Histamine in cancer: the dual faces of the coin.

Commentary to:The role of histamine in human mammary carcinogenesis: H3 and H4 receptors as potential therapeutic targets for breast cancer treatment.Vanina Medina, Maximo Croci, Ernesto Crescenti, Nora Mohamad, Francisca Sanchez-Jimenez, Noelia Massari, Mariel Nunez, Graciela Cricco, Gabriela Martin, Rosa Bergoc, Elena River

Implementing the environmental dimension of the EU’s urban agenda 2014-2020

This work illustrates the planning experience carried out Sustainable Urban Development (SSUD), whose general objectives are strengthening territorial cohesion and to increase accessibility to the local resources. The SSUD action plan, being funded with around 70 millions euro, through which such objectives can be better achieved and reciprocally integrated. After a brief description of the territory targeted by the concept within the broader debate on sustainable mobility. In section 3, a series of evidences are provided to identify the demand and potential for the development the fourth section, after describing the expceted results is suggested why in this area a greenway is the better solution to increase accessibility to a broad range of natural resources and functions (natural sites, landscapes, cultural heritage, urban functions)

Breast Fistula Repair after Autologous Fat Graft: A Case Report

We report the case of a 55-year-old female patient who attended our clinic for the presence of a scar retraction in the upper pole of the left breast as a complication of breast augmentation. In the scar area, we observed an orifice that probing revealed to be a fistula. The patient was referred to surgical intervention under general anesthesia to obtain scar contracture release using autologous fat graft; one month after autologous fat injection, following healing of the fistula, the patient underwent a second surgical procedure to replace the left breast implant. Unexpectedly, two weeks after the surgical procedure, complete healing of the breast fistula within the scar area was observed; this observation was confirmed during the second surgical step for left breast implant repositioning, when we observed the absence of the fistula orifice in the breast implant cavity. Upon clinical examination at 1-year followup, tissue integrity was preserved. The patient's satisfaction was excellent. We have observed a possible additional effect of fat graft

Acute epiploic appendagitis : ultrasound and computed tomography findings of a rare case of acute abdominal pain and the role of other imaging techniques

Purpose: Acute epiploic appendagitis (EA) is a relatively rare, benign and local inflammatory disease involving the epiploic appendices. Unlike its mimics, EA is generally a self-limiting inflammatory disease and can be treated conservatively. Case presentation: A 33-year-old Caucasian man presented to our emergency department with a sever and sharp left iliac fossa pain. He underwent abdominal X-ray, ultrasound (US) and computed tomography (CT) evaluations. Conclusion: We illustrate US and CT findings to increase the radiologists’ awareness of this condition and to avoid diagnostic delay and unnecessary use of antibiotics, hospitalization and surgery

Cardiovascular features of possible autonomous cortisol secretion in patients with adrenal incidentalomas

Background: Low-grade incomplete post-dexamethasone cortisol suppression in patients with adrenal incidentalomas – recently defined as possible autonomous cortisol secretion (pACS) – has been associated with increased cardiovascular events and mortality. However, prospective studies documenting cardiac abnormalities in these patients are lacking. Subjects and methods: Between July 2016 and September 2017, 71 consecutive patients with adrenal lesions were prospectively screened for hypercortisolism by dexamethasone suppression test (NCT 02611258). Complete anthropometric, metabolic and hormonal parameters were recorded along with full cardiac ultrasound assessment and noninvasive measurement of arterial stiffness. All patients underwent chemical-shift magnetic resonance imaging to characterize the lesions. Cardiovascular outcomes were recorded in blind. Results: According to post-dexamethasone suppression cortisol values (post-DST), 34 patients had pACS and 37 nonfunctioning adenomas (NFA). The two groups were similar in sex, BMI, age distribution, cardiovascular risk factors and comorbidities. Left ventricular mass index (LVMIBSA) was increased in pACS compared to NFA (P=0.006) and mildly correlated to the post-DST cortisol level (rho=0.347; P=0.004). The post-DST cortisol levels explained up to 13.7% of LVMIBSAvariance (P=0.002). Compared to NFA, patients with pACS had a higher prevalence of diastolic dysfunction (35.1% vs 82.6%; P=0.001) and worse arterial stiffness assessed by pulse wave velocity (P=0.033). Conclusions: In apparently asymptomatic patients, mild autonomous cortisol secretion can sustain early cardiac and vascular remodeling, independently of other risk factors. The morphological and functional cardiovascular changes observed in pACS underline the need for further studies to correctly define the long-term management of this relatively common condition

Treatment of Chronic Posttraumatic Leg Injury Using Autologous Fat Graft

We present the results obtained in a case of a 20-year-old Caucasian woman with a posttraumatic injury “hard-to-heal” of the left leg treated using autologous fat graft. Considering our experience in treatment of chronic posttraumatic ulcers by autologous fat graft, we decided to use this surgical technique to induce a regenerative effect in this young patient. We have had complete wound closure with only a single surgical procedure after 1 month; after the second intervention of autologous fat graft we observed an improvement in the quality of the scar tissue. The patient satisfaction was excellent. The results were long lasting and remained virtually unchanged after 1 year

Establishing a new baseline for monitoring the status of EU Spatial Data Infrastructure: Experiences and conclusions from INSPIRE 2019 monitoring and reporting

The INSPIRE Directive, which aims to establish a pan-European Spatial Data Infrastructure for the purposes of EU environmental policies, requires Member States to monitor and report on the implementation status on an annual basis. The way the INSPIRE monitoring and reporting process was performed in 2019 was driven by Commission Implementing Decision (EU) 2019/1372, which introduced the automated calculation of 19 new indicators through the direct use of the INSPIRE Geoportal and the INSPIRE Reference Validator to process the metadata harvested from Member States discovery services. These indicators are grouped into 5 categories: availability of spatial data and services, conformity of metadata, conformity of spatial data sets, accessibility of spatial data sets through view and download services, and conformity of network services. Most indicators are calculated as a percentage, thus providing a direct measure of performance and allowing also country-by-country comparisons. For each indicator, this report provides a detailed description of the calculation method, the values achieved for all Member States and some summary statistics to capture the overall performance trends. The results show that the status of INSPIRE implementation is very heterogeneous across the EU, with some countries performing well and some others still lagging behind. However, after 13 years from the entry into force of the Directive, there is no single country which has yet achieved full implementation according to the roadmap. The accessibility of data sets through view or download services is on average only about 30%, while the conformity of metadata, data sets and network services varies between 30% and 45% on average. In addition to providing an objective snapshot of the current status of INSPIRE implementation, the results of 2019 monitoring and reporting represent a reliable baseline to monitor the evolution of the EU Spatial Data Infrastructure and its contribution to the European Green Deal data space in the years to come.JRC.B.6-Digital Econom

Composite Techniques for Quality Analysis in Automotive Laser Welding

A - -Real-time monitoring of the laser-based applications is becoming a main issue for quality analysis in the steel manufacturing industry. The paper suggests a solution achieving an automated real-time quality inspection in laser welding applications. A composite system composed of softcomputing and traditional techniques has been considered for itsposifive impact on the reduced computational once compared with more traditional approaches

Intra-and extra-hospitalization monitoring of vital signs. Two sides of the same coin. Perspectives from Lims and Greenline study operators

Background: In recent years, due to the epidemiological transition, the burden of very complex patients in hospital wards has increased. Telemedicine usage appears to be a potential high-impact factor in helping with patient management, allowing hospital personnel to assess conditions in out-of-hospital scenarios. Methods: To investigate the management of chronic patients during both hospitalization for disease and discharge, randomized studies (LIMS and Greenline-HT) are ongoing in the Internal Medicine Unit at ASL Roma 6 Castelli Hospital. The study endpoints are clinical outcomes (from a patient’s perspective). In this perspective paper, the main findings of these studies, from the operators’ point of view, are reported. Operator opinions were collected from structured and unstructured surveys conducted among the staff involved, and their main themes are reported in a narrative manner. Results: Telemonitoring appears to be linked to a reduction in side-events and side-effects, which represent some of most commons risk factors for re-hospitalization and for delayed discharge during hospitalization. The main perceived advantages are increased patient safety and the quick response in case of emergency. The main disadvantages are believed to be related to low patient compliance and an infrastructural lack of optimization. Conclusions: The evidence of wireless monitoring studies, combined with the analysis of activity data, suggests the need for a model of patient management that envisages an increase in the territory of structures capable of offering patients subacute care (the possibility of antibiotic treatments, blood transfusions, infusion support, and pain therapy) for the timely management of chronic patients in the terminal phase, for which treatment in acute wards must be guaranteed only for a limited time for the management of the acute phase of their diseases