13 research outputs found

    Real-time Focusing of Light through a Multimode Fiber

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    Power Consumption Influence Test of Castor Disc-Cutting Device

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    This study theoretically analyzed the cutting process of castor and determined the structural parameters of the key component of the castor disc-cutting device, aiming to obtain the optimal operation parameter combination and reduce the cutting resistance and power consumption during the harvesting process. The effects of the cutting-disc thickness, cutting-disc rotational speed, feeding speed, and edge angle on the cutting power consumption were studied using an orthogonal rotation combination experiment. The response surface method was used to optimize the parameters, and the mathematical relationship model between the cutting power consumption and each factor was established to determine the optimal parameter combination for disc cutting. The simulation results showed that the optimal combination of cutting parameters was cutting-disc thickness of 3 mm, cutting-disc rotational speed of 550 r/min, feeding speed of 0.6 m/s, and edge angle of 20°. Under these conditions, the cutting power consumption was 1.20375 J. The test results were basically consistent with the model prediction results. Therefore, this study provided a theoretical basis and reference for the design and improvement of castor harvesters

    Bioinformatic analysis reveals an association between Metadherin with breast cancer prognosis and tumor immune infiltration

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    Abstract Breast cancer metastasis and invasion are both promoted by the oncoprotein Metadherin (MTDH). However, the the role of Metadherin in breast cancer progression and its role in the immune microenvironment. Are not clear. A bioinformatic analysis was performed to demonstrate the prognostic value of Metadherin in BC. In the present study, we found that Metadherin is overexpressed in BC and is significantly correlated with individual cancer stage, age, subclasses, menopause and nodal metastasis status. Metadherin overexpression was associated with a significant decrease in OS and DSS. Cox multivariate analysis indicated that Metadherin was an independent negative prognostic indicator for OS and DSS. Moreover, Metadherin hypomethylation status was associated with poor prognosis. A negative correlation was also noted between Metadherin overexpression and the number of plasmacytoid dendritic cells, cluster of differentiation 8+ T cells, and natural killer cells. Association patterns varied with different subtypes. Various associations between Metadherin levels and immune cell surface markers were revealed. A total of 40 groups of BC and adjacent normal breast tissue samples were collected. Metadherin mRNA was detected by PCR, and its expression levels in BC tissues were significantly increased compared with those noted in normal tissues. The expression levels of Metadherin were also measured in normal and BC cell lines, respectively, and similar conclusions were obtained. The Metadherin mRNA levels were knocked down in SK-BR3 and MDA-MB-231 cell lines and the cell proliferative and migratory activities were determined using Cell Counting Kit-8 and scratch assays, respectively. The results indicated that the cell proliferative and migratory abilities were reduced following knockdown of Metadherin expression. Therefore, Metadherin may be considered as a novel prognostic biomarker in BC

    400-W near diffraction-limited single-frequency all-solid photonic bandgap fiber amplifier

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    An ytterbium-doped large-mode area photonic bandgap fiber is used to demonstrate 400 W of single-frequency output at 1064 nm with excellent beam quality and minimal stimulated Brillouin scattering. The fiber possesses all-solid microstructures embedded in the cladding and a core composed of phosphosilicate with a diameter of ∼50  μm. As the signal power is pushed beyond 450 W, there is degradation in the beam quality due to the modal instability. We briefly discuss techniques to alleviate this problem in future designs. To the best of our knowledge, the 400-W single-frequency near diffraction-limited output far exceeds the current state-of-the-art from such type of fiber amplifier

    400-W near diffraction-limited single-frequency all-solid photonic bandgap fiber amplifier

    No full text
    An ytterbium-doped large-mode area photonic bandgap fiber is used to demonstrate 400 W of single-frequency output at 1064 nm with excellent beam quality and minimal stimulated Brillouin scattering. The fiber possesses all-solid microstructures embedded in the cladding and a core composed of phosphosilicate with a diameter of ∼50  μm. As the signal power is pushed beyond 450 W, there is degradation in the beam quality due to the modal instability. We briefly discuss techniques to alleviate this problem in future designs. To the best of our knowledge, the 400-W single-frequency near diffraction-limited output far exceeds the current state-of-the-art from such type of fiber amplifier

    Dynamic Analysis and Parameter Optimization of the Cutting System for Castor Harvester Picking Devices

    No full text
    Our study aimed to identify a design which would reduce cutting resistance during the harvesting of castor. This paper presents a theoretical study of the wave-type disc cutter, which plays an important role in castor harvesting. Based on the SPH–FEM coupling algorithm, a combined orthogonal rotation experiment was performed to study the effects of disc cutter thickness, edge angle, disc cutter rotation speed, and feeding speed on the maximum cutting force. The response surface method was used to achieve an optimal combination of all the test factors. Mathematical modeling of the maximum cutting force and influencing factors was utilized to obtain the optimal parameters for a cutting system consisting of wave-type disc cutters. The optimal results were obtained with a computer-simulated disc cutter rotation speed of 844.2–942.1 r/min, a feeding speed of 0.89–1.01 m/s, a disc cutter thickness of 2.71–3.15 mm, and an edge angle of 29.2–33.9°. Under these conditions, the maximum cutting force was less than 50 N. Finally, the experimental data and numerical computer simulation results were compared using cutting performance test verification. The analysis found that the test results and simulation results were largely consistent. Therefore, the simulation model was judged to be effective and reasonable

    Dynamic Analysis and Parameter Optimization of the Cutting System for Castor Harvester Picking Devices

    No full text
    Our study aimed to identify a design which would reduce cutting resistance during the harvesting of castor. This paper presents a theoretical study of the wave-type disc cutter, which plays an important role in castor harvesting. Based on the SPH–FEM coupling algorithm, a combined orthogonal rotation experiment was performed to study the effects of disc cutter thickness, edge angle, disc cutter rotation speed, and feeding speed on the maximum cutting force. The response surface method was used to achieve an optimal combination of all the test factors. Mathematical modeling of the maximum cutting force and influencing factors was utilized to obtain the optimal parameters for a cutting system consisting of wave-type disc cutters. The optimal results were obtained with a computer-simulated disc cutter rotation speed of 844.2–942.1 r/min, a feeding speed of 0.89–1.01 m/s, a disc cutter thickness of 2.71–3.15 mm, and an edge angle of 29.2–33.9°. Under these conditions, the maximum cutting force was less than 50 N. Finally, the experimental data and numerical computer simulation results were compared using cutting performance test verification. The analysis found that the test results and simulation results were largely consistent. Therefore, the simulation model was judged to be effective and reasonable

    High-resolution photoacoustic imaging with focused laser and ultrasonic beams

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    We report a photoacoustic imager that utilizes a focused laser beam in combination with a 20 MHz ultrasound focusing transducer to obtain micron-resolution tissue images over a long working distance. The imager is based on a ring transducer that combines ultrasonic and laser beams collinearly and confocally in a monolithic element. The combination of focused laser beam and short pulse irradiation led to significant improvement in lateral and axial resolutions compared to the pulse-echo ultrasonic imaging technique or photoacoustic imaging with an unfocused laser. Potential applications include clinical examination of the eye and characterization of thin and superficial tissues
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