Surface roughness and height-height correlations dependence on thickness of YBaCuO thin films

For high Tc superconducting multilayer applications, smooth interfaces between the individual layers are required. However, in general, e.g., YBaCuO grows in a 3D screw-dislocation or island nucleation growth mode, introducing a surface roughness. In this contribution we study the surface layer roughness as a function of different deposition techniques as well as deposition parameters. Special attention will be paid to the increase in film roughness with increasing film thickness. For these studies we used scanning probe microscopy. From these experiments, we obtained an island density decreasing with a square root dependence on the film thickness. Furthermore, height-height correlations indicate that the film growth can be described by a ballistic growth process, with very limited effective surface diffusion. The correlation lengths ¿ are on the order of the island size, inferring that the island size forms the mean diffusion barrier. This results in a representation of non-correlated islands, which can be considered as autonomous systems

An Assessment and Extension of the Mechanism-Based Approach to the Identification of Age-Period-Cohort Models.

: Many methods have been proposed to solve the age-period-cohort (APC) linear identification problem, but most are not theoretically informed and may lead to biased estimators of APC effects. One exception is the mechanism-based approach recently proposed and based on Pearl's front-door criterion; this approach ensures consistent APC effect estimators in the presence of a complete set of intermediate variables between one of age, period, cohort, and the outcome of interest, as long as the assumed parametric models for all the relevant causal pathways are correct. Through a simulation study mimicking APC data on cardiovascular mortality, we demonstrate possible pitfalls that users of the mechanism-based approach may encounter under realistic conditions: namely, when (1) the set of available intermediate variables is incomplete, (2) intermediate variables are affected by two or more of the APC variables (while this feature is not acknowledged in the analysis), and (3) unaccounted confounding is present between intermediate variables and the outcome. Furthermore, we show how the mechanism-based approach can be extended beyond the originally proposed linear and probit regression models to incorporate all generalized linear models, as well as nonlinearities in the predictors, using Monte Carlo simulation. Based on the observed biases resulting from departures from underlying assumptions, we formulate guidelines for the application of the mechanism-based approach (extended or not).<br/

Consequences of fragmentation for the ability to adapt to novel environments in experimental <i>Drosophila</i> metapopulations

We used experimental populations of Drosophila melanogaster, which had either been subdivided (metapopulations) or kept undivided for 40 generations, to study the consequences of population subdivision for the tolerance and adaptive response after six generations of exposure to novel environmental factors (high temperature, medium with ethanol or salt added) for traits with different genetic architectures. In this setup, we attempted to separate the effects of the loss of fitness due to inbreeding (i.e., the survival upon first exposure to stress) from the loss of adaptive potential due to the lack of genetic variation. To place our experimental results in a more general perspective, we used individual-based simulations combining different options of levels of gene flow, intensity of selection and genetic architecture to derive quantitative hypotheses of the effects of these factors on the adaptive response to stress. We observed that population subdivision resulted in substantial inter-deme variation in tolerance due to redistribution of genetic variation from within demes to among demes. In line with the simulation results, the adaptive response was generally lower in the subdivided than in the undivided populations, particularly so for high temperature. We observed pronounced differences between stress factors that are likely related to the different genetic architectures involved in resistance to these factors. From a conservation genetics viewpoint, our results have two important implications: (i) Long-term fragmentation in combination with restricted gene flow will limit the adaptive potential of individual subpopulations because adaptive variation will become distributed among populations rather than within populations. (ii) The genetic architecture of the trait(s) under selection is of great significance to understand the possible responses to novel stresses that may be expected

Boson induced s-wave pairing in dilute boson-fermion mixtures

We show that in dilute boson-fermion mixtures with fermions in two internal states, even when the bare fermion-fermion interaction is repulsive, the exchange of density fluctuations of the Bose condensate may lead to an effective fermion-fermion attraction, and thus to a Cooper instability in the s-wave channel. We give an analytical method to derive the associated $T_c$ in the limit where the phonon branch of the Bogoliubov excitation spectrum of the bosons is important. We find a $T_c$ of the same order as for a pure Fermi gas with bare attraction.Comment: 12 pages, no figure

Controlling the cold collision shift in high precision atomic interferometry

We present here a new method based on a transfer of population by adiabatic passage that allows to prepare cold atomic samples with a well defined ratio of atomic density and atom number. This method is used to perform a measurement of the cold collision frequency shift in a laser cooled cesium clock at the percent level, which makes the evaluation of the cesium fountains accuracy at the $10^{-16}$ level realistic. With an improved set-up, the adiabatic passage would allow measurements of atom number-dependent phase shifts at the $10^{-3}$ level in high precision experiments.Comment: 4 pages, 3 figures, 2 table

Thermodynamic properties of confined interacting Bose gases - a renormalization group approach

A renormalization group method is developed with which thermodynamic properties of a weakly interacting, confined Bose gas can be investigated. Thereby effects originating from a confining potential are taken into account by periodic boundary conditions and by treating the resulting discrete energy levels of the confined degrees of freedom properly. The resulting density of states modifies the flow equations of the renormalization group in momentum space. It is shown that as soon as the characteristic length of confinement becomes comparable to the thermal wave length of a weakly interacting and trapped Bose gas its thermodynamic properties are changed significantly. This is exemplified by investigating characteristic bunching properties of the interacting Bose gas which manifest themselves in the second order coherence factor

The Kohn mode for trapped Bose gases within the dielectric formalism

The presence of undamped harmonic center of mass oscillations of a weakly interacting Bose gas in a harmonic trap is demonstrated within the dielectric formalism for a previously introduced finite temperature approximation including exchange. The consistency of the approximation with the Kohn theorem is thereby demonstrated. The Kohn modes are found explicitly, generalizing an earlier zero-temperature result found in the literature. It is shown how the Kohn mode disappears from the single-particle spectrum, while remaining in the density oscillation spectrum, when the temperature increases from below to above the condensation temperature.Comment: 6 pages revte

Transition Temperature of a Uniform Imperfect Bose Gas

We calculate the transition temperature of a uniform dilute Bose gas with repulsive interactions, using a known virial expansion of the equation of state. We find that the transition temperature is higher than that of an ideal gas, with a fractional increase K_0(na^3)^{1/6}, where n is the density and a is the S-wave scattering length, and K_0 is a constant given in the paper. This disagrees with all existing results, analytical or numerical. It agrees exactly in magnitude with a result due to Toyoda, but has the opposite sign.Comment: Email correspondence to [email protected] ; 2 pages using REVTe

Establishment and characterization of immortalized Gli-null mouse embryonic fibroblast cell lines

<p>Abstract</p> <p>Background</p> <p>Hedgehog (Hh) signaling is a conserved morphogenetic pathway which plays critical roles in embryonic development, with emerging evidence also supporting a role in healing and repair processes and tumorigenesis. The Gli family of transcription factors (Gli1, 2 and 3) mediate the Hedgehog morphogenetic signal by regulating the expression of downstream target genes. We previously characterized the individual and cooperative roles of the Gli proteins in Hh target gene regulation using a battery of primary embryonic fibroblasts from Gli null mice.</p> <p>Results</p> <p>Here, we describe the establishment of spontaneously immortalized mouse embryonic fibroblast (iMEF) cell lines lacking single and multiple Gli genes. These non-clonal cell lines recapitulate the unique ligand mediated transcriptional response of primary MEFs. While loss of Gli1 had no effect on target gene induction, Gli2 null cells demonstrated reduced target gene induction while Gli3 null cells exhibited elevated basal and ligand-induced expression. Target gene response in <it>Gli1</it>^-/-<it>2</it>^-/-iMEFs was severely reduced while <it>Gli2</it>^-/-<it>3</it>^-/-iMEFs were incapable of ligand-induced transcriptional response. However, we found that both <it>Gli1</it>^-/-<it>2</it>^-/-and <it>Gli2</it>^-/-<it>3</it>^-/-iMEFs exhibited robust leukotriene synthesis-dependent migration responses to Hh ligand, demonstrating that this response is not transcriptionally-dependent.</p> <p>Conclusion</p> <p>This study provides fundamental characterizations of the transcriptional and non-transcriptional Hh responsiveness of a battery of Gli-null iMEFs. Moving forward, these cell lines should prove a valuable tool set to study the unique functional regulation of the Gli proteins in a Hh-responsive cell-type.</p