1,198 research outputs found
Trends in studies of edge influence on vegetation at human created and natural forest edges across time and space
Submitted VersionForest edges, or boundaries between adjacent ecosystems, play important ecological roles. Both anthropogenic and natural forest edges affect vegetation while contributing to landscape heterogeneity. The recent proliferation of studies on vegetation at edges suggests that a comprehensive review of global edge studies is timely. We reviewed the literature on forest edges to identify trends in edge studies over time, determine types and localities of studied edges, and compare findings on edge influence. We found 446 studies conducted in 55 different countries that considered edge influence on vegetation structure and (or) composition. Research on vegetation at anthropogenic edges has increased and expanded geographically, but studies are still scarce in some areas and at natural forest edges. Forest edges were generally characterized by greater species diversity and nonnative species abundance than interior forest. Distance of edge influence on vegetation extended furthest at tropical anthropogenic forest edges compared with other edge types and locations. Edge influence on responses caused by indirect effects of edges generally extended further into the forest than edge influence on responses related to forest structure. Our findings indicate that vegetation characteristics differ between edge and forest types and should be considered in the sustainable management of heterogeneous forested landscapes. [ABSTRACT FROM AUTHOR
Simvastatin suppresses experimental aortic aneurysm expansion
ObjectiveAbdominal aortic aneurysm (AAA) formation is a result of inflammation and extracellular matrix (ECM) remodeling mediated by matrix metalloproteinases (MMPs). Hydroxymethylglutaryl-coenzyme A inhibitors (statins), although clinically used as lipid-lowering agents, have also been demonstrated to have anti-inflammatory effects. This study was designed to determine whether the hydroxymethylglutaryl-coenzyme A inhibitor simvastatin suppresses aneurysm formation in an elastase-induced rat AAA model.MethodsAneurysms were created in adult male Wistar rats by infusion of elastase into isolated infrarenal aortic segments. The rats were randomized to receive either simvastatin (n = 17) or placebo (n = 17) by gastric lavage daily starting the day before surgery. The rats were euthanized and the infrarenal aortas harvested on postoperative day 7. Aortic diameters were measured before infusion, immediately after infusion, and at the time of harvesting. Protein expression was measured by immunoblot analysis. Gene expression profiling using Affymetrix U34A rat genome chips was performed to identify changes in gene expression caused by simvastatin treatment.ResultsMean aneurysm diameter was significantly less in the simvastatin treatment group compared with controls (3.4 ± 0.08 mm vs 4.3 ± 0.19 mm; P = .0001). MMP-9 and nuclear factor-κB protein levels were decreased in the aortas of simvastatin-treated animals. Gene microarray analysis revealed 315 genes with statistically significant changes in expression (P < .05) in the simvastatin group. Genes related to inflammation, ECM remodeling, and oxidative stress function were downregulated. These included genes for interleukin 1, interleukin 4, inducible nitric oxide synthase, P-selectin, platelet-derived growth factor α, tumor necrosis factor, and several chemokines.ConclusionsSimvastatin significantly suppresses experimental aneurysm expansion and reduces protein levels of MMP-9 and nuclear factor-κB. Gene array analysis provides evidence that several mediators of inflammation, matrix remodeling, and oxidative stress are downregulated by simvastatin treatment. This suggests that simvastatin inhibits AAA formation by blocking the expression of certain proinflammatory genes. Simvastatin may be useful as an adjuvant therapy to suppress the growth of small aneurysms.Clinical RelevanceHuman aortic aneurysms are characterized histologically by an inflammatory infiltrate with severe proteolytic destruction. Statins, although used clinically as lipid-lowering agents, have been shown to have anti-inflammatory effects. Simvastatin reduced experimental aneurysm size in this study. It seems that this reduction is mediated by interfering with multiple pathways, including oxidative stress, inflammation, and ECM and matrix remodeling. Further study into the effect of statins in reducing the growth of AAAs in patients is warranted
Octet magnetic moments and the Coleman-Glashow sum rule violation in the chiral quark model
Baryon octet magnetic moments when calculated within the chiral quark model,
incorporating the orbital angular momentum as well as the quark sea
contribution through the Cheng-Li mechanism, not only show improvement over the
non relativistic quark model results but also gives a non zero value for the
right hand side of Coleman-Glashow sum rule. When effects due to spin-spin
forces between constituent quarks as well as `mass adjustments' due to
confinement are added, it leads to an excellent fit for the case of p,
\Sigma^+, \Xi^o and violation of Coleman-Glashow sum rule, whereas in almost
all the other cases the results are within 5% of the data.Comment: 5 RevTeX pages, accepted for publication in PRD(Rapid Communication
The Isgur-Wise function in a relativistic model for system
We use the Dirac equation with a ``(asymptotically free) Coulomb + (Lorentz
scalar) linear '' potential to estimate the light quark wavefunction for mesons in the limit . We use these wavefunctions to
calculate the Isgur-Wise function for orbital and radial
ground states in the phenomenologically interesting range . We find a simple expression for the zero-recoil slope, , where is the energy eigenvalue
of the light quark, which can be identified with the parameter
of the Heavy Quark Effective Theory. This result implies an upper bound of
for the slope . Also, because for a very light quark the size of the meson is determined mainly by the
``confining'' term in the potential , the shape of
is seen to be mostly sensitive to the dimensionless
ratio . We present results for the ranges of
parameters , and
light quark masses and compare to existing
experimental data and other theoretical estimates. Fits to the data give:
,
and [ARGUS
'93]; , and
[CLEO '93]; ${\bar\Lambda_{u,d}}^2/Comment: 22 pages, Latex, 4 figures (not included) available by fax or via
email upon reques
Light-cone QCD Sum Rules for the Baryon Electromagnetic Form Factors and its magnetic moment
We present the light-cone QCD sum rules up to twist 6 for the electromagnetic
form factors of the baryon. To estimate the magnetic moment of the
baryon, the magnetic form factor is fitted by the dipole formula. The numerical
value of our estimation is , which is in
accordance with the experimental data and the existing theoretical results. We
find that it is twist 4 but not the leading twist distribution amplitudes that
dominate the results.Comment: 13 page, 7 figures, accepted for publication in Euro. Phys. J.
Can forest management based on natural disturbances maintain ecological resilience?
Given the increasingly global stresses on forests, many ecologists argue that managers must maintain ecological resilience: the capacity of ecosystems to absorb disturbances without undergoing fundamental change. In this review we ask: Can the emerging paradigm of natural-disturbance-based management (NDBM) maintain ecological resilience in managed forests? Applying resilience theory requires careful articulation of the ecosystem state under consideration, the disturbances and stresses that affect the persistence of possible alternative states, and the spatial and temporal scales of management relevance. Implementing NDBM while maintaining resilience means recognizing that (i) biodiversity is important for long-term ecosystem persistence, (ii) natural disturbances play a critical role as a generator of structural and compositional heterogeneity at multiple scales, and (iii) traditional management tends to produce forests more homogeneous than those disturbed naturally and increases the likelihood of unexpected catastrophic change by constraining variation of key environmental processes. NDBM may maintain resilience if silvicultural strategies retain the structures and processes that perpetuate desired states while reducing those that enhance resilience of undesirable states. Such strategies require an understanding of harvesting impacts on slow ecosystem processes, such as seed-bank or nutrient dynamics, which in the long term can lead to ecological surprises by altering the forest's capacity to reorganize after disturbance
Occurrence of male-specific and somatic coliphages and relationship with rainfall in privately-owned wells from peri‑urban and rural households
Privately-owned drinking water wells serving fewer than 25 people (private wells) are prevalent and understudied across most of the US. Private wells primarily serve rural households located outside of municipal drinking water and sewerage service coverage areas. These wells are not regulated by United States Environmental Protection Agency (EPA) under the Safe Drinking Water Act, are not regularly monitored by any public agency or utility, and generally do not undergo disinfection treatment. Coliphages are a group of viruses that infect coliform bacteria and are useful viral surrogates for fecal contamination in water systems in much the same way that fecal indicator bacteria (FIB), such as E. coli and to a lesser extent total coliforms, are used to quantify fecal contamination. Coliphages are approved by the EPA for regulatory monitoring in groundwater wells in the USA, but are not routinely used for this purpose. The present study characterizes the occurrence of male-specific and somatic coliphages, along with FIB, in private wells (n = 122) across two different counties in North Carolina. While occurrences of E. coli were rare and frequency of total coliform was generally low (~20%), male-specific and somatic coliphages were detectable in 66% and 54% of samples, respectively. Concentrations of male-specific coliphages were higher than somatics at each county and on a monthly basis. Rainfall appears to be partly influencing higher coliphage concentrations in December, January and February. This research underscores the need for increased surveillance in private wells and consideration of using coliphages in order to better characterize occurrence of fecal contamination at the time of sampling, especially during rainier months
Tumour subregion analysis of colorectal liver metastases using semi-automated clustering based on DCE-MRI: Comparison with histological subregions and impact on pharmacokinetic parameter analysis.
PURPOSE: To use a novel segmentation methodology based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to define tumour subregions of liver metastases from colorectal cancer (CRC), to compare these with histology, and to use these to compare extracted pharmacokinetic (PK) parameters between tumour subregions. MATERIALS AND METHODS: This ethically-approved prospective study recruited patients with CRC and ≥1 hepatic metastases scheduled for hepatic resection. Patients underwent DCE-MRI pre-metastasectomy. Histological sections of resection specimens were spatially matched to DCE-MRI acquisitions and used to define histological subregions of viable and non-viable tumour. A semi-automated voxel-wise image segmentation algorithm based on the DCE-MRI contrast-uptake curves was used to define imaging subregions of viable and non-viable tumour. Overlap of histologically-defined and imaging subregions was compared using the Dice similarity coefficient (DSC). DCE-MRI PK parameters were compared for the whole tumour and histology-defined and imaging-derived subregions. RESULTS: Fourteen patients were included in the analysis. Direct histological comparison with imaging was possible in nine patients. Mean DSC for viable tumour subregions defined by imaging and histology was 0.738 (range 0.540-0.930). There were significant differences between Ktrans and kep for viable and non-viable subregions (p < 0.001) and between whole lesions and viable subregions (p < 0.001). CONCLUSION: We demonstrate good concordance of viable tumour segmentation based on pre-operative DCE-MRI with a post-operative histological gold-standard. This can be used to extract viable tumour-specific values from quantitative image analysis, and could improve treatment response assessment in clinical practice
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