The Chadwicks and Lord Raglan: A Retrospective Analysis

Article

High strain rate behavior of aluminum die cast components

Abstract Research results of static and dynamic mechanical tests (ɛ = 1 * 10-3 s-1 and ɛ ~ 5 * 102 s-1 conducted on samples obtained from three different die cast products (component A, B and C) of AlSi10MnMg alloy are reported. All the components have thin-walled geometry except some thicker positions of component C. The dynamic (high strain rate) mechanical characterization shows an increase of tensile properties, in respect to static tensile ones (tensile strength increases approximately 15%, and the yield strength 30%, for all the die cast components) together with an evident plastic deformation, with consequent necked region in the fractured section, substantially negligible in case of static tensile tests. Moreover, fractographic observations are conducted on specimens undergone static and high strain rate test conditions, to observe the fracture morphology, together with metallographic analysis on the only polished or etched transverse specimens to reveal the porosity, and the microstructure of dendrite and inter-dendrite morphologies

Solunto archaeological park in Sicily: life under mosaic tesserae

Biodeterioration is a complex process induced by the growing and metabolic activity of a wide range of macro and microorganisms, becoming a revelling problem also for the mosaic tesserae of “Casa di Leda” in the Greco - Roman site of Solunto in Sicily. In this case-study, a thick biofilm inducing a deep alteration of mortar and consequently the mosaic tesserae detachment has been highlighted during the restoration plan. The biofilm microbial consortium has been investigated by an integrate approach based on Microscopy analysis (O.M., C.L.S.M.), in vitro culture (Nutrien and Saboraud media) and molecular biology investigation (DNA target sequence amplification, sequencing, sequence analysis). A microbial diversity has been revealed belonging to bacteria (Bacillus) and fungi (Alternaria, Aspergillus), besides cyanobacteria (Chroococcus) and green algae (Chlorella). In order to control the biofilm colonization two essential oils (EO), Thymus vulgaris and Origanum vulgare, have been utilized and their antimicrobial activity, preliminarily in vitro (agar disc diffusion methods) and after ex situ and in situ evaluated. This experimentation is aimed at identifying and implementing green biocides for the control of microbial colonization, a promising technology with a reduced impact on human health and environment, able to replace traditional biocide action

Can brands claim ignorance? Unauthorized subcontracting in apparel supply chains

Unauthorized subcontracting—when suppliers outsource part of their production to a third party without the retailer’s consent—has been common practice in the apparel industry and is often tied to noncompliant working conditions. Because retailers are unaware of the third party, the production process becomes obscure and cannot be tracked. In this paper, we present an empirical study of the factors that can lead suppliers to engage in unauthorized subcontracting. We use data provided by a global supply chain manager with more than 30,000 orders, of which 36% were subcontracted without authorization. We find that the frequency of unauthorized subcontracting across factories has a pronounced bimodal distribution. Moreover, the degree of unauthorized subcontracting in the past is highly related to the probability of engaging in unauthorized subcontracting in the future, which suggests that factories behave as if they choose a strategic level of unauthorized subcontracting. At the order level, we find that state dependence (i.e., the status of an order carrying over to the next one) and price pressure are the key drivers of unauthorized subcontracting. Buyer reputation and lead time also play a role. Finally, we show that unauthorized subcontracting can be predicted correctly for more than 80% of the orders in out-of-sample tests and for about 70% of suppliers. This indicates that retailers can use business analytics to predict unauthorized subcontracting and help prevent it

Type II muscle fibers atrophy associated with silent corticotroph adenoma in a dog.

The Silent Corticotroph Adenoma (SCA) is a pituitary adenoma variant characterized by the immunoreactivity for adrenocorticotropic hormone (ACTH) and related peptides, without the clinical signs of Cushing's disease. SCA has been postulated to either secrete structurally abnormal ACTH that is inactive but detectable by immunohistochemistry or radioimmunoassay, or to secrete ACTH intermittently or at low levels continuously. Excess of ACTH has been associated to type II muscle atrophy. We describe a case of type II muscle fibers atrophy associated with silent corticotroph adenoma in a dog. The dog showed moderate to severe proximal muscle wasting and weakness with normal levels of muscle-associated enzymes. In the limb muscle biopsies, type II fibers were uniformly smaller than type I fibers. In temporalis muscles, there were few atrophic fibers, and several irregular areas of loss of enzymatic activity observed in NADH, SDH and COX stains. The tumour showed a trabecular growth pattern and immunohistochemical analysis demonstrated the presence of cytoplasmic immunoreactivity for ACTH. The muscle atrophy was considered to be related to an excess of inactive ACTH. Studying spontaneous occurring rare diseases in animals could help to understand the mechanism of similar diseases in human has well

Improvement of resveratrol permeation through sublingual mucosa: Chemical permeation enhancers versus spray drying technique to obtain fast-disintegrating sublingual mini-tablets

Resveratrol (RSV) is a natural polyphenol with several interesting broad-spectrum pharmacological properties. However, it is characterized by poor oral bioavailability, extensive first-pass effect metabolism and low stability. Indeed, RSV could benefit from the advantage of the sublingual route of administration. In this view, RSV attitudes to crossing the porcine sublingual mucosa were evaluated and promoted both by six different chemical permeation enhancers (CPEs) as well as by preparing four innovative fast-disintegrating sublingual mini-tablets by spray drying followed by direct compression. Since RSV by itself exhibits a low permeation aptitude, this could be significantly enhanced by the use of CPEs as well as by embedding RSV in a spray-dried powder to be compressed in order to prepare fast-disintegrating mini-tablets. The most promising observed CPEs (menthol, lysine and urea) were then inserted into the most promising spray-dried excipients’ compositions (RSV-B and RSV-C), thus preparing CPE-loaded mini-tablets. However, this procedure leads to unsatisfactory results which preclude the possibility of merging the two proposed approaches. Finally, the best spray-dried composition (RSV-B) was further evaluated by SEM, FTIR, XRD and disintegration as well as dissolution behavior to prove its effectiveness as a sublingual fast-disintegrating formulation

Machine learning models to predict daily actual evapotranspiration of citrus orchards under regulated deficit irrigation

Precise estimations of actual evapotranspiration (ETa) are essential for various environmental issues, including those related to agricultural ecosystem sustainability and water management. Indeed, the increasing demands of agricultural production, coupled with increasingly frequent drought events in many parts of the world, necessitate a more careful evaluation of crop water requirements. Artificial Intelligence-based models represent a promising alternative to the most common measurement techniques, e.g. using expensive Eddy Covariance (EC) towers. In this context, the main challenges are choosing the best possible model and selecting the most representative features. The objective of this research is to evaluate two different machine learning algorithms, namely Multi-Layer Perceptron (MLP) and Random Forest (RF), to predict daily actual evapotranspiration (ETa) in a citrus orchard typical of the Mediterranean ecosystem using different feature combinations. With many features available coming from various infield sensors, a thorough analysis was performed to measure feature importance, scatter matrix observations, and Pearson's correlation coefficient calculation, which resulted in the selection of 12 promising feature combinations. The models were calibrated under regulated deficit irrigation (RDI) conditions to estimate ETa and save irrigation water. On average up to 38.5% water savings were obtained, compared to full irrigation. Moreover, among the different input variables adopted, the soil water content (SWC) feature appears to have a prominent role in the prediction of ETa. Indeed, the presented results show that by choosing the appropriate input features, the accuracy of the proposed machine learning models remains acceptable even when the number of features is reduced to only 4. The best performance was achieved by the Random Forest method, with seven input features, obtaining a root mean square error (RMSE) and a coefficient of determination (R2) of 0.39 mm/day and 0.84, respectively. Finally, the results show that the joint use of SWC, weather and satellite data significantly improves the performance of evapotranspiration forecasts compared to models using only meteorological variables

Do patients’ information needs decrease over the course of radiotherapy?

PURPOSE: We aimed to investigate if cancer patients’ information needs decrease during radiotherapy and if so, which patient, consultation and radiation oncologist characteristics are associated with a decrease in information needs over time. METHODS: In this longitudinal study, patients (n = 104) completed a baseline questionnaire a week before the initial radiotherapy consultation, immediately following this initial consultation, and 1 week prior to the first follow-up visit, which took place on average 3–5 weeks after the initial visit. Besides information needs, measured by the Information Preference for Radiotherapy Patients scale, the questionnaire assessed patient, consultation and radiation oncologist characteristics. RESULTS: Information needs decreased over time, but remained at a high level. Being religious, being male, having low health literacy and higher perceived involvement during the consultation were all statistically significantly associated to a decrease in information needs on specific domains (e.g. procedures or side effects). CONCLUSIONS: Cancer patients’ information needs decline between the initial consultation and the first follow-up visit, but remain high. It is therefore advised to investigate the patients’ information needs at every radiotherapy visit and not rely on giving information just once. Furthermore, radiation oncologists should check if the information given at first consultation is understood and remembered. By those means, tailored information giving becomes possible

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D

Phosphodiesterase 4 (PDE4) inhibitors, i.e. rolipram, are being extensively investigated as therapeutic agents in several diseases. Emesis is one of the most common side effects of PDE4 inhibitors. Given the fact that the area postrema is considered the chemoreceptor trigger zone for vomiting, the present study investigates the regional distribution and cellular localization of the four gene transcripts of the PDE4 subfamily (PDE4A, PDE4B, PDE4C and PDE4D) in human brainstem. In situ hybridization histochemistry was used to locate the mRNA distribution of the four PDE4 subfamilies in the area postrema and related nuclei of human postmortem brainstem. We have found that in the brainstem PDE4B and PDE4D mRNA expression is abundant and distributed not only in neuronal cells, but also in glial cells, and on blood vessels. The hybridization signals for PDE4B and PDE4D mRNAs in the area postrema were stronger than those in any other nuclei in the brainstem. They were also found in vomiting-related nuclei such as the nucleus of the solitary tract and the dorsal vagal motor nucleus. These findings suggest that cAMP signaling modification in the area postrema could mediate the emetic effects of PDE4 inhibitors in human brainstem.This work was supported by grants from Ministerio de Educación y Ciencia and Fondo Europeo de Desarrollo Regional (SAF2006-10243). F.M. was on sabbatical leave from Hirosaki University School of Medicine. S.P.-T. was recipient of a predoctoral fellowship from CIRIT (Generalitat de Catalunya).Peer Reviewe