10 research outputs found
Les microARNs
MiRNAs are small non-coding RNAs ensuring the post-transcriptional regulation of gene expression. Their expression is tissue-specific and some miRNAs have diagnostic and / or prognostic value for tumor classes. MiRNAs are involved in tumorigenesis by two mechanisms: amplification or deletion of chromosomal regions containing clusters of genes encoding miRNAs (quantitative effect) or modification of the effects of miRNAs on their target genes by mutation in the region of interaction with the mRNA (qualitative effect). Their specificity, the possibility for miRNA measurement in blood, must now lead to consider miRNAs as markers for therapeutic management. A better understanding of the different regulatory mechanisms involving miRNAs will also consider new therapeutic approaches
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Prototyping the BOPTEST framework for simulation-based testing of advanced control strategies in buildings
Advanced control strategies are becoming increasingly necessary in buildings in order to meet and balance requirements for energy efficiency, demand flexibility, and occupant comfort. Additional development and widespread adoption of emerging control strategies, however, ultimately require low implementation costs to reduce payback period and verified performance to gain control vendor, building owner, and operator trust. This is difficult in an already first-cost driven and risk-averse industry. Recent innovations in building simulation can significantly aid in meeting these requirements and spurring innovation at early stages of development by evaluating performance, comparing state-of-the-art to new strategies, providing installation experience, and testing controller implementations. This paper presents the development of a simulation framework consisting of test cases and software platform for the testing of advanced control strategies (BOPTEST - Building Optimization Performance Test). The objectives and requirements of the framework, components of a test case, and proposed software platform architecture are described, and the framework is demonstrated with a prototype implementation and example test case
The second Sandia Fracture Challenge: predictions of ductile failure under quasi-static and moderate-rate dynamic loading
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Prototyping the BOPTEST framework for simulation-based testing of advanced control strategies in buildings
Advanced control strategies are becoming increasingly necessary in buildings in order to meet and balance requirements for energy efficiency, demand flexibility, and occupant comfort. Additional development and widespread adoption of emerging control strategies, however, ultimately require low implementation costs to reduce payback period and verified performance to gain control vendor, building owner, and operator trust. This is difficult in an already first-cost driven and risk-averse industry. Recent innovations in building simulation can significantly aid in meeting these requirements and spurring innovation at early stages of development by evaluating performance, comparing state-of-the-art to new strategies, providing installation experience, and testing controller implementations. This paper presents the development of a simulation framework consisting of test cases and software platform for the testing of advanced control strategies (BOPTEST - Building Optimization Performance Test). The objectives and requirements of the framework, components of a test case, and proposed software platform architecture are described, and the framework is demonstrated with a prototype implementation and example test case