Enabling Proactive Adaptation through Just-in-time Testing of Conversational Services

Service-based applications (SBAs) will increasingly be composed of third-party services available over the Internet. Reacting to failures of those third-party services by dynamically adapting the SBAs will become a key enabler for ensuring reliability. Determining when to adapt an SBA is especially challenging in the presence of conversational (aka. stateful) services. A conversational service might fail in the middle of an invocation sequence, in which case adapting the SBA might be costly; e.g., due to the necessary state transfer to an alternative service. In this paper we propose just-in-time testing of conversational services as a novel approach to detect potential problems and to proactively trigger adaptations, thereby preventing costly compensation activities. The approach is based on a framework for online testing and a formal test-generation method which guarantees functional correctness for conversational services. The applicability of the approach is discussed with respect to its underlying assumptions and its performance. The benefits of the approach are demonstrated using a realistic example

Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy: contribution of vascular absorption and tissue background absorption

The possibility of measuring the blood oxygenation in the brain with near infrared light has been studied. The goal of this study was to quantify the influence of different brain layers on brain blood oxygenation measurements. Experimental results obtained from time resolved reflectance measurements on layered tissue phantoms were compared to Monte Carlo simulations of layered models, diffusion theory, and in vivo measurements on the human head. Both the experimental results and simulations show that the absorption coefficient (mu) a, which is closely related to the blood oxygenation, of deeper layers can be accessed in the time domain. Thus fitting analytical expressions found from diffusion theory only to the late part of the time resolved reflectance allows us to determine (mu) a and subsequently the blood oxygenation of the deepest medium (e.g. brain tissue)

Screening of emerging pollutants (Eps) in estuarine water and phytoremediation capacity of tripolium pannonicum under controlled conditions

The increasing number of pharmaceuticals in the environment and their difficult biodegra-dation, can lead to bioaccumulation in different trophic compartments. Their bioaccumulation can have negative consequences, especially in the generation of bacterial resistance by antibiotics, but also in the impairment of plant and animal metabolism. The Tejo estuary in Portugal is the habitat for many plant and animal species, which are also prone to this type of contamination. There-fore, in the present study different classes of emerging pollutants (EPs) were surveyed in water samples in the Tejo estuary, including antibiotics, anticonvulsants, antidepressants, lipid-lowering drugs, anti-inflammatory drugs, beta-blockers and analgesics. According to the results, only four compounds were detected in water samples collected at the three selected salt marshes, including carbamazepine, fluoxetine hydrochloride, venlafaxine hydrochloride and acetaminophen. Having the detected substances as a basis, a subsequent study was performed aiming to investigate the uptake and biodegradation capacity of halophytes, using Tripolium pannonicum as a model plant culti-vated under controlled conditions with different concentrations of the found EPs. This experimental approach showed that T. pannonicum was able to uptake and degrade xenobiotics. Moreover, the application of sulfamethazine, as a model antibiotic, showed also that this species can uptake and degrade this compound, although the degradation rate and process proved to be compound-specific. This was also confirmed using crude plant extracts spiked with the different EPs. Thus this species is a potential candidate for the remediation of marine water and sediments contaminated with environmentally-significant EPs. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

A World Full of Privacy and Security (Mis)conceptions? Findings of a Representative Survey in 12 Countries

Misconceptions about digital security and privacy topics in the general public frequently lead to insecure behavior. However, little is known about the prevalence and extent of such misconceptions in a global context. In this work, we present the results of the first large-scale survey of a global population on misconceptions: We conducted an online survey with n = 12, 351 participants in 12 countries on four continents. By investigating influencing factors of misconceptions around eight common security and privacy topics (including E2EE, Wi-Fi, VPN, and malware), we find the country of residence to be the strongest estimate for holding misconceptions. We also identify differences between non-Western and Western countries, demonstrating the need for region-specific research on user security knowledge, perceptions, and behavior. While we did not observe many outright misconceptions, we did identify a lack of understanding and uncertainty about several fundamental privacy and security topics

Targeting atypical protein kinase C iota reduces viability in glioblastoma stem-like cells via a notch signaling mechanism

In a previous study, Protein Kinase C iota (PRKCI) emerged as an important candidate gene for glioblastoma (GBM) stem-like cell (GSC) survival. Here, we show that PKCι is overexpressed and activated in patient derived GSCs compared with normal neural stem cells and normal brain lysate, and that silencing of PRKCI in GSCs causes apoptosis, along with loss of clonogenicity and reduced proliferation. Notably, PRKCI silencing reduces tumor growth in vivo in a xenograft mouse model. PKCι has been intensively studied as a therapeutic target in non-small cell lung cancer, resulting in the identification of an inhibitor, aurothiomalate (ATM), which disrupts the PKCι/ERK signaling axis. However, we show that, although sensitive to pharmacological inhibition via a pseudosubstrate peptide inhibitor, GSCs are much less sensitive to ATM, suggesting that PKCι acts along a different signaling axis in GSCs. Gene expression profiling of PRKCI-silenced GSCs revealed a novel role of the Notch signaling pathway in PKCι mediated GSC survival. A proximity ligation assay showed that Notch1 and PKCι are in close proximity in GSCs. Targeting PKCι in the context of Notch signaling could be an effective way of attacking the GSC population in GBM

On three-dimensional misorientation spaces.

Determining the local orientation of crystals in engineering and geological materials has become routine with the advent of modern crystallographic mapping techniques. These techniques enable many thousands of orientation measurements to be made, directing attention towards how such orientation data are best studied. Here, we provide a guide to the visualization of misorientation data in three-dimensional vector spaces, reduced by crystal symmetry, to reveal crystallographic orientation relationships. Domains for all point group symmetries are presented and an analysis methodology is developed and applied to identify crystallographic relationships, indicated by clusters in the misorientation space, in examples from materials science and geology. This analysis aids the determination of active deformation mechanisms and evaluation of cluster centres and spread enables more accurate description of transformation processes supporting arguments regarding provenance

Determination of the blood oxygenation in the brain by time-resolved reflectance spectroscopy: contribution of vascular absorption and tissue background absorption

The possibility of measuring the blood oxygenation in the brain with near infrared light has been studied. The goal of this study was to quantify the influence of different brain layers on brain blood oxygenation measurements. Experimental results obtained from time resolved reflectance measurements on layered tissue phantoms were compared to Monte Carlo simulations of layered models, diffusion theory, and in vivo measurements on the human head. Both the experimental results and simulations show that the absorption coefficient (mu) a, which is closely related to the blood oxygenation, of deeper layers can be accessed in the time domain. Thus fitting analytical expressions found from diffusion theory only to the late part of the time resolved reflectance allows us to determine (mu) a and subsequently the blood oxygenation of the deepest medium (e.g. brain tissue)

Weather, the Forgotten Factor in Business Cycle Analyses

In periods of unusual weather, forecasters face a problem of interpreting economic data: Which part goes back to the underlying economic trend and which part arises from a special weather effect? In this paper, we discuss ways to disentangle weather-related from business cycle-related influences on economic indicators. We find a significant influence of weather variables at least on a number of monthly indicators. Controlling for weather effects within these indicators should thus create opportunities to increase the accuracy of indicator-based forecasts. Focusing on quarterly GDP growth in Germany, we find that the accuracy of the RWI short term forecasting model improves but advances are small and not significant

Quantitative Modeling of Cerenkov Light Production Efficiency from Medical Radionuclides

There has been recent and growing interest in applying Cerenkov radiation (CR) for biological applications. Knowledge of the production efficiency and other characteristics of the CR produced by various radionuclides would help in accessing the feasibility of proposed applications and guide the choice of radionuclides. To generate this information we developed models of CR production efficiency based on the Frank-Tamm equation and models of CR distribution based on Monte-Carlo simulations of photon and β particle transport. All models were validated against direct measurements using multiple radionuclides and then applied to a number of radionuclides commonly used in biomedical applications. We show that two radionuclides, Ac-225 and In-111, which have been reported to produce CR in water, do not in fact produce CR directly. We also propose a simple means of using this information to calibrate high sensitivity luminescence imaging systems and show evidence suggesting that this calibration may be more accurate than methods in routine current use

IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression

Immune checkpoint blockade therapy induces the AHR-activating enzyme IL4I1, which promotes tumor progression, through its effects on tumor cell motility and adaptive immunity