Passive heat maintenance after an initial warm-up improves high intensity activity during an interchange rugby league match simulation protocol.

This is an Accepted Manuscript of an article published by Lippincott, Williams & Wilkins in Journal of Strength and Conditioning Research on publication 01/01/2019, available online: https//doi.org/10.1519/JSC.0000000000003061This study examined using passive heat maintenance to maintain core temperature after a warm-up and its effect on first half running performance in rugby players. Thirteen male rugby players completed this randomized crossover study. Tympanic temperature was taken before a warm-up and then after a further 15 minutes passive recovery either with (PHM) or without (CON) a passive heat maintenance garment. Participants then completed 23 min of the rugby league match simulation protocol (RLMSP-i). Differences in tympanic temperature were unclear between CON and PHM before (35.7 ± 1.3 cf. 36.0 ± 1.1oC; ES = 0.20) and during exercise (34.5 ± 0.1 cf. 35.2 ± 0.1oC; ES = 0.26-0.35). High-intensity running (ES = 0.27) and peak sprint speed were higher (ES = 0.46-0.56) during the PHM compared to the CON trial. Time spent above 20 W.kg-1 also increased in the first quartile of PHM compared to CON trial (ES = 0.18). All other between trial comparisons of performance were unclear. HRmean (ES = 0.38) was higher in PHM compared to CON, while differences in RPEmean (ES = -0.19) were unclear. There are small to large increases in high intensity work performed during a playing bout when rugby players wear a PHM garment after a warm-up. Rugby players should consider PHM during extended periods of time between a warm-up and starting a match

Alcohol Use and Trauma Exposure Among Male and Female Veterans Before, During, and After Military Service

Background: The present study examined lifespan and combat-related trauma exposure as predictors of alcohol use among male and female veterans. Posttraumatic stress and depressive symptoms were examined as mediators of the effects of trauma exposure on alcohol use. Methods: Data were examined from 1825 (1450 male, 375 female) veterans and active duty service members who took part in a multi-site research study conducted through the Department of Veterans Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center (VISN 6 MIRECC). Results: For both men and women, depressive symptoms significantly mediated the effects of non-combat trauma exposure experienced before, during and after the military, as well as combat-exposure, on alcohol use. With posttraumatic stress symptoms, the models for men and women differed. For men, the effects of non-combat trauma exposure during and after military service, and combat exposure, on alcohol use were mediated by PTSD symptoms; however, for women, PTSD symptoms did not mediate these relationships. Conclusion: Findings are discussed in the context of potential gender differences in response to trauma such as use of alcohol to cope with traumatic events

Aha! Vivat Homo Sapiens

Program for the twelfth and final annual RISD Cabaret held in the Cellar at the top of the Waterman Building.https://digitalcommons.risd.edu/liberalarts_cabaret_programs/1011/thumbnail.jp

Rationale, design and methods for a community-based study of clustering and cumulative effects on chronic disease process and their effects on ageing: the Busselton healthy ageing study

Background: The global trend of increased life expectancy and increased prevalence of chronic and degenerative diseases will impact on health systems. To identify effective intervention and prevention strategies, greater understanding of the risk factors for and cumulative effects of chronic disease processes and their effects on function and quality of life is needed. The Busselton Healthy Ageing Study aims to enhance understanding of ageing by relating the clustering and interactions of common chronic conditions in adults to function. Longitudinal (3–5 yearly) follow-up is planned. Methods/design: Phase I (recruitment) is a cross-sectional community-based prospective cohort study involving up to 4,000 ‘Baby Boomers’ (born from 1946 to 1964) living in the Busselton Shire, Western Australia. The study protocol involves a detailed, self-administered health and risk factor questionnaire and a range of physical assessments including body composition and bone density measurements, cardiovascular profiling (blood pressure, ECG and brachial pulse wave velocity), retinal photography, tonometry, auto-refraction, spirometry and bronchodilator responsiveness, skin allergy prick tests, sleep apnoea screening, tympanometry and audiometry, grip strength, mobility, balance and leg extensor strength. Cognitive function and reserve, semantic memory, and pre-morbid intelligence are assessed. Participants provide a fasting blood sample for assessment of lipids, blood glucose, C-reactive protein and renal and liver function, and RNA, DNA and serum are stored. Clinically relevant results are provided to all participants. The prevalence of risk factors, symptoms and diagnosed illness will be calculated and the burden of illness will be estimated based on the observed relationships and clustering of symptoms and illness within individuals. Risk factors for combinations of illness will be compared with those for single illnesses and the relation of combinations of illness and symptoms to cognitive and physical function will be estimated. Discussion: This study will enable a thorough characterization of multiple disease processes and their risk factors within a community-based sample of individuals to determine their singular, interactive and cumulative effects on ageing. The project will provide novel cross-sectional data and establish a cohort that will be used for longitudinal analyses of the genetic, lifestyle and environmental factors that determine whether an individual ages well or with impairment

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.Swedish Research Council et al.Manuscrip

Specific treatment of problems of the spine (STOPS): design of a randomised controlled trial comparing specific physiotherapy versus advice for people with subacute low back disorders

<p>Abstract</p> <p>Background</p> <p>Low back disorders are a common and costly cause of pain and activity limitation in adults. Few treatment options have demonstrated clinically meaningful benefits apart from advice which is recommended in all international guidelines. Clinical heterogeneity of participants in clinical trials is hypothesised as reducing the likelihood of demonstrating treatment effects, and sampling of more homogenous subgroups is recommended. We propose five subgroups that allow the delivery of specific physiotherapy treatment targeting the pathoanatomical, neurophysiological and psychosocial components of low back disorders. The aim of this article is to describe the methodology of a randomised controlled trial comparing specific physiotherapy treatment to advice for people classified into five subacute low back disorder subgroups.</p> <p>Methods/Design</p> <p>A multi-centre parallel group randomised controlled trial is proposed. A minimum of 250 participants with subacute (6 weeks to 6 months) low back pain and/or referred leg pain will be classified into one of five subgroups and then randomly allocated to receive either physiotherapy advice (2 sessions over 10 weeks) or specific physiotherapy treatment (10 sessions over 10 weeks) tailored according to the subgroup of the participant. Outcomes will be assessed at 5 weeks, 10 weeks, 6 months and 12 months following randomisation. Primary outcomes will be activity limitation measured with a modified Oswestry Disability Index as well as leg and back pain intensity measured on separate 0-10 Numerical Rating Scales. Secondary outcomes will include a 7-point global rating of change scale, satisfaction with physiotherapy treatment, satisfaction with treatment results, the Sciatica Frequency and Bothersomeness Scale, quality of life (EuroQol-5D), interference with work, and psychosocial risk factors (Orebro Musculoskeletal Pain Questionnaire). Adverse events and co-interventions will also be measured. Data will be analysed according to intention to treat principles, using linear mixed models for continuous outcomes, Mann Whitney U tests for ordinal outcomes, and Chi-square, risk ratios and risk differences for dichotomous outcomes.</p> <p>Discussion</p> <p>This trial will determine the difference in outcomes between specific physiotherapy treatment tailored to each of the five subgroups versus advice which is recommended in guidelines as a suitable treatment for most people with a low back disorder.</p> <p>Trial registration</p> <p>Australia and New Zealand Clinical Trials Register (ANZCTR): <a href="http://www.anzctr.org.au/ACTRN12609000834257.aspx">ACTRN12609000834257</a>.</p

A systematic review of randomised controlled trials assessing effectiveness of prosthetic and orthotic interventions.

BACKGROUND: Assistive products are items which allow older people and people with disabilities to be able to live a healthy, productive and dignified life. It has been estimated that approximately 1.5% of the world's population need a prosthesis or orthosis. OBJECTIVE: The objective of this study was to systematically identify and review the evidence from randomized controlled trials assessing effectiveness and cost-effectiveness of prosthetic and orthotic interventions. METHODS: Literature searches, completed in September 2015, were carried out in fourteen databases between years 1995 and 2015. The search results were independently screened by two reviewers. For the purpose of this manuscript, only randomized controlled trials which examined interventions using orthotic or prosthetic devices were selected for data extraction and synthesis. RESULTS: A total of 342 randomised controlled trials were identified (319 English language and 23 non-English language). Only 4 of these randomised controlled trials examined prosthetic interventions and the rest examined orthotic interventions. These orthotic interventions were categorised based on the medical conditions/injuries of the participants. From these studies, this review focused on the medical condition/injuries with the highest number of randomised controlled trials (osteoarthritis, fracture, stroke, carpal tunnel syndrome, plantar fasciitis, anterior cruciate ligament, diabetic foot, rheumatoid and juvenile idiopathic arthritis, ankle sprain, cerebral palsy, lateral epicondylitis and low back pain). The included articles were assessed for risk of bias using the Cochrane Risk of Bias tool. Details of the clinical population examined, the type of orthotic/prosthetic intervention, the comparator/s and the outcome measures were extracted. Effect sizes and odds ratios were calculated for all outcome measures, where possible. CONCLUSIONS: At present, for prosthetic and orthotic interventions, the scientific literature does not provide sufficient high quality research to allow strong conclusions on their effectiveness and cost-effectiveness

An Examination of the Field-Based Training Practices in European Super League’s first Quadruple Winning Champions

Using a case study approach, the primary aim of this thesis was to develop an understanding of field-based training practices of a successful professional rugby league team. The research findings were applied to inform the coaching practices of the club but also offered insight that might be of interest more widely given the success of the team over an extended period. Chapter 4 quantified the types of training used during a preseason by the team. There was a 4-week increase in external load, followed by a “regeneration week” in week 5 before an increase in load during week 6. A weekly cycle also emerged with Monday primarily comprising Rugby Skill drills and Speed drills, Tuesday largely Rugby Skill based alongside Conditioning and Game-Based Training, Thursday was a mix of training types with Friday primarily consisting of Game-Based Training that also coincided with the week’s highest values for total distance, high-speed running, and high metabolic distance. Chapter 5 examined the associations between the types of training in preseason and improvements in intermittent running performance (i.e., prone Yo-Yo IR1). The intensity (r = 0.61; 95% CI 0.18, 0.84) and PlayerLoadTM (r = 0.44; 95% CI -0.05, 0.76) during Game-Based Training and high-speed running (r = 0.61; 95% CI 0.18, 0.84) in Conditioning had positive associations with the mean change in prone Yo-Yo IR1 performance (200 ± 143 m [18.1 ± 13.5%]). Total duration of Game-Based Training had a negative association with change in prone Yo-Yo IR1 performance (r = -0.57; 95% CI -0.82, -0.12). These data enable the manipulation of training practices to target specific external metrics (e.g., intensity, PlayerLoadTM, high-speed running) when improvements in intermittent running capacity of professional rugby league players is the desired goal. Chapter 6 examined the differences in external and internal load of field-based training between the three different in-season match-day microcycles and assessed the differences in external demands of matches between the microcycles. Game-Based Training contributed the most to external (total distance, high metabolic distance and PlayerLoadTM) and internal load (highest HRmax, time spent in HR band 5 and HR band 6) for the main training day in long (MD-5), medium (MD-4), and short (MD-2) turnarounds. Both short (86.7 ± 7.9 m.min-1) and medium (86.5 ± 10.9 m.min-1) turnaround matches resulted in lower intensity values than long turnarounds (89.5 ± 7.6m.min-1; P < 0.05). No other differences in external demands were observed between the 3 different match-day microcycles. The consistency in match-day external demands is a desirable outcome as the training week has effectively prepared athletes to perform in match. Additionally, the extensive use of Game-Based Training allowed for the maintenance of physical qualities whilst technically and tactically developing and preparing players for competition. Chapter 7 examined the effect altering match rules (because of COVID-19) had on the external demands of match play. There were increases in whole team high-speed running (r = 0.09; 95% CI 0.02, 0.15 c.f. r = 0.29; 95% CI 0.20, 0.38) and an increased ball-in-play time (52.16 ± 5.01 min c.f. 55.58 ± 4.04 min). These changes highlight the impact of rule changes on the movement demands of professional rugby league matches and the implications for the design of appropriate training practices to better prepare players. Chapter 8 assessed the effects altering the area size per-person of Game-Based Training and the length of Conditioning drills has on key external load metrics. The study showed that increasing the area of Game-Based Training by 10 m2 per-person resulted in athletes covering greater distance (539.3 ± 49.6 m c.f. 500.9 ± 62.9 m & 555.4 ± 55.9 m c.f. 491.4 ± 40.1 m), higher intensities (132.1 ± 12.1 m.min-1 c.f. 122.4 ± 15.4 m.min-1 & 136.8 ± 13.8 m.min-1 c.f. 121.4 ± 9.9 m.min-1), and greater high metabolic distances (122.4 ± 32.0 m c.f. 81.8 ± 22.9 m & 153.0 ± 33.0 m c.f. 120.3 ± 27.1 m). However, the smaller area Game-Based Training showed significantly greater cognitive load (dRPE-C; 73.2 ± 7.8 c.f. 56.3 ± 17.9 AU), possibly due to increased technical/tactical involvements. Increasing the length of conditioning drills resulted in an increase in all external metrics for the shuttle runs, with the linear run experiencing an increase in intensity but a reduction in total distance and PlayerLoadTM. Chapter 8 also found that the coefficient of variation (%CV) between-players during Game-Based Training was higher than previously reported in soccer, with high-speed distance found to have the highest level of variability (23 – 58%), whereas linear running Conditioning drills had much lower variability (4 – 5 %). Game-Based Training is an effective training method, however the variability experienced could leave players under or over trained if this method was solely used, highlighting the importance of using it as a part of balanced programme

The content and load of preseason field-based training in a championship winning professional rugby league team: A case study

Fairbank, M., Daniels, M., Highton, J., & Twist, C., The content and load of preseason field-based training in a championship winning professional rugby league team: A case study, International Journal of Sports Science and Coaching (Journal Volume Number and Issue Number) pp. xx-xx. Copyright © [year] (Copyright Holder). Reprinted by permission of SAGE Publications.This study reports on the content and periodisation of the preseason field-based training for a professional rugby league team. Thirty elite male rugby league players (26 ± 5 y, 180.9 ± 6.5 cm, 94 ± 9 kg) completed an 8-week preseason. Global positioning system devices and heart rate were used to monitor physical and physiological responses of different field-based training components (speed, conditioning, rugby skill and game-based training). Rugby skill training contributed the most to total distance covered, conditioning was the greatest contributor to high-speed running (>15 km.h-1) and game-based training provided the greatest high metabolic distance (>20 W.kg-1) and overall external load. Game-based training provided the greatest time with heart rate 80% estimated maximum. Field-based training comprised a 4-week increase in total distance, followed by a “regeneration week” in week 5 before a peak in load during week 6. The weekly pre-season cycle had lower loads on Monday and Thursday whereas Tuesday and Friday produced the highest loads. The preseason described herein adopted a progressive overload comprising a weekly undulating cycle. This study emphasises how skill and games-based training contributes significantly to the overall load of a professional rugby league team’s preseason with more traditional conditioning promoting high speed running load and high metabolic load

Passive Heat Maintenance After an Initial Warm-up Improves High-Intensity Activity During an Interchange Rugby League Movement Simulation Protocol

From Crossref journal articles via Jisc Publications RouterPublication status: PublishedFairbank, M, Highton, J, Twist, C. Passive heat maintenance after an initial warm-up improves high-intensity activity during an interchange rugby league movement simulation protocol. J Strength Cond Res 35(7): 1981–1986, 2021—This study examined using passive heat maintenance (PHM) to maintain core temperature after a warm-up and its effect on simulated first half running performance in rugby players. Thirteen male rugby players completed this randomized crossover study. Tympanic temperature was taken before a warm-up and then after a further 15 minutes of passive recovery either with (PHM) or without (CON) a PHM garment. Subjects then completed 23 minutes of the rugby league movement simulation protocol (RLMSP-i). Differences in tympanic temperature were unclear between CON and PHM before (35.7 ± 1.3 cf. 36.0 ± 1.1° C; effect size [ES] = 0.20) and during exercise (34.5 ± 0.1 cf. 35.2 ± 0.1° C; ES = 0.26–0.35). High-intensity running (ES = 0.27) and peak sprint speed were higher (ES = 0.46–0.56) during the PHM compared with the CON trial. Time spent above 20 W·kg−1 also increased in the first quartile of the PHM compared with the CON trial (ES = 0.18). All other between trial comparisons of performance were unclear. HRmean (ES = 0.38) was higher in PHM compared with CON, while differences in RPEmean (ES = −0.19) were unclear. There are small to large increases in high-intensity activity performed during a playing bout when rugby players wear a PHM garment after a warm-up. Rugby players should consider PHM during extended periods between a warm-up and starting a match