Brentano’s lectures on positivism (1893-1894) and his relationship to Ernst Mach

This paper is mainly about Brentano’s commentaries on Ernst Mach in his lectures “Contemporary philosophical questions” which he held one year before he left Austria. I will first identify the main sources of Brentano’s interests in Comte’s and J. S. Mill’s positivism during his Würzburg period. The second section provides a short overview of Brentano’s 1893-1894 lectures and his criticism of Comte, Kirchhoff, and Mill. The next sections bear on Brentano’s criticism of Mach’s monism and Brentano’s argument against the reduction of the mental based on his theory of intentionality. The last section is about Brentano’s proposal to replace the identity relation in Mach’s theory of elements by that of intentional correlation. I conclude with a remark on the history of philosophy in Austria

Computation of forces in strongly nonlinear magnetic fields using higher-order eggshell algorithm

A novel version of the eggshell-based procedure for numerical computation of magnetic forces and torques acting on ferromagnetic bodies in highly nonlinear magnetic fields is presented. The procedure works with a fully adaptive higher-order finite element method developed for years in our research group, that is implemented in own code Agros2D and library Hermes. The power of the methodology and both codes is demonstrated on the solution of two typical examples: computation of the static characteristic of a magnetic actuator and torque characteristic of a flux-switched permanent-magnet machine. The results obtained are compared with data calculated by several other available codes

Common inflammatory mediators orchestrate pathophysiological processes in rheumatoid arthritis and atherosclerosis

RA is characterized by a systemic inflammatory state, in which immune cells and soluble mediators play a crucial role. These inflammatory processes resemble those in other chronic inflammatory diseases, such as atherosclerosis. The chronic systemic inflammation in RA can be considered as an independent risk factor for the development of atherosclerosis, and represents an important field to investigate the reasons of the increase of acute cardiovascular events in RA. In the present review, we focused on several mediators of autoimmunity, inflammation and endothelial dysfunction, which can be considered the most promising targets to prevent atherogenesis in RA. Among several mediators, the pro-inflammatory cytokine TNF-α has been shown as a crucial factor to induce atherosclerosis in RA patient

Leukocyte recruitment in atherosclerosis: Potential targets for therapeutic approaches?

Abstract.: Atherosclerosis is a complex inflammatory disease involving cellular migration and interaction. Vascular injury in response to different cardiovascular risk factors enhances endothelial dysfunction, which in turn promotes the expression of inflammatory markers and transendothelial leukocyte migration. Recruitment of leukocytes from the blood stream into the vessel intima is a crucial step for the development of the disease. Recent findings have highlighted the role of chemokines, chemokine receptors, adhesion molecules, and gap junctions in this process by acting as chemoattractant, adhesive, or intercellular communication molecules. In this short review, we summarize new data concerning the different steps from leukocyte arrest to transendothelial migration and discuss potential new therapeutic approaches concerning these processe

On the stability of self-gravitating accreting flows

Analytic methods show stability of the stationary accretion of test fluids but they are inconclusive in the case of self-gravitating stationary flows. We investigate numerically stability of those stationary flows onto compact objects that are transonic and rich in gas. In all studied examples solutions appear stable. Numerical investigation suggests also that the analogy between sonic and event horizons holds for small perturbations of compact support but fails in the case of finite perturbations.Comment: 10 pages, accepted for publication in PR

Amplitude control of quantum interference

Usually, the oscillations of interference effects are controlled by relative phases. We show that varying the amplitudes of quantum waves, for instance by changing the reflectivity of beam splitters, can also lead to quantum oscillations and even to Bell violations of local realism. We first study theoretically a generalization of the Hong-Ou-Mandel experiment to arbitrary source numbers and beam splitter transmittivity. We then consider a Bell type experiment with two independent sources, and find strong violations of local realism for arbitrarily large source number $N$; for small $N$, one operator measures essentially the relative phase of the sources and the other their intensities. Since, experimentally, one can measure the parity of the number of atoms in an optical lattice more easily than the number itself, we assume that the detectors measure parity.Comment: 4 pages; 4 figure

A 0.80pJ/flop, 1.24Tflop/sW 8-to-64 bit Transprecision Floating-Point Unit for a 64 bit RISC-V Processor in 22nm FD-SOI

The crisis of Moore's law and new dominant Machine Learning workloads require a paradigm shift towards finely tunable-precision (a.k.a. transprecision) computing. More specifically, we need floating-point circuits that are capable to operate on many formats with high flexibility. We present the first silicon implementation of a 64-bit transprecision floating-point unit. It fully supports the standard double, single, and half precision, alongside custom bfloat and 8 bit formats. Operations occur on scalars or 2, 4, or 8-way SIMD vectors. We have integrated the 247 kGE unit into a 64 bit application-class RISC-V processor core, where the added transprecision support accounts for an energy and area overhead of merely 11 and 9, respectively; yet achieving speedups and per-datum energy gains of 7.3x and 7.94x. We implemented the design in a 22 nm FD-SOI technology. The unit achieves energy efficiencies between 75 Gflop/sW and 1.24 Tflop/sW, and a performance between 1.85 Gflop/s and 14.83 Gflop/s, across formats

Learning to Lead in the Liberal Arts

The liberal arts include the arts and sciences - fields that introduce students to general knowledge and develop the basic intellectual skills that are needed to succeed in our society

A New interpretation of MOND based on Mach principle and an Unruh like effect

A new interpretation is introduced for MOND based on the Sciama's interpretation of Mach principle and an Unruh like effect, in the context of a generalized equivalence principle. It is argued that in a locally accelerated frame with acceleration $a$ the appearance of a Rindler horizon may give rise to a constant acceleration $a_0$ as the local properties of cosmological horizon or Hubble length. The total gravitational acceleration inside this frame becomes the combination of $a$ with $a_0$. For $a\gg a_0$, the conventional gravitational mass $m_g$ interacts with the dominant acceleration as $m_g a$ and application of Sciama's interpretation leads to the standard Newtonian dynamics. For $a\ll a_0$, however, a reduced gravitational mass $\bar{m}_g$ interacts with the dominant acceleration as $\bar{m}_g a_0$ and the application of Sciama's interpretation on this reduced gravitational mass leads to MOND. This introduces a third proposal for MOND: {\it The modification of gravitational mass}.Comment: 11 pages, throughout revisio

Internationalisation des élites académiques suisses au 20ème siècle : convergences et contrastes

A partir d'une base de données originale sur les professeurs de droit et de sciences économiques des universités suisses sur l'ensemble du XXe siècle, cet article rend compte des diverses dynamiques d'internationalisation de ces élites. Trois enseignements majeurs peuvent être tirés de nos analyses. D'abord, d'un point de vue diachronique, il est possible de diviser le XXe siècle en trois phases historiques : une internationalité forte des élites académiques au début du siècle, une nationalisation ou « relocalisation » suite à la Première Guerre mondiale, puis une « ré-internationalisation » à partir des années 1960 et de manière accélérée depuis les années 1980. Ensuite, les professeurs de sciences économiques, en terme de nationalités ou de lieu de formation, sont plus cosmopolites et ont moins d'ancrage local que leurs homologues juristes. Enfin, la prédominance germanique parmi les professeurs des universités suisses au début du siècle, qui s'explique autant par une internationalité d'« excellence » que de « proximité », laisse place, surtout en sciences économiques, à une montée de l'influence des Etats-Unis, révélatrice d'un effritement de l'internationalité de « proximité »