Immune checkpoint blockade therapy induces the AHR-activating enzyme IL4I1, which promotes tumor progression, through its effects on tumor cell motility and adaptive immunity

Berdel, Bianca

Burhenne, Jürgen

Böhme, Alexander

Escher, Beate I

Faessler, Erik

Foerster, Kathrin I

Guevara, Carina Ramallo

Haefeli, Walter E

Hahn, Udo

Hassel, Jessica C

Hielscher, Thomas

Hopf, Carsten

Ishaque, Naveed

Iskar, Murat

Jäger, Evelyn

Kalter, Verena

Kirst, Isabelle

Loth, Stefanie

Mohapatra, Soumya R

Opitz, Christiane A

Panitz, Verena

Pfänder, Pauline

Poschet, Gernot

Prentzell, Mirja Tamara

Reinhardt, Annekathrin

Reuter, Friederike

Sadik, Ahmed

Salem, Heba

Schlichting, Rita

Schäuble, Sascha

Secker, Philipp F

Seiffert, Martina

Sobeh, Mansour

Somarribas Patterson, Luis F

Thedieck, Kathrin

Trump, Saskia

von Deimling, Andreas

Zapatka, Marc

Öztürk, Selcen

English

NARCIS 

IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression

Immune checkpoint blockade therapy induces the AHR-activating enzyme IL4I1, which promotes tumor progression, through its effects on tumor cell motility and adaptive immunity.</p

University of Groningen

University of GroningenIL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes TumorProgressionSadik, Ahmed; Somarribas Patterson, Luis F; Öztürk, Selcen; Mohapatra, Soumya R; Panitz,Verena; Secker, Philipp F; Pfänder, Pauline; Loth, Stefanie; Salem, Heba; Prentzell, MirjaTamaraPublished in:CellDOI:10.1016/j.cell.2020.07.038IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2020Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Sadik, A., Somarribas Patterson, L. F., Öztürk, S., Mohapatra, S. R., Panitz, V., Secker, P. F., Pfänder, P.,Loth, S., Salem, H., Prentzell, M. T., Berdel, B., Iskar, M., Faessler, E., Reuter, F., Kirst, I., Kalter, V.,Foerster, K. I., Jäger, E., Guevara, C. R., ... Opitz, C. A. (2020). IL4I1 Is a Metabolic Immune Checkpointthat Activates the AHR and Promotes Tumor Progression. Cell, 182(5), 1252-1270.e34.https://doi.org/10.1016/j.cell.2020.07.038CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 31-12-2025View PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDF

ARTS repository - University of Groningen

   University of GroningenIL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes TumorProgressionSadik, Ahmed; Somarribas Patterson, Luis F; Öztürk, Selcen; Mohapatra, Soumya R; Panitz,Verena; Secker, Philipp F; Pfänder, Pauline; Loth, Stefanie; Salem, Heba; Prentzell, MirjaTamaraPublished in:CellDOI:10.1016/j.cell.2020.07.038IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2020Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Sadik, A., Somarribas Patterson, L. F., Öztürk, S., Mohapatra, S. R., Panitz, V., Secker, P. F., Pfänder, P.,Loth, S., Salem, H., Prentzell, M. T., Berdel, B., Iskar, M., Faessler, E., Reuter, F., Kirst, I., Kalter, V.,Foerster, K. I., Jäger, E., Guevara, C. R., ... Opitz, C. A. (2020). IL4I1 Is a Metabolic Immune Checkpointthat Activates the AHR and Promotes Tumor Progression. Cell, 182(5), 1252-1270.e34.https://doi.org/10.1016/j.cell.2020.07.038CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.View PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDF

   University of GroningenIL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes TumorProgressionSadik, Ahmed; Somarribas Patterson, Luis F; Öztürk, Selcen; Mohapatra, Soumya R; Panitz,Verena; Secker, Philipp F; Pfänder, Pauline; Loth, Stefanie; Salem, Heba; Prentzell, MirjaTamaraPublished in:CellDOI:10.1016/j.cell.2020.07.038IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2020Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Sadik, A., Somarribas Patterson, L. F., Öztürk, S., Mohapatra, S. R., Panitz, V., Secker, P. F., Pfänder, P.,Loth, S., Salem, H., Prentzell, M. T., Berdel, B., Iskar, M., Faessler, E., Reuter, F., Kirst, I., Kalter, V.,Foerster, K. I., Jäger, E., Guevara, C. R., ... Opitz, C. A. (2020). IL4I1 Is a Metabolic Immune Checkpointthat Activates the AHR and Promotes Tumor Progression. Cell, 182(5), 1252-1270.e34.https://doi.org/10.1016/j.cell.2020.07.038CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 26-12-2020View PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDFView PDF

Mediamusic (E-Journal)

https://pure.rug.nl/ws/files/133484151/Head_and_Neck_IMPT_probabilistic_dose_accumulation_feasibility_of_a_2_mm_setup_uncertainty_setting_Elsevier_Enhanced_Reader.pdf

IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression

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University of Groningen

ARTS repository - University of Groningen

University of Groningen

Mediamusic (E-Journal)

University of Groningen

ARTS repository - University of Groningen