Supersymmetric type-III seesaw: lepton flavour violating decays and dark matter

We study a supersymmetric version of the seesaw mechanism type-III. The model consists of the MSSM particle content plus three copies of 24 superfields. The fermionic part of the SU(2) triplet contained in the 24 is responsible for the type-III seesaw, which is used to explain the observed neutrino masses and mixings. Complete copies of 24 are introduced to maintain gauge coupling unification. These additional states change the beta functions of the gauge couplings above the seesaw scale. Using mSUGRA boundary conditions we calculate the resulting supersymmetric mass spectra at the electro-weak scale using full 2-loop renormalization group equations. We show that the resulting spectrum can be quite different compared to the usual mSUGRA spectrum. We discuss how this might be used to obtain information on the seesaw scale from mass measurements. Constraints on the model space due to limits on lepton flavour violating decays are discussed. The main constraints come from the bounds on the decay mu to e and gamma but there are also regions where the decay tau to mu and gamma gives stronger constraints. We also calculate the regions allowed by the dark matter constraint. For the sake of completeness, we compare our results with those for the supersymmetric seesaw type-II and, to some extent, with type-I.Comment: 32 pages, 16 eps figures. One ref. added; small changes in tex

Lepton flavor violation in low-scale seesaw models: SUSY and non-SUSY contributions

Taking the supersymmetric inverse seesaw mechanism as the explanation for neutrino oscillation data, we investigate charged lepton flavor violation in radiative and 3-body lepton decays as well as in neutrinoless $\mu-e$ conversion in muonic atoms. In contrast to former studies, we take into account all possible contributions: supersymmetric as well as non-supersymmetric. We take CMSSM-like boundary conditions for the soft supersymmetry breaking parameters. We find several regions where cancellations between various contributions exist, reducing the lepton flavor violating rates by an order of magnitude compared to the case where only the dominant contribution is taken into account. This is in particular important for the correct interpretation of existing data as well as for estimating the reach of near future experiments where the sensitivity will be improved by one to two orders of magnitude. Moreover, we demonstrate that ratios like BR($\tau\to 3 \mu$)/BR($\tau\to \mu e^+ e^-$) can be used to determine whether the supersymmetric contributions dominate over the $W^\pm$ and $H^\pm$ contributions or vice versa.Comment: 75 pages, 7 figures. v3: references and comments added. Matches published versio

The generalised NMSSM at one loop: fine tuning and phenomenology

We determine the degree of fine tuning needed in a generalised version of the NMSSM that follows from an underlying Z4 or Z8 R symmetry. We find that it is significantly less than is found in the MSSM or NMSSM and extends the range of Higgs mass that have acceptable fine tuning up to Higgs masses of mh ~ 130 GeV. For universal boundary conditions analogous to the CMSSM the phenomenology is rather MSSM like with the singlet states typically rather heavy. For more general boundary conditions the singlet states can be light, leading to interesting signatures at the LHC and direct detection experiments.Comment: 20 pages, 9 figures, matches published versio

Decoupling of heavy sneutrinos in low-scale seesaw models

Peer reviewe

Enhancing lepton flavour violation in the supersymmetric inverse seesaw beyond the dipole contribution

In minimal supersymmetric models the $Z$-penguin usually provides sub-dominant contributions to charged lepton flavour violating observables. In this study, we consider the supersymmetric inverse seesaw in which the non-minimal particle content allows for dominant contributions of the $Z$-penguin to several lepton flavour violating observables. In particular, and due to the low-scale (TeV) seesaw, the penguin contribution to, for instance, \Br(\mu \to 3e) and $\mu-e$ conversion in nuclei, allows to render some of these observables within future sensitivity reach. Moreover, we show that in this framework, the $Z$-penguin exhibits the same non-decoupling behaviour which had previously been identified in flavour violating Higgs decays in the Minimal Supersymmetric Standard Model.Comment: 29 pages, 9 figures, 4 tables; v2: minor corrections, version to appear in JHE

Two loop electroweak corrections to Bˉ→Xsγ\bar B\rightarrow X_s\gamma and Bs0→μ+μ−B_s^0\rightarrow \mu^+\mu^- in the B-LSSM

The rare decays $\bar B\rightarrow X_s\gamma$ and $B_s^0\rightarrow \mu^+\mu^-$ are important to research new physics beyond standard model. In this work, we investigate two loop electroweak corrections to $\bar B\rightarrow X_s\gamma$ and $B_s^0\rightarrow \mu^+\mu^-$ in the minimal supersymmetric extension of the SM with local $B-L$ gauge symmetry (B-LSSM), under a minimal flavor violating assumption for the soft breaking terms. In this framework, new particles and new definition of squarks can affect the theoretical predictions of these two processes, with respect to the MSSM. Considering the constraints from updated experimental data, the numerical results show that the B-LSSM can fit the experimental data for the branching ratios of $\bar B\rightarrow X_s\gamma$ and $B_s^0\rightarrow \mu^+\mu^-$. The results of the rare decays also further constrain the parameter space of the B-LSSM.Comment: 33 pages, 9 figures, Published in EPJ

Determination of the Oswestry Disability Index score equivalent to a "satisfactory symptom state" in patients undergoing surgery for degenerative disorders of the lumbar spine-a Spine Tango registry-based study.

BACKGROUND CONTEXT The achievement of a given change score on a valid outcome instrument is commonly used to indicate whether a clinically relevant change has occurred after spine surgery. However, the achievement of such a change score can be dependent on baseline values and does not necessarily indicate whether the patient is satisfied with the current state. The achievement of an absolute score equivalent to a patient acceptable symptom state (PASS) may be a more stringent measure to indicate treatment success. PURPOSE This study aimed to estimate the score on the Oswestry Disability Index (ODI, version 2.1a; 0-100) corresponding to a PASS in patients who had undergone surgery for degenerative disorders of the lumbar spine. STUDY DESIGN/SETTING This is a cross-sectional study of diagnostic accuracy using follow-up data from an international spine surgery registry. PATIENT SAMPLE The sample includes 1,288 patients with degenerative lumbar spine disorders who had undergone elective spine surgery, registered in the EUROSPINE Spine Tango Spine Surgery Registry. OUTCOME MEASURES The main outcome measure was the ODI (version 2.1a). METHODS Surgical data and data from the ODI and Core Outcome Measures Index (COMI) were included to determine the ODI threshold equivalent to PASS at 1 year (±1.5 months; n=780) and 2 years (±2 months; n=508) postoperatively. The symptom-specific well-being item of the COMI was used as the external criterion in the receiver operating characteristic (ROC) analysis to determine the ODI threshold equivalent to PASS. Separate sensitivity analyses were performed based on the different definitions of an "acceptable state" and for subgroups of patients. JF is a copyright holder of the ODI. RESULTS The ODI threshold for PASS was 22, irrespective of the time of follow-up (area under the curve [AUC]: 0.89 [sensitivity {Se}: 78.3%, specificity {Sp}: 82.1%] and AUC: 0.91 [Se: 80.7%, Sp: 85.6] for the 1- and 2-year follow-ups, respectively). Sensitivity analyses showed that the absolute ODI-22 threshold for the two follow-up time-points were robust. A stricter definition of PASS resulted in lower ODI thresholds, varying from 16 (AUC=0.89; Se: 80.2%, Sp: 82.0%) to 18 (AUC=0.90; Se: 82.4%, Sp: 80.4%) depending on the time of follow-up. CONCLUSIONS An ODI score ≤22 indicates the achievement of an acceptable symptom state and can hence be used as a criterion of treatment success alongside the commonly used change score measures. At the individual level, the threshold could be used to indicate whether or not a patient with a lumbar spine disorder is a "responder" after elective surgery

Automated DBS Extraction Prior to Hilic/RP LC-MS/MS Target Screening of Drugs

This article describes a rapid LC-MS/MS target screening method based on an automated extraction of 5 mu L dried blood spots (DBS), two 5 min chromatographic runs on orthogonal phase columns (RP and Hilic) and a data dependent acquisition (DDA) of product ions spectra for the reliable identification of the detected compounds. The extraction step was performed in 2 min by using the LC autosampler itself in 96-well plates. This procedure was evaluated using 22 model compounds frequently encountered in forensic investigations, i.e., cocaine, benzodiazepines, amphetamines, opioids, antidepressants and antipsychotics. These investigations showed that even if the extraction step was reduced to a minimum, the extraction recoveries were satisfactory (median value of 40 %) and allowed for the detection of the model compounds in their therapeutic ranges, with the exception of morphine. Moreover, the use of two different chromatographic columns broadened the number of screening targets to those that behaved poorly under RP conditions, such as amphetamines or glucuronides, while keeping chromatographic gradients very short. This procedure was applied to 34 authentic post-mortem cases. It allowed the detection of 89 % of the compounds that were quantified in the routine procedures and the formal identification of 77 % of the compounds using their product ions spectra. These results were considered more than satisfactory compared to routine screening alone (GC-MS and LC-DAD, 55 % compound identification). The method described in this article is therefore a powerful approach for a fast, reliable and efficient target screening of drugs in forensic and clinical investigations