Cross-tolerance to abiotic stresses in halophytes: Application for phytoremediation of organic pollutants

International audienceHalopytes are plants able to tolerate high salt concentrations but no clear definition was retained for them. In literature, there are more studies that showed salt-enhanced tolerance to other abiotic stresses compared to investigations that found enhanced salt tolerance by other abiotic stresses in halophytes. The phenomenon by which a plant resistance to a stress induces resistance to another is referred to as cross-tolerance. In this work, we reviewed cross-tolerance in halophytes at the physiological, biochemical, and molecular levels. A special attention was accorded to the cross-tolerance between salinity and organic pollutants that could allow halophytes a higher potential of xenobiotic phytoremediation in comparison with glycophytes

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 x10(-8)), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD

Robust second order sliding mode controller for electropneumatic actuator

International audienceThis paper deals with the robust control problem of a pneumatic actuator subjected to parameters uncertainties and load disturbances. The control strategies are based on second order sliding mode approaches. Implementation results of the proposed sliding mode control schemes on an experimental set-up are given to illustrate the developments

Seismic Evaluation and Innovative Retrofit of a Historical Building in Tunisia

This paper summarizes work conducted within the framework of a European Commission funded project on the use of appropriate modern seismic protective systems in the conservation of Mediterranean historical buildings in earthquake-prone areas. The case study is the one-and-a-half-century-old Palace of Ksar Said, located near the Capital of Tunisia. At the center of the palace, a collection of portraits and furniture are preserved in a room of great architectural and historical value which is the most precious part of the building to be protected. Ambient vibration tests were conducted to measure the acceleration at selected locations of the building. Output-only modal identification techniques were applied to extract the modal signature of the structure. A finite element model of the palace was elaborated based on the measured characteristics of stone and mortar and updated according to its measured vibratory response. Seismic vulnerability assessment of the building was carried out via three-dimensional time-history dynamic analyses of the structure. Results indicate a high vulnerability that confirms the need for intervention. A retrofit scheme is proposed that consists of a steel frame directly, attached to the portrait room structure with added fluid viscous dampers. Vulnerability assessment of the retrofitted building reveals a substantial improvement especially in the vicinity of the portrait room. Copyright © 2004 John Wiley & Sons, Ltd