Morphometric study of the true S1 and S2 of the normal and dysmorphic sacralized sacra

Background/aim: This study aimed to generate data for the S1 and S2 alar pedicle and body and the alar orientations for both dysmorphic and normal sacra

THE RELATION OF ORLISTAT AND GREEN TEA WITH BETA-CATENIN AND PROLIFERATION ON GASTROINTESTINAL EPITHELIAL CELLS

Objective. To investigate the relation of gastrointestinal effects of orlistat and green tea with beta-catenin and proliferation immunohistochemically

Evaluation of maternal serum hypoxia inducible factor-1α, progranulin and syndecan-1 levels in pregnancies with early- and late-onset preeclampsia

© 2017 Informa UK Limited, trading as Taylor & Francis Group.Objective: To determine the serum levels of HIF-1 α, progranulin, and syndecan-1 in preeclampsia (PE) and normal pregnancy, and to compare whether these markers demonstrate any difference between early-onset PE (EO-PE) and late-onset PE (LO-PE). Methods: This cross-sectional study was conducted on 27 women with EO-PE, 27 women with LO-PE, and 26 healthy normotensive pregnant controls matched for gestational age. Maternal levels of serum HIF-1 α, progranulin, and syndecan-1 were measured with the use of an enzyme-linked immunosorbent assay kit. Results: Statistical analysis revealed significant differences between the control and the PE groups in progranulin (p <.001) and syndecan-1 (p <.001) levels. There were no significant differences in the serum HIF-1 α levels between these groups (p=.069). When PE patients were evaluated by considering subgroups; statistical analysis revealed significant inter-group differences in all biomarkers. Serum progranulin levels were significantly higher in LO-PE compared with the other two groups (EO-PE versus LO-PE and LO-PE versus controls p =.000). Control group presented significantly higher syndecan-1 levels, than EO and LO-PE (p <.001). HIF-1 α levels positively correlated with progranulin levels (r =.439, p=.000). Conclusions: Serum progranulin may have potential to be used as a biomarker for the differentiation of EO-PE and LO-PE. The co-operative action between HIF-1 α and progranulin might play a key role in the pathogenesis of LO-PE. The predominant feature of LO-PE seems to be an inflammatory process, whereas in EO-PE placentation problem seems to be the main pathology

Retrospective analysis on efficacy of convalescent plasma in acute respiratory distress syndrome due to COVID-19

BACKGROUND: Coronavirus disease 2019 (COVID-19) is an ongoing global health threat. However, currently, no standard therapy has been approved for the disease