1,581 research outputs found
On the growth of the Bergman kernel near an infinite-type point
We study diagonal estimates for the Bergman kernels of certain model domains
in near boundary points that are of infinite type. To do so, we
need a mild structural condition on the defining functions of interest that
facilitates optimal upper and lower bounds. This is a mild condition; unlike
earlier studies of this sort, we are able to make estimates for non-convex
pseudoconvex domains as well. This condition quantifies, in some sense, how
flat a domain is at an infinite-type boundary point. In this scheme of
quantification, the model domains considered below range -- roughly speaking --
from being ``mildly infinite-type'' to very flat at the infinite-type points.Comment: Significant revisions made; simpler estimates; very mild
strengthening of the hypotheses on Theorem 1.2 to get much stronger
conclusions than in ver.1. To appear in Math. An
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Time Course of Changes in Peripheral Blood Gene Expression During Medication Treatment for Major Depressive Disorder.
Changes in gene expression (GE) during antidepressant treatment may increase understanding of the action of antidepressant medications and serve as biomarkers of efficacy. GE changes in peripheral blood are desirable because they can be assessed easily on multiple occasions during treatment. We report here on GE changes in 68 individuals who were treated for 8 weeks with either escitalopram alone, or escitalopram followed by bupropion. GE changes were assessed after 1, 2, and 8 weeks of treatment, with significant changes observed in 156, 121, and 585 peripheral blood gene transcripts, respectively. Thirty-one transcript changes were shared between the 1- and 8-week time points (seven upregulated, 24 downregulated). Differences were detected between the escitalopram- and bupropion-treated subjects, although there was no significant association between GE changes and clinical outcome. A subset of 18 genes overlapped with those previously identified as differentially expressed in subjects with MDD compared with healthy control subjects. There was statistically significant overlap between genes differentially expressed in the current and previous studies, with 10 genes overlapping in at least two previous studies. There was no enrichment for genes overexpressed in nervous system cell types, but there was a trend toward enrichment for genes in the WNT/β-catenin pathway in the anterior thalamus; three genes in this pathway showed differential expression in the present and in three previous studies. Our dataset and other similar studies will provide an important source of information about potential biomarkers of recovery and for potential dysregulation of GE in MDD
Geometric phase around exceptional points
A wave function picks up, in addition to the dynamic phase, the geometric
(Berry) phase when traversing adiabatically a closed cycle in parameter space.
We develop a general multidimensional theory of the geometric phase for
(double) cycles around exceptional degeneracies in non-Hermitian Hamiltonians.
We show that the geometric phase is exactly for symmetric complex
Hamiltonians of arbitrary dimension and for nonsymmetric non-Hermitian
Hamiltonians of dimension 2. For nonsymmetric non-Hermitian Hamiltonians of
higher dimension, the geometric phase tends to for small cycles and
changes as the cycle size and shape are varied. We find explicitly the leading
asymptotic term of this dependence, and describe it in terms of interaction of
different energy levels.Comment: 4 pages, 1 figure, with revisions in the introduction and conclusio
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Concomitant medication use and clinical outcome of repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder.
BackgroundRepetitive Transcranial Magnetic Stimulation (rTMS) is commonly administered to Major Depressive Disorder (MDD) patients taking psychotropic medications, yet the effects on treatment outcomes remain unknown. We explored how concomitant medication use relates to clinical response to a standard course of rTMS.MethodsMedications were tabulated for 181 MDD patients who underwent a six-week rTMS treatment course. All patients received 10 Hz rTMS administered to left dorsolateral prefrontal cortex (DLPFC), with 1 Hz administered to right DLPFC in patients with inadequate response to and/or intolerance of left-sided stimulation. Primary outcomes were change in Inventory of Depressive Symptomatology Self Report (IDS-SR30) total score after 2, 4, and 6 weeks.ResultsUse of benzodiazepines was associated with less improvement at week 2, whereas use of psychostimulants was associated with greater improvement at week 2 and across 6 weeks. These effects were significant controlling for baseline variables including age, overall symptom severity, and severity of anxiety symptoms. Response rates at week 6 were lower in benzodiazepine users versus non-users (16.4% vs. 35.5%, p = 0.008), and higher in psychostimulant users versus non-users (39.2% vs. 22.0%, p = 0.02).ConclusionsConcomitant medication use may impact rTMS treatment outcome. While the differences reported here could be considered clinically significant, results were not corrected for multiple comparisons and findings should be replicated before clinicians incorporate the evidence into clinical practice. Prospective, hypothesis-based treatment studies will aid in determining causal relationships between medication treatments and outcome
Potato breeding methods 2: selection in inbred lines
This archival publication may not reflect current scientific knowledge or recommendations
3D integrated superconducting qubits
As the field of superconducting quantum computing advances from the few-qubit
stage to larger-scale processors, qubit addressability and extensibility will
necessitate the use of 3D integration and packaging. While 3D integration is
well-developed for commercial electronics, relatively little work has been
performed to determine its compatibility with high-coherence solid-state
qubits. Of particular concern, qubit coherence times can be suppressed by the
requisite processing steps and close proximity of another chip. In this work,
we use a flip-chip process to bond a chip with superconducting flux qubits to
another chip containing structures for qubit readout and control. We
demonstrate that high qubit coherence (, s) is
maintained in a flip-chip geometry in the presence of galvanic, capacitive, and
inductive coupling between the chips
Anisotropic fragmentation in low-energy dissociative recombination
On a dense energy grid reaching up to 75 meV electron collision energy the
fragmentation angle and the kinetic energy release of neutral dissociative
recombination fragments have been studied in a twin merged beam experiment. The
anisotropy described by Legendre polynomials and the extracted rotational state
contributions were found to vary on a likewise narrow energy scale as the
rotationally averaged rate coefficient. For the first time angular dependences
higher than 2 order could be deduced. Moreover, a slight anisotropy at
zero collision energy was observed which is caused by the flattened velocity
distribution of the electron beam.Comment: 8 pages, 4 figures; The Article will be published in the proceedings
of DR 2007, a symposium on Dissociative Recombination held in Ameland, The
Netherlands (18.-23. July 2008); Reference 19 has been published meanwhile in
S. Novotny, PRL 100, 193201 (2008
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