Chronic obstructive pulmonary disease (COPD) as a disease of early aging: evidence from the epiChron cohort

Background: Aging is an important risk factor for most chronic diseases. Patients with COPD develop more comorbidities than non-COPD subjects. We hypothesized that the development of comorbidities characteristically affecting the elderly occur at an earlier age in subjects with the diagnosis of COPD. Methods and findings: We included all subjects carrying the diagnosis of COPD (n = 27,617), and a similar number of age and sex matched individuals without the diagnosis, extracted from the 727,241 records of individuals 40 years and older included in the EpiChron Cohort (Aragon, Spain). We compared the cumulative number of comorbidities, their prevalence and the mortality risk between both groups. Using network analysis, we explored the connectivity between comorbidities and the most influential comorbidities in both groups. We divided the groups into 5 incremental age categories and compared their comorbidity networks. We then selected those comorbidities known to affect primarily the elderly and compared their prevalence across the 5 age groups. In addition, we replicated the analysis in the smokers' subgroup to correct for the confounding effect of cigarette smoking. Subjects with COPD had more comorbidities and died at a younger age compared to controls. Comparison of both cohorts across 5 incremental age groups showed that the number of comorbidities, the prevalence of diseases characteristic of aging and network's density for the COPD group aged 56-65 were similar to those of non-COPD 15 to 20 years older. The findings persisted after adjusting for smoking. Conclusion: Multimorbidity increases with age but in patients carrying the diagnosis of COPD, these comorbidities are seen at an earlier age

3D Correlations in the Lyman-α\alpha Forest from Early DESI Data

We present the first measurements of Lyman-$\alpha$ (Ly$\alpha$) forest correlations using early data from the Dark Energy Spectroscopic Instrument (DESI). We measure the auto-correlation of Ly$\alpha$ absorption using 88,509 quasars at $z>2$, and its cross-correlation with quasars using a further 147,899 tracer quasars at $z\gtrsim1.77$. Then, we fit these correlations using a 13-parameter model based on linear perturbation theory and find that it provides a good description of the data across a broad range of scales. We detect the BAO peak with a signal-to-noise ratio of $3.8\sigma$, and show that our measurements of the auto- and cross-correlations are fully-consistent with previous measurements by the Extended Baryon Oscillation Spectroscopic Survey (eBOSS). Even though we only use here a small fraction of the final DESI dataset, our uncertainties are only a factor of 1.7 larger than those from the final eBOSS measurement. We validate the existing analysis methods of Ly$\alpha$ correlations in preparation for making a robust measurement of the BAO scale with the first year of DESI data

A transcriptomic approach to study the effect of long-term starvation and diet composition on the expression of mitochondrial oxidative phosphorylation genes in gilthead sea bream (Sparus aurata)

Abstract Background The impact of nutritional status and diet composition on mitochondrial oxidative phosphorylation (OXPHOS) in fish remains largely unknown. To identify biomarkers of interest in nutritional studies, herein we obtained a deep-coverage transcriptome by 454 pyrosequencing of liver and skeletal muscle cDNA normalised libraries from long-term starved gilthead sea bream (Sparus aurata) and fish fed different diets. Results After clean-up of high-throughput deep sequencing reads, 699,991 and 555,031 high-quality reads allowed de novo assembly of liver and skeletal muscle sequences, respectively (average length: 374 and 441 bp; total megabases: 262 and 245 Mbp). An additional incremental assembly was completed by integrating data from both tissues (hybrid assembly). Assembly of hybrid, liver and skeletal muscle transcriptomes yielded, respectively, 19,530, 11,545 and 10,599 isotigs (average length: 1330, 1208 and 1390 bp, respectively) that were grouped into 15,954, 10,033 and 9189 isogroups. Following annotation, hybrid transcriptomic data were used to construct an oligonucleotide microarray to analyse nutritional regulation of the expression of 129 genes involved in OXPHOS in S. aurata. Starvation upregulated cytochrome c oxidase components and other key OXPHOS genes in the liver, which exhibited higher sensitive to food deprivation than the skeletal muscle. However, diet composition affected OXPHOS in the skeletal muscle to a greater extent than in the liver: most of genes upregulated under starvation presented higher expression among fish fed a high carbohydrate/low protein diet. Conclusions Our findings indicate that the expression of coenzyme Q-binding protein (COQ10), cytochrome c oxidase subunit 6A2 (COX6A2) and ADP/ATP translocase 3 (SLC25A6) in the liver, and cytochrome c oxidase subunit 5B isoform 1 (COX5B1) in the liver and the skeletal muscle, are sensitive markers of the nutritional condition that may be relevant to assess the effect of changes in the feeding regime and diet composition on fish farming

Morphological and molecular characterization of Heterocapsa claromecoensis sp. nov. (Peridiniales, Dinophyceae) from Buenos Aires coastal waters (Argentina).

A new species of the marine dinophyte genus Heterocapsa Stein is described. Two clonal strains originating from Argentinean coastal waters were examined with light and electron microscopy and LSU and ITS rDNA sequence data were obtained. Heterocapsa claromecoensis sp. nov. is described as a distinctive species with a conical epitheca, a similar sized and rounded hypotheca, a single reticulate chloroplast situated in the periphery of the cell, and a large pyrenoid in the episome, above an ellipsoidal to rounded nucleus in the hyposome. The plate tabulation pattern of Po (pore plate), cp (cover plate), X (X-plate or canal plate), 5ꞌ, 3a, 7ꞌꞌ, 6c, 5s, 5ꞌꞌꞌ, 2ꞌꞌꞌꞌ was as for most other species of Heterocapsa. H. claromecoensis sp. nov. differs from all other species of Heterocapsa by the microarchitecture of two different types of organic body scales, which uniquely were different in height. Phylogenetic trees based on LSU and ITS rDNA sequences placed H. claromecoensis in a separate branch, with a sequence assigned to H. orientalis being the closest match based on LSU rDNA

Becas de Verano 2012 del Instituto Balseiro – Informes

El programa de Becas de Verano del Instituto Balseiro ofrece a estudiantes universitarios avanzados o recientemente egresados de carreras de grado en Ciencias o Ingenierías la posibilidad de realizar una pasantía durante el mes de febrero. El objetivo de la misma es familiarizarse con técnicas experimentales y colaborar en tareas de investigación en laboratorios del Centro Atómico Bariloche. Anualmente, 15 estudiantes son seleccionados y reciben ayuda económica completa. Cada participante elige un único tema de investigación entre una serie de propuestas y es guiado por un grupo de investigadores del Centro Atómico Bariloche. La pasantía finaliza con la entrega de un informe y la presentación de un póster en el que se detallan los resultados obtenidos a lo largo del mes de trabajo

Chronic obstructive pulmonary disease (COPD) as a disease of early aging: evidence from the epiChron cohort

Background: Aging is an important risk factor for most chronic diseases. Patients with COPD develop more comorbidities than non-COPD subjects. We hypothesized that the development of comorbidities characteristically affecting the elderly occur at an earlier age in subjects with the diagnosis of COPD. Methods and findings: We included all subjects carrying the diagnosis of COPD (n = 27,617), and a similar number of age and sex matched individuals without the diagnosis, extracted from the 727,241 records of individuals 40 years and older included in the EpiChron Cohort (Aragon, Spain). We compared the cumulative number of comorbidities, their prevalence and the mortality risk between both groups. Using network analysis, we explored the connectivity between comorbidities and the most influential comorbidities in both groups. We divided the groups into 5 incremental age categories and compared their comorbidity networks. We then selected those comorbidities known to affect primarily the elderly and compared their prevalence across the 5 age groups. In addition, we replicated the analysis in the smokers' subgroup to correct for the confounding effect of cigarette smoking. Subjects with COPD had more comorbidities and died at a younger age compared to controls. Comparison of both cohorts across 5 incremental age groups showed that the number of comorbidities, the prevalence of diseases characteristic of aging and network's density for the COPD group aged 56-65 were similar to those of non-COPD 15 to 20 years older. The findings persisted after adjusting for smoking. Conclusion: Multimorbidity increases with age but in patients carrying the diagnosis of COPD, these comorbidities are seen at an earlier age