How Do Women Decide to Work in Pakistan?

The incidence of women labour force participation is very low in Pakistan. According to the Labour Force Survey, 1999-2000 female participation rate was merely 14 percent of the total labour force. Even though average annual growth rate of female labour force participation has been increasing slightly in Pakistan; it was 4 percent in 1980-99 and has gone up to 5.1 percent during 1995-98,1 however, this rate is still very low as compared to the other South Asian countries—42 percent in Bangladesh, 41 percent in Nepal, 32 percent in India and Bhutan, 37 percent in Sri Lanka [World Bank (2002)]. This paper is an attempt to identify household related factors that lead to women participation in the economic activities. This issue has been taken up in a number of other studies.2 The innovative aspect of this paper is that it relates women’s decision to participate in economic activities with their empowerment—who makes the decision to participate in the labour force—whether it is the women themselves or others. We would like to state at the very onset that this paper is a first cut to explore the issues of women’s participation in economic activities and their and empowerment. We hope to get feedback in the conference to improve the technical aspects of this paper and explore other aspects of this issue. Some key empirical findings of this paper are that the women economic participation is significantly influenced by factors such as their age, education and marital status. The employment status of the head of the household (generally a male), presence of male member, and children of ages 0–5 are also important variables that significantly affect women’s participation in economic activities. We identified marital status, education level, family size, household’s financial status and area of residence as the main causal factors behind women making their own decisions about paid employment.

How Do Women Decide to Work in Pakistan?

The incidence of women labour force participation is very low in Pakistan. According to the Labour Force Survey, 1999-2000 female participation rate was merely 14 percent of the total labour force. Even though average annual growth rate of female labour force participation has been increasing slightly in Pakistan; it was 4 percent in 1980-99 and has gone up to 5.1 percent during 1995-98,1 however, this rate is still very low as compared to the other South Asian countries—42 percent in Bangladesh, 41 percent in Nepal, 32 percent in India and Bhutan, 37 percent in Sri Lanka [World Bank (2002)]. This paper is an attempt to identify household related factors that lead to women participation in the economic activities. This issue has been taken up in a number of other studies.2 The innovative aspect of this paper is that it relates women’s decision to participate in economic activities with their empowerment—who makes the decision to participate in the labour force—whether it is the women themselves or others. We would like to state at the very onset that this paper is a first cut to explore the issues of women’s participation in economic activities and their and empowerment. We hope to get feedback in the conference to improve the technical aspects of this paper and explore other aspects of this issue

Abnormality Detection in Musculoskeletal Radiographs Using Capsule Network

To treat the diseases or injuries of the joints, bones, muscles, and spine in both adult and pediatric imaging the musculoskeletal radiographs bring a significant depth of expertise. Abnormality detection in the musculoskeletal study is backbreaking as more than 1.7 billion people are affected by musculoskeletal condition (BMU, 2017). Hence if we want to create enough opportunity to treat a maximum amount of patients, machine learning and deep learning can play a crucial role. CNN is an excellent deep learning method for image classification and other computer vision tasks. But CNN has exhibited some serious limitations when the images are rotated and deformed. Hence capsule network architecture is introduced in this paper for musculoskeletal radiographs abnormality detection and this capsnet architecture has shown very promising features that can help to vanquish the limitations of CNN. In addition, this capsule network has scored 10% higher kappa score than 169 layer densenet using less training data in the case of musculoskeletal radiographs abnormality detection. This feature of capsule network can help to use deep learning in such cases where an aggregate of a large amount of data is not possible. For image quality investigation, blind image spatial quality evaluator (BRISQUE) and naturalness image quality evaluator (NIQE) scores are measured and it is found that when the pixel size of the resized images are more close to the pixel size of the original images, we get a better approximation. Hence in the case of musculoskeletal radiographs abnormality detection, our method outperforms state-of-the-art method using a less amount of training data

Integrative Discovery of Epigenetically Derepressed Cancer Testis Antigens in NSCLC

Background: Cancer/testis antigens (CTAs) were first discovered as immunogenic targets normally expressed in germline cells, but differentially expressed in a variety of human cancers. In this study, we used an integrative epigenetic screening approach to identify coordinately expressed genes in human non-small cell lung cancer (NSCLC) whose transcription is driven by promoter demethylation. Methodology/Principal Findings: Our screening approach found 290 significant genes from the over 47,000 transcripts incorporated in the Affymetrix Human Genome U133 Plus 2.0 expression array. Of the top 55 candidates, 10 showed both differential overexpression and promoter region hypomethylation in NSCLC. Surprisingly, 6 of the 10 genes discovered by this approach were CTAs. Using a separate cohort of primary tumor and normal tissue, we validated NSCLC promoter hypomethylation and increased expression by quantitative RT-PCR for all 10 genes. We noted significant, coordinated coexpression of multiple target genes, as well as coordinated promoter demethylation, in a large set of individual tumors that was associated with the SCC subtype of NSCLC. In addition, we identified 2 novel target genes that exhibited growth- promoting effects in multiple cell lines. Conclusions/Significance: Coordinated promoter demethylation in NSCLC is associated with aberrant expression of CTAs and potential, novel candidate protooncogenes that can be identified using integrative discovery techniques. These findings have significant implications for discovery of novel CTAs and CT antigen directed immunotherapy. © 2009 Glazer et al

Contribution of patient, physician, and environmental factors to demographic and health variation in colonoscopy follow-up for abnormal colorectal cancer screening test results

BACKGROUND: Patient, physician, and environmental factors were identified, and the authors examined the contribution of these factors to demographic and health variation in colonoscopy follow-up after a positive fecal occult blood test/fecal immunochemical test (FOBT/FIT) screening. METHODS: In total, 76,243 FOBT/FIT-positive patients were identified from 120 Veterans Health Administration (VHA) facilities between August 16, 2009 and March 20, 2011 and were followed for 6 months. Patient demographic (race/ethnicity, sex, age, marital status) and health characteristics (comorbidities), physician characteristics (training level, whether primary care provider) and behaviors (inappropriate FOBT/FIT screening), and environmental factors (geographic access, facility type) were identified from VHA administrative records. Patient behaviors (refusal, private sector colonoscopy use) were estimated with statistical text mining conducted on clinic notes, and follow-up predictors and adjusted rates were estimated using hierarchical logistic regression. RESULTS: Roughly 50% of individuals completed a colonoscopy at a VHA facility within 6 months. Age and comorbidity score were negatively associated with follow-up. Blacks were more likely to receive follow-up than whites. Environmental factors attenuated but did not fully account for these differences. Patient behaviors (refusal, private sector colonoscopy use) and physician behaviors (inappropriate screening) fully accounted for the small reverse race disparity and attenuated variation by age and comorbidity score. Patient behaviors (refusal and private sector colonoscopy use) contributed more to variation in follow-up rates than physician behaviors (inappropriate screening). CONCLUSIONS: In the VHA, blacks are more likely to receive colonoscopy follow-up for positive FOBT/FIT results than whites, and follow-up rates markedly decline with advancing age and comorbidity burden. Patient and physician behaviors explain race variation in follow-up rates and contribute to variation by age and comorbidity burden. Cancer 2017;123:3502-12. Published 2017. This article is a US Government work and is in the public domain in the USA

Engagement with Care, Substance Use, and Adherence to Therapy in HIV/AIDS

Engagement with care for those living with HIV is aimed at establishing a strong relationship between patients and their health care provider and is often associated with greater adherence to therapy and treatment (Flickinger, Saha, Moore, and Beach, 2013). Substance use behaviors are linked with lower rates of engagement with care and medication adherence (Horvath, Carrico, Simoni, Boyer, Amico, and Petroli, 2013). This study is a secondary data analysis using a cross-sectional design from a larger randomized controlled trial (n = 775) that investigated the efficacy of a self-care symptom management manual for participants living with HIV. Participants were recruited from countries of Africa and the US. This study provides evidence that substance use is linked with lower self-reported engagement with care and adherence to therapy. Data on substance use and engagement are presented. Clinical implications of the study address the importance of utilizing health care system and policy factors to improve engagement with care

Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network.

OBJECTIVE: This report presents data from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network on care of and morbidity and mortality rates for very low birth weight infants, according to gestational age (GA). METHODS: Perinatal/neonatal data were collected for 9575 infants of extremely low GA (22-28 weeks) and very low birth weight (401-1500 g) who were born at network centers between January 1, 2003, and December 31, 2007. RESULTS: Rates of survival to discharge increased with increasing GA (6% at 22 weeks and 92% at 28 weeks); 1060 infants died at CONCLUSION: Although the majority of infants with GAs of \u3eor=24 weeks survive, high rates of morbidity among survivors continue to be observed

Clinical profile and treatment of infantile spasms using vigabatrin and ACTH - a developing country perspective

Background: Infantile spasms represent a serious epileptic syndrome that occurs in the early infantile age. ACTH and Vigabatrin are actively investigated drugs in its treatment. This study describes the comparison of their efficacy in a large series of Patients with infantile spasms from Pakistan. Methods: All Patients with infantile spasms who presented to Aga Khan University Hospital, Karachi, Pakistan from January, 2006 to April, 2008 were included in this study. Inclusion criteria were clinical symptoms of infantile spasms, hypsarrythmia or modified hyparrythmia on electroencephalography, at least six months of follow-up period and receipt of any of the two drugs mentioned above. The type of drug distribution was random according to the availability, cost and ease of administration. Results: Fifty six cases fulfilled the inclusion criteria. 62.5% were males. Mean age at onset of seizures was 5 +/- 1.4 months. Fifty two (92.8%) Patients demonstrated hypsarrythmia on electroencephalography. 64.3% cases were identified as symptomatic while 19.6% were cryptogenic and 16.1% were idiopathic. Eighteen Patients received ACTH while 38 Patients received Vigabatrin as first line therapy. Initial response to first line therapy was similar (50% for ACTH and 55.3% for Vigabatrin). Overall, the symptomatic and idiopathic groups responded better to Vigabatrin. The relapse rate was higher for ACTH as compared to Vigabatrin (55.5% vs. 33.3%) when considering the first line therapy. Four Patients evolved to Lennox-Gastaut variant, all of these Patients had initially received Vigabatrin and then ACTH. Conclusion: Vigabatrin and ACTH showed no significant difference in the initial treatment of infantile spasms. However, Patients receiving ACTH were 1.2 times more likely to relapse as compared to the Patients receiving Vigabatrin when considering monotherapy. We suggest that Vigabatrin should be the initial drug of choice in Patients presenting with infantile spasms. However, larger studies from developing countries are required to validate the therapeutic trends observed in this study