Diet in the Sardinian Bronze Age: models, collagen isotopic data, issues and perspectives

Traditional reconstructions depict Sardinian Bronze Age economy as a mixed one characterized by a remarkable importance of pastoralism, opposed to a more ‘agricultural’ Neolithic. The first few isotopic data, though not unambiguously, seem to indicate quite the opposite compared with earlier times, reflecting possibly a higher dependence on vegetal foods, with possible marginal contributions of aquatic foods and/or C4 plants at one coastal site. However, the importance of ecosystem-wide shifts in interpreting collagen data for comparative purposes is underlined, with specific examples from Sardinia, and so is the rarity of collections including faunal and botanical specimens alongside humans, which would help establish a local isotopic baseline. Efforts to discriminate animal vs. vegetal contributions in Bronze Age diets that are fully based on C3 ecosystems, therefore, remain tentative. Isotopic research in progress on Sardinian diet and climate from the Copper Age up to the Nuragic Late Bronze (2800-1100 BC) is expected to provide a better grasp on temporal and geographic variation.Les reconstitutions alimentaires traditionnelles dépeignent l’économie de l’âge du Bronze en Sardaigne comme une économie mixte caractérisée par une grande importance de l’élevage des moutons, juxtaposée à une période néolithique plus agricole. Les premières données isotopiques, bien que peu nombreuses encore, semblent, d’une façon ambigüe, plutôt indiquer le contraire lorsqu’on les compare aux données des périodes précédentes. Elles montrent une plus grande dépendance des aliments végétaux avec peut-être la contribution marginale d’aliments aquatiques et/ou des plantes issues du milieu côtier. Afin de palier le manque d’études sur les restes fauniques et botaniques et dans le but de réaliser des comparaisons à l’échelle de la Sardaigne, une analyse détaillée des données isotopiques des collagènes a été réalisée pour cerner l’importance de modifications isotopiques de l’écosystème tout entier. Une recherche en cours sur la diète et sur le climat dans la Sardaigne à partir du Néolithique jusqu’à l’âge du Fer (4700-500 avant J.C.) devrait permettre une meilleure interprétation de la variabilité isotopique d’un point de vue chronologique et géographique

Delta-Globin Gene Expression Is Enhanced in vivo by Interferon Type I

Beta hemoglobinopathies are widely spread monogenic lethal diseases. Delta-globin gene activation has been proposed as a possible approach for curing these pathologies. The therapeutic potential of delta-globin, the non-alpha component of Hemoglobin A2 (α2δ2; HbA2), has been demonstrated in a mouse model of beta thalassemia, while its anti-sickling effect, comparable to that of gamma globin, was established some time ago. Here we show that the delta-globin mRNA level is considerably increased in a Deoxyribonuclease II-alpha knockout mouse model in which type 1 interferon (interferon beta, IFNb) is activated. IFNb activation in the fetal liver improves the delta-globin mRNA level, while the beta-globin mRNA level is significantly reduced. In addition, we show that HbA2 is significantly increased in patients with multiple sclerosis under type 1 interferon treatment. Our results represent a proof of principle that delta-globin expression can be enhanced through the use of molecules. This observation is potentially interesting in view of a pharmacological approach able to increase the HbA2 level

La diète à l'âge du Bronze en Sardaigne : modèles, donnés isotopiques du collagène, problèmes et perspectives

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Authoritarian Neoliberalism and Democratic Backsliding in Turkey: Beyond the Narratives of Progress

Unpacking the core themes that are discussed in this collection, this article both offers a research agenda to re-analyse Turkey’s ‘authoritarian turn’ and mounts a methodological challenge to the conceptual frameworks that reinforce a strict analytical separation between the ‘economic’ and the ‘political’ factors. The paper problematises the temporal break in scholarly analyses of the AKP period and rejects the argument that the party’s methods of governance have shifted from an earlier ‘democratic’ model – defined by ‘hegemony’ – to an emergent ‘authoritarian’ one. In contrast, by retracing the mechanisms of the state-led reproduction of neoliberalism since 2003, the paper demonstrates that the party’s earlier ‘hegemonic’ activities were also shaped by authoritarian tendencies which manifested at various levels of governance

Ethiopian indigenous goats offer insights into past and recent demographic dynamics and localadaptation in sub-Saharan African goats

Abstract Knowledge on how adaptive evolution and human socio‐cultural and economic interests shaped livestock genomes particularly in sub‐Saharan Africa remains limited. Ethiopia is in a geographic region that has been critical in the history of African agriculture with ancient and diverse human ethnicity and bio‐climatic conditions. Using 52K genome‐wide data analysed in 646 individuals from 13 Ethiopian indigenous goat populations, we observed high levels of genetic variation. Although runs of homozygosity (ROH) were ubiquitous genome‐wide, there were clear differences in patterns of ROH length and abundance and in effective population sizes illustrating differences in genome homozygosity, evolutionary history, and management. Phylogenetic analysis incorporating patterns of genetic differentiation and gene flow with ancestry modelling highlighted past and recent intermixing and possible two deep ancient genetic ancestries that could have been brought by humans with the first introduction of goats in Africa. We observed four strong selection signatures that were specific to Arsi‐Bale and Nubian goats. These signatures overlapped genomic regions with genes associated with morphological, adaptation, reproduction and production traits due possibly to selection under environmental constraints and/or human preferences. The regions also overlapped uncharacterized genes, calling for a comprehensive annotation of the goat genome. Our results provide insights into mechanisms leading to genome variation and differentiation in sub‐Saharan Africa indigenous goats

Analysis of genome-wide DNA arrays reveals the genomic population structure and diversity in autochthonous Greek goat breeds

Goats play an important role in the livestock sector in Greece. The national herd consists mainly of two indigenous breeds, the Eghoria and Skopelos. Here, we report the population structure and genomic profiles of these two native goat breeds using Illumina's Goat SNP50 BeadChip. Moreover, we present a panel of candidate markers acquired using different genetic models for breed discrimination. Quality control on the initial dataset resulted in 48,841 SNPs kept for downstream analysis. Principal component and admixture analyses were applied to assess population structure. The rate of inbreeding within breed was evaluated based on the distribution of runs of homozygosity in the genome and respective coefficients, the genomic relationship matrix, the patterns of linkage disequilibrium, and the historic effective population size. Results showed that both breeds exhibit high levels of genetic diversity. Level of inbreeding between the two breeds estimated by the Wright's fixation index FST was low (Fst = 0.04362), indicating the existence of a weak genetic differentiation between them. In addition, grouping of farms according to their geographical locations was observed. This study presents for the first time a genome-based analysis on the genetic structure of the two indigenous Greek goat breeds and identifies markers that can be potentially exploited in future selective breeding programs for traceability purposes, targeted genetic improvement schemes and conservation strategies

New trends in cellulitis

Cellulitis is a severe infection of the soft tissues, with a variable aetiology from Gram-positive to Gram-negative bacteria and deep fungal infections, whose early recognition is mandatory to avoid potentially life threatening complications. Some pathogens might cause very similar clinical entities, and cellulitis differentiation at presentation towards abscess, necrotising fasciitis, and gangrene, requires expertise. Many mimics are also to be excluded, conditioning the treatment and patient’s prognosis. The dermatologist is in a lead position to avoid misdiagnosis, to evaluate the type of assessment, and address initial treatment. Besides, skin and soft tissue infections are a common reason for emergency room visits and hospital admission, lacking precise clinical definition and managed with empirical antibiotic treatments. History, physical examination and laboratory data can help characterise the severity of the disease, and the probability of complications development, mainly necrotising fasciitis. Several admittance scores have been proposed to address the emergency decisions, and guidelines for treatment proposed. The present review will focus on clinical challenges