 11 figures; v2: references added, minor change
Primary Coenzyme Q Deficiency in Pdss2 Mutant Mice Causes Isolated Renal Disease
Coenzyme Q (CoQ) is an essential electron carrier in the respiratory chain whose deficiency has been implicated in a wide variety of human mitochondrial disease manifestations. Its multi-step biosynthesis involves production of polyisoprenoid diphosphate in a reaction that requires the enzymes be encoded by PDSS1 and PDSS2. Homozygous mutations in either of these genes, in humans, lead to severe neuromuscular disease, with nephrotic syndrome seen in PDSS2 deficiency. We now show that a presumed autoimmune kidney disease in mice with the missense Pdss2kd/kd genotype can be attributed to a mitochondrial CoQ biosynthetic defect. Levels of CoQ9 and CoQ10 in kidney homogenates from B6.Pdss2kd/kd mutants were significantly lower than those in B6 control mice. Disease manifestations originate specifically in glomerular podocytes, as renal disease is seen in Podocin/cre,Pdss2loxP/loxP knockout mice but not in conditional knockouts targeted to renal tubular epithelium, monocytes, or hepatocytes. Liver-conditional B6.Alb/cre,Pdss2loxP/loxP knockout mice have no overt disease despite demonstration that their livers have undetectable CoQ9 levels, impaired respiratory capacity, and significantly altered intermediary metabolism as evidenced by transcriptional profiling and amino acid quantitation. These data suggest that disease manifestations of CoQ deficiency relate to tissue-specific respiratory capacity thresholds, with glomerular podocytes displaying the greatest sensitivity to Pdss2 impairment
Effective Theory of a Dynamically Broken Electroweak Standard Model at NLO
We consider the Standard Model as an effective theory at the weak scale
of a generic new strong interaction that dynamically breaks electroweak
symmetry at the energy scale (few) TeV. Assuming only the
minimal field content with the Standard Model fermions and gauge bosons, but
without a light Higgs particle, we construct the complete Lagrangian through
next-to-leading order, that is, including terms of order . The
systematics behind this expansion is clarified. Although similar to chiral
perturbation theory, it is not governed by the dimension of operators alone,
but depends in an essential way on the loop expansion. Power-counting formulas
are derived that indicate the classes of operators required at the
next-to-leading order. The complete set of operators at leading and
next-to-leading order is then listed, based on the restrictions implied by the
Standard-Model gauge symmetries. We recover the well-known operators discussed
in the literature in connection with the electroweak chiral Lagrangian and in
similar contexts, but we collect a complete and systematic list of all terms
through order . This includes some operators not discussed in
explicit terms before. We also show that a few of the previously considered
operators can be eliminated via the equations of motion. As another important
result we confirm the known list of dimension-6 operators in the Standard Model
with an elementary Higgs doublet, essentially as a special case of our
scenario.Comment: 35 pages, 1 figure; references adde
The High-Risk Plaque Initiative: Primary Prevention of Atherothrombotic Events in the Asymptomatic Population
The High-Risk Plaque (HRP) Initiative is a research and development effort to advance the understanding, recognition, and management of asymptomatic individuals at risk for a near-term atherothrombotic event such as myocardial infarction or stroke. Clinical studies using the newest technologies have been initiated, including the BioImage Study in which novel approaches are tested in a typical health plan population. Asymptomatic at-risk individuals were enrolled, including a survey-only group (n = 865), a group undergoing traditional risk factor scoring (n = 718), and a group in which all were assessed for both risk factors and subclinical atherosclerosis (n = 6104). The latter two groups underwent baseline examination in a dedicated mobile facility equipped with advanced imaging tools suitable for noninvasive screening for subclinical atherosclerosis (coronary artery calcium by computed tomography [CT], carotid and aortic disease by ultrasound, and ankle-brachial index). Selected participants were offered advanced imaging (contrast-enhanced CT, magnetic resonance imaging, and positron emission tomography/CT). Plasma, PAXgene RNA, and DNA samples were obtained for biomarker discovery studies. All individuals will be followed until 600 major atherothrombotic events have occurred in those undergoing imaging
A consistent picture for large penguins in D -> pi+ pi-, K+ K-
A long-standing puzzle in charm physics is the large difference between the
D0 -> K+ K- and D0 -> pi+ pi- decay rates. Recently, the LHCb and CDF
collaborations reported a surprisingly large difference between the direct CP
asymmetries, Delta A_CP, in these two modes. We show that the two puzzles are
naturally related in the Standard Model via s- and d-quark "penguin
contractions". Their sum gives rise to Delta A_CP, while their difference
contributes to the two branching ratios with opposite sign. Assuming nominal
SU(3) breaking, a U-spin fit to the D0 -> K+ pi-, pi+ K-, pi+ pi-, K+ K- decay
rates yields large penguin contractions that naturally explain Delta A_CP.
Expectations for the individual CP asymmetries are also discussed.Comment: 24 pages, 8 figure
Enhancement of Tumour-Specific Immune Responses In Vivo by ‘MHC Loading-Enhancer’ (MLE)
BACKGROUND:Class II MHC molecules (MHC II) are cell surface receptors displaying short protein fragments for the surveillance by CD4+ T cells. Antigens therefore have to be loaded onto this receptor in order to induce productive immune responses. On the cell surface, most MHC II molecules are either occupied by ligands or their binding cleft has been blocked by the acquisition of a non-receptive state. Direct loading with antigens, as required during peptide vaccinations, is therefore hindered. PRINCIPAL FINDINGS:Here we show, that the in vivo response of CD4+ T cells can be improved, when the antigens are administered together with 'MHC-loading enhancer' (MLE). MLE are small catalytic compounds able to open up the MHC binding site by triggering ligand-release and stabilizing the receptive state. Their enhancing effect on the immune response was demonstrated here with an antigen from the influenza virus and tumour associated antigens (TAA) derived from the NY-ESO-1 protein. The application of these antigens in combination with adamantane ethanol (AdEtOH), an MLE compound active on human HLA-DR molecules, significantly increased the frequency of antigen-specific CD4+ T cells in mice transgenic for the human MHC II molecule. Notably, the effect was evident only with the MLE-susceptible HLA-DR molecule and not with murine MHC II molecules non-susceptible for the catalytic effect of the MLE. CONCLUSION:MLE can specifically increase the potency of a vaccine by facilitating the efficient transfer of the antigen onto the MHC molecule. They may therefore open a new way to improve vaccination efficacy and tumour-immunotherapy
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