Traitement de la schistosomiase à S. mansoni : quelle alternative au praziquantel ?

Les schistosomiases sont des maladies parasitaires causées par des helminthes du genre Schistosoma (S.) qui touchent 200 millions de personnes dans le monde, mais restent rares chez le voyageur. Contrairement à S. heamatobium, agent de la bilharziose urinaire, S. mansoni, présent en Afrique subsaharienne, en Egypte ainsi qu'aux Antilles, au Surinam et dans le nordest du Brésil, est responsable des formes hépato-intestinales de la maladie. Les larves, vivant en eaux douces contaminées par des selles infectées, peuvent pénétrer la peau des baigneurs sans que l'individu ne s'en rende compte. Les parasites adultes s'établissent dans le système veineux digestif où ils se reproduisent et excrètent des oeufs qui migreront dans la lumière intestinale. Cette revue systématique évalue les effets des médicaments antibilharziens, utilisés seuls ou en association, pour traiter l'infection à S. mansoni

High-resolution Observations of OH(1720 MHz) Masers Toward the Galactic Center

High-resolution VLA observations of 1720 MHz OH maser emission from Sgr A East and the circumnuclear disk with spatial and spectral resolutions of $\approx$ 2\dasec5 $\times$ 1\dasec3 and 0.27 \kms are reported. This follow-up observational study focuses on the recent discovery of a number of such OH maser features and their intense circularly polarized maser lines detected toward these Galactic center sources. The 1720 MHz maser line of OH arises from collisionally excited gas behind a C-type shock and is an important diagnostic of the interaction process that may occur between molecular clouds and associated X-ray emitting shell-type supernova remnants. The present observations have confirmed that the observed Stokes $V$ signal is due to Zeeman splitting and that the OH masers are angularly broadened by the scattering medium toward the Galactic center. The scale length of the magnetic field fluctuations in the scattering medium toward the Galactic center is estimated to be greater than 0.1-0.2 pc using the correlation of the position angles of the scatter-broadened maser spots. In addition, the kinematics of the maser spots associated with Sgr A East are used to place a 5 pc displacement between this extended radio structure and the Galactic center.Comment: 13 pages, 2 Tables and 2 figures, to be published in Ap

Hot gas and dust in a protostellar cluster near W3(OH

We used the IRAM Interferometer to obtain sub-arcsecond resolution observations of the high-mass star-forming region W3(OH) and its surroundings at a frequency of 220 GHz. With the improved angular resolution, we distinguish 3 peaks in the thermal dust continuum emission originating from the hot core region about 6 arcsec (0.06 pc) east of W3(OH). The dust emission peaks are coincident with known radio continuum sources, one of which is of non-thermal nature. The latter source is also at the center of expansion of a powerful bipolar outflow observed in water maser emission. We determine the hot core mass to be 15 solar masses based on the integrated dust continuum emission. Simultaneously many molecular lines are detected allowing the analysis of the temperature structure and the distribution of complex organic molecules in the hot core. From HNCO lines, spanning a wide range of excitation, two 200 K temperature peaks are found coincident with dust continuum emission peaks suggesting embedded heating sources within them.Comment: 12 pages, 3 figure

How many young star clusters exist in the Galactic center?

We study the evolution and observability of young compact star clusters within about 200pc of the Galactic center. Calculations are performed using direct N-body integration on the GRAPE-4, including the effects of both stellar and binary evolution and the external influence of the Galaxy. The results of these detailed calculations are used to calibrate a simplified model applicable over a wider range of cluster initial conditions. We find that clusters within 200 pc from the Galactic center dissolve within about 70 Myr. However, their projected densities drop below the background density in the direction of the Galactic center within 20 Myr, effectively making these clusters undetectable after that time. Clusters farther from the Galactic center but at the same projected distance are more strongly affected by this selection effect, and may go undetected for their entire lifetimes. Based on these findings, we conclude that the region within 200 pc of the Galactic center could easily harbor some 50 clusters with properties similar to those of the Arches or the Quintuplet systems.Comment: ApJ Letters in pres

The Stellar Winds of Galactic Centre and the Low Accretion Rate of Sgr A*

An attempt is made to reconcile the large wind-loss rates of stars in the Galactic Centre (GC) with the predicted low accretion rate for Sgr A*, the putative blackhole at the heart of the Milky Way. It is found that, independent of the details of the accretion, the bound but unaccreted gas has been accumulating in the potential well of Sgr A* for <1000 yrs and thus is not in equilibrium. Otherwise, the gas flows of the region would be visible in both the IR and X-ray. It appears that the blackhole was more active in the recent past due to the passing of a supernova blast shock but is presently in a short-lived dormant phase. The extended low frequency radio emission from the central parsec should visibily increase over the next few decades, as the shock passes completely in front of the absorbing gas and dust near Sgr A*. The GC may become more active in < 100,000 yrs due to either another supernova or sufficient accumulation of stellar winds in the central arcsecond.Comment: accepted by A&A Letter

Systemic Dissemination of Pneumocystis Carinii in a Patient with Acquired Immunodeficiency Syndrome

Pneumocystis carinii is usually considered a respiratory tract pathogen; however, there are reported cases of limited and generalized dissemination of the organism from the lungs of immunocompromised patients. We present the autopsy findings of a 29-year-old male with acquired immunodeficiency syndrome (AIDS) and recurrent Pneumocystis carinii pneumonia who developed abnormal liver function tests. The patient had received aerosolized pentamidine because of toxic reactions to other modes of therapy. The postmortem examination revealed Pneumocystis in the lungs, liver, spleen, kidney, myocardium, thymus, pancreas, thyroid gland, bilateral parathyroid and adrenal glands, gastrointestinal mucosa, perihilar and mesenteric lymph nodes, and bone marrow. A high index of suspicion, especially in patients treated with aerosolized pentamidine, may lead to an increased recognition of disseminated pneumocystosis. Dissemination of the infection may be due to failure of the aerosolized drug to achieve adequate blood levels. As AIDS patients survive longer because of the developing therapeutic arsenal, disseminated pneumocystosis may be encountered with increasing frequency in these immunocompromised patients

The Detection of Cold Dust in Cas A: Evidence for the Formation of Metallic Needles in the Ejecta

Recently, Dunne et al. (2003) obtained 450 and 850 micron SCUBA images of CasA, and reported the detection of 2-4 M_sun of cold, 18K, dust in the remnant. Here we show that their interpretation of the observations faces serious difficulties. Their inferred dust mass is larger than the mass of refractory material in the ejecta of a 10 to 30 M_sun star. The cold dust model faces even more difficulties if the 170 micron observations of the remnant are included in the analysis, decreasing the cold dust temperature to ~ 8K, and increasing its mass to > 20 M_sun. We offer here a more plausible interpretation of their observation, in which the cold dust emission is generated by conducting needles with properties that are completely determined by the combined submillimeter and X-ray observations of the remnant. The needles consist of metallic whiskers with <1% of embedded impurities that may have condensed out of blobs of material that were expelled at high velocities from the inner metal-rich layers of the star in an asymmetric explosion. The needles are collisionally heated by the shocked gas to a temperature of 8K. Taking the destruction of needles into account, a dust mass of only 1E-4 to 1E-3M_sun is needed to account for the observed SCUBA emission. Aligned in the magnetic field, needles may give rise to observable polarized emission. The detection of submillimeter polarization will therefore offer definitive proof for a needle origin for the cold dust emission. Supernovae may still be proven to be important sources of interstellar dust, but the evidence is still inconclusive.Comment: 18 pages including 4 figures. Accepted for publication in the ApJ. Missing reference adde

The Distance to the Soft Gamma Repeater SGR 1627-41

We report millimeter observations of the line of sight to the recently discovered Soft Gamma Repeater, SGR 1627-41, which has been tentatively associated with the supernova remnant SNR G337.0-0.1 Among the eight molecular clouds along the line of sight to SGR 1627-41, we show that SNR G337.0-0.1 is probably interacting with one of the most massive giant molecular clouds (GMC) in the Galaxy, at a distance of 11 kpc from the sun. Based on the high extinction to the persistent X-ray counterpart of SGR 1627-41, we present evidence for an association of this new SGR with the SNR G337.0-0.1; they both appear to be located on the near side of the GMC. This is the second SGR located near an extraordinarily massive GMC. We suggest that SGR 1627-41 is a neutron star with a high transverse velocity (~ 1,000 \kms) escaping the young (~ 5,000 years) supernova remnant G337.0-0.1Comment: 17 pages, including 2 figures. Accepted for publication in the Astrophysical Journal Letter

The Dynamics of Molecular Material Within 15 pcs of the Galactic Center

We report the results of a 5-field mosaic of the central 15pc of the Galaxy in the (1,1) and (2,2) lines of NH3. Two narrow filaments or streamers are seen running parallel to the Galactic plane. The southern streamer appears to carry gas directly toward the nuclear region from the 20 km/s cloud. The eastern streamer, which we will denote the molecular ridge, appears to be the denser part of the 50 km/s cloud which lies immediately east of the Sgr A East complex and extends in the south towards the 20 km/s cloud. This ridge of gas carries the kinematical signatures of interactions with Sgr A East as well as a SNR which lies south of the Galactic center. The bulk motion of the gas, the enhanced line widths, and the heating of the molecular material all suggest an active evolutionary phase for the gas immediately adjacent to the nucleus.Comment: 11 pages, 13 figures, to appear in The Astrophysical Journa