Growth pattern of tumours in mice induced by murine Moloney sarcoma-virus and sarcoma-virus-transformed cells.

Transplantation of a Moloney sarcoma-virus (MSV-M)-transformed producer cell line (Sac(+)) induced progressively or regressively growing tumours in mice. Progressive growth always occurred after transplantation of an MSV-M non-producer transformant (Sac(-)), whereas the MSV-M released from the producer cells (Sac virus) always induced tumours which regressed. In contrast to the non-producer, the producer transformant Sac(+) as well as Sac virus induced a strong immune response, detected in vitro by cell- and antibody-mediated cytotoxicity assays, and in vivo by transplantation immunity. Implantation of Sac(-) cells led to solid, under-vascularized tumours, consisting histologically of uniform densely packed tumour cells. Sac-virus-induced tumours, however, were very well vascularized and arose by proliferation of different connective-tissue cells. After transplantation of Sac(+) cells, tumours were found to consist of typical tumour cells morphologically similar to Sac(-) cells intermingled with proliferated connective-tissue cells. Cultivation of tumour fragments from Sac(+) and Sac(-) tumours was followed by outgrowth of transformed tumour cells with the properties of the originally implanted cells. Tumour explant cultures from Sac-virus-induced tumours did not lead to growth of stably transformed cells. Co-culture of mouse embryo fibroblasts (MEF) with Sac(+) cells resulted in overgrowth of the transformed cells. Infection of MEF with Sac virus led to transiently transformed cells. It is concluded that Sac(+) cell tumours will resist the strong immune defence mechanisms they induce and grow progressively, if the inoculated cells are able to build up a solid, poorly vascularized nodule in the tissue. This always happens after implantation of 10(6) cells, but only occasionally when fewer cells are inoculated. Sac-virus-induced tumours will always regress owing to the strong immune response. The regression is furthered by the fact that MSV-M infection rarely if ever leads to a stable transformation

Heat-transfer characteristics of a water-to- cryogenic-hydrogen heat exchanger

Heat transfer characteristics of water/cryogenic hydrogen heat exchanger for nuclear rocket reacto

Measurement of Local Heat Transfer Coefficients for Flow of Hydrogen and Helium in a Smooth Tube at High Surface to Fluid Bulk Temperature Ratios

Local values of heat transfer coefficients have been measured experimentally for helium and hydrogen gas flowing through an electrically heated inconel tube. The experiment was conducted primarily to determine the effect on the heat transfer coefficient of a large density change, radially, in the heat transfer fluid. This large density change was accomplished with relatively high surface temperatures as compared to fluid bulk temperatures or more commonly referred to as high surface to fluid bulk temperature ratio. The large temperature ratio was achieved by precooling the gas with liquid nitrogen. Data were measured for local values of surface to fluid bulk temperature ratios up to 4.5, Reynolds numbers in the turbulent flow region, surface temperatures up to 2300 R, heat flux up to 1,600,000 Btu/(hr)(sq ft) and length to diameter ratio of 250. A comparison of this data with the conventional heat transfer correlation equation (Dittus-Boelter eq.) is shown on a curve of Nusselt number divided by Prandtl number versus the Reynolds number. The gas properties were evaluated at the film temperature and the Reynolds number was modified by evaluating the velocity term at the fluid bulk temperature and the density at the film temperature

When can Fokker-Planck Equation describe anomalous or chaotic transport?

The Fokker-Planck Equation, applied to transport processes in fusion plasmas, can model several anomalous features, including uphill transport, scaling of confinement time with system size, and convective propagation of externally induced perturbations. It can be justified for generic particle transport provided that there is enough randomness in the Hamiltonian describing the dynamics. Then, except for 1 degree-of-freedom, the two transport coefficients are largely independent. Depending on the statistics of interest, the same dynamical system may be found diffusive or dominated by its L\'{e}vy flights.Comment: 4 pages. Accepted in Physical Review Letters. V2: only some minor change

Lepton flavor violation in low-scale seesaw models: SUSY and non-SUSY contributions

Taking the supersymmetric inverse seesaw mechanism as the explanation for neutrino oscillation data, we investigate charged lepton flavor violation in radiative and 3-body lepton decays as well as in neutrinoless $\mu-e$ conversion in muonic atoms. In contrast to former studies, we take into account all possible contributions: supersymmetric as well as non-supersymmetric. We take CMSSM-like boundary conditions for the soft supersymmetry breaking parameters. We find several regions where cancellations between various contributions exist, reducing the lepton flavor violating rates by an order of magnitude compared to the case where only the dominant contribution is taken into account. This is in particular important for the correct interpretation of existing data as well as for estimating the reach of near future experiments where the sensitivity will be improved by one to two orders of magnitude. Moreover, we demonstrate that ratios like BR($\tau\to 3 \mu$)/BR($\tau\to \mu e^+ e^-$) can be used to determine whether the supersymmetric contributions dominate over the $W^\pm$ and $H^\pm$ contributions or vice versa.Comment: 75 pages, 7 figures. v3: references and comments added. Matches published versio

A multi-sensor system for robotics proximity operations

Robots without sensors can perform only simple repetitive tasks and cannot cope with unplanned events. A multi-sensor system is needed for a robot to locate a target, move into its neighborhood and perform operations in contact with the object. Systems that can be used for such tasks are described

Flight Hardware Fabricated for Combustion Science in Space

NASA Glenn Research Center s Telescience Support Center (TSC) allows researchers on Earth to operate experiments onboard the International Space Station (ISS) and the space shuttles. NASA s continuing investment in the required software, systems, and networks provides distributed ISS ground operations that enable payload developers and scientists to monitor and control their experiments from the Glenn TSC. The quality of scientific and engineering data is enhanced while the long-term operational costs of experiments are reduced because principal investigators and engineering teams can operate their payloads from their home institutions