Garcia, J.

Miceli, Diego Daniel

Mierowski, A.

Muschner, Adriana Cunha

Peña, M.

Pöppl, Alan Gomes

Schnabel, A.

Tavares, F.

Vecino, C.

Weege, K.

Zapata Montoya, M.

Journal of Veterinary Internal Medicine

English

Lume 5.8

A B S T R A C TRESEARCH COMMUNICATIONSOF THE32ndECVIM-CA CONGRESS1-3 September 2022Swedish Exhibition and Congress CentreGöteborg, SwedenThe European College of Veterinary Internal Medicine – Companion Animals (ECVIM-CA) Congress and the Journal of Veterinary Internal Medicine(JVIM) are not responsible for the content or dosage recommendations in the abstracts. The abstracts are not peer reviewed before publication. The opin-ions expressed in the abstracts are those of the author(s) and may not represent the views or position of the ECVIM-CA. The authors are solely responsi-ble for the content of the abstracts.LIST OF ORAL RESEARCH COMMUNICATIONSESVC – European Society of Veterinary CardiologyThursday 1 September09.00‐09.15 ESVC‐O‐1 Kurogochi Long‐term results of mitral valve repair with artificial chordae and annuloplasty in small‐breed dogs09.15‐09.30 ESVC‐O‐2 Menciotti Differences in mitral valve morphology between Cavalier King Charles Spaniels with mildmitral regurgitation and without mitral regurgitation.09.30‐09.45 ESVC‐O‐3 Silva Analysis of pimobendan prescriptions in small breed dogs with myxomatous mitral valvedisease using Electronic Health Records in Primary Care Veterinary Practices in theUnited Kingdom09.45‐10.00 ESVC‐O‐4 Pires Routine echocardiography in healthy senior cats. How reliable are left ventricular wallmeasurements?10.00‐10.15 ESVC‐O‐5 Colpitts Genes of inflammation and coagulation are activated in hearts from cats withhypertrophic cardiomyopathy10.15‐10.30 ESVC‐O‐6 den Toom Genome wide association study of congenital pulmonic stenosis in French Bulldogs11.20‐11.35 ESVC‐O‐7 Franchini Agreement between different 2‐D transthoracic views and 3‐D transthoracicechocardiography in identifying mitral valve prolapse in dogs11.35‐11.50 ESVC‐O‐8 Dutton Aortic annular plane systolic excursion in cats with hypertrophic cardiomyopathy: 151cases11.50‐12.05 ESVC‐O‐9 Zoia An overview on the inflammatory and systemic fibrinolysis status in cats with heartdisease stratified by the presence and type of congestive heart failure12.05‐12.20 ESVC‐O‐10 Van Renterghem The impact of chronic right ventricular pressure overload on right and left heartmorphology and function(Continues)Received: 20 September 2022 Accepted: 20 September 2022DOI: 10.1111/jvim.16559This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium,provided the original work is properly cited.© 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC. on behalf of the American College of Veterinary Internal Medicine.J Vet Intern Med. 2022;36:2455–2551. wileyonlinelibrary.com/journal/jvim 2455protein that is required for SSTR2 and DRD2 expression and signaling,was expressed in all CAs, indicating that these signaling pathways arepotentially activated. Interestingly, DRD2 and SSTR2 expression levelswere strongly correlated, highlighting the possibility of combined tar-geting of these receptor subtypes.DisclosuresDisclosures to report, please report belowFederico Fracassi: Financial support: Dechra, MSD Speaking & consul-tancies: Boehringer Ingelheim, Dechra, MSD, Royal Canin, Hill’s, Nes-tlé Purina, La Vallonea. Stefania Golinelli: Financial support: PhDscholarship funded by Dechra Speaking & consultancies: DechraESVE-P-10 | ESVE - European Society of VeterinaryEndocrinologyLaparoscopic versus open adrenalectomy in 70 dogs with functionalor hormonally silent adrenal tumorsK.L. Bokhorst, S. Galac, H.S. Kooistra, B. NimwegenUtrecht University Utrecht NetherlandsAdrenalectomy is the treatment of choice in hormone-secreting adre-nal tumors to reverse clinical signs associated with hormone excessand to avoid complications of uncontrolled tumor growth. Surgery isalso indicated in hormonally silent adrenal tumors when malignancy issuspected. In recent years, laparoscopic adrenalectomy gained popu-larity, however, clinical studies on larger groups of dogs including theirendocrine diagnoses and outcome are still scarce. In this retrospectivestudy the hormone analyses, perioperative- and recurrence data of70 dogs that underwent adrenalectomy by laparoscopy or laparotomybetween 2008 and 2022 are described.Diagnosis was based on history, clinical signs, endocrine testingincluding measurement of plasma endogenous ACTH, (nor)metane-phrines and aldosterone concentrations, and advanced diagnosticimaging. Endocrine diagnoses were naturally occurring hypercortiso-lism (n=52), pheochromocytoma (n=8) and hormonally silent ‘inciden-talomas’ (n=10). Median age at adrenalectomy was 10 years (range5.8-13 years). Most dogs (n=55) were neutered (25 male, 30 female),15 were intact (12 male, 3 female).Laparoscopic adrenalectomy was performed in 45 dogs (medianweight 13.9 kg, range 5.1-50.3) of which 3 cases were converted tolaparotomy. In the remaining 25 dogs (median weight 18.0 kg, range6.0-43.6) a laparotomy approach was used. Bilateral adrenalectomywas performed in 8/70 dogs (6 laparoscopic, 2 laparotomy). Based onpreoperative imaging, median maximal adrenal tumor dimension was2.4 (range 1.0-5.2) and 3.2 cm (range 1.6-9.9) in the laparoscopy andlaparotomy group, respectively (p=0.029). Surgical time of laparo-scopic and open adrenalectomy did not differ significantly (p=0.147and p=0.102 for unilateral and bilateral cases, respectively). Histopa-thology of hormonally silent adrenal tumors revealed a cortical ade-noma in 7/10, carcinoma in 2/10 and unspecified adrenocorticaltumor in 1/10 dogs. Forty-three out of 45 dogs in the laparoscopygroup and 24/25 dogs in the laparotomy group survived to discharge.Median duration of hospitalization was shorter after laparoscopic(1 day, range 1-11) versus laparotomic unilateral adrenalectomy(2 days, range 1-4; p=0.012). Relapse, defined by recurrence of clini-cal signs of hypercortisolism or catecholamine-excess and/orregrowth of adrenal tumor or metastasis, was not different in the lap-aroscopy (7/43) versus laparotomy group (4/24; p=1.00).This study shows a favorable outcome of laparoscopic adrenalectomyin dogs with various endocrinopathies due to adrenal tumors. Basedon shorter hospitalization time and comparable long-term outcome indogs treated with laparoscopic adrenalectomy, this is considered thepreferred technique whenever clinically possible.DisclosuresNo disclosures to reportESVE-P-11 | ESVE - European Society of VeterinaryEndocrinologyTrilostane treatment for feline hypercortisolism: Latin Americamulticenter study, 43 cases (2012-2022)D. Miceli, F Tavares, M Zapata Montoya, J García, M Peña, K Weege,A Muschner, C Vecino, A Mierowski, A Schnabel, A PöpplCaba ArgentinaSpontaneous hypercortisolism (HC), or Cushing's syndrome, is a rarecondition in cats (Felis catus). Feline HC is characterized by presenceof diabetes mellitus (DM), with variable degrees of insulin resistance.Trilostane is a competitive 3-β hydroxysteroid dehydrogenase inhibi-tor with high safety and efficacy in canine HC. Large case series offeline HC and studies assessing the use of trilostane in cats are lack-ing. The aim of this study was to evaluate clinical features, clinicopath-ologic findings, diagnostic imaging, safety and efficacy of trilostanetreatment in cats with HC. In this multicenter descriptive retrospec-tive study, fourty-three (n=43) client-owned cats were diagnosedwith spontaneous HC. All cats received an initial lower dose of trilos-tane (0.3-2.9 mg/kg q12h, PO) than previously reported. Values wereexpressed as mean±SD or, median and range (p<0.05). Twenty-sixcats were male (60%) and 17 were female (40%); mean age was 10.4±2.8 years; mean body weight was 5.3±1.5 kg. Thirty-six cats weredomestic shorthairs, four Persian, two domestic longhairs and oneRussian blue. Thirty-five of 43 (81%) cats had pituitary-dependentHC, whereas eight of 43 (19%) cats had adrenal-dependent HC (1/8bilateral adrenal tumor). The mean initial and final dose of trilostanewere 1.3±0.6 and 1.9±1.4 mg/kg q12h (p<0.01). Nineteen of 43 cases(44%) required an increase in the trilostane dose, 20 of 43 (47%) main-tained the dose and four of 43 (9%) reduced the dose. Most cats(53%) had an improvement in the clinical signs after trilostane treat-ment. Thirty-four of 43 (79%) cats had concurrent DM. The mean ini-tial and final dose of insulin were 0.5±0.4 and 0.6±0.6 IU/kg q12h(p<0.4). Sixteen of 34 cases (47%) improved the diabetic control, ninecases (26%) required a reduction in insulin dose and five cases (15%)2548 ABSTRACTS 19391676, 2022, 6, Downloaded from https://onlinelibrary.wiley.com/doi/10.1111/jvim.16559 by CAPES, Wiley Online Library on [30/04/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons Licenseachieved diabetic remission after trilostane treatment. Adverse effectswere observed in 19% of cases, and included: reduced appetite(3/43), diarrhea (2/43), vomiting (2/43), neurological signs (1/43), andincreased libido (1/43). Six of 34 cats (18%) had plantigrade stance.The most common complications were: chronic kidney disease(13/43) and pancreatitis (5/43). The median survival time was657 days (60-2555). This is the largest study to date to describe casesof feline HC. This study shows that low-doses of trilostane couldimprove clinical signs of HC and DM control in 53% and 47% cases,respectively. In addition, trilostane treatment allows remission of DMin 15% of diabetic cats with HC.DisclosuresNo disclosures to reportESVCN-P-1 | ESVCN - European society of Veterinary &Comparative NutritionThe perception of Portuguese pet owners about veterinaryapproach to nutrition and weight management in companion animalsM. Pires Gonçalves 1, R. Leal 1, M. Hervera 21 CIISA - Centre for Interdisciplinary Research in Animal Health LISBOAPortugal; 2 Expert Pet Nutrition Zurich SwitzerlandObesity numbers in humans and pets keep rising. While it is easy toconsider the owner as the main influencer for obesity in dogs andcats, it is also important to evaluate the performance of veterinaryteams and the owners' perception of this. This study aims to assessthe impression of Portuguese pet owners about how the veterinarycommunity approaches nutrition and weight management in pets.An observational cross sectional survey developed for pet owners wasimplemented on waiting rooms of Portuguese veterinary practices. Thestudy comprised 21 questions covering good practices in nutrition byveterinarians, advice from clinicians on diet and exercise, and whetherclients were aware of the existence of weight management programmesand if they would consider this service if their pet was overweight.A total of 432 answers were obtained from 292 (68%) veterinary hospi-tals and 140 (32%) clinics. Based on the recommendations of WSAVAand AAHA Nutritional and Weight Management Guidelines, it wasobserved that 93% of the animals were always or frequently weighedin consultation. However, the body condition score was only 49% rou-tinely evaluated and a nutritional assessment was regularly performedin just 27% of the cases. Nevertheless, 97% of the pet owners sur-veyed, wanted their veterinarian to make a food recommendation and92% a physical exercise plan. The majority (93%) of pet owners agreedthat veterinarians have warned them about the risk of obesity in pets,mainly in paediatric visits or at the time of spay/neuter surgery. How-ever, 65% of the respondents were unaware of the existence of weightmanagement programmes for pets, and only 9% of the remaining men-tioned that this service existed in the practice they visit. Lastly, a totalof 82% of pet owners admit that if their animal was overweight theywould resort to the help of this health service.This study supports that pet owners are being informed by their vet-erinarians about obesity in pets. However, procedures like body con-dition score and nutritional assessment, which are needed to manageoverweight animals, are not being performed often enough. Mostowners reinforce the need of food and physical exercise recommen-dations by clinicians. Although veterinarians acknowledge that abouthalf of the animals they observe are overweight, the majority of therespondents were not aware of the existence of weight managementprogrammes, which raises the question if obesity is being properlymanaged.DisclosuresDisclosures to report, please report belowThis work was supported by FCT - Fundação para a Ciência e Tecno-logia IP, grant UIDB/00276/2020.ESVCN-P-2 | ESVCN - European society of Veterinary &Comparative NutritionDifferent starch to protein ratios in kibble diets fed ad libitum onbody weight control, body composition, water turnover and physicalactivity in neutered cats living in homesC. Goloni, L. Pacheco, L. Warde Luis, S. Souza Theodoro, L. BassiScarpim, C. Torres, A. Cavalieri CarciofiSão Paulo State University - UNESP Jaboticabal BrazilThe intake of diets with different starch to protein ratios was com-pared in neutered cats housed in homes. Male (M) and female (F),obese (OB) and non-obese (NO) client owned cats were fed ad libitumfor four months kibble diets high in starch (HS: Starch 40%, protein38%; on dry matter basis) or high in protein (HP: Starch 20%, protein52%), in a cross-over design. Physical activity was evaluated with anaccelerometer fixed to chest collar previously adapted to cats, andbody composition (BC), energy expenditure (EE) and water turnover(WT) were evaluated by the doubly labeled water method. Resultswere compared in a 2 diets x 2 sex x 2 body conditions factorialarrangement, totally 8 treatments, and submitted to variance analysis,Tukey test and Pearson correlation (P≤0.05 as significant; P≤0.10 astrend). A total of 30 cats, belonged to 23 owners finished the project:F-NO with 2.9±2.1 years (n=9); F-OB with 4.2±1.6 years (n=7); M-NO with 2.0±1.1 years (n=9); M-OB with 4.5±2.6 years (n=5). Themean age of the groups differed (P<0.05), and then age was used inthe statistical analysis as a co-variate. Cats fed HS diet maintained aconstant body weight (BW) along the 4 months of diet intake(P>0.05). However, the lean mass (LM) tended to reduce in F-OB(P=0.07), which presented a numerically lower EE (324±7 kJ/kg0.67/day) than the other groups. This may limited food and protein intake(6.84±0.38 g of CP/kg0.67/day), explaining the tendency of LM reduc-tion. The intake of HP diet induced an increase on cats BW and LM(P<0.05), but fat mass also increased 17% on F-NO (P=0.04) andtended to increase 7% in F-OB (P=0.06). The EE tended to be higherin M (351±8 kJ/kg0.67/day) than F (330±8; P=0.06), was not affectedABSTRACTS 2549 19391676, 2022, 6, Downloaded from https://onlinelibrary.wiley.com/doi/10.1111/jvim.16559 by CAPES, Wiley Online Library on [30/04/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

Trilostane treatment for feline hypercortisolism : Latin America multicenter study, 43 cases (2012-2022)

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Trilostane treatment for feline hypercortisolism : Latin America multicenter study, 43 cases (2012-2022)

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