Outdoor flat-plate collector performance prediction from solar simulator test data

Solar collector performance data obtained from tests with a simulator was modified for real-life conditions. The data obtained with the simulator was corrected for the variable conditions of ambient temperature, wind, incident angle, flow rate, etc., that are encountered outdoors. Modification of simulator data was accomplished by combining experiment with theory. The technique was demonstrated by application to a spectrally selective and a nonselective type of collector. This kind of modified simulator collector performance data should be valuable in solar systems analysis and for collector performance ranking based on all-day calculated conditions

Real-time growth rate for general stochastic SIR epidemics on unclustered networks

Networks have become an important tool for infectious disease epidemiology. Most previous theoretical studies of transmission network models have either considered simple Markovian dynamics at the individual level, or have focused on the invasion threshold and final outcome of the epidemic. Here, we provide a general theory for early real-time behaviour of epidemics on large configuration model networks (i.e. static and locally unclustered), in particular focusing on the computation of the Malthusian parameter that describes the early exponential epidemic growth. Analytical, numerical and Monte-Carlo methods under a wide variety of Markovian and non-Markovian assumptions about the infectivity profile are presented. Numerous examples provide explicit quantification of the impact of the network structure on the temporal dynamics of the spread of infection and provide a benchmark for validating results of large scale simulations.Comment: 45 pages, 8 figures, submitted to Mathematical Biosciences on 29/11/2014; Version 2: resubmitted on 15/04/2015; accepted on 17/04/2015. Changes: better explanations in introduction; restructured section 3.3 (3.3.3 added); section 6.3.1 added; more precise terminology; typos correcte

Role of the surface in the measurement of the Leidenfrost temperature

Role of surfaces in measuring Leidenfrost temperatur

TDP1/TOP1 ratio as a promising indicator for the response of small cell lung cancer to topotecan

BACKGROUND AND OBJECTIVE Small cell lung cancer (SCLC) is one of the most challenging tumors to treat due to high proliferation rate, early metastatic dissemination and rapid development of chemotherapy resistance. The current treatment protocols involve the use of topoisomerase 1 (TOP1) poisons such as irinotecan and topotecan in combination with platinum-based compounds. TOP1 poisons kill cancer cells by trapping TOP1 on DNA, generating lethal DNA double-strand breaks. A potential mechanism employed by cancer cells to resist killing by TOP1 poisons is to overexpress enzymes involved in the repair of TOP1-DNA breaks. Tyrosyl DNA phosphodiesterase 1 (TDP1) is a key player in this process and despite its importance, no data is currently available to correlate TDP1 protein and mRNA levels with catalytic activity in SCLC. In addition, it is not known if TDP1 and TOP1 protein levels correlate with the cellular response of SCLC to TOP1 based therapies. METHODS AND RESULTS We report a remarkable variation in TDP1 and TOP1 protein levels in a panel of SCLC cell lines. TDP1 protein level correlates well with TDP1 mRNA and TDP1 catalytic activity, as measured by two newly developed independent activity assays, suggesting the potential utility of immunohistochemistry in assessing TDP1 levels in SCLC tissues. We further demonstrate that whilst TDP1 protein level alone does not correlate with topotecan sensitivity, TDP1/TOP1 ratio correlates well with sensitivity in 8 out of 10 cell lines examined. CONCLUSION This study provides the first cellular analyses of TDP1 and TOP1 in SCLC and suggests the potential utility of TDP1/TOP1 ratio to assess the response of SCLC to topotecan. The establishment and validation of an easy-to-use TDP1 enzymatic assay in cell extracts could be exploited as a diagnostic tool in the clinic. These findings may help in stratifying patients that are likely to benefit from TOP1 poisons and TDP1 inhibitors currently under development

Assumptions that imply quantum dynamics is linear

A basic linearity of quantum dynamics, that density matrices are mapped linearly to density matrices, is proved very simply for a system that does not interact with anything else. It is assumed that at each time the physical quantities and states are described by the usual linear structures of quantum mechanics. Beyond that, the proof assumes only that the dynamics does not depend on anything outside the system but must allow the system to be described as part of a larger system. The basic linearity is linked with previously established results to complete a simple derivation of the linear Schrodinger equation. For this it is assumed that density matrices are mapped one-to-one onto density matrices. An alternative is to assume that pure states are mapped one-to-one onto pure states and that entropy does not decrease.Comment: 10 pages. Added references. Improved discussion of equations of motion for mean values. Expanded Introductio

Quantum to Classical Transition of the Charge Relaxation Resistance of a Mesoscopic Capacitor

We present an analysis of the effect of dephasing on the single channel charge relaxation resistance of a mesoscopic capacitor in the linear low frequency regime. The capacitor consists of a cavity which is via a quantum point contact connected to an electron reservoir and Coulomb coupled to a gate. The capacitor is in a perpendicular high magnetic field such that only one (spin polarized) edge state is (partially) transmitted through the contact. In the coherent limit the charge relaxation resistance for a single channel contact is independent of the transmission probability of the contact and given by half a resistance quantum. The loss of coherence in the conductor is modeled by attaching to it a fictitious probe, which draws no net current. In the incoherent limit one could expect a charge relaxation resistance that is inversely proportional to the transmission probability of the quantum point contact. However, such a two terminal result requires that scattering is between two electron reservoirs which provide full inelastic relaxation. We find that dephasing of a single edge state in the cavity is not sufficient to generate an interface resistance. As a consequence the charge relaxation resistance is given by the sum of one constant interface resistance and the (original) Landauer resistance. The same result is obtained in the high temperature regime due to energy averaging over many occupied states in the cavity. Only for a large number of open dephasing channels, describing spatially homogenous dephasing in the cavity, do we recover the two terminal resistance, which is inversely proportional to the transmission probability of the QPC. We compare different dephasing models and discuss the relation of our results to a recent experiment.Comment: 10 pages, 8 figure

Coarse Graining Makes It Hard to See Micro-Macro Entanglement

Observing quantum effects such as superpositions and entanglement in macroscopic systems requires not only a system that is well protected against environmental decoherence, but also sufficient measurement precision. Motivated by recent experiments, we study the effects of coarse-graining in photon number measurements on the observability of micro-macro entanglement that is created by greatly amplifying one photon from an entangled pair. We compare the results obtained for a unitary quantum cloner, which generates micro-macro entanglement, and for a measure-and-prepare cloner, which produces a separable micro-macro state. We show that the distance between the probability distributions of results for the two cloners approaches zero for a fixed moderate amount of coarse-graining. Proving the presence of micro-macro entanglement therefore becomes progressively harder as the system size increases.Comment: 5 pages, 3 figure

Condensation of achiral simple currents in topological lattice models: a Hamiltonian study of topological symmetry breaking

We describe a family of phase transitions connecting phases of differing non-trivial topological order by explicitly constructing Hamiltonians of the Levin-Wen[PRB 71, 045110] type which can be tuned between two solvable points, each of which realizes a different topologically ordered phase. We show that the low-energy degrees of freedom near the phase transition can be mapped onto those of a Potts model, and we discuss the stability of the resulting phase diagram to small perturbations about the model. We further explain how the excitations in the condensed phase are formed from those in the original topological theory, some of which are split into multiple components by condensation, and we discuss the implications of our results for understanding the nature of general achiral topological phases in 2+1 dimensions in terms of doubled Chern-Simons theories