Secukinumab shows high efficacy irrespective of HLA-Cw6 status in patients with moderate-to-severe plaque-type psoriasis: SUPREME study

Background: Understanding genetic variations is important in predicting treatment response and forms the basis for identifying new pharmacogenetic and pharmacogenomic targets for psoriasis treatment. There are limited data on the efficacy of secukinumab in relation to genetic markers. Objectives: To evaluate the efficacy and safety of secukinumab 300 mg in HLA-Cw6-positive (Cw6-POS) and HLA-Cw6-negative (Cw6-NEG) patients with moderate-to-severe chronic plaque-type psoriasis. Methods: SUPREME was a 24-week, phase IIIb study with an extension period up to 72 weeks. Primary end point was Psoriasis Area Severity Index (PASI) 90 response rate after 16 weeks. Results: In total, 434 patients were recruited: 185 (42\ub76%) were Cw6-POS and 246 (56\ub77%) were Cw6-NEG (three not assessed). Mean \ub1 SD age was 45\ub72 \ub1 13\ub72 years (Cw6-POS 42\ub77 \ub1 13\ub71; Cw6-NEG 47\ub72 \ub1 12\ub79). The baseline PASI score was comparable between the cohorts [Cw6-POS 20\ub77 \ub1 8\ub799; Cw6-NEG 21\ub75 \ub1 9\ub799 (P = 0\ub7777)]. At week 16, PASI 90 was achieved in 80\ub74% of Cw6-POS and 79\ub77% of Cw6-NEG patients (difference 0\ub776; 95% confidence interval 127\ub704 to 8\ub723). No differences in absolute PASI at week 16 (Cw6-POS 1\ub736 \ub1 3\ub758; Cw6-NEG 1\ub718 \ub1 2\ub729) were observed. The overall safety profile of secukinumab was consistent with that previously reported. No statistically significant difference was detected in the rate of treatment-emergent adverse events [Cw6-POS 42\ub77%; Cw6-NEG 49\ub76% (P = 0\ub7295)]. A high PASI 90 response was achieved with secukinumab with a fast reduction in absolute PASI. Conclusions: Determination of HLA-Cw6 status for secukinumab therapy is unnecessary, as it is highly effective regardless of HLA-Cw6 status

Methodological study to evaluate the psychometric properties of FACIT-CD in a sample of Brazilian women with cervical intraepithelial neoplasia

Background: The occurrence of cervical intraepithelial neoplasia (CIN) is associated with changes in health-related quality of life, including psychological factors, such as fear and shame, and changes in sexuality and sexual satisfaction, such as decreased sexual desire and frequency of sexual intercourse. Personal relationships are the most affected because CIN is sexually transmitted and many women tend to blame their partner for disease transmission. The aim of this study was to evaluate the psychometric properties of the FACIT-CD questionnaire in Brazilian women diagnosed with CIN. Methods: The properties of the FACIT-CD questionnaire were tested on a sample of 439 women seen at the Department of Prevention of Barretos Cancer Hospital, including 329 patients who were diagnosed with CIN and 110 women who were not diagnosed with the disease. The analysed parameters included internal consistency (Cronbach's alpha), reproducibility (intraclass correlation coefficient), structural validity, convergent validity (correlation with the SF-12 and EORTC QLQ-CX24 questionnaires), discriminant validity (according to disease status, and self-rating of health), sensitivity, and responsiveness. Results: The Cronbach alpha values of the FACIT-CD scales were higher than 0.70 with the exception of the relationship scale (0.66). The FACIT-CD reproducibility was satisfactory, with variation in the intraclass correlation coefficients ranging between 0.50 and 0.83, although the 95% confidence interval (CI) was lower than 0.40 (0.33-0.64) on the treatment satisfaction scale. Regarding structural validity, only one item on the physical well-being scale was not kept in the original domain. The expected correlations between the FACIT-CD and SF-12 were not confirmed, whereas the correlations between the FACIT-CD and EORTC QLQ-CX24 were confirmed. The questionnaire was able to discriminate the groups according to disease status and self-rating of health. The sensitivity was low for the relationship scale and moderate for the other scales. The responsiveness of the FACIT-CD questionnaire varied between the groups that denominate the self-perception of health as no change, improvement or worsening. Conclusion: Our results are encouraging and indicate that the FACIT-CD questionnaire is a promising tool for the analysis of the quality of life of women with CIN.The postdoctoral fellowship was supported by Sao Paulo Research Foundation (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP, Sao Paulo, Brazil). Process number: FAPESP 2014/10158-3. The funding body had no role in the design of the study and collection, analysis and interpretation of data and in writing the manuscript.info:eu-repo/semantics/publishedVersio

CAD-oriented modeling of the optically-controlled GaAs MESFET

A CAD-oriented circuit model for the optically-controlled GaAs MESFET was developed on the basis of a dedicated characterization method. By exploiting separation of direct and indirect photo-induced effects, a simple but accurate modeling of both the static and microwave characteristics of the illuminated transistor was achieved. As demonstrated by the test circuits implemented, good agreement between measured and simulated performances can thus be obtained with limited device parameter identification effort

Trasporto di merci pericolose in un'area strategica

\uc8 stato svolto uno studio per individuare e definire il ruolo e i percorsi formativi di esperti in materia di merci pericolose e di sicurezza nel campo del trasporto merci. Lo studio riguarda l\u2019area situata a sud della provincia di Varese e che comprende l\u2019aeroporto di Malpens

An innovative strategic route to the green synthesis of CsPbBr3 films on rigid and flexible substrates

Recently, the all-inorganic halide perovskites have attracted great attention due to their unique optical prop-erties, which make them appealing, if available in form of films, for application in different devices, such as photodetectors, catalysis, or energy conversion systems like solar cells.We report a facile, one-step approach using the beta-diketonate metal -organic precursors, [Pb(hfa)2diglyme]2 and Cs(hfa) to obtain CsPbBr3 halide perovskite microcrystals. The CsPbBr3 suspension in ethanol has been deposited on a wide range of rigid and flexible substrates by spray-coating. The entire process has been carried out at room temperature and at atmospheric pressure in air. The X-ray diffraction (XRD) and Energy Dispersive X-ray analysis (EDX) confirmed the formation of pure stoichiometric CsPbBr3 phase films, while the field-emission scanning electron microscopy (FE-SEM) indicates the growth of a compact and homogeneous layer independently on the substrate nature. The optical energy band-gap (Eg) of CsPbBr3 films on quartz, estimated through the Tauc equation, is equal to 2.31 eV. Steady state Photoluminescence (PL), Time Resolved Photo-luminescence (TRPL), and Photoluminescence Quantum Yield (PLQY) investigations have been carried out confirming the quality of the films in agreement with literature. This synthetic approach allows the fabrication of perovskite CsPbBr3 films on a variety of substrates, as well as providing a proof-of-concept method to extend this simple, practical, and versatile route for the production of mixed halide perovskite phases