Molecular classification and pharmacogenetics of primary plasma cell leukemia: an initial approach toward precision medicine

Primary plasma cell leukemia (pPCL) is a rare and aggressive variant of multiple myeloma (MM) which may represent a valid model for high-risk MM. This disease is associated with a very poor prognosis, and unfortunately, it has not significantly improved during the last three decades. New high-throughput technologies have allowed a better understanding of the molecular basis of this disease and moved toward risk stratification, providing insights for targeted therapy studies. This knowledge, added to the pharmacogenetic profile of new and old agents in the analysis of efficacy and safety, could contribute to help clinical decisions move toward a precision medicine and a better clinical outcome for these patients. In this review, we describe the available literature concerning the genomic characterization and pharmacogenetics of plasma cell leukemia (PCL)

Towards the installation and use of an extended array for cosmic ray detection: The EEE Project

The Extreme Energy Events (EEE) project started to use an array of cosmic ray telescopes for muon detection, distributed over the italian territory. The use of such telescopes, based on Multigap Resistive Plate Chambers (MRPC) allows the study of the local muon flux, the detection of cosmic ray showers and the search for correlations between distant showers. The project is also intended to involve high school teams in an advanced research work. The present status of the installation and the first physics results are discussed here

A multigap resistive plate chamber array for the Extreme Energy Events project

The Extreme Energy Events (EEE) Project is a Centro Fermi - CERN - INFN - MIUR Collaboration Project for the study of extremely high energy cosmic rays, which exploits the Multigap Resistive Plate Chamber (MRPC) technology. The excellent time resolution and good tracking capability of this kind of detector allows us to study Extensive Air Showers (EAS) with an array of MRPC telescopes distributed across the Italian territory. Each telescope is installed in a high school, with the further goal to introduce students to particle and astroparticle Physics. The status of the experiment and the results obtained are reported

First detection of Extensive Air Showers with the EEE experiment

The Extreme Energy Events (EEE) project is devoted to search extremely high energy cosmic rays, by means of an array of hodoscopes distributed over the Italian territory. These stations are based on the use of Multigap Resistive Plate Chambers (MRPC), that have excellent time resolution and good tracking capability. They are installed in selected secondary school institutes, where students are involved in the research work. In this article the analysis of the first extensive air shower detected is presented

A Multigap Resistive Plate Chambers array for the Extreme Energy Events Project

The Extreme Energy Events (EEE) Project is a Centro Fermi - CERN - INFN - MIUR Collaboration Project, for the study of extremely high-energy cosmic rays, which exploits the Multigap Resistive Plate Chamber (MRPC) technology. The excellent time resolution and good tracking capability of this detector allows us to study Extensive Air Showers (EAS) with an array of telescopes distributed all over the Italian territory. Each telescope is installed in a High School, with the additional goal to introduce students to particle and astroparticle Physics. The EEE array is composed, so far, of 47 telescopes, each made of three MRPC planes, spanning more than 10 degrees in latitude and 11 in longitude, organized in clusters and single telescope stations. The status of the experiment and the results, obtained during two recent coordinated data taking periods, will be reported. The observation of Forbush decreases, coincidence events among different telescopes and the muon decay, using more than 5 billion tracks collected in the last few months, are of particular interest

Looking at the sub-TeV sky with cosmic muons detected in the EEE MRPC telescopes

Distributions of secondary cosmic muons were measured by the Multigap Resistive Plate Chambers (MRPC) telescopes of the Extreme Energy Events (EEE) Project, spanning a large angular and temporal acceptance through its sparse sites, to test the possibility to search for any anomaly over long runs. After correcting for the time exposure and geometrical acceptance of the telescopes, data were transformed into equatorial coordinates, and equatorial sky maps were obtained from different sites on a preliminary dataset of 110M events in the energy range at sub-TeV scale

Recent results and performance of the multi-gap resistive plate chambers network for the EEE Project

The Extreme Energy Events (EEE) Project is devoted to the study of Extensive Atmospheric Showers through a network of muon telescopes, installed in High Schools, with the further aim of introducing young students to particle and astroparticle physics. Each telescope is a tracking detector composed of three Multi-gap Resistive Plate Chambers (MRPC) with an active area of 1.60 × 0.80 m(2). Their characteristics are similar to the ones built for the Time Of Flight array of the ALICE Experimentat LHC . The EEE Project started with a few pilot towns, where the telescopes have been taking data since 2008, and it has been constantly extended, reaching at present more than 50 MRPCs telescopes. They are spread across Italy with two additional stations at CERN, covering an area of around 3 × 10(5) km(2), with a total surface area for all the MRPCs of 190 m(2). A comprehensive description of the MRPCs network is reported here: efficiency, time and spatial resolution measured using cosmic rays hitting the telescopes. The most recent results on the detector and physics performance from a series of coordinated data acquisition periods are also presented