Polymorphisme de l’apolipoprotéine E dans la population du nord du Maroc: fréquence et influence sur les paramètres lipidiques

Introduction: L'objectif de ce travail est de déterminer les fréquences alléliques et génotypiques des sites polymorphes situés dans le gène de l'apolipoprotéine E (apo E) ainsi que leur impact sur les paramètres cliniques et lipidiques dans un échantillon de la population du nord du Maroc cliniquement diagnostiqué ADH. Méthodes: Le génotype de l'apo E a été analysé par séquençage direct chez 46 patients cliniquement diagnostiqués ADH selon les critères standards. Résultats: Les fréquences des allèles epsilon 3, epsilon 2 et epsilon 4 ont été respectivement 78.3%, 2.2% et 19.6%. La fréquence de l'allèle epsilon 4 est très élevée chez la population du nord du Maroc en comparaison avec les populations des autres régions marocaines. Elle est similaire à celle rapportée dans les pays de l'Europe du nord. Les taux du cholestérol total, du cholestérol LDL ainsi que la présence des xanthomes et les maladies cardiovasculaires ne différent pas entre les génotypes de l'apoE. En revanche, les résultats ont montré une influence de l'allèle epsilon4 sur le taux des triglycérides chez les sujets obèses. Conclusion: Le génotype de l'apoE ne peut expliquer le phénotype clinique et biochimique présenté par des patients du Nord du Maroc cliniquement diagnostiqués ADH.Key words: Paramètres lipidiques, Maladies cardiovasculaires, Polymorphisme génétique, Gène APO

Analytical and experimental study of electrical conductivity in the lithium tantalate nonstoichiometric structure

We have been interested to experimental and analytical studies of ionic conductivity of nonstoichiometric LiTaO3 solid solutions. Theoretical approach combined with lithium and tantalate vacancy models has been performed. A comparative study between the calculated and measured values is presented taking into account the temperature and composition effects on the conductivity.We have been interested to experimental and analytical studies of ionic conductivity of nonstoichiometric LiTaO3 solid solutions. Theoretical approach combined with lithium and tantalate vacancy models has been performed. A comparative study between the calculated and measured values is presented taking into account the temperature and composition effects on the conductivity

First and second-order derivatives for CP and INDSCAL

In this paper we provide the means to analyse the second-order differential structure of optimization functions concerning CANDECOMP/PARAFAC and INDSCAL. Closed-form formulas are given under two types of constraint: unit-length columns or orthonormality of two of the three component matrices. Some numerical problems that might occur during the computation of the Jacobian and Hessian matrices are addressed. The use of these matrices is illustrated in three applications. (C) 2010 Elsevier B.V. All rights reserved

Tumeurs des deux surrénales. A propos d’un cas

Les tumeurs surrénaliennes bilatérales sont rares. Nous rapportons un cas de phéochromocytome surrénalien associé à un corticosurrénalome controlatéral chez une patiente de 65 ans. L’association d’une hypertension artérielle à des céphalées, sueurs, et palpitations a orienté vers le diagnostic de phéochromocytome. Le bilan biologique basé sur le dosage urinaire des dérivés méthoxylés a confirmé ce diagnostic. L’échographie et le scanner ont montré la présence de deux massessurrénaliennes bilatérales de structure tissulaire. Les deux masses sont discrètement rehaussées après injection du produit de contraste. Devant ce tableau clinique, biologique et morphologique, le diagnostic de phéochromocytome surrénalien bilatéral est retenu. Par conséquent unesurrénalectomie bilatérale par voie bi-sous-costale a été réalisée. L’examen anatomopathologique a révélé la coexistence d’un phéochromocytome sur la pièce de surrénalectomie droite et d’un carcinome corticosurrénalien sur la pièce de surrénalectomie gauche, ce qui était imprévu. Les suites opératoires ont été bonnes, sans récidive, avec un recul de 4 ans. A la lumière de cette observation et d’une revue de la littérature, nous discutons les différentes  caractéristiques de cetteassociation inhabituelle

Application of the JJ-matrix Method to Faddeev-Merkuriev equation: beyond pseudostates

A version of the $J$-matrix method for solving numerically the three-body Faddeev-Merkuriev differential equations is proposed. This version allows to take into account the full spectrum of the two-body Coulomb subsystem. As a result, a discrete analog of the Lippmann-Schwinger equation is obtained which allows to interpret correctly the three-body wave function in two-body domains. The scheme is applied to calculations of the fully resolved absolute differential cross sections for the He$(e,2e)$He$^+$ and He$(e,3e)$He$^{++}$ reactions at small energy and momentum transfers. The results are in good agreement with the experiment both in shape and in absolute value.Comment: 22 pages, 7 figure

Shared detection of Porphyromonas gingivalis in cohabiting family members: a systematic review and meta-analysis

Introduction: Periodontitis is an inflammatory dysbiotic disease. Among putative dysbiosis causes, transmission of Porphyromonas gingivalis between individuals of the same family remains unclear. The aim of this systematic review and meta-analysis is to assess the likelihood of shared detection of Porphyromonas gingivalis among cohabiting family members. Methods: A literature search?was conducted on different databases up to September 2018. Articles assessing the presence of P.gingivalis between members of the same family were screened. Only English literature was retrieved, whereas no limits were applied for bacterial sampling and detection methods. Results: Overall, 26 articles published between 1993 and 2017 met the inclusion criteria. Of these, 18 articles were used for meta-analyses. Based on bacterial culture, the likelihood of an intra-familial transmission of P.gingivalis once a member of the family harbors the bacterium is estimated at 63.5% (n = 132 pairs of family members); this drops to 45% when pooling together culture and Polymerase-Chain-Reaction (n = 481 pairs), whereas it is estimated at 35.7% when genotyping is applied (n = 137 pairs). Conclusion: Pooled results suggest that the likelihood of detecting P.gingivalis within within family members is moderately frequent. Personalized periodontal screening and prevention may consider intra-familial co-occurrence of P.gingivalis as feasible

Genetic gain of grain yield and quality in bread wheat cultivars representing 40 years of breeding in Morocco

Background. Knowledge about the genetic gain for fundamental traits over time is essential for a critical assessment and improvement of breeding programs, especially regarding staple crops like bread wheat.Materials and methods. To estimate the genetic gain in bread wheat breeding in Morocco, grain yield (GY) and grain protein content (GPC) data were collected from 12 multi-environment field trials for 20 bread wheat cultivars released between 1980 and 2022.Results and discussion. Analysis of variance highlighted a high significant variability between environments (E), cultivars (G), and a significant G × E interaction (P < 0.001). Based on stability analysis, the modern cultivars released during the two last decades (2002–2012 and 2013–2022) showed the highest performances and wider stability than old ones, especially in low-yielding environments. Genetic gain (GG) for GY was 21.4 kg ha−1 yr−1 (0.75% yr–1) over 4 decades of breeding. This progress was declining when advancing in decades and ranged from 11% (from 1980–1990 to 1991–2001) to less than 7% (from 2002–2012 to 2013–2022). The GG in low and intermediate yielding environments were the most important (17.34% and 6.88% yr–1 respectively), while GG was nonsignificant in high-yielding environments (4.62% yr–1). Within the same period, GPC showed a nonsignificant negative trend of –0.007% (–0.002% yr–1), while derivative parameters from GY and GPC indicated high positive genetic progress. More efforts should be deployed to implement a good balance between yield performance and quality in the new released cultivars despite the negative correlation between these two traits (r = –0.36; P < 0.001).Conclusion. Adopting advanced technologies, like genomic selection, adequate agronomic practices, and more efficient selection criteria are essential steps to further increase simultaneously grain yield and quality traits

The immunophenotype of adult t acute lymphoblastic leukemia in Morocco

Background: There is paucity of detailed studies of adult T cell acute lymphoblastic leukemia (T-ALL) in developing countries reflecting the condition of these patients including clinical and biological features. Objective: This study was carried out to analyze the immunophenotypic characteristics of 40 Moroccan patients with T-ALL and its association with biological and clinical features. Patients and Methods: Between 2006 and 2009, 130 adult patients diagnosed with acute lymphoblastic leukemia (ALL) were immunophenotyped by 3-color flow cytometry using a panel of monoclonal antibodies. Cases presenting features of a T-lineage phenotype were subjected to detailed analysis including immunophenotypic, clinical and biological parameters. Results: Proportion of T-ALL among ALL Moroccan patients was 31.0%. Median age of patients was 28 years. Twenty-nine patients were females and 11 were males. 45.0% of patients (18/40) had features of immature T-ALL stages (pro-T and pre-T ALL), 30.0% (12/40) of CD1a+ cortical T-ALL stage and 25.0% (10/40) had a characteristic phenotype of medullary T-ALL. The frequencies of progenitor cell markers CD10, CD34 and TdT expression were 14.0; 57.5% and 50.0% respectively. The aberrant expression of B li­neage associated antigen CD79a were positive in 20.5% of the cases and the aberrant expression of myeloid antigens CD13 and/or CD33 was found in 22 (55.0%) cases. No significant association was encountered between TdT, CD34 or myeloid antigens positivity and high risk features at presentation as age, sex, and white blood cells. However, myeloid antigens (CD13 and/or CD33) was significantly associated with T-cell maturation stages (p = 0.009). Conclusion: To the best of our knowledge, this is the first report from North Africa of immunophenotypic study on adult T-ALL. Our findings indicate that the proportion of T-ALL among ALL in Morocco is similar to that reported in others Mediterranean countries like France and Italy and that myeloid-associated antigens expression is frequently associated with immature immunophenotype. Key Words: adult T cell acute lymphoblastic leukemia, immunophenotypic analysis, immunological subtypes, myeloid and T-cell antigens