Quantifying bed roughness of ice streams using palaeo-glacial landscapes

The roughness of the bed beneath ice is an important control on ice stream location and dynamics. Deglaciated terrain provides the opportunity to explore bed roughness in greater detail and over larger areas compared to glaciated terrain. This thesis examines three differ- ent aspects of palaeo-ice streams bed roughness. Firstly, this thesis explores methods used to measure bed roughness in glaciology. The choices made by researchers on transect orien- tation, window size, detrending and roughness methods have an impact on results. The Fast Fourier Transform analysis and Standard Deviation methods are both useful for calculating bed roughness in glaciology. Secondly, this thesis directly compares the roughness of contemporary and palaeo-ice stream beds. The bed roughness of Minch Palaeo-Ice Stream (MPIS) is compared to the Institute and M ̈oller Ice Streams (IMIS). The MPIS has a rough bed along major flow paths in the onshore onset zones. The results from the MPIS demonstrate that the presence of sediment does not necessarily correspond with fast flowing ice. The spacing of Radio Echo Sounding (RES) transects (10 x 30 km) used to measure bed roughness under contemporary- ice streams was too wide to capture bed roughness of MPIS glacial landforms. Thirdly, this thesis investigates whether glacial landforms have unique bed roughness signatures. The results show that groups of glacial landforms have unique bed roughness signatures when anisotropy is taken into account. Bed roughness signatures of glacial land- forms have the potential to be compared with known and unknown areas of glacial landforms at the bed of contemporary-ice streams. Future studies should acquire RES transects where a rough bed or glacial landforms are inferred. 250 m transect spacing would be desirable but 1 km transect spacing is likely to be more practical because it would allow orthogonal and parallel transects to be acquired

Pheasant (Phasianus colchicus) hens of different origin. Dispersion and habitat use after release

Because of the importance of pheasants as a game bird species in many European Countries, information on the success of the restocking programs is interesting for evaluation. For this reason the survival, behaviour and habitat selection of 10 wild translocated and 20 released ring-necked pheasants (10 offspring of wild captured and 10 from the farmed strain, both farm-reared) was studied using radio-telemetry during March-August (fixes were grouped in 3 categorized periods: March 2 - April 18; April 19 - May 28; May 29 - August 16). All the captive reared pheasants were reared according to the new disciplinary rules set forth by the Toscana region for the production of pheasants destined to be released in the wild as part of a game repopulation program. The study was carried out in a hilly area of the Tuscany characterised by 18.1% woodland (core: 1654895E, 4850468N). Results showed that live weights were higher in the farm-reared pheasants (either directly captured or offspring of the captured, P<0.05). The tarsus length statistically differed between the farmed offspring of the captured pheasants and the farm strain (P<0.05). The survival rates and breeding success of the surviving subjects were very high and did not differ between groups (survival rates: 50.0%, 70.0% and 80.0%, and breeding success: 60.0%, 28.6% and 50.0%, for the captive-reared offspring of captured wild pheasants, the captive-reared farm pheasants and the captured wild pheasants, respectively). The dispersion increased with time in the wild translocated pheasants (576 m, 889 m and 1209 m) while the offspring of the captured wild pheasants and the farm strain remained in the vicinity of the releasing site. The wild pheasants showed an increasing distance from the country houses, contrary to the offspring of captured wild pheasants and the farm strain. Artificial feeding stations were better used by the farmreared pheasants, which remained in the vicinity of the artificial feeding points. The results of our study showed that pheasants, reared according to the disciplinary rules stated for the production of pheasants for wildlife reproduction programs, although more expensive, can guarantee the genetic identity with the resident populations and are able to provide good survival rates and breeding success of the released pheasants, of course when restocking is carried out in areas suitable for pheasant wildlife

Captive rearing technologies and survival of pheasants (Phasianus colchicus L.) after release

Studies have repeatedly emphasized the limited survival of pheasants reared using traditional methods compared to the wild one. For this reason we performed a field trial to compare survival rates, home ranges and habitat uses of pheasants artificial hatched and reared (traditional method) with pheasants artificial hatched and reared by fostering mothers (hens). A total of 117 artificially hatched pheasants, 57 artificially brooded after hatch and 60 brooded by fostering hens, were equipped with a radio necklace tag or a poncho tag. Both groups were localized two-three times a week after their release in the wild. The survival rates of the brooded-by-hen pheasants showed an improvement of survival rates, either poncho or radio tagged (P<0.05), 90.0% vs 57.1% and 35.0% vs 21.1%, respectively. The average maximum dispersion was 390 and 426 m and the home range were 12.0 and 11.6 ha in artificially brooded and brooded-by-hen pheasants, respectively. The land use showed that the woods were less represented than the available in the home range of every pheasant. For this reason the woods can be reduced in the agricultural areas interspersed with natural Mediterranean vegetation

Using bed-roughness signatures to characterise glacial landform assemblages beneath contemporary and palaeo ice-sheets

Palaeo-glacial landforms can give insights into bed roughness that currently cannot be captured underneath contemporary-ice streams. A few studies have measured bed roughness of palaeo-ice streams but the bed roughness of specific landform assemblages has not been assessed. If glacial landform assemblages have a characteristic bed-roughness signature, this could potentially be used to constrain where certain landform assemblages exist underneath contemporary-ice sheets. To test this, bed roughness was calculated along 5 m × 5 m resolution transects (NEXTMap DTM, 5 m resolution), which were placed over glacial landform assemblages (e.g. drumlins) in the UK. We find that a combination of total roughness and anisotropy of roughness can be used to define characteristic roughness signatures of glacial landform assemblages. The results show that different window sizes are required to determine the characteristic roughness for a wide range of landform types and to produce bed-roughness signatures of these. Mega scale glacial lineations on average have the lowest bed-roughness values and are the most anisotropic landform assemblage

Quantifying bed roughness beneath contemporary and palaeo-ice streams

Bed roughness is an important control on ice-stream location and dynamics. The majority of previous bed roughness studies have been based on data derived from radio echo sounding (RES) transects across Antarctica and Greenland. However, the wide spacing of RES transects means that the links between roughness and flow are poorly constrained. Here, we use Digital Terrain Model (DTM)/bathymetry data from a well-preserved palaeo-ice stream to investigate basal controls on the behaviour of contemporary ice streams. Artificial transects were set up across the Minch Palaeo-Ice Stream (NW Scotland) to mimic RES flight lines over Institute and Möller Ice Streams (Antarctica). We then explored how different data-resolution, transect orientation and spacing, and different methods, impact upon roughness measurements. Our results show that fast palaeo-ice flow can occur over a rough, hard bed, not just a smooth, soft bed, which much previous work has suggested. Smooth areas of the bed occur over both bedrock and sediment covered regions. Similar trends in bed roughness values were found using Fast Fourier Transform analysis and standard deviation methods. Smoothing of bed roughness results can hide important details. We propose that the typical spacing of RES transects is too wide to capture different landform assemblages, and that transect orientation influences bed roughness measurements in both contemporary and palaeo-ice-stream setting

Socioeconomic deprivation worsens the outcomes of Italian women with hormone receptor-positive breast cancer and decreases the possibility of receiving standard care.

BACKGROUND: Socioeconomic factors influence access to cancer care and survival. This study investigated the role of socioeconomic status on the risk of breast cancer recurrence and on the delivery of appropriate cancer care (sentinel lymph node biopsy and breast-conserving surgery plus radiotherapy), by patients' age and hormone receptor status. METHODS: 3,462 breast cancer cases diagnosed in 2003-2005 were selected from 7 Italian cancer registries and assigned to a socioeconomic tertile on the basis of the deprivation index of their census tract. Multivariable models were applied to assess the delivery of sentinel lymph node biopsy and of breast-conserving surgery plus radiotherapy within socioeconomic tertiles. RESULTS: In the 1,893 women younger than 65 years, the 5-year risk of recurrence was higher in the most deprived group than in the least deprived, but this difference was not significant (16.4% vs. 12.9%, log-rank p=0.08); no difference was seen in women ≥65 years. Among the 2,024 women with hormone receptor-positive cancer, the 5-year risk was significantly higher in the most deprived group than in the least deprived one (13.0% vs. 8.9%, p=0.04); no difference was seen in cases of hormone receptor-negative cancer. The most deprived women were less likely than the least deprived women to receive sentinel lymph node biopsy (adjusted odds ratio (ORa), 0.69; 95% CI, 0.56-0.86) and to undergo breast-conserving surgery plus radiotherapy (ORa=0.66; 95% CI, 0.51-0.86). Conclusions: Socioeconomic inequalities affect the risk of recurrence, among patients with hormone receptor-positive cancer, and the opportunity to receive standard care

ITALIAN CANCER FIGURES - REPORT 2015: The burden of rare cancers in Italy = I TUMORI IN ITALIA - RAPPORTO 2015: I tumori rari in Italia

OBJECTIVES: This collaborative study, based on data collected by the network of Italian Cancer Registries (AIRTUM), describes the burden of rare cancers in Italy. Estimated number of new rare cancer cases yearly diagnosed (incidence), proportion of patients alive after diagnosis (survival), and estimated number of people still alive after a new cancer diagnosis (prevalence) are provided for about 200 different cancer entities. MATERIALS AND METHODS: Data herein presented were provided by AIRTUM population- based cancer registries (CRs), covering nowadays 52% of the Italian population. This monograph uses the AIRTUM database (January 2015), which includes all malignant cancer cases diagnosed between 1976 and 2010. All cases are coded according to the International Classification of Diseases for Oncology (ICD-O-3). Data underwent standard quality checks (described in the AIRTUM data management protocol) and were checked against rare-cancer specific quality indicators proposed and published by RARECARE and HAEMACARE (www.rarecarenet.eu; www.haemacare.eu). The definition and list of rare cancers proposed by the RARECAREnet "Information Network on Rare Cancers" project were adopted: rare cancers are entities (defined as a combination of topographical and morphological codes of the ICD-O-3) having an incidence rate of less than 6 per 100,000 per year in the European population. This monograph presents 198 rare cancers grouped in 14 major groups. Crude incidence rates were estimated as the number of all new cancers occurring in 2000-2010 divided by the overall population at risk, for males and females (also for gender-specific tumours).The proportion of rare cancers out of the total cancers (rare and common) by site was also calculated. Incidence rates by sex and age are reported. The expected number of new cases in 2015 in Italy was estimated assuming the incidence in Italy to be the same as in the AIRTUM area. One- and 5-year relative survival estimates of cases aged 0-99 years diagnosed between 2000 and 2008 in the AIRTUM database, and followed up to 31 December 2009, were calculated using complete cohort survival analysis. To estimate the observed prevalence in Italy, incidence and follow-up data from 11 CRs for the period 1992-2006 were used, with a prevalence index date of 1 January 2007. Observed prevalence in the general population was disentangled by time prior to the reference date (≤2 years, 2-5 years, ≤15 years). To calculate the complete prevalence proportion at 1 January 2007 in Italy, the 15-year observed prevalence was corrected by the completeness index, in order to account for those cancer survivors diagnosed before the cancer registry activity started. The completeness index by cancer and age was obtained by means of statistical regression models, using incidence and survival data available in the European RARECAREnet data. RESULTS: In total, 339,403 tumours were included in the incidence analysis. The annual incidence rate (IR) of all 198 rare cancers in the period 2000-2010 was 147 per 100,000 per year, corresponding to about 89,000 new diagnoses in Italy each year, accounting for 25% of all cancer. Five cancers, rare at European level, were not rare in Italy because their IR was higher than 6 per 100,000; these tumours were: diffuse large B-cell lymphoma and squamous cell carcinoma of larynx (whose IRs in Italy were 7 per 100,000), multiple myeloma (IR: 8 per 100,000), hepatocellular carcinoma (IR: 9 per 100,000) and carcinoma of thyroid gland (IR: 14 per 100,000). Among the remaining 193 rare cancers, more than two thirds (No. 139) had an annual IR &lt;0.5 per 100,000, accounting for about 7,100 new cancers cases; for 25 cancer types, the IR ranged between 0.5 and 1 per 100,000, accounting for about 10,000 new diagnoses; while for 29 cancer types the IR was between 1 and 6 per 100,000, accounting for about 41,000 new cancer cases. Among all rare cancers diagnosed in Italy, 7% were rare haematological diseases (IR: 41 per 100,000), 18% were solid rare cancers. Among the latter, the rare epithelial tumours of the digestive system were the most common (23%, IR: 26 per 100,000), followed by epithelial tumours of head and neck (17%, IR: 19) and rare cancers of the female genital system (17%, IR: 17), endocrine tumours (13% including thyroid carcinomas and less than 1% with an IR of 0.4 excluding thyroid carcinomas), sarcomas (8%, IR: 9 per 100,000), central nervous system tumours and rare epithelial tumours of the thoracic cavity (5%with an IR equal to 6 and 5 per 100,000, respectively). The remaining (rare male genital tumours, IR: 4 per 100,000; tumours of eye, IR: 0.7 per 100,000; neuroendocrine tumours, IR: 4 per 100,000; embryonal tumours, IR: 0.4 per 100,000; rare skin tumours and malignant melanoma of mucosae, IR: 0.8 per 100,000) each constituted &lt;4% of all solid rare cancers. Patients with rare cancers were on average younger than those with common cancers. Essentially, all childhood cancers were rare, while after age 40 years, the common cancers (breast, prostate, colon, rectum, and lung) became increasingly more frequent. For 254,821 rare cancers diagnosed in 2000-2008, 5-year RS was on average 55%, lower than the corresponding figures for patients with common cancers (68%). RS was lower for rare cancers than for common cancers at 1 year and continued to diverge up to 3 years, while the gap remained constant from 3 to 5 years after diagnosis. For rare and common cancers, survival decreased with increasing age. Five-year RS was similar and high for both rare and common cancers up to 54 years; it decreased with age, especially after 54 years, with the elderly (75+ years) having a 37% and 20% lower survival than those aged 55-64 years for rare and common cancers, respectively. We estimated that about 900,000 people were alive in Italy with a previous diagnosis of a rare cancer in 2010 (prevalence). The highest prevalence was observed for rare haematological diseases (278 per 100,000) and rare tumours of the female genital system (265 per 100,000). Very low prevalence (&lt;10 prt 100,000) was observed for rare epithelial skin cancers, for rare epithelial tumours of the digestive system and rare epithelial tumours of the thoracic cavity. COMMENTS: One in four cancers cases diagnosed in Italy is a rare cancer, in agreement with estimates of 24% calculated in Europe overall. In Italy, the group of all rare cancers combined, include 5 cancer types with an IR&gt;6 per 100,000 in Italy, in particular thyroid cancer (IR: 14 per 100,000).The exclusion of thyroid carcinoma from rare cancers reduces the proportion of them in Italy in 2010 to 22%. Differences in incidence across population can be due to the different distribution of risk factors (whether environmental, lifestyle, occupational, or genetic), heterogeneous diagnostic intensity activity, as well as different diagnostic capacity; moreover heterogeneity in accuracy of registration may determine some minor differences in the account of rare cancers. Rare cancers had worse prognosis than common cancers at 1, 3, and 5 years from diagnosis. Differences between rare and common cancers were small 1 year after diagnosis, but survival for rare cancers declined more markedly thereafter, consistent with the idea that treatments for rare cancers are less effective than those for common cancers. However, differences in stage at diagnosis could not be excluded, as 1- and 3-year RS for rare cancers was lower than the corresponding figures for common cancers. Moreover, rare cancers include many cancer entities with a bad prognosis (5-year RS &lt;50%): cancer of head and neck, oesophagus, small intestine, ovary, brain, biliary tract, liver, pleura, multiple myeloma, acute myeloid and lymphatic leukaemia; in contrast, most common cancer cases are breast, prostate, and colorectal cancers, which have a good prognosis. The high prevalence observed for rare haematological diseases and rare tumours of the female genital system is due to their high incidence (the majority of haematological diseases are rare and gynaecological cancers added up to fairly high incidence rates) and relatively good prognosis. The low prevalence of rare epithelial tumours of the digestive system was due to the low survival rates of the majority of tumours included in this group (oesophagus, stomach, small intestine, pancreas, and liver), regardless of the high incidence rate of rare epithelial cancers of these sites. This AIRTUM study confirms that rare cancers are a major public health problem in Italy and provides quantitative estimations, for the first time in Italy, to a problem long known to exist. This monograph provides detailed epidemiologic indicators for almost 200 rare cancers, the majority of which (72%) are very rare (IR&lt;0.5 per 100,000). These data are of major interest for different stakeholders. Health care planners can find useful information herein to properly plan and think of how to reorganise health care services. Researchers now have numbers to design clinical trials considering alternative study designs and statistical approaches. Population-based cancer registries with good quality data are the best source of information to describe the rare cancer burden in a population

Cancer data quality and harmonization in Europe: the experience of the BENCHISTA Project – international benchmarking of childhood cancer survival by stage

IntroductionVariation in stage at diagnosis of childhood cancers (CC) may explain differences in survival rates observed across geographical regions. The BENCHISTA project aims to understand these differences and to encourage the application of the Toronto Staging Guidelines (TG) by Population-Based Cancer Registries (PBCRs) to the most common solid paediatric cancers.MethodsPBCRs within and outside Europe were invited to participate and identify all cases of Neuroblastoma, Wilms Tumour, Medulloblastoma, Ewing Sarcoma, Rhabdomyosarcoma and Osteosarcoma diagnosed in a consecutive three-year period (2014-2017) and apply TG at diagnosis. Other non-stage prognostic factors, treatment, progression/recurrence, and cause of death information were collected as optional variables. A minimum of three-year follow-up was required. To standardise TG application by PBCRs, on-line workshops led by six tumour-specific clinical experts were held. To understand the role of data availability and quality, a survey focused on data collection/sharing processes and a quality assurance exercise were generated. To support data harmonization and query resolution a dedicated email and a question-and-answers bank were created.Results67 PBCRs from 28 countries participated and provided a maximally de-personalized, patient-level dataset. For 26 PBCRs, data format and ethical approval obtained by the two sponsoring institutions (UCL and INT) was sufficient for data sharing. 41 participating PBCRs required a Data Transfer Agreement (DTA) to comply with data protection regulations. Due to heterogeneity found in legal aspects, 18 months were spent on finalizing the DTA. The data collection survey was answered by 68 respondents from 63 PBCRs; 44% of them confirmed the ability to re-consult a clinician in cases where stage ascertainment was difficult/uncertain. Of the total participating PBCRs, 75% completed the staging quality assurance exercise, with a median correct answer proportion of 92% [range: 70% (rhabdomyosarcoma) to 100% (Wilms tumour)].ConclusionDifferences in interpretation and processes required to harmonize general data protection regulations across countries were encountered causing delays in data transfer. Despite challenges, the BENCHISTA Project has established a large collaboration between PBCRs and clinicians to collect detailed and standardised TG at a population-level enhancing the understanding of the reasons for variation in overall survival rates for CC, stimulate research and improve national/regional child health plans

New Evidence of Mediterranean Climate Change and Variability from Sea Surface Temperature Observations

Estimating long-term modifications of the sea surface temperature (SST) is crucial for evaluating the current state of the oceans and to correctly assess the impact of climate change at regional scales. In this work, we analyze SST variations within the Mediterranean Sea and the adjacent Northeastern Atlantic box (west of the Strait of Gibraltar) over the last 37 years, by using a satellite-based dataset from the Copernicus Marine Environment Monitoring Service (CMEMS). We found a mean warming trend of 0.041 &plusmn; 0.006 ∘ C/year over the whole Mediterranean Sea from 1982 to 2018. The trend has an uneven spatial pattern, with values increasing from 0.036 &plusmn; 0.006 ∘ C/year in the western basin to 0.048 &plusmn; 0.006 ∘ C/year in the Levantine&ndash;Aegean basin. The Northeastern Atlantic box and the Mediterranean show a similar trend until the late 1990s. Afterwards, the Mediterranean SST continues to increase, whereas the Northeastern Atlantic box shows no significant trend, until ~2015. The observed change in the Mediterranean Sea affects not only the mean trend but also the amplitude of the Mediterranean seasonal signal, with consistent relative increase and decrease of summer and winter mean values, respectively, over the period considered. The analysis of SST changes occurred during the &ldquo;satellite era&rdquo; is further complemented by reconstructions also based on direct in situ SST measurements, i.e., the Extended Reconstructed SST (ERSST) and the Hadley Centre Sea Ice and Sea Surface Temperature dataset (HadISST), which go back to the 19th century. The analysis of these longer time series, covering the last 165 years, indicates that the increasing Mediterranean trend, observed during the CMEMS operational period, is consistent with the Atlantic Multidecadal Oscillation (AMO), as it closely follows the last increasing period of AMO. This coincidence occurs at least until 2007, when the apparent onset of the decreasing phase of AMO is not seen in the Mediterranean SST evolution