Photon rings as tests for alternative spherically symmetric geometries with thin accretion disks

The imaging by the Event Horizon Telescope (EHT) of the supermassive central objects at the heart of the M87 and Milky Way (Sgr A$^\star$) galaxies, has marked the first step into peering at the shadow and photon rings that characterize the optical appearance of black holes surrounded by an accretion disk. Recently, Vagnozzi et. al. [S.~Vagnozzi, \textit{et al.} arXiv:2205.07787 [gr-qc]] used the claim by the EHT that the size of the shadow of Sgr A$^\star$ can be inferred by calibrated measurements of the bright ring enclosing it, to constrain a large number of spherically symmetric space-time geometries. In this work we use this result to study some features of the first and second photon rings of a restricted pool of such geometries in thin accretion disk settings. The emission profile of the latter is described by calling upon three analytic samples belonging to the family introduced by Gralla, Lupsasca and Marrone, in order to characterize such photon rings using the Lyapunov exponent of nearly bound orbits and discuss its correlation with the luminosity extinction rate between the first and second photon rings. We finally elaborate on the chances of using such photon rings as observational discriminators of alternative black hole geometries using very long baseline interferometry.Comment: 17 pages, 58 figures/image

Granular packings of elongated faceted particles deposited under gravity

We report experimental and theoretical results of the effect that particle shape has on the packing properties of granular materials. We have systematically measured the particle angular distribution, the cluster size distribution and the stress profiles of ensembles of faceted elongated particles deposited in a bidimensional box. Stress transmission through this granular system has been numerically simulated using a two-dimensional model of irregular particles. For grains of maximum symmetry (squares), the stress propagation localizes and forms chain-like forces analogous to those observed for granular materials composed of spheres. For thick layers of grains, a pressure saturation is observed for deposit depths beyond a characteristic length. This scenario correlates with packing morphology and can be understood in terms of stochastic models of aggregation and random multiplicative processes. As grains elongate and lose their symmetry, stress propagation is strongly affected. Lateral force transmission becomes less favored than vertical transfer, and hence, an increase in the pressure develops with depth, hindering force saturation

Vitamin C modulates the interaction between adipocytes and macrophages

Scope: Increased adiposity is related with monocyte infiltration into the adipose tissue that accentuates inflammation. Antioxidant treatments emerge as approaches to counteract this phenomenon. Methods and results: Cocultures of differentiated 3T3-L1 adipocytes and RAW264.7 macrophages were incubated for 24-72 h with/without 100 nM insulin and/or 200 μM vitamin C (VC). Nitric oxide (NO) secretion (24 h) was measured. Also, expression (24 h) and secretion (72 h) of MCP-1, leptin and apelin were analyzed. NO secretion was significantly inhibited by insulin and VC only in cocultures. MCP-1 expression/secretion was enhanced in cocultures. Insulin incubation reduced MCP-1 expression in both cultures and VC only in controls. Both treatments inhibited MCP-1 secretion in cocultures. Apelin gene expression was induced in cocultures. Insulin induced apelin mRNA expression, but VC inhibited its expression in cocultures under insulin treatment. Apelin secretion was notably induced by insulin and inhibited by VC in cocultures. Leptin expression was decreased in coculture, while presented no effects by VC. Conclusion: VC importantly modulates the established pro-inflammatory state in the interaction between adipocytes and macrophages

Fat intake leads to differential response of rat adipocytes to glucose, insulin and ascorbic acid

Antioxidant-based treatments have emerged as novel and interesting approaches to counteract fat accumulation in obesity and associated metabolic disturbances. Adipocytes from rats that were fed on chow or high-fat diet (HFD) for 50 d were isolated (primary adipocytes) and incubated (72 h) on low (LG; 5.6 mmol/L) or high (HG; 25 mmol/L) glucose levels, in the presence or absence of 1.6 nmol/L insulin and 200 μmol/L vitamin C (VC). Adipocytes from HFD-fed animals presented lower insulin-induced glucose uptake, lower lactate and glycerol release, and lower insulin-induced secretion of some adipokines as compared with controls. HG treatment restored the blunted response to insulin regarding apelin secretion in adipocytes from HFD-fed rats. VC treatment inhibited the levels of nearly all variables, irrespective of the adipocytes' dietary origin. The HG treatment reduced adipocyte viability, and VC protected from this toxic effect, although more drastically in control adipocytes. Summing up, in vivo chow or HFD intake determines a differential response to insulin and glucose treatments that appears to be dependent on the insulin-resistance status of the adipocytes, while VC modifies some responses from adipocytes independently of the previous dietary intake of the animals

Obesity induced by a pair-fed high fat sucrose diet: methylation and expression pattern of genes related to energy homeostasis.

BACKGROUND: The expression of some genes controlling energy homeostasis could be regulated by epigenetic mechanisms that may play a role in body weight regulation. Thus, it is known that various nutritional factors affect DNA methylation. In order to assess whether the macronutrient composition of the diet could be related to the epigenetic regulation of gene expression and with obesity development, we investigated the effects on methylation and expression patterns of two pair-fed isocaloric diets in rats: control (rich in starch) and HFS (rich in fat and sucrose). RESULTS: The pair-fed HFS diet induced higher weight gain and adiposity as compared to the controls as well as liver triglyceride accumulation and oxidative stress. Feeding the HFS diet impaired glucose tolerance and serum triglycerides and cholesterol. Liver glucokinase expression, a key glycolytic gene, remained unaltered, as well as the mRNA values of fatty acid synthase and NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 (NDUFB6) in liver and visceral adipocytes, which regulate lipogenesis and mitochondrial oxidative metabolism, respectively. Liver expression of hydroxyacyl-coenzyme A dehydrogenase (HADHB), a key gene of beta-oxidation pathway, was higher in the HFS-fed animals. However, the methylation status of CpG islands in HADHB and glucokinase genes remained unchanged after feeding the HFS diet. CONCLUSIONS: These results confirm that the distribution and type of macronutrients (starch vs. sucrose, and percent of fat) influence obesity onset and the associated metabolic complications. HFS diets produce obesity independently of total energy intake, although apparently no epigenetic (DNA methylation) changes accompanied the modifications observed in gene expression

Glucose and insulin modify thrombospondin 1 expression and secretion in primary adipocytes from diet-induced obese rats.

Thrombospondin 1 (TSP-1), an anti-angiogenic factor and TGF-β activity regulator, has been recently recognized as an adipokine that correlates with obesity, inflammation and insulin-resistance processes. In the present study, epididymal adipocytes of rats that were fed a chow (C) or a high fat diet (HFD) for 50 days, were isolated and incubated (24-72 h) in low (LG; 5.6 mM) or high (HG; 25 mM) glucose, in presence or absence of 1.6 nM insulin. Rats fed the HF diet showed an established obesity state. Serum TSP-1 levels and TSP-1 mRNA basal expression of adipocytes from HFD rats were higher than those from controls. Adipocytes from HFD animals presented an insulin-resistance state, as suggested by the lower insulin-stimulated glucose uptake as compared to controls. TSP-1 expression in culture was higher in adipocytes from obese animals at 24 h, but when the adipocytes were treated with HG, these expression levels dropped dramatically. Later at 72 h, TSP-1 expression was lower in adipocytes from HFD rats, and no effects of the other treatments were observed. Surprisingly, the secretion levels of this protein at 72 h were increased significantly by the HG treatment in both types of adipocytes, although they were even higher in adipocytes from obese animals. Finally, cell viability was significantly reduced by HG treatment in both types of adipocytes. In summary, TSP-1 expression/secretion was modulated in an in vitro model of insulin-resistant adipocytes. The difference between expression and secretion patterns suggests a post-transcriptional regulation. The present study confirms that TPS-1 is closely associated with obesity-related mechanisms

Selectividad y eficacia de algunos herbicidas en vivero de palmáceas

Con el fin de reducir la competencia herbácea en viveros de Phoenix canariensis Chabaud y Washingtonia filifera Linden se han realizado unos tratamientos de preemergencia con los herbicidas simazina, diuron y metabenzotiazuron, en los que también se ha evaluado la tolerancia, en distintas condiciones, de estas palmáceas. Según los resultados obtenidos, ambas especies se muestran intolerantes a todas las dosis ensayadas de diuron. Simazina fué selectiva a 1 y 3 kg/ha para P.canariensis y para W. filifera solo en tratamiento dirigido, aunque buenos resultados contra malas hierbas se obtuvieron con las dosis altas. Metabenzotiazuron fue selectivo a 1 y 3 kg/ha para P.canariensis, mientras VW. filifera sólo toleró 1 kg/ha en tratamiento dirigido; con ambas dosis se obtuvo un buen control de la vegetación espontánea. En tratamiento no dirigido Y. filifera sólo toleró dosis de 0,5 kg/ha de estos herbicidas