Charged di-boson production at the LHC in a 4-site model with a composite Higgs boson

We investigate the scope of the LHC in probing the parameter space of a 4-site model supplemented by one composite Higgs state, assuming all past, current and future energy and luminosity stages of the CERN machine. We concentrate on the yield of charged di-boson production giving two opposite-charge different-flavour leptons and missing (transverse) energy, i.e., events induced via the subprocess $q\bar q\to e^+\nu_e \mu^-\bar\nu_\mu$ + ${\rm{c.c.}}$, which enables the production in the intermediate step of all additional neutral and charged gauge bosons belonging to the spectrum of this model, some of which in resonant topologies. We find this channel accessible over the background at all LHC configurations after a dedicated cut-based analysis. We finally compare the yield of the di-boson mode to that of Drell-Yan processes and establish that they have complementary strengths, one covering regions of parameter space precluded to the others and vice versa.Comment: 36 pages, 13 figures, 13 table

HTR2C Gene Variant and Salivary Cortisol Levels after Endurance Physical Activity: A Pilot Study

Introduction: The 5-hydroxytryptamine 2C receptor (HTR2C) rs6318 polymorphism has been associated with increased sensitivity to stress. This study investigated whether the rs6318 genotype modified the cortisol response to endurance physical activity. Methods: The HTR2C SNP was genotyped in a population of agonistic cyclists, and salivary cortisol levels were measured before and after an endurance competition. Results and Conclusion: Salivary cortisol levels increased after the competition (from 20.72 ± 12.36 ng/mL to 33.80 ± 21.53 ng/mL; p = 3.189 × 10-5). rs6318 C carriers displayed higher baseline cortisol levels compared to G carriers (26.60 ± 9.35 ng/mL vs. 19.50 ± 12.63 ng/mL; p = 0.04). Baseline cortisol levels were able to predict the cortisol response to exercise (β = -0.846; p = 1.2 × 10-5). Although regression analysis did not identify an association between HTR2C genotype and change in cortisol levels, a secondary analysis in which the population was classified by median cortisol changes suggested that they might be weakly associated, thus warranting further investigation

Demonstration of a heterogeneously integrated III-V/SOI single wavelength tunable laser

A heterogeneously integrated III-V-on-silicon laser is reported, integrating a III-V gain section, a silicon ring resonator for wavelength selection and two silicon Bragg grating reflectors as back and front mirrors. Single wavelength operation with a side mode suppression ratio higher than 45 dB is obtained. An output power up to 10 mW at 20 °C and a thermo-optic wavelength tuning range of 8 nm are achieved. The laser linewidth is found to be 1.7 MHz

A Short-Range FMCW Radar-Based Approach for Multi-Target Human-Vehicle Detection

In this article, a new microwave-radar-based technique for short-range detection and classification of multiple human and vehicle targets crossing a monitored area is proposed. This approach, which can find applications in both security and infrastructure surveillance, relies upon the processing of the scattered-field data acquired by low-cost off-The-shelf components, i.e., a 24 GHz frequency-modulated continuous wave (FMCW) radar module and a Raspberry Pi mini-PC. The developed method is based on an ad hoc processing chain to accomplish the automatic target recognition (ATR) task, which consists of blocks performing clutter and leakage removal with an infinite impulse response (IIR) filter, clustering with a density-based spatial clustering of applications with noise (DBSCAN) approach, tracking using a Benedict-Bordner $alpha$-$eta$ filter, features extraction, and finally classification of targets by means of a $k$-nearest neighbor ( $k$-NN) algorithm. The approach is validated in real experimental scenarios, showing its capabilities in correctly detecting multiple targets belonging to different classes (i.e., pedestrians, cars, motorcycles, and trucks)

Evidence for the Concreteness of Abstract Language: A Meta-Analysis of Neuroimaging Studies

The neural mechanisms subserving the processing of abstract concepts remain largely debated. Even within the embodiment theoretical framework, most authors suggest that abstract concepts are coded in a linguistic propositional format, although they do not completely deny the role of sensorimotor and emotional experiences in coding it. To our knowledge, only one recent proposal puts forward that the processing of concrete and abstract concepts relies on the same mechanisms, with the only difference being in the complexity of the underlying experiences. In this paper, we performed a meta-analysis using the Activation Likelihood Estimates (ALE) method on 33 functional neuroimaging studies that considered activations related to abstract and concrete concepts. The results suggest that (1) concrete and abstract concepts share the recruitment of the temporo-fronto-parietal circuits normally involved in the interactions with the physical world, (2) processing concrete concepts recruits fronto-parietal areas better than abstract concepts, and (3) abstract concepts recruit Broca’s region more strongly than concrete ones. Based on anatomical and physiological evidence, Broca’s region is not only a linguistic region mainly devoted to speech production, but it is endowed with complex motor representations of different biological effectors. Hence, we propose that the stronger recruitment of this region for abstract concepts is expression of the complex sensorimotor experiences underlying it, rather than evidence of a purely linguistic format of its processing

Low Loss MMI Couplers for High Performance MZI Modulators

Optical splitters and combiners which can provide precise splitting with low loss, high thermal stability, large optical bandwidth, high compactness and insensitivity to fabrication tolerances are essential components for high performance MZI based optical modulators. In this paper we theoretically and experimentally investigate the MMI and the reduction in optical loss achievable through the use of linear tapers at the input and output ports. Our data shows that losses can be reduced to below 1dB/MMI without affecting the static extinction when employed in MZIs

Fatal viral and bacterial septicemia in a seventeen-year-old woman with immunodepressive influenza A H1N1: an autopsy case

: The Influenza A H1N1 subtype can present with a wide spectrum of severity, from mild symptoms of influenza to severe respiratory distress. The morbidity and mortality connected to influenza are mostly associated with secondary bacterial infections. The influenza syndrome alone can cause a massive release of cytokines with dysregulation of the immune system, and it can act in synergy with other bacteria which can enhance cytokines secretion. This article deals with a case of severe pneumonia of H1N1 in a 17-year-old woman with bacterial superinfection with Staphylococcus aureus characterized by a high level of interleukine-6 (105900 pg/mL) and the appearance of severe leukopenia with immuno-suppression, such that HIV infection and hematological diseases were included in the initial differential diagnosis. After death, the autopsy confirmed the presence of severe pneumonia, in addition to an hepatic steatosis in absence of other risk factors. This case reports the rapid and lethal course of influenza A /H1N1 in a young and healthy subject without comorbidities, in an age group in which mortality is about 0.3 deaths per 100,000. The case underlines the importance of quickly diagnosis of viral infections and the differential diagnoses with other immunosuppressive diseases, which can be fatal even in adolescent and healthy subjects

High-contrast 40 Gb/s operation of a 500 um long silicon carrier-depletion slow wave modulator

This paper was published in OPTICS LETTERS and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://dx.doi.org/10.1364/OL.37.003504. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under law[EN] In this Letter, we demonstrate a highly efficient, compact, high-contrast and low-loss silicon slow wave modulator based on a traveling-wave Mach¿Zehnder interferometer with two 500 μm long slow wave phase shifters. 40 Gb ∕ s operation with 6.6 dB extinction ratio at quadrature and with an on-chip insertion loss of only 6 dB is shown. These results confirm the benefits of slow light as a means to enhance the performance of silicon modulators based on the plasma dispersion effect.Funding by the European Commission (EC) under project Photonics Electronics Functional Integration on CMOS (HELIOS) (FP7224312) and PROMETEO-2010- 087 R&D Excellency Program are acknowledged. F.Y.G, D.J.T. and G.T.R. acknowledge funding support from the United Kingdom Engineering and Physical Sciences Research Council (EPSRC) under the grant “UK Silicon Photonics”.Brimont, ACJ.; Thomson, DJ.; Gardes, FY.; Fedeli, JM.; Reed, GT.; Martí Sendra, J.; Sanchis Kilders, P. (2012). High-contrast 40 Gb/s operation of a 500 um long silicon carrier-depletion slow wave modulator. Optics Letters. 37(17):3504-3506. https://doi.org/10.1364/OL.37.003504S350435063717Liao, L., Liu, A., Rubin, D., Basak, J., Chetrit, Y., Nguyen, H., … Paniccia, M. (2007). 40 Gbit/s silicon optical modulator for high-speed applications. Electronics Letters, 43(22), 1196. doi:10.1049/el:20072253Gardes, F. Y., Thomson, D. J., Emerson, N. G., & Reed, G. T. (2011). 40 Gb/s silicon photonics modulator for TE and TM polarisations. Optics Express, 19(12), 11804. doi:10.1364/oe.19.011804Thomson, D. J., Gardes, F. Y., Hu, Y., Mashanovich, G., Fournier, M., Grosse, P., … Reed, G. T. (2011). High contrast 40Gbit/s optical modulation in silicon. Optics Express, 19(12), 11507. doi:10.1364/oe.19.011507Brimont, A., Thomson, D. J., Sanchis, P., Herrera, J., Gardes, F. Y., Fedeli, J. M., … Martí, J. (2011). High speed silicon electro-optical modulators enhanced via slow light propagation. Optics Express, 19(21), 20876. doi:10.1364/oe.19.020876Ziebell, M., Marris-Morini, D., Rasigade, G., Fédéli, J.-M., Crozat, P., Cassan, E., … Vivien, L. (2012). 40 Gbit/s low-loss silicon optical modulator based on a pipin diode. Optics Express, 20(10), 10591. doi:10.1364/oe.20.010591Dong, P., Chen, L., & Chen, Y. (2012). High-speed low-voltage single-drive push-pull silicon Mach-Zehnder modulators. Optics Express, 20(6), 6163. doi:10.1364/oe.20.006163Taylor, H. F. (1999). Enhanced electrooptic modulation efficiency utilizing slow-wave optical propagation. Journal of Lightwave Technology, 17(10), 1875-1883. doi:10.1109/50.793770O’Faolain, L., Beggs, D. M., White, T. P., Kampfrath, T., Kuipers, K., & Krauss, T. F. (2010). Compact Optical Switches and Modulators Based on Dispersion Engineered Photonic Crystals. IEEE Photonics Journal, 2(3), 404-414. doi:10.1109/jphot.2010.2047918Brimont, A., Vicente Galán, J., Maria Escalante, J., Martí, J., & Sanchis, P. (2010). Group-index engineering in silicon corrugated waveguides. Optics Letters, 35(16), 2708. doi:10.1364/ol.35.002708Soref, R., & Bennett, B. (1987). Electrooptical effects in silicon. IEEE Journal of Quantum Electronics, 23(1), 123-129. doi:10.1109/jqe.1987.1073206Nguyen, H. C., Sakai, Y., Shinkawa, M., Ishikura, N., & Baba, T. (2011). 10 Gb/s operation of photonic crystal silicon optical modulators. Optics Express, 19(14), 13000. doi:10.1364/oe.19.013000Dong, P., Liao, S., Liang, H., Qian, W., Wang, X., Shafiiha, R., … Asghari, M. (2010). High-speed and compact silicon modulator based on a racetrack resonator with a 1 V drive voltage. Optics Letters, 35(19), 3246. doi:10.1364/ol.35.00324

Early-Life Exposure to Commercial Formulation Containing Deltamethrin and Cypermethrin Insecticides Impacts Redox System and Induces Unexpected Regional Effects in Rat Offspring Brain

Several studies have shown that the oxidative impact of pesticides is most prevalent in rural environments where they are intensively used. At different levels, pyrethroids are reported to promote neurodegeneration; they share the ability to promote oxidative stress, and to induce mitochondrial impairments, a-synuclein overexpression and neuronal cell loss. The present study evaluates the impact of early-life exposure to a commercial formulation containing deltamethrin (DM) and cypermethrin (CYP) at a dose of 1/100 LD50 (1.28 and 2.5 mg/kg, respectively). Rats aged 30 days old, treated from the 6th to the 21st day of life, were tested for brain antioxidant activity and a-synuclein levels. Four regions of the brain were analyzed: the striatum, cerebellum, cortex and hippocampus. Our data demonstrated a significant increase in catalase (CAT), superoxide dismutase (SOD) and glutathione (GSH) antioxidant levels in the brain regions compared to the controls. Pups exhibited no significant changes in protein carbonyl levels and lipid peroxidation. Striatal a-synuclein expression was significantly reduced in the rats exposed to DM + CYP, while the treatment resulted in a non-significant increase in the other brain areas. These findings indicate unexpected effects of postnatal treatment with the commercial formulation containing DM and CYP on brain redox state and a-synuclein expression, suggesting an adaptive response