An adaptive POD approximation method for the control of advection-diffusion equations

We present an algorithm for the approximation of a finite horizon optimal control problem for advection-diffusion equations. The method is based on the coupling between an adaptive POD representation of the solution and a Dynamic Programming approximation scheme for the corresponding evolutive Hamilton-Jacobi equation. We discuss several features regarding the adaptivity of the method, the role of error estimate indicators to choose a time subdivision of the problem and the computation of the basis functions. Some test problems are presented to illustrate the method.Comment: 17 pages, 18 figure

Leptogenesis and Low-energy Observables

We relate leptogenesis in a class of theories to low-energy experimental observables: quark and lepton masses and mixings. With reasonable assumptions motivated by grand unification, one can show that the CP-asymmetry parameter takes a universal form. Furthermore the dilution mass is related to the light neutrino masses. Overall, these models offer a natural explanation for a lepton asymmetry in the early universe.Comment: 10 pages, revised discussion on light neutrino masse

Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease

Near-Infrared Spectroscopy (NIR) can be employed to monitor local changes in haemodynamics and oxygenation of human tissues. A preliminary study has been performed in order to evaluate the NIRS transmittance response to induced forearm ischaemia in patients with coronary artery disease (CAD). The population consists in 40 patients with cardiovascular risk factors and angiographically documented CAD, compared to a group of 13 normal subjects. By inflating and subsequently deflating a cuff placed around the patient arm, an ischaemia has been induced and released, and the patients have been observed until recovery of the basal conditions. A custom LAIRS spectrometer (IRIS) has been used to collect the backscattered light intensities from the patient forearm throughout the ischaemic and the recovery phase. The time dependence of the near-infrared transmittance on the control group is consistent with the available literature. On the contrary, the magnitude and dynamics of the NIRS signal on the CAD patients show deviations from the documented normal behavior, which can be tentatively attributed to abnormal vessel stiffness. These preliminary results, while validating the performance of the IRIS spectrometer, are strongly conducive towards the applicability of the NIRS technique to ischaemia analysis and to endothelial dysfunction characterization in CAD patients with cardiovascular risk factors.Publisher PD

Neutrinoless double beta decay in SO(10) inspired seesaw models

By requiring the lower limit for the lightest right-handed neutrino mass, obtained in the baryogenesis from leptogenesis scenario, and a Dirac neutrino mass matrix similar to the up-quark mass matrix we predict small values for the $\nu_e$ mass and for the matrix element $m_{ee}$ responsible of the neutrinoless double beta decay, $m_{\nu_e}$ around $5\cdot10^{-3}$ eV and $m_{ee}$ smaller than $10^{-3}$ eV, respectively. The allowed range for the mass of the heaviest right-handed neutrino is centered around the value of the scale of B - L breaking in the SO(10) gauge theory with Pati-Salam intermediate symmetry.Comment: 9 pages, RevTex4. Revised, title change

The networking dynamics of the Italian biofuel industry in time of crisis: Finding an effective instrument mix for fostering a sustainable energy transition

This paper aims to design the effective instrument mixes for fostering a sustainable energy transition in times of crises. We focus on a sufficiently developed green niche – namely the Italian biofuel sector – implementing a two-step investigation: 1) a social network analysis, to study the effects of the crisis on the basic niche development mechanisms, with the aim of eliciting its development needs; 2) a fuzzy inference simulation based on a causal-effect map drawn from experts' knowledge to identify the most effective instrument mix for the development of the niche studied. The major needs emerged in the case investigated are for an increase of actors' expectations towards the further development of the sector, and a need for a tailored networking activity, devoted to attracting specific knowledgeable actors. The results indicate that, among others, effective policy instruments are, in this case, the cooperation that has the best outcome in terms of networking, and the public procurement, which remarkably increases the level of expectation. The analysis presented constitutes a model to evaluate single policy drivers and their combinations to find adequate policy actions to promote the green energy transition in times of crisis

MTOR cross-talk in cancer and potential for combination therapy

The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions. mTOR functions through two functionally and structurally distinct multi-component complexes, mTORC1 and mTORC2, which interact with each other and with several elements of other signaling pathways. In the past few years, many new insights into mTOR function and regulation have been gained and extensive genetic and pharmacological studies in mice have enhanced our understanding of how mTOR dysfunction contributes to several diseases, including cancer. Single-agent mTOR targeting, mostly using rapalogs, has so far met limited clinical success; however, due to the extensive cross-talk between mTOR and other pathways, combined approaches are the most promising avenues to improve clinical efficacy of available therapeutics and overcome drug resistance. This review provides a brief and up-to-date narrative on the regulation of mTOR function, the relative contributions of mTORC1 and mTORC2 complexes to cancer development and progression, and prospects for mTOR inhibition as a therapeutic strategy

Survey data for assessing the socio-economic performance of End of Life options of a bio-based product based on expert knowledge

This data article aims at providing a data description about the manuscript entitled “A socio-economic indicator for EoL strategies for bio-based products” [1]. Data regarding the socio-economic assessment of End of Life (EoL) options for the specific case of PLA-based film for food packaging are presented, with a special emphasis on policy recommendations and actions for the EoL practices in the bioeconomy sectors. A new framework, based on data gathering and validation through experts involvement, is proposed in order to calculate a new indicator to measure the socio-economic performance of EoL practices (SEI-EoL) for bio-based products. Experts were identified from the Horizon 2020 LIFE-funded projects and/or Scopus databases. Two rounds of survey were carried out to determine the weights of socio-economic criteria for bio-based products and the values for the selected case study. The aggregation of these data enabled us to obtain a final ranking of different EoL alternatives. Finally, a third round of survey was conducted to further deepen our understanding of actions and recommendations needed to improve EoL practices in bio-based sectors. Resulting data have a mix of quantitative and qualitative characterization. A potential reuse of these data can allow future estimations, empirical analyses or a direct comparison with the use of experimental observations

A Combined method to model policy interventions for local communities based on people knowledge

Policy interventions to promote innovative industries in peripheral regions are often hampered by lack of information on the functioning of the local socio-economic systems, due to their complexity. This might result in mismatches between policy objectives and the actual needs and capability of local communities. To overcome this drawback, it is crucial to obtain appropriate knowledge on the local system, which nevertheless is typically embedded in local actors’ minds in uncodified and tacit form. Fuzzy Cognitive Maps (FCMs) have been employed to decode this kind of knowledge in a reproducible manner. However, some problems remain as to how to integrate the necessary vagueness of local actors’ heuristic with experts’ knowledge into a rational framework. The following methodology customization is proposed: • Combine the FCMs with the Discourse Analysis to obtain relevant narratives (i.e. concepts, visions, insights, etc.) needed to define system boundaries and variables. • Employ individual interviews – rather than a participatory approach – to define the causal relations among system variables. • Integrate tacit and uncodified knowledge embedded in local actors within experts’ scientific knowledge

Meson Correlation Function and Screening Mass in Thermal QCD

Analytical results for the spatial dependence of the correlation functions for all meson excitations in perturbative Quantum Chromodynamics, the lowest order, are calculated. The meson screening mass is obtained as a large distance limit of the correlation function. Our analysis leads to a better understanding of the excitations of Quark Gluon Plasma at sufficiently large temperatures and may be of relevance for future numerical calculations with fully interacting Quantum Chromodynamics.Comment: 11 page

Seesaw mechanism, baryon asymmetry and neutrinoless double beta decay

A simplified but very instructive analysis of the seesaw mechanism is here performed. Assuming a nearly diagonal Dirac neutrino mass matrix, we study the forms of the Majorana mass matrix of right-handed neutrinos, which reproduce the effective mass matrix of left-handed neutrinos. As a further step, the important effect of a non diagonal Dirac neutrino mass matrix is explored. The corresponding implications for the baryogenesis via leptogenesis and for the neutrinoless double beta decay are reviewed. We propose two distinct models where the baryon asymmetry is enhanced.Comment: 21 pages, RevTex. Revise