39 research outputs found

    Spatiotemporal Amplitude and Phase Retrieval of Bessel-X pulses using a Hartmann-Shack Sensor

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    We propose a new experimental technique, which allows for a complete characterization of ultrashort optical pulses both in space and in time. Combining the well-known Frequency-Resolved-Optical-Gating technique for the retrieval of the temporal profile of the pulse with a measurement of the near-field made with an Hartmann-Shack sensor, we are able to retrieve the spatiotemporal amplitude and phase profile of a Bessel-X pulse. By following the pulse evolution along the propagation direction we highlight the superluminal propagation of the pulse peak

    Preclinical Tests for Cerebral Stroke

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    Stroke is the second single highest cause of death in Europe. The low reliability of animal models in replicating the human disease is one of the most serious problems in the field of medical and pharmaceutical research about stroke. The standard models for the study of ischemic stroke are often poorly predictive as they simulate only partially the human disease. This work aims at investigating animal models with diseases typically associated with the onset of stroke in human patients. We have designed and realised a knowledge base for collecting, elaborating, and extracting analytical results of genomic, proteomic, biochemical, morphological investigations from animal models of cerebral stroke. Data analysis techniques are tailored to make the data available for processing and correlation, in order to increase the predictive value of the preclinical data, to perform biosimulation studies, and to support both academic and industrial research in the area of cerebral stroke therapy. A first statistical analysis of the retrieved information leads to the validation of our animal models and suggests a predictive and translational value for parameters related to a specific model. In particular, concerning gene expression data, we have applied a data analysis pipeline that initially takes into account an initial set of 64,000 genes and brings down the focus on a few tens of them

    Evidence Based Development of a Novel Lateral Fibula Plate (VariAx Fibula) Using a Real CT Bone Data Based Optimization Process During Device Development

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    Development of novel implants in orthopaedic trauma surgery is based on limited datasets of cadaver trials or artificial bone models. A method has been developed whereby implants can be constructed in an evidence based method founded on a large anatomic database consisting of more than 2.000 datasets of bones extracted from CT scans. The aim of this study was the development and clinical application of an anatomically pre-contoured plate for the treatment of distal fibular fractures based on the anatomical database

    Progetto di Parco scientifico e dell'istruzione superiore e Complesso per attività terziarie e culturali a Sesto S.Giovanni (MI)

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    in AA.VV., Architettura italiana da tre sedi universitarie. Milano-Bovisa Politecnico; Venezia I.U.A.V.; Roma, "La Sapienza" e Tor Vergata, a cura di E.Bordogna, Milano 2000

    Spatiotemporal amplitude and phase retrieval of space-time coupled ultrashort pulses using the Shackled-FROG technique

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    Abstract: We propose a new experimental technique, which allows for a complete characterization of ultrashort optical pulses both in space and in time. Combining the well-known Frequency-Resolved-Optical-Gating technique for the retrieval of the temporal profile of the pulse with a measurement of the near-field made with an Hartmann-Shack sensor, we are able to retrieve the spatiotemporal amplitude and phase profile of a Bessel-X pulse. By following the pulse evolution along the propagation direction we highlight the superluminal propagation of the pulse peak. Degiorgio, P. Di Trapani, "Complete retrieval of the field of ultrashort optical pulses using the angle-frequency spectrum," Opt. Lett. 33, 2952Lett. 33, -2955Lett. 33, (2008. 9. P. Migdal, P. Fita, C. Radzewicz, and L. Mazurek, "Wavefront sensor with Fresnel zone plates for use in an undergraduate laboratory," Am
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