Intra-accumbens Microinfusion of the Dopamine D3 Receptor Partial Agonist (±)VK4-40 Does Not Affect Basal Locomotion in Mice

The opioid epidemic remains a pressing public health crisis, prompting the search for alternative pharmacotherapies for Opioid Use Disorder (OUD). This study explores the potential of the dopamine D3 receptor (D3R) partial agonist, (±)VK4-40, as a novel treatment option. We investigated the impact of intra-nucleus accumbens (NAc) microinfusion of VK4-40 on basal locomotion in mice. Results indicate that VK4-40 did not significantly alter basal locomotion, suggesting that its therapeutic effects may not be mediated through disruptions in generalized motor function. Future research will focus on elucidating the neuropharmacological mechanisms underlying VK4-40\u27s therapeutic actions and exploring its effects on psychostimulant-induced hyperlocomotion. These findings provide valuable insights into potential D3R-targeted pharmacotherapies for managing OUD

A lichen protected by a super-hydrophobic and breathable structure

A species of lichen, Lecanora conizaeoides, is shown to be super-hydrophobic. It uses a combination of hydrophobic compounds and multi-layered roughness to shed water effectively. This is combined with gas channels to produce a biological analogue of a waterproof, breathable garment. The particular lichen grows mostly during wet seasons and is unusually resistant to acid rain [Hauck, M., 2003. The Bryotogist 106(2), 257-269; Honegger, R., 1998. Lichenologist 30(3),193-212]. The waterproof, breathable surface allows this lichen to photosynthesise when other species are covered with a layer of water. In addition, rainwater runs off the surface of the organism, reducing its intake of water from above and probably contributing to its resistance to acid rain

Pregnancy experiences of Western Australian women attending a specialist childbirth and mental illness antenatal clinic

Our purpose was to explore the pregnancy experiences of Australian women attending a specialized Childbirth and Mental Illness (CAMI) antenatal clinic. A qualitative exploratory design was selected to give voice to women with a severe mental illness receiving antenatal care. Telephone interviews with 41 women, 24 primiparous and 17 multiparous, were analysed using thematic analysis. Three themes emerged: ‘Building relationships’, ‘Acknowledged me as a person with special needs’ and ‘Respect and understanding without stigma’. Findings offer insight into care experiences possible within a multidisciplinary model developed to addresses psychiatric and obstetric needs of pregnant women with severe mental illness

Wave propagation in axion electrodynamics

In this paper, the axion contribution to the electromagnetic wave propagation is studied. First we show how the axion electrodynamics model can be embedded into a premetric formalism of Maxwell electrodynamics. In this formalism, the axion field is not an arbitrary added Chern-Simon term of the Lagrangian, but emerges in a natural way as an irreducible part of a general constitutive tensor.We show that in order to represent the axion contribution to the wave propagation it is necessary to go beyond the geometric approximation, which is usually used in the premetric formalism. We derive a covariant dispersion relation for the axion modified electrodynamics. The wave propagation in this model is studied for an axion field with timelike, spacelike and null derivative covectors. The birefringence effect emerges in all these classes as a signal of Lorentz violation. This effect is however completely different from the ordinary birefringence appearing in classical optics and in premetric electrodynamics. The axion field does not simple double the ordinary light cone structure. In fact, it modifies the global topological structure of light cones surfaces. In CFJ-electrodynamics, such a modification results in violation of causality. In addition, the optical metrics in axion electrodynamics are not pseudo-Riemannian. In fact, for all types of the axion field, they are even non-Finslerian

Evaluating GAIA performances on eclipsing binaries. I. Orbits and stellar parameters for V505 Per, V570 Per and OO Peg

The orbits and physical parameters of three detached, double-lined A-F eclipsing binaries have been derived combining H_P, V_T, B_T photometry from the Hipparcos/Tycho mission with 8500-8750 Ang ground-based spectroscopy, mimicking the photometric+spectroscopic observations that should be obtained by GAIA, the approved Cornerstone 6 mission by ESA. This study has two main objectives, namely (a) to derive reasonable orbits for a number of new eclipsing binaries and (b) to evaluate the expected performances by GAIA on eclipsing binaries and the accuracy achievable on the determination of fundamental stellar parameters like masses and radii. It is shown that a 1% precision in the basic stellar parameters can be achieved by GAIA on well observed detached eclipsing binaries provided that the spectroscopic observations are performed at high enough resolution. Other types of eclipsing binaries (including semi-detached and contact types) and different spectral types will be investigated in following papers along this series.Comment: A&A, 11 pages, 5 figures, 5 table

A convolution of observational and model data to estimate age of air spectra in the northern hemispheric lower stratosphere

Derivation of mean age of air (AoA) and age spectra from atmospheric measurements remains a challenge and often requires output from atmospheric models. This study tries to minimize the direct influence of model output and presents an extension and application of a previously established inversion method to derive age spectra from mixing ratios of long- and short-lived trace gases. For a precise description of cross-tropopause transport processes, the inverse method is extended to incorporate air entrainment into the stratosphere across the tropical and extratropical tropopause. We first use simulations with the Chemical Lagrangian Model of the Stratosphere (CLaMS) to provide a general proof of concept of the extended principle in a controllable and consistent environment, where the method is applied to an idealized set of 10 trace gases with predefined constant lifetimes and compared to reference model age spectra. In the second part of the study we apply the extended inverse method to atmospheric measurements of multiple long- and short-lived trace gases measured aboard the High Altitude and Long Range (HALO) research aircraft during the two research campaigns POLSTRACC–GW-LCYCLE–SALSA (PGS) and Wave-driven Isentropic Exchange (WISE). As some of the observed species undergo significant loss processes in the stratosphere, a Monte Carlo simulation is introduced to retrieve age spectra and chemical lifetimes in stepwise fashion and to account for the large uncertainties. Results show that in the idealized model scenario the inverse method retrieves age spectra robustly on annual and seasonal scales. The extension to multiple entry regions proves reasonable as our CLaMS simulations reveal that in the model between 50 % and 70 % of air in the lowermost stratosphere has entered through the extratropical tropopause (30–90∘ N and S) on annual average. When applied to observational data of PGS and WISE, the method derives age spectra and mean AoA with meaningful spatial distributions and quantitative range, yet large uncertainties. Results indicate that entrainment of fresh tropospheric air across both the extratropical and tropical tropopause peaked prior to both campaigns, but with lower mean AoA for WISE than PGS data. The ratio of moments for all retrieved age spectra for PGS and WISE is found to range between 0.52 and 2.81 years. We conclude that the method derives reasonable and consistent age spectra using observations of chemically active trace gases. Our findings might contribute to an improved assessment of transport with age spectra in future studies