Distribution of soft bottom sediments in the Portuguese Continental Shelf

This work presents a simplified map of the spatial distribution of surficial sediments and rock outcrops along the Portuguese continental shelf in ArcGIS format. Nearly 500 samples of soft bottom shelf sediments were collected in the scope of several research projects and analyzed for grain-size. Based on the raw grain-size data, the samples were classified according to a modified version of the Folk classification system and used to create a new sediment distribution map and develop an easy-to-use GIS interface

A broad scale seabed substrate map of the Portuguese coast

The MeshAtlantic project aimed to generate a broad-scale habitat map for the shelf and coastal area of the Atlantic Area. Till 2012, a detailed seabed substrate map of the Portuguese coast, which covers a great extension of the Western Iberian coast, was not known

A Bottom Sediment Distribution Map for the Portuguese Continental Shelf in ArcGis Format: Mapa da Distribuição de Sedimentos Superficiais da Plataforma Continental Portuguesa em Formato ArcGis

This work presents a simplified map of the spatial distribution of surficial sediments and rock outcrops along the Portuguese continental shelf in ArcGIS format. Preliminary map preparation involved scanning, georeferencing and digitizing of pre-existing base maps from the Portuguese Hydrographic Institute and harmonization with other published and non-published cartographic information. Samples of soft bottom shelf sediments from nearly 500 sites, collected in the scope of the MeshAtlantic, RENSUB and ACOSHELF projects, were analyzed for grain-size and total organic matter. Grain-size analysis was performed using dry and wet sieving. The procedure includes chemical destruction of organic matter with H2O2, chemical dispersion with tetra-sodium pyrophosphate, separation of the mud fraction by wet sieving and dry sieving of both sand and gravel fractions. Raw grain-size data were expressed as weight percentages and classified according to a modified version of the Folk classification system. Grain size data for the whole set of samples were used to create a new sediment distribution map and develop an easy-to-use GIS interface, that will be available in the MeshAtlantic website, as part of a global broadscale habitat map for the Atlantic Area. Overall, the bottom sediment distribution patterns show that: (a) the coarser deposits occur mainly in the inner and mid-shelf of the northwestern sector of the Portuguese shelf, to the south of the Nazaré and Setúbal canyons, and are sparsely represented in the southern shelf; (b) sand banks dominate in the near shore shelf, but can sporadically be found at greater depths; (c) muddy sands characterize the deeper shelf; (d) patches of sandy mud and mud reflecting a less energetic hydrodynamic regime cover a large sector of the southern shelf and areas located off the mouths of major rivers in the western shelf; (e) mixed sediments are residual; (f) rock outcrops are unevenly distributed throughout the entire shelf

The tale of TILs in breast cancer : a report from The International Immuno-Oncology Biomarker Working Group

The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potentially benefit from ICI targeting the programmed death 1 (PD-1)/PD-L1 signaling axis. The use of tumor-infiltrating lymphocytes (TILs) as predictive and prognostic biomarkers has been under intense examination. Emerging data suggest that TILs are associated with response to both cytotoxic treatments and immunotherapy, particularly for patients with triple-negative BC. In this review from The International Immuno-Oncology Biomarker Working Group, we discuss (a) the biological understanding of TILs, (b) their analytical and clinical validity and efforts toward the clinical utility in BC, and (c) the current status of PD-L1 and TIL testing across different continents, including experiences from low-to-middle-income countries, incorporating also the view of a patient advocate. This information will help set the stage for future approaches to optimize the understanding and clinical utilization of TIL analysis in patients with BC

Levedura seca integral na alimentação de vacas lactantes

Os efeitos da inclusão de levedura seca de cana-de-açúcar (Saccharomyces cerevisiae) na dieta de vacas lactantes foram avaliados com base no fornecimento de quatro dietas constituídas de diferentes níveis de substituição do farelo de soja pela levedura de cana-de-açúcar (0,00; 0,33; 0,67 e 1,00kg/kg de MS). O delineamento utilizado foi o quadrado latino 4 × 4. Não houve efeito dos tratamentos sobre o consumo de MS, MO, EE, FDNi e NDT, porém ocorreu redução linear no consumo de PB e FDNcp e aumento do consumo de CNF. Diferenças estatísticas não foram verificadas para os coeficientes de digestibilidade aparente da MS, MO, PB, CNF e NDT; no entanto os coeficientes do FDNcp e do EE decresceram linearmente. Não foi observado efeito sobre a produção e eficiência de síntese microbiana, utilização dos componentes nitrogenados e produção e composição do leite. Conclui-se que a levedura seca pode substituir 100% o farelo de soja na alimentação de vacas lactantes

Internação domiciliar: o perfil dos pacientes assistidos pelo Programa HU em Casa Home care: profile of patients attended by a home care program

Internação domiciliar é uma modalidade de atendimento à saúde que está se transformando em uma alternativa importante para minimizar alguns dos principais problemas inerentes aos sistemas de saúde vigentes, especialmente os da rede pública. O objetivo do estudo foi descrever o perfil sociodemográfico e clínico da população assistida pelo Programa de Internação Domiciliar (PID) HU em Casa do Hospital Universitário Clemente de Faria da Universidade Estadual de Montes Claros. O estudo foi descritivo e retrospectivo por meio da análise de prontuários, realizada de maio de 2005 a maio de 2008. Foram analisados 137 pacientes, sendo 75 do gênero feminino (54,7%) e 62 do masculino (45,3%). O grupo de 61 a 80 anos foi mais prevalente (37,2%) e 73% dos pacientes residiam em bairros periféricos do município de Montes Claros-MG. Dos agravos mais comuns na primeira internação, a pneumonia foi prevalente, 22 casos (16,1%). A maioria dos pacientes foi encaminhada ao PID pela clinica médica (84,7%), com intervalo de maior prevalência de duas a três internações (42,4%). Do total de pacientes, 120 (87,6%) permaneceram internados por 16 a 30 dias e 51,8% não necessitaram passar novamente pelo PID para uma segunda internação. Com relação à resolutividade clínica, 130 (94,9%) tiveram alta clínica, no PID, na primeira internação. O PID mostrou-se ser um programa de alta resolutividade, atendendo mais ao público idoso feminino, de baixa renda e com períodos de internação relativamente curtos.<br>The home care is a modality of health care which is becoming an important alternative to minimize some of mainly relevant problems of world health, especially the public health network. This paper aimed to describe the socio-demographic and clinical population assisted by the Home Care Program HU em Casa, of the University Hospital Clemente de Faria, Universidade Estadual de Montes Claros. It is a descriptive and retrospective study analyzing medical records from May 2005 to May 2008. Of the 137 analyzed patients, 75 were females (54.7%) and 62 males (45.3%). Concerning age, the 61-80 year group was the most prevalent (37.2%) and 73% lived and was attended in the peripheral districts of Montes Claros city. Among the most important diseases in the first admission, the most prevalent was pneumonia (22 cases, 16.1%). Most patients were referred to the HU em Casa Home Care Program for the medical clinic (84.7%) with a range of higher prevalence of 2 to 3 admissions (42.4%). Of the total patients, 120 (87.6%) stayed in hospital for 16 to 30 days. Referring to resolutivity, 130 (94.9%) patients were discharged to the program on the first admission. The PID proved to be a high-solving program, attended mainly elderly women with low income and with periods of relatively short hospitalization