Housing ‘Lunatics’ in Nigeria: A Study in the History of Eco-Psychiatry and Psychiatric Epidemiology

Housing people with mental disorders has been a long-standing problem in Nigeria since the colonial era. Whereas biomedical and social analysis of psychiatric administration in Nigeria exists, these studies are lacking in historical, ecological and epidemiological perspectives. Thus, this paper discusses the trend of accommodating the mentally ill in Nigeria in the context of eco-psychiatry and psychiatric epidemiology. Underpinned by the historical analysis of colonial administrative and medical records, personal observations, interviews, newspaper reports and the literature, this work concludes that the contemporary challenges to mental health management in Nigeria are rooted in the colonial transformation and intervention that focuses solely on confinement as a tool of psychiatric epidemic control. Hence, the provision of social security schemes and the establishment of appropriate up-to-date psychiatric facilities in Nigeria are important in the face of the socioeconomic pressure of modern life

Integrating Resistivity Techniques for Optimum Groundwater Exploration and Development within a Hotel Facility in Osogbo, Southwestern Nigeria

This work is an attempt to combine dipole-dipole profiling and vertical electrical sounding techniques of electrical resistivity methods to investigate the groundwater potential within the premises of a 3-star hotel facility in Osogbo, Nigeria by delineating the geoelectric layers, delineating the low resistivity layers, determining the lithologies and hence, delineating the groundwater bearing zones. The five vertical electrical sounding data were collected along two pre-surveyed dipole-dipole traverses at right angle to each other beside the fences of the premises using the ABEM SAS 300c terrameter. The observed data were interpreted quantitatively using curve matching and computer-assisted iteration method using the WinResist and Dipro software. The results of the inversion show that the lithology comprises of the top soil and an intermittent sequence of sand and lateritic clay having varying resistivity and thickness. The aquiferous layer was observed to be located at a depth of 23 m to 25 m due to the low resistivity and high thickness of the aquiferous layer. The result of the 2-D imaging closely correlates with the result of the vertical electrical sounding. Thus, combining these techniques in groundwater investigation has achieved similar result as the Werner technique and has reduced ambiguity and error in positioning for drilling. Keywords: Resistivity, Groundwater Exploration, Dipole-Dipol

Integrating Resistivity Techniques for Optimum Groundwater Exploration and Development within a Hotel Facility in Osogbo, Southwestern Nigeria

This work is an attempt to combine dipole-dipole profiling and vertical electrical sounding techniques of electrical resistivity methods to investigate the groundwater potential within the premises of a 3-star hotel facility in Osogbo, Nigeria by delineating the geoelectric layers, delineating the low resistivity layers, determining the lithologies and hence, delineating the groundwater bearing zones. The five vertical electrical sounding data were collected along two pre-surveyed dipole-dipole traverses at right angle to each other beside the fences of the premises using the ABEM SAS 300c terrameter. The observed data were interpreted quantitatively using curve matching and computer-assisted iteration method using the WinResist and Dipro software. The results of the inversion show that the lithology comprises of the top soil and an intermittent sequence of sand and lateritic clay having varying resistivity and thickness. The aquiferous layer was observed to be located at a depth of 23 m to 25 m due to the low resistivity and high thickness of the aquiferous layer. The result of the 2-D imaging closely correlates with the result of the vertical electrical sounding. Thus, combining these techniques in groundwater investigation has achieved similar result as the Werner technique and has reduced ambiguity and error in positioning for drilling

Corporate Governance, Measurement of

The increased focus on good governance and the development of best practice guidelines, often supported by legislation, has been in response to corporate scandals, such as Enron and Worldcom in the early 2000s, and the 2008 banking crisis. Good governance is increasingly recognised as a process where the ‘best practices\u27 of yesterday become the standard practices of today. This increased focus has also coincided with a worldwide movement for corporate reporting on sustainability and corporate social responsibility (CSR) issues and a growing demand within the investment industry for investment products that are socially responsible (Benn and Dunphy 2013). Sustainable development is now part of the best practice model of corporate governance. There is a more equal recognition of stakeholders’ interests and the role of not only economic, but also social and environmental issues in laying the foundations for a new long-term model of economic growth. This is in contrast to the historic governing model that focused on the creation of shareholder value. However, despite increased attention and interest by policymakers and academics alike, a challenge that has not been unanimously resolved is the definition and measurement of ‘good corporate governance’. This chapter evaluates the main approaches to the measurement of corporate governance

Detection of human, porcine and canine picornaviruses in municipal sewage sludge using pan-enterovirus amplicon-based long-read Illumina sequencing

We describe the successful detection of human, porcine and canine picornaviruses (CanPV) in sewage sludge (at each stage of treatment) from Louisville, Kentucky, USA, using Pan-enterovirus amplicon-based long-read Illumina sequencing. Based on publicly available sequence data in GenBank, this is the first detection of CanPV in the USA and the first detection globally using wastewater-based epidemiology. Our findings also suggest there might be clusters of endemic porcine enterovirus (which have been shown capable of causing systemic infection in porcine) circulation in the USA that have not been sampled for around two decades. Our findings highlight the value of WBE coupled with amplicon based long-read Illumina sequencing for virus surveillance and demonstrates this approach can provide an avenue that supports a “One Health” model to virus surveillance. Finally, we describe a new CanPV assay targeting the capsid protein gene region that can be used globally, especially in resource limited settings for its detection and molecular epidemiology

High-throughput sequencing of SARS-CoV-2 in wastewater provides insights into circulating variants

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) likely emerged from a zoonotic spill-over event and has led to a global pandemic. The public health response has been predominantly informed by surveillance of symptomatic individuals and contact tracing, with quarantine, and other preventive measures have then been applied to mitigate further spread. Non-traditional methods of surveillance such as genomic epidemiology and wastewater-based epidemiology (WBE) have also been leveraged during this pandemic. Genomic epidemiology uses high-throughput sequencing of SARS-CoV-2 genomes to inform local and international transmission events, as well as the diversity of circulating variants. WBE uses wastewater to analyse community spread, as it is known that SARS-CoV-2 is shed through bodily excretions. Since both symptomatic and asymptomatic individuals contribute to wastewater inputs, we hypothesized that the resultant pooled sample of population-wide excreta can provide a more comprehensive picture of SARS-CoV-2 genomic diversity circulating in a community than clinical testing and sequencing alone. In this study, we analysed 91 wastewater samples from 11 states in the USA, where the majority of samples represent Maricopa County, Arizona (USA). With the objective of assessing the viral diversity at a population scale, we undertook a single-nucleotide variant (SNV) analysis on data from 52 samples with \u3e90% SARS-CoV-2 genome coverage of sequence reads, and compared these SNVs with those detected in genomes sequenced from clinical patients. We identified 7973 SNVs, of which 548 were “novel” SNVs that had not yet been identified in the global clinical-derived data as of 17th June 2020 (the day after our last wastewater sampling date). However, between 17th of June 2020 and 20th November 2020, almost half of the novel SNVs have since been detected in clinical-derived data. Using the combination of SNVs present in each sample, we identified the more probable lineages present in that sample and compared them to lineages observed in North America prior to our sampling dates. The wastewater-derived SARS-CoV-2 sequence data indicates there were more lineages circulating across the sampled communities than represented in the clinical-derived data. Principal coordinate analyses identified patterns in population structure based on genetic variation within the sequenced samples, with clear trends associated with increased diversity likely due to a higher number of infected individuals relative to the sampling dates. We demonstrate that genetic correlation analysis combined with SNVs analysis using wastewater sampling can provide a comprehensive snapshot of the SARS-CoV-2 genetic population structure circulating within a community, which might not be observed if relying solely on clinical cases

Director Characteristics and Firm Performance

The traditional methodology examining optimal boards relates a simple board variable (e.g. independence or board demography) to firm performance, however, ig- noring other board characteristics. This paper investigates how the education and business experience of directors affect firm performance. The sample consists of 1,574 directorships from 224 listed firms in Switzerland. Using OLS and including control variables, the results show that graduates of minor Swiss universities are negatively related to Tobin’s Q, and industrial knowledge and Tobin’s Q are nega- tively correlated if the firm has more divisions. In addition, director fixed effects (or unobserved characteristics) are significant, but improve the explanatory power of the models only by 5 percent

Does codetermination affect the composition of variable versus fixed parts of executive compensation?

Contrary to previous literature we hypothesize that interests of labor may well – like that of shareholders – aim at securing the long-run survival of the firm. Consequently, employee representatives on the supervisory board could well have an interest in increasing incentive-based compensation to avoid excessive risk taking and short-run orientated decisions. We compile unique panel data on executive compensation over the periods 2006 to 2011 for 405 listed companies and use a Hausman-Taylor approach to estimate the effect of codetermination on the compensation design. Finally, codetermination has a significantly positive effect on performance-based components of compensation, which supports our hypothesis

HIV-1 drug resistance mutations emerging on darunavir therapy in PI-naive and -experienced patients in the UK

\ua9 The Author 2016. Background: Darunavir is considered to have a high genetic barrier to resistance. Most darunavir-associated drug resistance mutations (DRMs) have been identified through correlation of baseline genotype with virological response in clinical trials. However, there is little information on DRMs that are directly selected by darunavir in clinical settings. Objectives: We examined darunavir DRMs emerging in clinical practice in the UK. Patients and methods: Baseline and post-exposure protease genotypes were compared for individuals in the UK Collaborative HIV Cohort Study who had received darunavir; analyses were stratified for PI history. A selection analysis was used to compare the evolution of subtype B proteases in darunavir recipients and matched PInaive controls. Results: Of 6918 people who had received darunavir, 386 had resistance tests pre- and post-exposure. Overall, 2.8% (11/386) of these participants developed emergent darunavir DRMs. The prevalence of baseline DRMs was 1.0% (2/198) among PI-naive participants and 13.8% (26/188) among PI-experienced participants. Emergent DRMs developed in 2.0% of the PI-naive group (4 mutations) and 3.7% of the PI-experienced group (12 mutations). Codon 77 was positively selected in the PI-naive darunavir cases, but not in the control group. Conclusions: Our findings suggest that although emergent darunavir resistance is rare, it may be more common among PI-experienced patients than those who are PI-naive. Further investigation is required to explore whether codon 77 is a novel site involved in darunavir susceptibility