83 research outputs found
Quantum bistability and spin current shot noise of a single quantum dot coupled to an optical microcavity
Here we explore spin dependent quantum transport through a single quantum dot
coupled to an optical microcavity. The spin current is generated by electron
tunneling between a single doped reservoir and the dot combined with intradot
spin flip transitions induced by a quantized cavity mode. In the limit of
strong Coulomb blockade, this model is analogous to the Jaynes-Cummings model
in quantum optics and generates a pure spin current in the absence of any
charge current. Earlier research has shown that in the classical limit where a
large number of such dots interact with the cavity field, the spin current
exhibits bistability as a function of the laser amplitude that drives the
cavity. We show that in the limit of a single quantum dot this bistability
continues to be present in the intracavity photon statistics. Signatures of the
bistable photon statistics manifest themselves in the frequency dependent shot
noise of the spin current despite the fact that the quantum mechanical average
spin current no longer exhibits bistability. Besides having significance for
future quantum dot based optoelectronic devices, our results shed light on the
relation between bistability, which is traditionally viewed as a classical
effect, and quantum mechanics
Neonatal acute liver failure with pulmonary yellow hyaline membrane and kernicterus
Background: Neonatal acute liver failure (NALF) is a rare and life-threatening condition. It causes bilirubin to accumulate to a dangerous level in the body, causing permanent damage to vital organs such as the brain and lungs. In many cases, the etiology of NALF remains unknown. Case presentation: We described a case of an 8-day-old baby girl who presented with poor oral intake, lethargy, and jaundice. Her clinical condition rapidly deteriorated with progression to multi-organ failure, and despite intensive resuscitation efforts, she expired. At autopsy, the most significant findings were liver necrosis, yellow hyaline membrane deposition in the lungs, and bilirubin deposition in the brain (kernicterus). Conclusions: NALF is a rare and potentially fatal condition necessitating prompt recognition and disease-specific treatment approaches. Toxic accumulation of bilirubin in the lungs can lead to hypoxia and precipitate further ischemic injury to the liver
The potential role of the extracellular matrix in the activity of trabectedin in UPS and L-sarcoma: evidences from a patientâderived primary culture case series in tridimensional and zebrafish models
Background: Soft tissue sarcomas (STS) are a rare group of solid neoplasm including among others liposarcoma, leiomyosarcoma (L-sarcoma) and undifferentiated pleomorphic sarcoma (UPS) entities. The current first-line treatment is represented by anthracycline based- regimens, second-line may include trabectedin. Currently the activity of trabectedin and its mechanism of action is not completely elucidated. Methods: Taking the advantages of our 3D patient-derived primary culture translational model we performed genomic-, chemobiogram, proteomic- and in vivo analysis in a UPS culture (S1). Furthermore pharmacological profiling of a UPS and L-sarcoma patient-derived case series and in silico analysis were carried out. Results: Trabectedin exhibited an increased activity in 3D respect to 2D cultures suggesting an extracellular matrix (ECM) and timp1 involvement in its mechanism of action. Moreover 3D S1 xenotranspanted zebrafish model showed an increased sensitivity to trabectedin. Finally the results were further validated in a UPS and L-sarcoma case series. Conclusions: Taken together these results confirmed the activity of trabectedin in these STS histotypes. Moreover the data underline the ECM involvement in the cytotoxic effect mediated by trabectedin and could open the door for researches aimed to focus on the patient setting that could benefit from this agent
Innovative approaches to establish and characterize primary cultures: an ex vivo 3D system and the zebrafish model
Animal science
Development of a Patient-Derived Xenograft (PDX) of Breast Cancer Bone Metastasis in a Zebrafish Model
Animal science
Metastatic chromophobe renal cell carcinoma treated with targeted therapies: A Renal Cross Channel Group study
Background: Treatment of nonâclear cell renal cell carcinoma (RCC) remains controversial despite several recent prospective studies of targeted therapies (TT). Often Vascular Endothelial growth Factor (VEGF) and Mammalian Target of Rapamycin (mTOR) inhibitors are used, extrapolating the data from use of these agents in clear cell RCC. Methods: We performed a retrospective data analysis within the Renal Cross Channel Group to determine metastatic chromophobe RCC (mChRCC) outcomes in the TT era. The end-points were overall response, overall survival (OS) and time to treatment failure (TTF). The two latter were estimated using the KaplanâMeier method. Results: 91 mChRCC patients from 26 centres were included. Median follow-up from the date of first metastasis was 6.1 years (range: 0â13.9). Median OS was 37.9 months (95% confidence interval [CI]: 21.4â46.8) from the diagnosis of metastatic disease. Among the 61 patients who received TT, 50 (82%) were treated with anti-angiogenic (AA) and 11 with mTOR inhibitors. Median TTF and OS in patients receiving a first line of AA was 8.7 months (95% CI: 5.2â10.9) and 22.9 months (95% CI: 17.8â49.2) versus 1.9 months (95% CI: 1.0â6.0) and 3.2 months (95% CI: 2.3ânot evaluable) with mTOR inhibitors, respectively. A stratified log-rank test was used to compare AA and mTOR inhibitors TT, while controlling the effect of the International Metastatic RCC Database Consortium risk group and no significant difference between AA and mTOR inhibitors was observed for TTF (p = 0.26) or for OS (p = 0.55). Conclusion: We report the largest retrospective cohort of patients with mChRCC treated with TT and no significant difference between AA and mTOR inhibitors was observed for TTF and OS
Metastatic chromophobe renal cell carcinoma treated with targeted therapies: A Renal Cross Channel Group study
Treatment of nonâclear cell renal cell carcinoma (RCC) remains controversial despite several recent prospective studies of targeted therapies (TT). Often Vascular Endothelial growth Factor (VEGF) and Mammalian Target of Rapamycin (mTOR) inhibitors are used, extrapolating the data from use of these agents in clear cell RCC.
We performed a retrospective data analysis within the Renal Cross Channel Group to determine metastatic chromophobe RCC (mChRCC) outcomes in the TT era. The end-points were overall response, overall survival (OS) and time to treatment failure (TTF). The two latter were estimated using the KaplanâMeier method.
91 mChRCC patients from 26 centres were included. Median follow-up from the date of first metastasis was 6.1 years (range: 0â13.9). Median OS was 37.9 months (95% confidence interval [CI]: 21.4â46.8) from the diagnosis of metastatic disease. Among the 61 patients who received TT, 50 (82%) were treated with anti-angiogenic (AA) and 11 with mTOR inhibitors. Median TTF and OS in patients receiving a first line of AA was 8.7 months (95% CI: 5.2â10.9) and 22.9 months (95% CI: 17.8â49.2) versus 1.9 months (95% CI: 1.0â6.0) and 3.2 months (95% CI: 2.3ânot evaluable) with mTOR inhibitors, respectively. A stratified log-rank test was used to compare AA and mTOR inhibitors TT, while controlling the effect of the International Metastatic RCC Database Consortium risk group and no significant difference between AA and mTOR inhibitors was observed for TTF (p = 0.26) or for OS (p = 0.55).
We report the largest retrospective cohort of patients with mChRCC treated with TT and no significant difference between AA and mTOR inhibitors was observed for TTF and OS
Consumo alimentar de crianças de 12 a 30 meses que frequentam Centros Municipais de Educação Infantil no municĂpio de Colombo, Sul do Brasil
Understanding the United States and Brazilâs response to obesity: institutional conversion, policy reform, and the lessons learned
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