Intensity Harmonization Techniques Influence Radiomics Features and Radiomics-based Predictions in Sarcoma Patients

International audienceIntensity harmonization techniques (IHT) are mandatory to homogenize multicentric MRIs before any quantitative analysis because signal intensities (SI) do not have standardized units. Radiomics combine quantification of tumors' radiological phenotype with machine-learning to improve predictive models, such as metastasticrelapse-free survival (MFS) for sarcoma patients. We post-processed the initial T2weighted-imaging of 70 sarcoma patients by using 5 IHTs and extracting 45 radiomics features (RFs), namely: classical standardization (IHTstd), standardization per adipose tissue SIs (IHTfat), histogram-matching with a patient histogra

HIV/AIDS in Indonesia: current treatment landscape, future therapeutic horizons, and herbal approaches

HIV/AIDS is still a major worldwide health concern, and Indonesia is making efforts to mitigate its effects. Antiretroviral therapy (ARV), which aims to decrease viral replication, boost immunological function, and lengthen the lifespans of persons living with HIV/AIDS, is the cornerstone of Indonesia’s strategy. The availability of ARV has significantly increased, yet problems including stigma and the requirement for regular medication adherence still exist. To address the broader needs of those affected by HIV/AIDS, Indonesia lays a major focus on comprehensive care, which includes mental health and social support, in addition to ARV. Data show that, despite progress, there is still a stigma surrounding HIV/AIDS, which affects patient outcomes and access to care. With vigorous research into cutting-edge antiretroviral medications and treatment techniques, Indonesia has a thriving future therapeutic landscape. The goals of these programs are to increase treatment effectiveness, decrease side effects, and increase access to cutting-edge treatments. Preventive methods, such as PrEP (pre-exposure prophylaxis), are making progress, and efforts to find a cure are gaining prominence. Notably, HIV/AIDS management plan of Indonesia heavily relies on natural remedies. Patient care incorporates traditional Indonesian medicine, such as jamu and several herbal medicines. Although there is little scientific proof to support the effectiveness of these herbal remedies, complementary and alternative therapies frequently employ them to manage symptoms and promote general wellness. In terms of the 95-95-95 targets, Indonesia is making an effort to comply with these international goals by seeking to diagnose 95% of HIV-positive individuals, provide sustained ARV to 95% of those diagnosed, and achieve viral suppression in 95% of ARV recipients. Although there are gaps in reaching these aims, progress is being made, in part because of the aforementioned challenges. In summary, Indonesia employs a multimodal approach to HIV/AIDS management, including traditional herbal cures, continuous research into cutting-edge treatments, and conventional ARV. In order to enhance overall health outcomes and create a healthier society, the future of HIV/AIDS treatment in Indonesia is concentrated on expanding therapeutic alternatives, reaching the 95-95-95 targets, decreasing stigma, and improving access to care

An Indo-Pacifc coral spawning database

The discovery of multi-species synchronous spawning of scleractinian corals on the Great Barrier Reef in the 1980s stimulated an extraordinary effort to document spawning times in other parts of the globe. Unfortunately, most of these data remain unpublished which limits our understanding of regional and global reproductive patterns. The Coral Spawning Database (CSD) collates much of these disparate data into a single place. The CSD includes 6178 observations (3085 of which were unpublished) of the time or day of spawning for over 300 scleractinian species in 61 genera from 101 sites in the Indo-Pacific. The goal of the CSD is to provide open access to coral spawning data to accelerate our understanding of coral reproductive biology and to provide a baseline against which to evaluate any future changes in reproductive phenology

ANALISIS DAN PERANCANGAN SISTEM BASIS DATA ADMINISTRASI KOPERASI BINA KASIH SEKOLAH SANTO YAKOBUS KELAPA GADING

ANALISIS DAN PERANCANGAN SISTEM BASIS DATA ADMINISTRASI KOPERASI BINA KASIH SEKOLAH SANTO YAKOBUS KELAPA GADING

Isolated metacarpal bone metastasis from advanced rectosigmoid carcinoma

Distant metastasis is a common sequelae of stage III colorectal adenocarcinoma. Liver and lungs are the most common sites for distant metastases, but, metastases to extremities are very rare. We report a case of rectosigmoid adenocarcinoma, which metastasizes to left first metacarpal bone, which is the first occurrence in our experience. The investigations and management of the patient are discussed

Systematic review of sarcomas radiomics studies: Bridging the gap between concepts and clinical applications?

International audienc

Synergistic effects of three Moroccan thyme essential oils with antibiotic cefixime

The association of essential oils (EOs) with antibiotics provides a promising solution towards combating resistant bacteria. Thus, the aim of this study was to examine for the first time the possible synergistic interaction between EOs of three Moroccan thymes, namely Thymus leptobotrys (carvacrol [79.1%]), Thymus pallidus (γ-terpinene [29.6%], thymol [26.8%] and p-cymene [18.9%]) and Thymus ciliatus (carvacrol [26.2%], p-cymene [19.6%], thymol [17.3%] and γ-terpinene [14.6%]) and the antibiotic cefixime against selected pathogenic bacteria. The results showed that all thyme EOs presented interesting antibacterial potency and important synergistic effects with cefixime. Thymus leptobotrys EO showed the strongest efficacy against all tested bacteria (minimum inhibitory concentration values 0.14 mg/mL to 73.92 mg/mL), and the best synergistic effect (fractional inhibitor concentration indices: 0.26 to 0.5; gain: 4- to 130-fold). This synergistic interaction between the studied thyme EOs and cefixime may provide a basis for future applications for the control of antibiotic-resistant bacteria

The depression anxiety stress scales (DASS-21): an Indonesian validation measure of the depression anxiety stress

This study attempts to evaluate the Indonesian adaptation of the DASS-21, a scale adapted from Peter F. and Sydney H. Lovibond 1995 to assess levels of stress, anxiety, and depression. Multistage random sampling taking from 1478 Indonesian. Additionally, we use The Rasch measurement model to examine psychometric properties of DASS-21. The results indicate that the DASS-21 fulfills the psychometric measurement aspect by providing evidence as a valid and reliable instrument, with a very good item reliability value .99 and sufficient person reliability (.89), as well as a Cronbach alpha value KR-20.  of .91, meaning that the quality of the items is very good for revealing depression, anxiety, and stress. Furthermore, the results are reinforced by the Principal Component Analysis (PCA) value to the residual of 39.7%, meaning that the items in DASS-21 are representative for measuring depression, anxiety, and stress. Therefore, it can be said that the DASS-21 is valid and reliable for assessing the levels of stress, anxiety, and depression. The Indonesian translation of the DASS-21 constructs can also be used to assess the stress, anxiety, and depression levels

The depression anxiety stress scales (DASS-21); an Indonesian validation measure of the depression anxiety stress

This study attempts to evaluate the Indonesian adaptation of the DASS-21, a scale adapted from Peter F. and Sydney H. Lovibond 1995 to assess levels of stress, anxiety, and depression. Multistage random sampling taking from 1478 Indonesian. Additionally, we use The Rasch measurement model to examine psychometric properties of DASS-21. The results indicate that the DASS-21 fulfills the psychometric measurement aspect by providing evidence as a valid and reliable instrument, with a very good item reliability value .99 and sufficient person reliability (.89), as well as a Cronbach alpha value KR-20.  of .91, meaning that the quality of the items is very good for revealing depression, anxiety, and stress. Furthermore, the results are reinforced by the Principal Component Analysis (PCA) value to the residual of 39.7%, meaning that the items in DASS-21 are representative for measuring depression, anxiety, and stress. Therefore, it can be said that the DASS-21 is valid and reliable for assessing the levels of stress, anxiety, and depression. The Indonesian translation of the DASS-21 constructs can also be used to assess the stress, anxiety, and depression levels